DE69320339D1 - Derivate des Dolastatin - Google Patents

Derivate des Dolastatin

Info

Publication number
DE69320339D1
DE69320339D1 DE69320339T DE69320339T DE69320339D1 DE 69320339 D1 DE69320339 D1 DE 69320339D1 DE 69320339 T DE69320339 T DE 69320339T DE 69320339 T DE69320339 T DE 69320339T DE 69320339 D1 DE69320339 D1 DE 69320339D1
Authority
DE
Germany
Prior art keywords
dolastatin
derivatives
novel
derivates
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69320339T
Other languages
English (en)
Other versions
DE69320339T2 (de
Inventor
Andreas Haupt
Franz Emling
Cynthia Romerdahl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF SE
Original Assignee
BASF SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BASF SE filed Critical BASF SE
Publication of DE69320339D1 publication Critical patent/DE69320339D1/de
Application granted granted Critical
Publication of DE69320339T2 publication Critical patent/DE69320339T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE69320339T 1992-05-20 1993-05-10 Derivate des Dolastatin Expired - Lifetime DE69320339T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US88578892A 1992-05-20 1992-05-20
US98569692A 1992-11-25 1992-11-25
PCT/EP1993/001138 WO1993023424A1 (en) 1992-05-20 1993-05-10 Derivatives of dolastatin

Publications (2)

Publication Number Publication Date
DE69320339D1 true DE69320339D1 (de) 1998-09-17
DE69320339T2 DE69320339T2 (de) 1998-12-17

Family

ID=27128772

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69320339T Expired - Lifetime DE69320339T2 (de) 1992-05-20 1993-05-10 Derivate des Dolastatin

Country Status (21)

Country Link
EP (1) EP0642530B1 (de)
JP (2) JP3523253B2 (de)
KR (1) KR100286242B1 (de)
CN (1) CN1065874C (de)
AT (1) ATE169637T1 (de)
AU (1) AU669710B2 (de)
CA (1) CA2136339C (de)
CZ (1) CZ292612B6 (de)
DE (1) DE69320339T2 (de)
DK (1) DK0642530T3 (de)
ES (1) ES2118955T3 (de)
FI (1) FI120692B (de)
HU (2) HUT71398A (de)
IL (1) IL105651A (de)
MX (1) MX9302927A (de)
NO (1) NO310465B1 (de)
NZ (1) NZ252147A (de)
RU (1) RU2116312C1 (de)
SI (1) SI9300267A (de)
UA (1) UA45304C2 (de)
WO (1) WO1993023424A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5831002A (en) * 1992-05-20 1998-11-03 Basf Aktiengesellschaft Antitumor peptides
DE4415997A1 (de) * 1994-05-06 1995-11-09 Basf Ag Neuer peptidischer Wirkstoff und dessen Herstellung
DE4415998A1 (de) * 1994-05-06 1995-11-09 Basf Ag Neue Tetrapeptide, ihre Herstellung Verwendung
DE19527575A1 (de) * 1995-07-28 1997-01-30 Basf Ag Verfahren zur Herstellung von peptidischer Wirkstoffe
DE19527574A1 (de) * 1995-07-28 1997-01-30 Basf Ag Verfahren zur Herstellung vona-(N,N-Dialkyl)-aminocaarbonsäureamiden
US5807984A (en) * 1995-11-09 1998-09-15 Basf Aktienegesellschaft Oligopeptides, the preparation and use thereof
AU775090B2 (en) * 1995-12-15 2004-07-15 Abbvie Deutschland Gmbh & Co Kg Antineoplastic peptides
US20010009901A1 (en) 1996-12-11 2001-07-26 Basf Aktiengesellschaft Germany Antineoplastic peptides
TW474946B (en) * 1995-12-15 2002-02-01 Basf Ag Novel compounds, the preparation and use thereof
US5939527A (en) * 1996-07-30 1999-08-17 Basf Aktiengesellschaft Tetrapeptides as antitumor agents
US5741892A (en) * 1996-07-30 1998-04-21 Basf Aktiengesellschaft Pentapeptides as antitumor agents
US5965537A (en) * 1997-03-10 1999-10-12 Basf Aktiengesellschaft Dolastatin 15 derivatives with carbonyl and heterocyclic functionalities at the C-terminus
US6143721A (en) * 1997-07-18 2000-11-07 Basf Aktiengesellschaft Dolastatin 15 derivatives
US6686445B1 (en) 1997-09-24 2004-02-03 Arizona Board Of Regents, Acting For And On Behalf Of Arizona State University Synthetic antineoplastic agents derived from dolastatin 15 and methods of making same
ATE293638T1 (de) * 1997-09-24 2005-05-15 Univ Arizona Synthetische antineoplastische wirkstoffe abgeleitet von dolastatin 15 sowie verfahren zu ihrer herstellung
US5985837A (en) * 1998-07-08 1999-11-16 Basf Aktiengesellschaft Dolastatin 15 derivatives
WO2004007529A2 (en) * 2002-07-15 2004-01-22 The Trustees Of Princeton University Iap binding compounds
DE04811862T1 (de) 2003-11-24 2006-03-02 Teva Gyogyszergyar Reszvenytarsasag Verfahren zur Reinigung von Pravastatin
JPWO2023033129A1 (de) 2021-09-03 2023-03-09

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4879278A (en) * 1989-05-16 1989-11-07 Arizona Board Of Regents Isolation and structural elucidation of the cytostatic linear depsipeptide dolastatin 15
EP0934950B1 (de) * 1991-08-09 2002-04-10 Teikoku Hormone Mfg. Co., Ltd. Tetrapeptide Derivat

Also Published As

Publication number Publication date
JP3523253B2 (ja) 2004-04-26
WO1993023424A1 (en) 1993-11-25
DK0642530T3 (da) 1998-10-26
RU94046434A (ru) 1996-10-27
RU2116312C1 (ru) 1998-07-27
IL105651A0 (en) 1993-09-22
CZ292612B6 (cs) 2003-11-12
EP0642530B1 (de) 1998-08-12
JPH07506580A (ja) 1995-07-20
UA45304C2 (uk) 2002-04-15
DE69320339T2 (de) 1998-12-17
FI945416A (fi) 1994-11-17
EP0642530A1 (de) 1995-03-15
FI120692B (fi) 2010-01-29
CN1065874C (zh) 2001-05-16
NO310465B1 (no) 2001-07-09
NO944419L (no) 1995-01-09
ES2118955T3 (es) 1998-10-01
FI945416A0 (fi) 1994-11-17
NO944419D0 (no) 1994-11-18
CA2136339A1 (en) 1993-11-25
KR100286242B1 (ko) 2001-04-16
HUT71398A (en) 1995-11-28
HU211745A9 (en) 1995-12-28
NZ252147A (en) 1996-10-28
AU669710B2 (en) 1996-06-20
ATE169637T1 (de) 1998-08-15
JP2004149538A (ja) 2004-05-27
MX9302927A (es) 1993-11-01
SI9300267A (sl) 1993-12-31
CN1085563A (zh) 1994-04-20
CZ284394A3 (en) 1995-05-17
CA2136339C (en) 2008-02-05
IL105651A (en) 1998-07-15
AU4066293A (en) 1993-12-13

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: BASF SE, 67063 LUDWIGSHAFEN, DE