ES2118677T3 - Una composicion que comprende un agente activo disuelto en un vehiculo formador de vidrio y un procedimiento para su preparacion. - Google Patents
Una composicion que comprende un agente activo disuelto en un vehiculo formador de vidrio y un procedimiento para su preparacion.Info
- Publication number
- ES2118677T3 ES2118677T3 ES96921197T ES96921197T ES2118677T3 ES 2118677 T3 ES2118677 T3 ES 2118677T3 ES 96921197 T ES96921197 T ES 96921197T ES 96921197 T ES96921197 T ES 96921197T ES 2118677 T3 ES2118677 T3 ES 2118677T3
- Authority
- ES
- Spain
- Prior art keywords
- active agent
- composition
- glass
- pct
- procedure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000013543 active substance Substances 0.000 title abstract 5
- 239000000203 mixture Substances 0.000 title abstract 5
- 238000000034 method Methods 0.000 title 1
- 238000007496 glass forming Methods 0.000 abstract 4
- 239000004014 plasticizer Substances 0.000 abstract 3
- 239000000126 substance Substances 0.000 abstract 2
- 238000000354 decomposition reaction Methods 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Glass Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Processing Of Solid Wastes (AREA)
- Medicines Containing Plant Substances (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Abstract
FORMULACION BIOLOGICAMENTE ACTIVA COMPUESTA DE UNA SOLUCION DE UN AGENTE ACTIVO DISUELTO EN UN VEHICULO VITRIFICANTE, QUE CONTIENE UNA SUSTANCIA VITRIFICANTE (A) CON UN PLASTIFICANTE (B) CUYA CANTIDAD DEBE SELECCIONARSE PREFERIBLEMENTE DE FORMA QUE LA FORMULACION ADQUIERA UNA CONSISTENCIA NO SOLIDA. LA FORMULACION PUEDE PREPARARSE DISOLVIENDO EL AGENTE ACTIVO EN UNA MEZCLA FUNDIDA DE LA SUSTANCIA VITRIFICANTE Y EL PLASTIFICANTE A UNA TEMPERATURA INFERIOR A LA TEMPERATURA DE DESINTEGRACION DEL AGENTE ACTIVO REFERIDO. UTILIZACION DEL VEHICULO VITRIFICANTE PARA LA DISOLUCION DE UN AGENTE BIOLOGICAMENTE ACTIVO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9502244A SE9502244D0 (sv) | 1995-06-20 | 1995-06-20 | A composition and a process for the preparation thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2118677T1 ES2118677T1 (es) | 1998-10-01 |
| ES2118677T3 true ES2118677T3 (es) | 2001-10-16 |
Family
ID=20398685
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES96921197T Expired - Lifetime ES2118677T3 (es) | 1995-06-20 | 1996-06-19 | Una composicion que comprende un agente activo disuelto en un vehiculo formador de vidrio y un procedimiento para su preparacion. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6083518A (es) |
| EP (1) | EP0833611B1 (es) |
| JP (1) | JP4020331B2 (es) |
| AT (1) | ATE204466T1 (es) |
| AU (1) | AU695622B2 (es) |
| CA (1) | CA2225286C (es) |
| DE (2) | DE833611T1 (es) |
| DK (1) | DK0833611T3 (es) |
| ES (1) | ES2118677T3 (es) |
| NZ (1) | NZ311208A (es) |
| PT (1) | PT833611E (es) |
| SE (1) | SE9502244D0 (es) |
| WO (1) | WO1997000670A1 (es) |
| ZA (1) | ZA965237B (es) |
Families Citing this family (92)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6136814A (en) * | 1997-12-08 | 2000-10-24 | Fujisawa Usa, Inc. | Aqueous acyclovir product |
| SE9801704D0 (sv) * | 1998-05-14 | 1998-05-14 | Bioglan Ab | Biologically active composition |
| SE9801705D0 (sv) * | 1998-05-14 | 1998-05-14 | Bioglan Ab | Biologically active composition |
| AU7604400A (en) * | 1999-09-21 | 2001-04-24 | Emory University | Methods and compositions for treating platelet-related disorders using mpl pathway inhibitory agents |
| US7364752B1 (en) | 1999-11-12 | 2008-04-29 | Abbott Laboratories | Solid dispersion pharamaceutical formulations |
| EP1175205B1 (en) * | 1999-11-12 | 2006-06-14 | Abbott Laboratories | Solid dispersion comprising ritonavir, fenofibrate or griseofulvin |
| DE10026698A1 (de) | 2000-05-30 | 2001-12-06 | Basf Ag | Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung |
| JP4512700B2 (ja) * | 2003-06-02 | 2010-07-28 | トーアエイヨー株式会社 | アシクロビル含有水溶液製剤 |
| US8025899B2 (en) | 2003-08-28 | 2011-09-27 | Abbott Laboratories | Solid pharmaceutical dosage form |
| US8377952B2 (en) | 2003-08-28 | 2013-02-19 | Abbott Laboratories | Solid pharmaceutical dosage formulation |
| US20050101605A1 (en) * | 2003-11-07 | 2005-05-12 | Ahmed Salah U. | Oral liquid formulations of methotrexate |
| WO2005113147A2 (en) | 2004-04-08 | 2005-12-01 | Biomatrica, Inc. | Integration of sample storage and sample management for life science |
| CN101583620B (zh) | 2005-11-28 | 2016-08-17 | 马里纳斯医药公司 | 加奈索酮组合物及其制备和使用方法 |
| GB2432528B (en) * | 2005-11-29 | 2011-04-06 | Ian Ripley | Anti-viral compositions comprising flavanone glycosides and fruit acids |
| JP5184342B2 (ja) | 2006-03-08 | 2013-04-17 | 日本農薬株式会社 | 外用の医薬組成物 |
| PL2005958T3 (pl) * | 2006-03-08 | 2013-11-29 | Nihon Nohyaku Co Ltd | Kompozycja farmaceutyczna do stosowania zewnętrznego |
| JP5184341B2 (ja) * | 2006-03-08 | 2013-04-17 | 日本農薬株式会社 | 外用の医薬組成物 |
| MX2008015599A (es) | 2006-06-14 | 2009-03-06 | Reddys Lab Ltd Dr | Composiciones topicas. |
| EA018573B1 (ru) | 2006-09-22 | 2013-09-30 | Фармасайкликс, Инк. | Ингибиторы тирозинкиназы брутона |
| KR100721126B1 (ko) | 2006-12-28 | 2007-05-23 | (주)바이오앤에이치엔티 | 모기 기피제 조성물 |
| WO2009031643A1 (ja) | 2007-09-05 | 2009-03-12 | Pola Pharma Inc. | 抗真菌組成物 |
| US20100204293A1 (en) * | 2007-09-05 | 2010-08-12 | Pola Pharma Inc. | Pharmaceutical composition |
| HUE030028T2 (en) * | 2007-09-05 | 2017-04-28 | Pola Pharma Inc | Antifungal drug |
| US8263641B2 (en) | 2007-09-10 | 2012-09-11 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
| JP5421901B2 (ja) | 2008-03-31 | 2014-02-19 | 国立大学法人広島大学 | エンテロウイルス属の非エンベロープウイルスに対する抗ウイルス剤および抗ウイルス用組成物 |
| GB2462022B (en) | 2008-06-16 | 2011-05-25 | Biovascular Inc | Controlled release compositions of agents that reduce circulating levels of platelets and methods thereof |
| EP2321303B1 (en) | 2008-08-27 | 2019-11-27 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
| HUE032022T2 (en) | 2009-01-09 | 2017-08-28 | Egyt Gyogyszervegyeszeti Gyar | Medicinal product with improved effect |
| EP2395839B1 (en) | 2009-02-13 | 2014-05-07 | Topica Pharmaceuticals, Inc | Anti-fungal formulation |
| EP2416757A2 (en) | 2009-04-09 | 2012-02-15 | Pola Pharma Inc. | Antimycotic pharmaceutical composition |
| JP5688406B2 (ja) | 2009-04-09 | 2015-03-25 | 株式会社ポーラファルマ | 抗真菌医薬組成物 |
| EP2470178B1 (en) | 2009-08-25 | 2018-10-17 | Pola Pharma Inc. | Antimycotic pharmaceutical composition |
| US7741330B1 (en) | 2009-10-12 | 2010-06-22 | Pharmacyclics, Inc. | Pyrazolo-pyrimidine inhibitors of Bruton's tyrosine kinase |
| EP2558866B1 (en) | 2010-04-15 | 2016-08-17 | Tracon Pharmaceuticals, Inc. | Potentiation of anti-cancer activity through combination therapy with ber pathway inhibitors |
| WO2011139489A2 (en) | 2010-04-27 | 2011-11-10 | Calcimedica Inc. | Compounds that modulate intracellular calcium |
| JP2013525448A (ja) | 2010-04-27 | 2013-06-20 | カルシメディカ,インク. | 細胞内カルシウムを調節する化合物 |
| EP2598661B1 (en) | 2010-07-26 | 2017-09-27 | Biomatrica, INC. | Compositions for stabilizing dna, rna and proteins in saliva and other biological samples during shipping and storage at ambient temperatures |
| WO2012018638A2 (en) | 2010-07-26 | 2012-02-09 | Biomatrica, Inc. | Compositions for stabilizing dna, rna and proteins in blood and other biological samples during shipping and storage at ambient temperatures |
| AU2011293201B2 (en) | 2010-08-27 | 2015-11-05 | Calcimedica Inc. | Compounds that modulate intracellular calcium |
| US8377946B1 (en) | 2011-12-30 | 2013-02-19 | Pharmacyclics, Inc. | Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors |
| WO2014059333A1 (en) | 2012-10-12 | 2014-04-17 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
| EP2934572A4 (en) | 2012-12-20 | 2016-11-23 | Biomatrica Inc | FORMULATIONS AND METHODS FOR STABILIZING PCR REAGENTS |
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| EP3331522A1 (en) | 2015-08-07 | 2018-06-13 | Patara Pharma LLC | Methods for the treatment of mast cell related disorders with mast cell stabilizers |
| US10265296B2 (en) | 2015-08-07 | 2019-04-23 | Respivant Sciences Gmbh | Methods for the treatment of systemic disorders treatable with mast cell stabilizers, including mast cell related disorders |
| JP6827048B2 (ja) | 2015-12-08 | 2021-02-10 | バイオマトリカ,インク. | 赤血球沈降速度の低下 |
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| CA3024556A1 (en) | 2016-05-12 | 2017-11-16 | The Regents Of The University Of Michigan | Ash1l inhibitors and methods of treatment therewith |
| EP3463576A4 (en) | 2016-05-25 | 2020-01-15 | Concentric Analgesics, Inc. | PRODRUGS BY PHENOLIC TRPV1 AGONISTS IN COMBINATION WITH LOCAL ANESTHETIC AND VASOCONSTRICTORS FOR IMPROVED LOCAL ANESTHESIA |
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| WO2017205769A1 (en) | 2016-05-27 | 2017-11-30 | Pharmacyclics Llc | Inhibitors of interleukin-1 receptor-associated kinase |
| WO2017205762A1 (en) | 2016-05-27 | 2017-11-30 | Pharmacyclics Llc | Inhibitors of interleukin-1 receptor-associated kinase |
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| CN110139646A (zh) | 2016-08-31 | 2019-08-16 | 瑞思皮万特科学有限责任公司 | 用于治疗由特发性肺纤维化引起的慢性咳嗽的色甘酸组合物 |
| WO2018067341A1 (en) | 2016-10-07 | 2018-04-12 | Patara Pharma, LLC | Cromolyn compositions for treatment of pulmonary fibrosis |
| WO2019094434A1 (en) | 2017-11-07 | 2019-05-16 | The Regents Of The University Of Michigan | Therapeutic combination for treatment of cerebellar ataxia |
| JP2021502388A (ja) | 2017-11-10 | 2021-01-28 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | Ash1l阻害剤及びそれを用いた治療方法 |
| WO2019113469A1 (en) | 2017-12-07 | 2019-06-13 | The Regents Of The University Of Michigan | Nsd family inhibitors and methods of treatment therewith |
| US11685722B2 (en) | 2018-02-28 | 2023-06-27 | Curtana Pharmaceuticals, Inc. | Inhibition of Olig2 activity |
| US11319302B2 (en) | 2018-06-07 | 2022-05-03 | The Regents Of The University Of Michigan | PRC1 inhibitors and methods of treatment therewith |
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| GB2591681A (en) | 2018-08-29 | 2021-08-04 | Ftf Pharma Private Ltd | Methotrexate pharmaceutical composition |
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| US12251405B2 (en) | 2018-10-03 | 2025-03-18 | Myos Corp. | Spray dried follistatin product |
| NL2021864B1 (en) * | 2018-10-24 | 2020-05-13 | Seranovo B V | Deep Eutectic Solvent Platform for Oral Pharmaceutical Formulations |
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| WO2020096660A1 (en) | 2018-11-06 | 2020-05-14 | Myos Rens Technology, Inc. | Methods and compositions for improving skeletal muscle protein fractional synthetic rate |
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| SG11202109899VA (en) | 2019-03-15 | 2021-10-28 | Unicycive Therapeutics Inc | Nicorandil derivatives |
| CN116113406B (zh) | 2020-07-10 | 2025-08-29 | 密歇根大学董事会 | Gas41抑制剂及其使用方法 |
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| AU2022325861A1 (en) | 2021-08-11 | 2024-02-29 | Biomea Fusion, Inc. | Covalent inhibitors of menin-mll interaction for diabetes mellitus |
| WO2023027966A1 (en) | 2021-08-24 | 2023-03-02 | Biomea Fusion, Inc. | Pyrazine compounds as irreversible inhibitors of flt3 |
| US20240409558A1 (en) | 2021-09-13 | 2024-12-12 | Biomea Fusion, Inc. | Irreversible inhibitors of kras |
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| JP2025502748A (ja) | 2021-12-30 | 2025-01-28 | バイオメア フュージョン,インコーポレイテッド | Flt3の阻害剤としてのピラジン化合物 |
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| EP4604978A2 (en) | 2022-10-19 | 2025-08-27 | Myos Corp. | Myogenic compounds |
| US20250002458A1 (en) | 2023-05-24 | 2025-01-02 | Unicycive Therapeutics Inc. | Salt forms of nicorandil derivative |
| WO2024249950A1 (en) | 2023-06-02 | 2024-12-05 | Biomea Fusion, Inc. | Fused pyrimidine compounds as inhibitors of menin |
| US20250145571A1 (en) | 2023-09-26 | 2025-05-08 | Unicycive Therapeutics, Inc. | Amino acid prodrugs of nicorandil |
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Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US33221A (en) * | 1861-09-03 | Improvement in soap | ||
| US4151273A (en) * | 1974-10-31 | 1979-04-24 | The Regents Of The University Of California | Increasing the absorption rate of insoluble drugs |
| USRE33221E (en) | 1982-04-29 | 1990-05-22 | American Dental Association Health Foundation | Dental restorative cement pastes |
| US5389677B1 (en) * | 1986-12-23 | 1997-07-15 | Tristrata Inc | Method of treating wrinkles using glycalic acid |
| EP0319988A1 (en) * | 1987-12-09 | 1989-06-14 | Showa Denko Kabushiki Kaisha | External dermatological composition |
| US5215757A (en) * | 1991-03-22 | 1993-06-01 | The Procter & Gamble Company | Encapsulated materials |
| US5162117A (en) * | 1991-11-22 | 1992-11-10 | Schering Corporation | Controlled release flutamide composition |
| WO1993011749A1 (en) * | 1991-12-18 | 1993-06-24 | Warner-Lambert Company | A process for the preparation of a solid dispersion |
| US5340591A (en) * | 1992-01-24 | 1994-08-23 | Fujisawa Pharmaceutical Co., Ltd. | Method of producing a solid dispersion of the sparingly water-soluble drug, nilvadipine |
-
1995
- 1995-06-20 SE SE9502244A patent/SE9502244D0/xx unknown
-
1996
- 1996-06-19 PT PT96921197T patent/PT833611E/pt unknown
- 1996-06-19 EP EP96921197A patent/EP0833611B1/en not_active Expired - Lifetime
- 1996-06-19 AT AT96921197T patent/ATE204466T1/de active
- 1996-06-19 US US08/973,902 patent/US6083518A/en not_active Expired - Lifetime
- 1996-06-19 AU AU62473/96A patent/AU695622B2/en not_active Expired
- 1996-06-19 DK DK96921197T patent/DK0833611T3/da active
- 1996-06-19 NZ NZ311208A patent/NZ311208A/xx not_active IP Right Cessation
- 1996-06-19 ES ES96921197T patent/ES2118677T3/es not_active Expired - Lifetime
- 1996-06-19 WO PCT/SE1996/000806 patent/WO1997000670A1/en not_active Ceased
- 1996-06-19 DE DE0833611T patent/DE833611T1/de active Pending
- 1996-06-19 CA CA002225286A patent/CA2225286C/en not_active Expired - Lifetime
- 1996-06-19 DE DE69614689T patent/DE69614689T2/de not_active Expired - Lifetime
- 1996-06-19 JP JP50378997A patent/JP4020331B2/ja not_active Expired - Lifetime
- 1996-06-20 ZA ZA965237A patent/ZA965237B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA965237B (en) | 1997-01-09 |
| ES2118677T1 (es) | 1998-10-01 |
| DE833611T1 (de) | 1999-01-07 |
| SE9502244D0 (sv) | 1995-06-20 |
| US6083518A (en) | 2000-07-04 |
| JP4020331B2 (ja) | 2007-12-12 |
| JPH11508250A (ja) | 1999-07-21 |
| ATE204466T1 (de) | 2001-09-15 |
| CA2225286A1 (en) | 1997-01-09 |
| WO1997000670A1 (en) | 1997-01-09 |
| DK0833611T3 (da) | 2001-10-08 |
| AU6247396A (en) | 1997-01-22 |
| HK1008774A1 (en) | 1999-05-21 |
| EP0833611B1 (en) | 2001-08-22 |
| CA2225286C (en) | 2003-06-10 |
| DE69614689D1 (de) | 2001-09-27 |
| AU695622B2 (en) | 1998-08-20 |
| PT833611E (pt) | 2002-01-30 |
| NZ311208A (en) | 1999-03-29 |
| EP0833611A1 (en) | 1998-04-08 |
| DE69614689T2 (de) | 2002-06-27 |
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