ES2118955T3 - Derivados de dolastatina. - Google Patents
Derivados de dolastatina.Info
- Publication number
- ES2118955T3 ES2118955T3 ES93909931T ES93909931T ES2118955T3 ES 2118955 T3 ES2118955 T3 ES 2118955T3 ES 93909931 T ES93909931 T ES 93909931T ES 93909931 T ES93909931 T ES 93909931T ES 2118955 T3 ES2118955 T3 ES 2118955T3
- Authority
- ES
- Spain
- Prior art keywords
- dolastatin derivatives
- dolastatin
- novel
- derivatives
- derivates
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Genetics & Genomics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
SE DESCRIBEN NUEVOS DERIVADOS DE DOLASTATINA DE FORMULA (I), EN LA QUE R1, R2, A, B, D, E, F, G, K, X, T, U, V, Y W TIENEN LOS SIGNIFICADOS ESTABLECIDOS EN LA DESCRIPCION, Y LA PREPARACION DE LOS MISMOS. LAS SUSTANCIAS NUEVAS TIENEN UN EFECTO ANTINEOPLASTICO.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US88578892A | 1992-05-20 | 1992-05-20 | |
US98569692A | 1992-11-25 | 1992-11-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2118955T3 true ES2118955T3 (es) | 1998-10-01 |
Family
ID=27128772
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES93909931T Expired - Lifetime ES2118955T3 (es) | 1992-05-20 | 1993-05-10 | Derivados de dolastatina. |
Country Status (21)
Country | Link |
---|---|
EP (1) | EP0642530B1 (es) |
JP (2) | JP3523253B2 (es) |
KR (1) | KR100286242B1 (es) |
CN (1) | CN1065874C (es) |
AT (1) | ATE169637T1 (es) |
AU (1) | AU669710B2 (es) |
CA (1) | CA2136339C (es) |
CZ (1) | CZ292612B6 (es) |
DE (1) | DE69320339T2 (es) |
DK (1) | DK0642530T3 (es) |
ES (1) | ES2118955T3 (es) |
FI (1) | FI120692B (es) |
HU (2) | HUT71398A (es) |
IL (1) | IL105651A (es) |
MX (1) | MX9302927A (es) |
NO (1) | NO310465B1 (es) |
NZ (1) | NZ252147A (es) |
RU (1) | RU2116312C1 (es) |
SI (1) | SI9300267A (es) |
UA (1) | UA45304C2 (es) |
WO (1) | WO1993023424A1 (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5831002A (en) * | 1992-05-20 | 1998-11-03 | Basf Aktiengesellschaft | Antitumor peptides |
DE4415997A1 (de) * | 1994-05-06 | 1995-11-09 | Basf Ag | Neuer peptidischer Wirkstoff und dessen Herstellung |
DE4415998A1 (de) * | 1994-05-06 | 1995-11-09 | Basf Ag | Neue Tetrapeptide, ihre Herstellung Verwendung |
DE19527574A1 (de) * | 1995-07-28 | 1997-01-30 | Basf Ag | Verfahren zur Herstellung vona-(N,N-Dialkyl)-aminocaarbonsäureamiden |
DE19527575A1 (de) * | 1995-07-28 | 1997-01-30 | Basf Ag | Verfahren zur Herstellung von peptidischer Wirkstoffe |
US5807984A (en) * | 1995-11-09 | 1998-09-15 | Basf Aktienegesellschaft | Oligopeptides, the preparation and use thereof |
TW474946B (en) * | 1995-12-15 | 2002-02-01 | Basf Ag | Novel compounds, the preparation and use thereof |
AU775090B2 (en) * | 1995-12-15 | 2004-07-15 | Abbvie Deutschland Gmbh & Co Kg | Antineoplastic peptides |
US20010009901A1 (en) | 1996-12-11 | 2001-07-26 | Basf Aktiengesellschaft Germany | Antineoplastic peptides |
US5741892A (en) * | 1996-07-30 | 1998-04-21 | Basf Aktiengesellschaft | Pentapeptides as antitumor agents |
US5939527A (en) * | 1996-07-30 | 1999-08-17 | Basf Aktiengesellschaft | Tetrapeptides as antitumor agents |
US5965537A (en) * | 1997-03-10 | 1999-10-12 | Basf Aktiengesellschaft | Dolastatin 15 derivatives with carbonyl and heterocyclic functionalities at the C-terminus |
US6143721A (en) | 1997-07-18 | 2000-11-07 | Basf Aktiengesellschaft | Dolastatin 15 derivatives |
WO1999015130A2 (en) * | 1997-09-24 | 1999-04-01 | ARIZONA BOARD OF REGENTS, actingon behalf of ARIZ ONA STATE UNIVERSITY | Synthetic antineoplastic agents derived from dolastatin 15 and methods of making same |
US6686445B1 (en) | 1997-09-24 | 2004-02-03 | Arizona Board Of Regents, Acting For And On Behalf Of Arizona State University | Synthetic antineoplastic agents derived from dolastatin 15 and methods of making same |
US5985837A (en) * | 1998-07-08 | 1999-11-16 | Basf Aktiengesellschaft | Dolastatin 15 derivatives |
ATE415413T1 (de) | 2002-07-15 | 2008-12-15 | Univ Princeton | Iap-bindende verbindungen |
ATE412409T1 (de) | 2003-11-24 | 2008-11-15 | Teva Gyogyszergyar Zartkoeruee | Verfahren zur reinigung von pravastatin |
WO2023033129A1 (ja) | 2021-09-03 | 2023-03-09 | 東レ株式会社 | 癌の治療及び/又は予防用医薬組成物 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4879278A (en) * | 1989-05-16 | 1989-11-07 | Arizona Board Of Regents | Isolation and structural elucidation of the cytostatic linear depsipeptide dolastatin 15 |
ATE190983T1 (de) * | 1991-08-09 | 2000-04-15 | Teikoku Hormone Mfg Co Ltd | Neue tetrapeptidderivate |
-
1993
- 1993-05-10 RU RU94046434A patent/RU2116312C1/ru active
- 1993-05-10 CA CA002136339A patent/CA2136339C/en not_active Expired - Lifetime
- 1993-05-10 DE DE69320339T patent/DE69320339T2/de not_active Expired - Lifetime
- 1993-05-10 KR KR1019940704157A patent/KR100286242B1/ko not_active IP Right Cessation
- 1993-05-10 UA UA94129207A patent/UA45304C2/uk unknown
- 1993-05-10 AU AU40662/93A patent/AU669710B2/en not_active Expired
- 1993-05-10 AT AT93909931T patent/ATE169637T1/de active
- 1993-05-10 HU HU9403320A patent/HUT71398A/hu unknown
- 1993-05-10 WO PCT/EP1993/001138 patent/WO1993023424A1/en active IP Right Grant
- 1993-05-10 ES ES93909931T patent/ES2118955T3/es not_active Expired - Lifetime
- 1993-05-10 NZ NZ252147A patent/NZ252147A/en not_active IP Right Cessation
- 1993-05-10 DK DK93909931T patent/DK0642530T3/da active
- 1993-05-10 CZ CZ19942843A patent/CZ292612B6/cs not_active IP Right Cessation
- 1993-05-10 IL IL10565193A patent/IL105651A/en not_active IP Right Cessation
- 1993-05-10 EP EP93909931A patent/EP0642530B1/en not_active Expired - Lifetime
- 1993-05-10 JP JP51985193A patent/JP3523253B2/ja not_active Expired - Lifetime
- 1993-05-19 MX MX9302927A patent/MX9302927A/es unknown
- 1993-05-20 SI SI9300267A patent/SI9300267A/sl unknown
- 1993-05-20 CN CN93107702A patent/CN1065874C/zh not_active Expired - Lifetime
-
1994
- 1994-11-17 FI FI945416A patent/FI120692B/fi not_active IP Right Cessation
- 1994-11-18 NO NO19944419A patent/NO310465B1/no not_active IP Right Cessation
-
1995
- 1995-06-30 HU HU95P/P00711P patent/HU211745A9/hu unknown
-
2003
- 2003-11-13 JP JP2003384393A patent/JP2004149538A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
KR100286242B1 (ko) | 2001-04-16 |
IL105651A0 (en) | 1993-09-22 |
HU211745A9 (en) | 1995-12-28 |
NO944419D0 (no) | 1994-11-18 |
CN1065874C (zh) | 2001-05-16 |
RU94046434A (ru) | 1996-10-27 |
FI945416A0 (fi) | 1994-11-17 |
AU669710B2 (en) | 1996-06-20 |
CZ284394A3 (en) | 1995-05-17 |
DK0642530T3 (da) | 1998-10-26 |
CN1085563A (zh) | 1994-04-20 |
EP0642530B1 (en) | 1998-08-12 |
JPH07506580A (ja) | 1995-07-20 |
HUT71398A (en) | 1995-11-28 |
RU2116312C1 (ru) | 1998-07-27 |
IL105651A (en) | 1998-07-15 |
SI9300267A (sl) | 1993-12-31 |
WO1993023424A1 (en) | 1993-11-25 |
CA2136339A1 (en) | 1993-11-25 |
NO944419L (no) | 1995-01-09 |
EP0642530A1 (en) | 1995-03-15 |
JP3523253B2 (ja) | 2004-04-26 |
DE69320339T2 (de) | 1998-12-17 |
NZ252147A (en) | 1996-10-28 |
NO310465B1 (no) | 2001-07-09 |
CZ292612B6 (cs) | 2003-11-12 |
MX9302927A (es) | 1993-11-01 |
FI945416A (fi) | 1994-11-17 |
DE69320339D1 (de) | 1998-09-17 |
UA45304C2 (uk) | 2002-04-15 |
ATE169637T1 (de) | 1998-08-15 |
AU4066293A (en) | 1993-12-13 |
FI120692B (fi) | 2010-01-29 |
JP2004149538A (ja) | 2004-05-27 |
CA2136339C (en) | 2008-02-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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