NO310465B1 - Peptider med anticancer aktivitet og farmasöytisk blanding derav - Google Patents
Peptider med anticancer aktivitet og farmasöytisk blanding derav Download PDFInfo
- Publication number
- NO310465B1 NO310465B1 NO19944419A NO944419A NO310465B1 NO 310465 B1 NO310465 B1 NO 310465B1 NO 19944419 A NO19944419 A NO 19944419A NO 944419 A NO944419 A NO 944419A NO 310465 B1 NO310465 B1 NO 310465B1
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- alkoxy
- phenoxy
- nitro
- halogen
- Prior art date
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- 108090000765 processed proteins & peptides Proteins 0.000 title claims description 92
- 239000000203 mixture Substances 0.000 title claims description 18
- 230000001093 anti-cancer Effects 0.000 title claims description 4
- 102000004196 processed proteins & peptides Human genes 0.000 title description 12
- -1 allo-isoleuccyl Chemical group 0.000 claims description 124
- 229910052736 halogen Inorganic materials 0.000 claims description 55
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- 125000001424 substituent group Chemical group 0.000 claims description 55
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 54
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- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 43
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 27
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- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims description 25
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 6
- 125000004014 thioethyl group Chemical group [H]SC([H])([H])C([H])([H])* 0.000 claims description 6
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- 125000002373 5 membered heterocyclic group Chemical group 0.000 claims description 2
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- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims description 2
- 125000002947 alkylene group Chemical group 0.000 claims description 2
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- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 claims description 2
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- 125000003983 fluorenyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3CC12)* 0.000 claims description 2
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88578892A | 1992-05-20 | 1992-05-20 | |
| US98569692A | 1992-11-25 | 1992-11-25 | |
| PCT/EP1993/001138 WO1993023424A1 (en) | 1992-05-20 | 1993-05-10 | Derivatives of dolastatin |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO944419D0 NO944419D0 (no) | 1994-11-18 |
| NO944419L NO944419L (no) | 1995-01-09 |
| NO310465B1 true NO310465B1 (no) | 2001-07-09 |
Family
ID=27128772
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19944419A NO310465B1 (no) | 1992-05-20 | 1994-11-18 | Peptider med anticancer aktivitet og farmasöytisk blanding derav |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP0642530B1 (es) |
| JP (2) | JP3523253B2 (es) |
| KR (1) | KR100286242B1 (es) |
| CN (1) | CN1065874C (es) |
| AT (1) | ATE169637T1 (es) |
| AU (1) | AU669710B2 (es) |
| CA (1) | CA2136339C (es) |
| CZ (1) | CZ292612B6 (es) |
| DE (1) | DE69320339T2 (es) |
| DK (1) | DK0642530T3 (es) |
| ES (1) | ES2118955T3 (es) |
| FI (1) | FI120692B (es) |
| HU (2) | HUT71398A (es) |
| IL (1) | IL105651A (es) |
| MX (1) | MX9302927A (es) |
| NO (1) | NO310465B1 (es) |
| NZ (1) | NZ252147A (es) |
| RU (1) | RU2116312C1 (es) |
| SI (1) | SI9300267A (es) |
| UA (1) | UA45304C2 (es) |
| WO (1) | WO1993023424A1 (es) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5831002A (en) * | 1992-05-20 | 1998-11-03 | Basf Aktiengesellschaft | Antitumor peptides |
| DE4415997A1 (de) * | 1994-05-06 | 1995-11-09 | Basf Ag | Neuer peptidischer Wirkstoff und dessen Herstellung |
| DE4415998A1 (de) * | 1994-05-06 | 1995-11-09 | Basf Ag | Neue Tetrapeptide, ihre Herstellung Verwendung |
| DE19527575A1 (de) * | 1995-07-28 | 1997-01-30 | Basf Ag | Verfahren zur Herstellung von peptidischer Wirkstoffe |
| DE19527574A1 (de) * | 1995-07-28 | 1997-01-30 | Basf Ag | Verfahren zur Herstellung vona-(N,N-Dialkyl)-aminocaarbonsäureamiden |
| US5807984A (en) * | 1995-11-09 | 1998-09-15 | Basf Aktienegesellschaft | Oligopeptides, the preparation and use thereof |
| AU775090B2 (en) * | 1995-12-15 | 2004-07-15 | Abbvie Deutschland Gmbh & Co Kg | Antineoplastic peptides |
| TW474946B (en) * | 1995-12-15 | 2002-02-01 | Basf Ag | Novel compounds, the preparation and use thereof |
| US20010009901A1 (en) | 1996-12-11 | 2001-07-26 | Basf Aktiengesellschaft Germany | Antineoplastic peptides |
| US5741892A (en) * | 1996-07-30 | 1998-04-21 | Basf Aktiengesellschaft | Pentapeptides as antitumor agents |
| US5939527A (en) * | 1996-07-30 | 1999-08-17 | Basf Aktiengesellschaft | Tetrapeptides as antitumor agents |
| US5965537A (en) * | 1997-03-10 | 1999-10-12 | Basf Aktiengesellschaft | Dolastatin 15 derivatives with carbonyl and heterocyclic functionalities at the C-terminus |
| US6143721A (en) * | 1997-07-18 | 2000-11-07 | Basf Aktiengesellschaft | Dolastatin 15 derivatives |
| US6686445B1 (en) | 1997-09-24 | 2004-02-03 | Arizona Board Of Regents, Acting For And On Behalf Of Arizona State University | Synthetic antineoplastic agents derived from dolastatin 15 and methods of making same |
| EP1049481B1 (en) * | 1997-09-24 | 2005-04-20 | Arizona Board Of Regents | Synthetic antineoplastic agents derived from dolastatin 15 and methods of making same |
| US5985837A (en) * | 1998-07-08 | 1999-11-16 | Basf Aktiengesellschaft | Dolastatin 15 derivatives |
| ES2318167T3 (es) * | 2002-07-15 | 2009-05-01 | The Trustees Of Princeton University | Compuestos de union a iap. |
| DE04811862T1 (de) | 2003-11-24 | 2006-03-02 | Teva Gyogyszergyar Reszvenytarsasag | Verfahren zur Reinigung von Pravastatin |
| CA3230737A1 (en) | 2021-09-03 | 2023-03-09 | Toray Industries, Inc. | Pharmaceutical composition for cancer treatment and/or prevention |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816444A (en) * | 1987-07-10 | 1989-03-28 | Arizona Board Of Regents, Arizona State University | Cell growth inhibitory substance |
| US4879278A (en) * | 1989-05-16 | 1989-11-07 | Arizona Board Of Regents | Isolation and structural elucidation of the cytostatic linear depsipeptide dolastatin 15 |
| KR0185440B1 (ko) * | 1991-08-09 | 1999-04-01 | 야마구찌 다까시 | 신규의 테트라 펩티트 유도체 |
-
1993
- 1993-05-10 RU RU94046434A patent/RU2116312C1/ru active
- 1993-05-10 IL IL10565193A patent/IL105651A/en not_active IP Right Cessation
- 1993-05-10 HU HU9403320A patent/HUT71398A/hu unknown
- 1993-05-10 WO PCT/EP1993/001138 patent/WO1993023424A1/en not_active Ceased
- 1993-05-10 NZ NZ252147A patent/NZ252147A/en not_active IP Right Cessation
- 1993-05-10 AU AU40662/93A patent/AU669710B2/en not_active Expired
- 1993-05-10 DE DE69320339T patent/DE69320339T2/de not_active Expired - Lifetime
- 1993-05-10 ES ES93909931T patent/ES2118955T3/es not_active Expired - Lifetime
- 1993-05-10 AT AT93909931T patent/ATE169637T1/de active
- 1993-05-10 CZ CZ19942843A patent/CZ292612B6/cs not_active IP Right Cessation
- 1993-05-10 DK DK93909931T patent/DK0642530T3/da active
- 1993-05-10 KR KR1019940704157A patent/KR100286242B1/ko not_active Expired - Lifetime
- 1993-05-10 EP EP93909931A patent/EP0642530B1/en not_active Expired - Lifetime
- 1993-05-10 CA CA002136339A patent/CA2136339C/en not_active Expired - Lifetime
- 1993-05-10 JP JP51985193A patent/JP3523253B2/ja not_active Expired - Lifetime
- 1993-05-10 UA UA94129207A patent/UA45304C2/uk unknown
- 1993-05-19 MX MX9302927A patent/MX9302927A/es unknown
- 1993-05-20 CN CN93107702A patent/CN1065874C/zh not_active Expired - Lifetime
- 1993-05-20 SI SI9300267A patent/SI9300267A/sl unknown
-
1994
- 1994-11-17 FI FI945416A patent/FI120692B/fi not_active IP Right Cessation
- 1994-11-18 NO NO19944419A patent/NO310465B1/no not_active IP Right Cessation
-
1995
- 1995-06-30 HU HU95P/P00711P patent/HU211745A9/hu unknown
-
2003
- 2003-11-13 JP JP2003384393A patent/JP2004149538A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| SI9300267A (sl) | 1993-12-31 |
| JP3523253B2 (ja) | 2004-04-26 |
| HU211745A9 (en) | 1995-12-28 |
| ES2118955T3 (es) | 1998-10-01 |
| NZ252147A (en) | 1996-10-28 |
| JPH07506580A (ja) | 1995-07-20 |
| RU94046434A (ru) | 1996-10-27 |
| EP0642530B1 (en) | 1998-08-12 |
| CZ292612B6 (cs) | 2003-11-12 |
| FI120692B (fi) | 2010-01-29 |
| CA2136339A1 (en) | 1993-11-25 |
| HUT71398A (en) | 1995-11-28 |
| AU669710B2 (en) | 1996-06-20 |
| UA45304C2 (uk) | 2002-04-15 |
| ATE169637T1 (de) | 1998-08-15 |
| EP0642530A1 (en) | 1995-03-15 |
| MX9302927A (es) | 1993-11-01 |
| NO944419D0 (no) | 1994-11-18 |
| KR100286242B1 (ko) | 2001-04-16 |
| AU4066293A (en) | 1993-12-13 |
| DE69320339D1 (de) | 1998-09-17 |
| NO944419L (no) | 1995-01-09 |
| DK0642530T3 (da) | 1998-10-26 |
| CN1085563A (zh) | 1994-04-20 |
| IL105651A0 (en) | 1993-09-22 |
| CN1065874C (zh) | 2001-05-16 |
| JP2004149538A (ja) | 2004-05-27 |
| WO1993023424A1 (en) | 1993-11-25 |
| FI945416L (fi) | 1994-11-17 |
| IL105651A (en) | 1998-07-15 |
| FI945416A0 (fi) | 1994-11-17 |
| RU2116312C1 (ru) | 1998-07-27 |
| CA2136339C (en) | 2008-02-05 |
| CZ284394A3 (en) | 1995-05-17 |
| DE69320339T2 (de) | 1998-12-17 |
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Legal Events
| Date | Code | Title | Description |
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| MK1K | Patent expired |