ES2118677T3 - Una composicion que comprende un agente activo disuelto en un vehiculo formador de vidrio y un procedimiento para su preparacion. - Google Patents
Una composicion que comprende un agente activo disuelto en un vehiculo formador de vidrio y un procedimiento para su preparacion.Info
- Publication number
- ES2118677T3 ES2118677T3 ES96921197T ES96921197T ES2118677T3 ES 2118677 T3 ES2118677 T3 ES 2118677T3 ES 96921197 T ES96921197 T ES 96921197T ES 96921197 T ES96921197 T ES 96921197T ES 2118677 T3 ES2118677 T3 ES 2118677T3
- Authority
- ES
- Spain
- Prior art keywords
- active agent
- composition
- glass
- pct
- procedure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
Abstract
FORMULACION BIOLOGICAMENTE ACTIVA COMPUESTA DE UNA SOLUCION DE UN AGENTE ACTIVO DISUELTO EN UN VEHICULO VITRIFICANTE, QUE CONTIENE UNA SUSTANCIA VITRIFICANTE (A) CON UN PLASTIFICANTE (B) CUYA CANTIDAD DEBE SELECCIONARSE PREFERIBLEMENTE DE FORMA QUE LA FORMULACION ADQUIERA UNA CONSISTENCIA NO SOLIDA. LA FORMULACION PUEDE PREPARARSE DISOLVIENDO EL AGENTE ACTIVO EN UNA MEZCLA FUNDIDA DE LA SUSTANCIA VITRIFICANTE Y EL PLASTIFICANTE A UNA TEMPERATURA INFERIOR A LA TEMPERATURA DE DESINTEGRACION DEL AGENTE ACTIVO REFERIDO. UTILIZACION DEL VEHICULO VITRIFICANTE PARA LA DISOLUCION DE UN AGENTE BIOLOGICAMENTE ACTIVO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9502244A SE9502244D0 (sv) | 1995-06-20 | 1995-06-20 | A composition and a process for the preparation thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2118677T1 ES2118677T1 (es) | 1998-10-01 |
ES2118677T3 true ES2118677T3 (es) | 2001-10-16 |
Family
ID=20398685
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES96921197T Expired - Lifetime ES2118677T3 (es) | 1995-06-20 | 1996-06-19 | Una composicion que comprende un agente activo disuelto en un vehiculo formador de vidrio y un procedimiento para su preparacion. |
Country Status (15)
Country | Link |
---|---|
US (1) | US6083518A (es) |
EP (1) | EP0833611B1 (es) |
JP (1) | JP4020331B2 (es) |
AT (1) | ATE204466T1 (es) |
AU (1) | AU695622B2 (es) |
CA (1) | CA2225286C (es) |
DE (2) | DE833611T1 (es) |
DK (1) | DK0833611T3 (es) |
ES (1) | ES2118677T3 (es) |
HK (1) | HK1008774A1 (es) |
NZ (1) | NZ311208A (es) |
PT (1) | PT833611E (es) |
SE (1) | SE9502244D0 (es) |
WO (1) | WO1997000670A1 (es) |
ZA (1) | ZA965237B (es) |
Families Citing this family (87)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6136814A (en) * | 1997-12-08 | 2000-10-24 | Fujisawa Usa, Inc. | Aqueous acyclovir product |
SE9801704D0 (sv) * | 1998-05-14 | 1998-05-14 | Bioglan Ab | Biologically active composition |
SE9801705D0 (sv) * | 1998-05-14 | 1998-05-14 | Bioglan Ab | Biologically active composition |
AU7604400A (en) * | 1999-09-21 | 2001-04-24 | Emory University | Methods and compositions for treating platelet-related disorders using mpl pathway inhibitory agents |
DE60028754T2 (de) * | 1999-11-12 | 2007-05-31 | Abbott Laboratories, Abbott Park | Feste dispersion mit ritonavir, fenofibrat oder griseofulvin |
US7364752B1 (en) | 1999-11-12 | 2008-04-29 | Abbott Laboratories | Solid dispersion pharamaceutical formulations |
DE10026698A1 (de) | 2000-05-30 | 2001-12-06 | Basf Ag | Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung |
JP4512700B2 (ja) * | 2003-06-02 | 2010-07-28 | トーアエイヨー株式会社 | アシクロビル含有水溶液製剤 |
US8025899B2 (en) | 2003-08-28 | 2011-09-27 | Abbott Laboratories | Solid pharmaceutical dosage form |
US8377952B2 (en) * | 2003-08-28 | 2013-02-19 | Abbott Laboratories | Solid pharmaceutical dosage formulation |
US20050101605A1 (en) * | 2003-11-07 | 2005-05-12 | Ahmed Salah U. | Oral liquid formulations of methotrexate |
KR101228356B1 (ko) | 2004-04-08 | 2013-02-05 | 바이오매트리카 인코포레이티드 | 생명과학용 시료 보관 및 시료 관리의 통합 |
ES2812250T3 (es) | 2005-11-28 | 2021-03-16 | Marinus Pharmaceuticals Inc | Formulaciones de ganaxolona y procedimientos para la preparación y uso de las mismas |
GB2432528B (en) * | 2005-11-29 | 2011-04-06 | Ian Ripley | Anti-viral compositions comprising flavanone glycosides and fruit acids |
NZ571819A (en) * | 2006-03-08 | 2011-04-29 | Nihon Nohyaku Co Ltd | External pharmaceutical composition comprising luliconazole and either N-methyl-2-pyrrolidone, propylene carbonate or crotamiton |
US8268876B2 (en) * | 2006-03-08 | 2012-09-18 | Nihon Nohyaku Co., Ltd. | Pharmaceutical composition for external use |
US8058303B2 (en) | 2006-03-08 | 2011-11-15 | Nihon Nohyaku Co, Ltd | Pharmaceutical composition for external use |
MX2008015599A (es) * | 2006-06-14 | 2009-03-06 | Reddys Lab Ltd Dr | Composiciones topicas. |
HUE031334T2 (hu) | 2006-09-22 | 2017-07-28 | Pharmacyclics Llc | Bruton-tirozinkináz inhibitorok |
KR100721126B1 (ko) | 2006-12-28 | 2007-05-23 | (주)바이오앤에이치엔티 | 모기 기피제 조성물 |
EP2191826B1 (en) * | 2007-09-05 | 2017-03-08 | Pola Pharma Inc. | Pharmaceutical composition |
PL2191828T3 (pl) * | 2007-09-05 | 2017-02-28 | Pola Pharma Inc. | Przeciwgrzybicza kompozycja farmaceutyczna |
WO2009031643A1 (ja) | 2007-09-05 | 2009-03-12 | Pola Pharma Inc. | 抗真菌組成物 |
WO2009035818A1 (en) | 2007-09-10 | 2009-03-19 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
CA2719358C (en) * | 2008-03-31 | 2017-10-24 | Altan Co., Ltd. | Antiviral agent and antiviral composition |
GB2460915B (en) | 2008-06-16 | 2011-05-25 | Biovascular Inc | Controlled release compositions of agents that reduce circulating levels of platelets and methods therefor |
US7981925B2 (en) | 2008-08-27 | 2011-07-19 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
EA021943B1 (ru) * | 2009-01-09 | 2015-10-30 | Эгиш Дьёдьсердьяр Ньильваношан Мюкеде Ресвеньтаршашаг | Способ изготовления вагинального суппозитория |
CA2752557A1 (en) * | 2009-02-13 | 2010-08-19 | Topica Pharmaceuticals, Inc. | Anti-fungal formulation |
CN102387786B (zh) | 2009-04-09 | 2015-09-09 | 宝丽制药股份有限公司 | 抗真菌药物组合物 |
JP5688405B2 (ja) | 2009-04-09 | 2015-03-25 | 株式会社ポーラファルマ | 抗真菌医薬組成物 |
KR101754697B1 (ko) | 2009-08-25 | 2017-07-06 | 가부시키가이샤 폴라 파마 | 항진균성 약제학적 조성물 |
US7718662B1 (en) | 2009-10-12 | 2010-05-18 | Pharmacyclics, Inc. | Pyrazolo-pyrimidine inhibitors of bruton's tyrosine kinase |
WO2011130689A1 (en) | 2010-04-15 | 2011-10-20 | Tracon Pharmaceuticals, Inc. | Potentiation of anti-cancer activity through combination therapy with ber pathway inhibitors |
HUE029570T2 (en) | 2010-04-27 | 2017-03-28 | Calcimedica Inc | Intracellular calcium modifying compounds |
US8754219B2 (en) | 2010-04-27 | 2014-06-17 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
CA2806670A1 (en) | 2010-07-26 | 2012-02-09 | Biomatrica, Inc. | Compositions for stabilizing dna, rna and proteins in blood and other biological samples during shipping and storage at ambient temperatures |
EP2598661B1 (en) | 2010-07-26 | 2017-09-27 | Biomatrica, INC. | Compositions for stabilizing dna, rna and proteins in saliva and other biological samples during shipping and storage at ambient temperatures |
CA2809830C (en) | 2010-08-27 | 2019-09-10 | Calcimedica, Inc. | Compounds comprising n-acyl-2-amino-1,3-thiazole for modulating intracellular calcium |
US8377946B1 (en) | 2011-12-30 | 2013-02-19 | Pharmacyclics, Inc. | Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors |
WO2014059333A1 (en) | 2012-10-12 | 2014-04-17 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
EP2934572A4 (en) | 2012-12-20 | 2016-11-23 | Biomatrica Inc | FORMULATIONS AND METHODS FOR STABILIZING PCR REAGENTS |
US9611263B2 (en) | 2013-10-08 | 2017-04-04 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
US9382246B2 (en) | 2013-12-05 | 2016-07-05 | Pharmacyclics Llc | Inhibitors of Bruton's tyrosine kinase |
CA2938996A1 (en) | 2014-02-10 | 2015-08-13 | Patara Pharma, LLC | Methods for the treatment of lung diseases with mast cell stabilizers |
CA2938994A1 (en) | 2014-02-10 | 2015-08-13 | Patara Pharma, LLC | Inhalable formulations of sodium cromolyn with improved bioavailability |
WO2015164213A1 (en) | 2014-04-23 | 2015-10-29 | The Research Foundation For The State University Of New York | A rapid and efficient bioorthogonal ligation reaction and boron-containing heterocycles useful in conjuction therewith |
EP3154338B1 (en) | 2014-06-10 | 2020-01-29 | Biomatrica, INC. | Stabilization of thrombocytes at ambient temperatures |
US9839644B2 (en) | 2014-09-09 | 2017-12-12 | ARKAY Therapeutics, LLC | Formulations and methods for treatment of metabolic syndrome |
US9359316B1 (en) | 2014-11-25 | 2016-06-07 | Concentric Analgesics, Inc. | Prodrugs of phenolic TRPV1 agonists |
US10227333B2 (en) | 2015-02-11 | 2019-03-12 | Curtana Pharmaceuticals, Inc. | Inhibition of OLIG2 activity |
US20180244631A1 (en) | 2015-02-27 | 2018-08-30 | Curtana Pharmaceuticals, Inc. | Inhibition of olig2 activity |
US10265296B2 (en) | 2015-08-07 | 2019-04-23 | Respivant Sciences Gmbh | Methods for the treatment of systemic disorders treatable with mast cell stabilizers, including mast cell related disorders |
US10238625B2 (en) | 2015-08-07 | 2019-03-26 | Respivant Sciences Gmbh | Methods for the treatment of mast cell related disorders with mast cell stabilizers |
KR20230145258A (ko) | 2015-12-08 | 2023-10-17 | 바이오매트리카 인코포레이티드 | 적혈구 침강 속도의 감소 |
US10851123B2 (en) | 2016-02-23 | 2020-12-01 | Concentric Analgesics, Inc. | Prodrugs of phenolic TRPV1 agonists |
JP2019516700A (ja) | 2016-05-12 | 2019-06-20 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | Ash1l阻害剤及びそれを用いた治療方法 |
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JP2019528320A (ja) | 2016-08-31 | 2019-10-10 | レシュピファント サイエンシス ゲゼルシャフト ミット ベシュレンクター ハフトゥングRespivant Sciences Gmbh | 特発性肺線維症による慢性咳の治療のためのクロモリン組成物 |
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EP3706867A4 (en) | 2017-11-07 | 2021-08-11 | The Regents Of The University Of Michigan | THERAPEUTIC COMBINATION FOR TREATMENT OF CEREBELLIC ATAXIA |
JP7424637B2 (ja) | 2017-11-10 | 2024-01-30 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | Ash1l分解剤及びそれを用いた治療方法 |
JP7414282B2 (ja) | 2017-12-07 | 2024-01-16 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | Nsdファミリー阻害物質及びそれによる治療の方法 |
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CN112533581A (zh) | 2018-06-07 | 2021-03-19 | 密歇根大学董事会 | Prc1抑制剂及用其进行治疗的方法 |
TW202019887A (zh) | 2018-07-27 | 2020-06-01 | 美商同心止痛劑股份有限公司 | 酚系trpv1促效劑之聚乙二醇化前藥 |
WO2020044114A2 (en) | 2018-08-29 | 2020-03-05 | Ftf Pharma Private Limited | Methotrexate pharmaceutical composition |
US20200069742A1 (en) | 2018-08-29 | 2020-03-05 | Myos Rens Technology Inc. | Methods for alleviating, inhibiting or reversing muscle disuse atrophy in mammals |
US20200108102A1 (en) | 2018-10-03 | 2020-04-09 | Myos Rens Technology Inc. | Spray dried follistatin product |
WO2020085904A2 (en) | 2018-10-24 | 2020-04-30 | SeraNovo B.V. | Deep eutectic solvent platform for oral pharmaceutical formulations |
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US10925904B2 (en) | 2018-11-06 | 2021-02-23 | Myos Rens Technology, Inc. | Methods and compositions for improving skeletal muscle protein fractional synthetic rate |
JP2022516057A (ja) | 2018-12-31 | 2022-02-24 | バイオメア フュージョン,エルエルシー | メニン-mll相互作用の不可逆的阻害剤 |
WO2020160113A1 (en) | 2019-02-01 | 2020-08-06 | Myos Rens Technology Inc. | Egg yolk powder for improving quality of life and increasing activity in aging and chronically ill mammals |
KR20220009373A (ko) | 2019-03-15 | 2022-01-24 | 유니사이시브 테라퓨틱스 인코포레이티드 | 니코란딜 유도체 |
CA3185209A1 (en) | 2020-07-10 | 2021-01-27 | Alyssa WINKLER | Gas41 inhibitors and methods of use thereof |
CA3202151A1 (en) | 2020-12-16 | 2022-06-23 | Biomea Fusion, Inc. | Fused pyrimidine compounds as inhibitors of menin-mll interaction |
TW202320796A (zh) | 2021-08-11 | 2023-06-01 | 美商拜歐米富士恩股份有限公司 | 用於糖尿病的menin-mll相互作用之共價抑制劑 |
WO2023027966A1 (en) | 2021-08-24 | 2023-03-02 | Biomea Fusion, Inc. | Pyrazine compounds as irreversible inhibitors of flt3 |
WO2023039240A1 (en) | 2021-09-13 | 2023-03-16 | Biomea Fusion, Inc. | IRREVERSIBLE INHIBITORS OF KRas |
WO2023086341A1 (en) | 2021-11-09 | 2023-05-19 | Biomea Fusion, Inc. | Inhibitors of kras |
TW202340177A (zh) | 2021-12-30 | 2023-10-16 | 美商拜歐米富士恩股份有限公司 | 作為 flt3抑制劑之吡嗪化合物 |
WO2023235618A1 (en) | 2022-06-03 | 2023-12-07 | Biomea Fusion, Inc. | Fused pyrimidine compounds as inhibitors of menin |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US33221A (en) * | 1861-09-03 | Improvement in soap | ||
US4151273A (en) * | 1974-10-31 | 1979-04-24 | The Regents Of The University Of California | Increasing the absorption rate of insoluble drugs |
USRE33221E (en) | 1982-04-29 | 1990-05-22 | American Dental Association Health Foundation | Dental restorative cement pastes |
US5389677B1 (en) * | 1986-12-23 | 1997-07-15 | Tristrata Inc | Method of treating wrinkles using glycalic acid |
EP0319988A1 (en) * | 1987-12-09 | 1989-06-14 | Showa Denko Kabushiki Kaisha | External dermatological composition |
US5215757A (en) * | 1991-03-22 | 1993-06-01 | The Procter & Gamble Company | Encapsulated materials |
US5162117A (en) * | 1991-11-22 | 1992-11-10 | Schering Corporation | Controlled release flutamide composition |
ES2109377T3 (es) * | 1991-12-18 | 1998-01-16 | Warner Lambert Co | Proceso para la preparacion de una dispersion solida. |
US5340591A (en) * | 1992-01-24 | 1994-08-23 | Fujisawa Pharmaceutical Co., Ltd. | Method of producing a solid dispersion of the sparingly water-soluble drug, nilvadipine |
-
1995
- 1995-06-20 SE SE9502244A patent/SE9502244D0/xx unknown
-
1996
- 1996-06-19 PT PT96921197T patent/PT833611E/pt unknown
- 1996-06-19 AT AT96921197T patent/ATE204466T1/de active
- 1996-06-19 AU AU62473/96A patent/AU695622B2/en not_active Expired
- 1996-06-19 ES ES96921197T patent/ES2118677T3/es not_active Expired - Lifetime
- 1996-06-19 WO PCT/SE1996/000806 patent/WO1997000670A1/en active IP Right Grant
- 1996-06-19 NZ NZ311208A patent/NZ311208A/xx not_active IP Right Cessation
- 1996-06-19 US US08/973,902 patent/US6083518A/en not_active Expired - Lifetime
- 1996-06-19 DK DK96921197T patent/DK0833611T3/da active
- 1996-06-19 DE DE0833611T patent/DE833611T1/de active Pending
- 1996-06-19 JP JP50378997A patent/JP4020331B2/ja not_active Expired - Lifetime
- 1996-06-19 EP EP96921197A patent/EP0833611B1/en not_active Expired - Lifetime
- 1996-06-19 DE DE69614689T patent/DE69614689T2/de not_active Expired - Lifetime
- 1996-06-19 CA CA002225286A patent/CA2225286C/en not_active Expired - Lifetime
- 1996-06-20 ZA ZA965237A patent/ZA965237B/xx unknown
-
1998
- 1998-07-29 HK HK98109537A patent/HK1008774A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DE69614689T2 (de) | 2002-06-27 |
EP0833611A1 (en) | 1998-04-08 |
PT833611E (pt) | 2002-01-30 |
ZA965237B (en) | 1997-01-09 |
EP0833611B1 (en) | 2001-08-22 |
AU695622B2 (en) | 1998-08-20 |
AU6247396A (en) | 1997-01-22 |
US6083518A (en) | 2000-07-04 |
NZ311208A (en) | 1999-03-29 |
HK1008774A1 (en) | 1999-05-21 |
DK0833611T3 (da) | 2001-10-08 |
CA2225286C (en) | 2003-06-10 |
DE69614689D1 (de) | 2001-09-27 |
SE9502244D0 (sv) | 1995-06-20 |
WO1997000670A1 (en) | 1997-01-09 |
DE833611T1 (de) | 1999-01-07 |
ES2118677T1 (es) | 1998-10-01 |
JPH11508250A (ja) | 1999-07-21 |
JP4020331B2 (ja) | 2007-12-12 |
CA2225286A1 (en) | 1997-01-09 |
ATE204466T1 (de) | 2001-09-15 |
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