ES2118383T3 - Instrumento dosificador, especialmente de inyeccion de liquido medicamentoso. - Google Patents
Instrumento dosificador, especialmente de inyeccion de liquido medicamentoso.Info
- Publication number
- ES2118383T3 ES2118383T3 ES94906248T ES94906248T ES2118383T3 ES 2118383 T3 ES2118383 T3 ES 2118383T3 ES 94906248 T ES94906248 T ES 94906248T ES 94906248 T ES94906248 T ES 94906248T ES 2118383 T3 ES2118383 T3 ES 2118383T3
- Authority
- ES
- Spain
- Prior art keywords
- pct
- sec
- user
- liquid injection
- designed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
- A61M5/31578—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod
- A61M5/3158—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod performed by axially moving actuator operated by user, e.g. an injection button
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31545—Setting modes for dosing
- A61M5/31548—Mechanically operated dose setting member
- A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
- A61M5/31553—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe without axial movement of dose setting member
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
- A61M5/31541—Means preventing setting of a dose beyond the amount remaining in the cartridge
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31545—Setting modes for dosing
- A61M5/31548—Mechanically operated dose setting member
- A61M5/31563—Mechanically operated dose setting member interacting with a displaceable stop member
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/3159—Dose expelling manners
- A61M5/31593—Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medicinal Preparation (AREA)
- Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
- Pens And Brushes (AREA)
Abstract
INSTRUMENTO DOSIFICADOR, PARA DISPENSAR VARIAS DOSIS DE UN LIQUIDO TOMADO SOBRE UNA CARGA DE DICHO LIQUIDO, QUE COMPRENDE: UN CUERPO TUBULAR (2), DESTINADO A SER SUJETO POR EL USUARIO, UN DEPOSITO (5) QUE CONTIENE EL LIQUIDO, UNA COLA (33) MONTADA EN EL INTERIOR Y EN EL EJE DEL CUERPO (2), LIBRE EN TRASLACION RESPECTO DE ESTE ULTIMO, PERO UNICAMENTE EN UN SENTIDO DE REFERENCIA, UN EMPUJADOR (22) AGARRABLE POR EL USUARIO, MONTADO LIBRE EN TRASLACION EN EL CUERPO (2), ACOPLADO CON LA COLA EN EL SENTIDO DE INYECCION. SEGUN LA INVENCION, LA COLA (33) COMPRENDE UNA CREMALLERA CONSTITUIDA POR MUESCAS ANULARES SUCESIVAS (34), EL CUERPO (2) COMPRENDE VARIAS RANURAS AXIALES (14, 21) REPARTIDAS EN SU PERIFERIA, Y EL EMPUJADOR (22) LLEVA UN ESPOLON (27) QUE SOBRESALE HACIA EL EXTERIOR, Y DESTINADO A SER INTRODUCIDO EN UNA DE LAS RANURAS DEL CUERPO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9301557A FR2701211B1 (fr) | 1993-02-08 | 1993-02-08 | Instrument doseur, notamment d'injection |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2118383T3 true ES2118383T3 (es) | 1998-09-16 |
Family
ID=9443973
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES94906248T Expired - Lifetime ES2118383T3 (es) | 1993-02-08 | 1994-02-07 | Instrumento dosificador, especialmente de inyeccion de liquido medicamentoso. |
Country Status (9)
Country | Link |
---|---|
US (1) | US5807346A (es) |
EP (1) | EP0773806B1 (es) |
AT (1) | ATE167065T1 (es) |
CA (1) | CA2155575C (es) |
DE (1) | DE69411039T2 (es) |
DK (1) | DK0773806T3 (es) |
ES (1) | ES2118383T3 (es) |
FR (1) | FR2701211B1 (es) |
WO (1) | WO1994017846A1 (es) |
Families Citing this family (111)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1228777B1 (de) * | 1994-05-30 | 2003-10-29 | B D Medico S.a.r.l. | Injektionsgerät |
ATE224216T1 (de) | 1996-04-02 | 2002-10-15 | Disetronic Licensing Ag | Injektionsgerät |
WO1997036626A1 (de) * | 1996-04-02 | 1997-10-09 | Disetronic Licensing Ag | Injektionsgerät |
WO1998001172A1 (de) * | 1996-07-05 | 1998-01-15 | Disetronic Licensing Ag | Injektionsgerät zum injizieren von flüssigkeit |
DE59610766D1 (de) | 1996-07-05 | 2003-11-13 | Disetronic Licensing Ag | Injektionsgerät zum injizieren von flüssigkeit |
DE19717107B4 (de) | 1997-04-23 | 2005-06-23 | Disetronic Licensing Ag | System aus Behältnis und Antriebsvorrichtung für einen Kolben, der in dem ein Medikamentfluid enthaltenden Behältnis gehalten ist |
EP1841095A3 (en) | 1997-04-24 | 2013-11-20 | Ntt Mobile Communications Network Inc. | Method and system for mobile communications |
DE19723647C1 (de) | 1997-06-05 | 1998-12-24 | Disetronic Licensing Ag | Rücksetzbare Anzeigeeinrichtung einer Vorrichtung zur dosierten Abgabe eines Medikamentfluids |
DE19740187C1 (de) * | 1997-09-12 | 1999-04-15 | Disetronic Licensing Ag | Vorrichtung zur dosierten Ausschüttung eines injizierbaren Produkts |
DE19755125B4 (de) | 1997-12-11 | 2006-04-20 | Tecpharma Licensing Ag | Nadelschutzvorrichtung für Injektionsgeräte |
US6290679B1 (en) | 1999-05-14 | 2001-09-18 | Disetronic Licensing Ag | Device for metered administration of an injectable product |
DE19822031C2 (de) | 1998-05-15 | 2000-03-23 | Disetronic Licensing Ag | Autoinjektionsgerät |
DE19821933C1 (de) | 1998-05-15 | 1999-11-11 | Disetronic Licensing Ag | Vorrichtung zur Verabreichung eines injizierbaren Produkts |
DE19845618A1 (de) * | 1998-10-05 | 2000-04-06 | Linhardt Gmbh & Co Kg | Injektonsspritze |
DE19900792C1 (de) | 1999-01-12 | 2000-06-15 | Disetronic Licensing Ag | Vorrichtung zur Verabreichung eines injizierbaren Produkts |
DE19900827C1 (de) * | 1999-01-12 | 2000-08-17 | Disetronic Licensing Ag | Vorrichtung zur dosierten Verabreichung eines injizierbaren Produkts |
SE9901366D0 (sv) | 1999-04-16 | 1999-04-16 | Pharmacia & Upjohn Ab | Injector device and method for its operation |
DE19947185C2 (de) * | 1999-10-01 | 2001-12-06 | Linhardt Gmbh & Co Kg | Injektionsspritze |
AU2001238169A1 (en) * | 2000-02-15 | 2001-08-27 | Comar, Inc. | Needleless access apparatus and system |
JP3788164B2 (ja) | 2000-02-21 | 2006-06-21 | 東海ゴム工業株式会社 | 流体封入式マウント |
US6607508B2 (en) | 2000-04-27 | 2003-08-19 | Invivotech, Inc. | Vial injector device |
CN1268405C (zh) * | 2000-10-09 | 2006-08-09 | 伊莱利利公司 | 用于甲状旁腺激素给药的笔式装置 |
US6673049B2 (en) | 2001-02-15 | 2004-01-06 | Disetronic Licensing Ag | Injection device for injecting fluid |
WO2003020347A2 (en) * | 2001-03-27 | 2003-03-13 | Eli Lilly And Company | Medication dispensing apparatus configured for pull to set dose and push to inject set dose functionality |
EP1409046B1 (en) * | 2001-07-16 | 2005-03-02 | Eli Lilly And Company | Medication dispensing apparatus configured for rotate to prime and pull/push to inject functionality |
EP1558307A1 (de) | 2002-04-17 | 2005-08-03 | Tecpharma Licensing AG | Vorrichtung zur verabreichung eines injizierbaren produkts |
GB0304822D0 (en) | 2003-03-03 | 2003-04-09 | Dca Internat Ltd | Improvements in and relating to a pen-type injector |
GB0304823D0 (en) | 2003-03-03 | 2003-04-09 | Dca Internat Ltd | Improvements in and relating to a pen-type injector |
US7086796B2 (en) * | 2003-08-01 | 2006-08-08 | Bonne Bell, Inc. | Dispensing device |
JP2007508074A (ja) * | 2003-10-16 | 2007-04-05 | テクファーマ・ライセンシング・アクチェンゲゼルシャフト | 流体製剤を投与する注射装置 |
DE102004004310A1 (de) * | 2004-01-28 | 2005-08-18 | Tecpharma Licensing Ag | Injektionsgerät mit verrastbarem Dosierglied |
DE102004020374A1 (de) * | 2004-04-23 | 2005-11-10 | Tecpharma Licensing Ag | Vorrichtung zur Verabreichung eines injizierbaren Produkts mit gesicherter Dosiereinrichtung |
DE202004006611U1 (de) * | 2004-04-23 | 2005-08-25 | Tecpharma Licensing Ag | Injektionsgerät zur Verabreichung eines injizierbaren Produkts mit gesicherter Dosiereinrichtung |
GB0414054D0 (en) | 2004-06-23 | 2004-07-28 | Owen Mumford Ltd | Improvements relating to automatic injection devices |
DE102004041151A1 (de) * | 2004-08-25 | 2006-03-02 | Tecpharma Licensing Ag | Dosiervorrichtung mit Ablaufsteuerung |
ES2427146T3 (es) | 2004-10-04 | 2013-10-29 | Sanofi-Aventis Deutschland Gmbh | Mecanismo accionador para un dispositivo de descarga de fármacos |
DE102004060145B4 (de) * | 2004-12-14 | 2016-07-14 | Tecpharma Licensing Ag | Zahneingriffsteuerung |
EP1704887B1 (de) * | 2005-03-26 | 2008-10-15 | Tecpharma Licensing AG | Dosiervorrichtung mit Priming-Funktion |
US7727201B2 (en) | 2005-04-29 | 2010-06-01 | Tecpharma Licensing Ag | Dosing device with priming function |
FR2890316B1 (fr) * | 2005-09-02 | 2007-10-05 | Aguettant Soc Par Actions Simp | Seringue destinee a etre remplie puis sterilisee par autoclavage a la vapeur. |
GB2433032A (en) * | 2005-12-08 | 2007-06-13 | Owen Mumford Ltd | Syringe with dose adjustment means |
DE102006004563A1 (de) * | 2006-01-17 | 2007-07-19 | Tecpharma Licensing Ag | Ausfahrbarer Dosierknopf |
DE102006004561A1 (de) * | 2006-01-17 | 2007-07-26 | Tecpharma Licensing Ag | Injektionsvorrichtung mit gesichertem Drehknopf |
DE102006004562A1 (de) * | 2006-01-17 | 2007-07-19 | Tecpharma Licensing Ag | Vorschubstange mit Koppelelement |
CN101370541B (zh) * | 2006-01-17 | 2012-10-03 | 特克法马许可公司 | 具有被固定的定量旋钮的注射装置 |
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EP2337596B1 (en) | 2008-09-18 | 2019-10-30 | Becton, Dickinson and Company | Medical injector with ratcheting plunger |
EP2468344B1 (en) | 2008-10-13 | 2013-08-28 | Sanofi-Aventis Deutschland GmbH | Drug delivery device and method of manufacturing a drug delivery device |
EP2196233A1 (en) | 2008-12-12 | 2010-06-16 | Sanofi-Aventis Deutschland GmbH | Resettable drive mechanism for a medication delivery device and medication delivery device |
GB0902354D0 (en) | 2009-02-13 | 2009-04-01 | 3M Innovative Properties Co | Syringes for dispensing multicomponent material |
JP5656972B2 (ja) | 2009-03-31 | 2015-01-21 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | ペンキャップ |
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US10286150B2 (en) | 2009-03-31 | 2019-05-14 | Michael Harms | Dose button for a drug delivery device and method for manufacturing a dose button |
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CN102802703B (zh) | 2009-04-30 | 2015-02-25 | 赛诺菲-安万特德国有限公司 | 用于给药装置的驱动机构的活塞杆到活塞的可轴向调节的连接 |
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TWI530306B (zh) | 2009-06-02 | 2016-04-21 | 賽諾菲阿凡提斯德意志有限公司 | 藥物傳送裝置總成及藥物傳送裝置 |
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JP6203247B2 (ja) | 2012-04-05 | 2017-09-27 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 窓要素を有するペン型注射器 |
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JP6768501B2 (ja) | 2013-03-15 | 2020-10-14 | アムゲン・インコーポレーテッド | 薬物カセット、自動注入機、および自動注入機システム |
CN105102028B (zh) | 2013-04-10 | 2019-02-01 | 赛诺菲 | 用于药物输送装置的驱动组件 |
WO2014184081A1 (en) | 2013-05-16 | 2014-11-20 | Sanofi-Aventis Deutschland Gmbh | Mechanism for a drug delivery device |
DK3003432T3 (da) | 2013-05-27 | 2020-03-30 | Sanofi Aventis Deutschland | Drivindretning til lægemiddeladministrationsanordning og lægemiddeladministrationsanordning |
ES2881077T3 (es) | 2013-08-29 | 2021-11-26 | Sanofi Aventis Deutschland | Conjunto de capuchón para un dispositivo de administración de fármacos y dispositivo de administración de fármacos |
JP6764786B2 (ja) | 2013-08-29 | 2020-10-07 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 外側金属部材および内側プラスチック部材で作られた注射デバイス用のハウジングおよびキャップ |
US11052200B2 (en) | 2013-08-29 | 2021-07-06 | Sanofi-Aventis Deutschland Gmbh | Cap for a drug delivery device |
EP3041538B1 (en) | 2013-09-03 | 2020-06-03 | Sanofi | Drive mechanism and injection device herewith |
PL3049131T3 (pl) | 2013-09-23 | 2021-04-19 | Sanofi-Aventis Deutschland Gmbh | Zespół urządzenia do dostarczania leku i urządzenie do dostarczania leku |
GB2521212B (en) * | 2013-12-13 | 2016-07-27 | Owen Mumford Ltd | Selectable dose injection device |
WO2015091763A1 (en) | 2013-12-20 | 2015-06-25 | Sanofi-Aventis Deutschland Gmbh | Assembly for a drug delivery device and drug delivery device |
EP2902061A1 (en) * | 2014-01-30 | 2015-08-05 | Sanofi-Aventis Deutschland GmbH | Medicament delivery device |
MA41101A (fr) | 2014-12-03 | 2017-10-10 | Lilly Co Eli | Dispositif d'injection de médicament automatique comportant une indication audible de progression d'injection |
US11400218B2 (en) | 2015-03-23 | 2022-08-02 | Sanofi-Aventis Deutschland Gmbh | Housing for an injection device and interconnection of housing components |
US20170367930A1 (en) * | 2016-06-28 | 2017-12-28 | Elizabeth Gompf | Emergency Medication Dose Device to Provide Error-Free Pediatric Medication Doses. |
FR3071161B1 (fr) * | 2017-09-19 | 2020-06-26 | Rovipharm | Systeme de dosage de liquide, en particulier de medicament |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1170312A (fr) * | 1957-03-25 | 1959-01-13 | Commande de seringue | |
EP0037696B1 (en) * | 1980-04-08 | 1984-05-23 | Greater Glasgow Health Board | Dispensing device |
GB8713810D0 (en) * | 1987-06-12 | 1987-07-15 | Hypoguard Uk Ltd | Measured dose dispensing device |
US4973318A (en) * | 1988-02-10 | 1990-11-27 | D.C.P. Af 1988 A/S | Disposable syringe |
FR2651314A1 (fr) * | 1989-08-25 | 1991-03-01 | Taddei Andre | Dispositif portatif pour effectuer des dosages multiples d'un produit liquide ou pateux. |
US5084017A (en) * | 1989-10-10 | 1992-01-28 | John Maffetone | Self disabling, single use, hypodermic syringe |
DK17890A (da) * | 1990-01-22 | 1991-07-23 | Novo Nordisk As | Fremgangsmaade og apparat til opblanding og injicering af et laegemiddel |
AU641206B2 (en) * | 1991-01-22 | 1993-09-16 | Eli Lilly And Company | Multiple dose injection pen |
EP0498737B1 (en) * | 1991-02-07 | 1995-07-19 | Terumo Kabushiki Kaisha | Dosing means for an injector |
IT221835Z2 (it) * | 1991-04-16 | 1994-12-06 | Mc Carthy Martin Charles | Siringa monouso autobloccante |
US5279586A (en) * | 1992-02-04 | 1994-01-18 | Becton, Dickinson And Company | Reusable medication delivery pen |
-
1993
- 1993-02-08 FR FR9301557A patent/FR2701211B1/fr not_active Expired - Fee Related
-
1994
- 1994-02-07 EP EP94906248A patent/EP0773806B1/fr not_active Expired - Lifetime
- 1994-02-07 DK DK94906248T patent/DK0773806T3/da active
- 1994-02-07 AT AT94906248T patent/ATE167065T1/de not_active IP Right Cessation
- 1994-02-07 CA CA002155575A patent/CA2155575C/fr not_active Expired - Fee Related
- 1994-02-07 US US08/500,951 patent/US5807346A/en not_active Expired - Lifetime
- 1994-02-07 ES ES94906248T patent/ES2118383T3/es not_active Expired - Lifetime
- 1994-02-07 DE DE69411039T patent/DE69411039T2/de not_active Expired - Lifetime
- 1994-02-07 WO PCT/FR1994/000137 patent/WO1994017846A1/fr active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
FR2701211B1 (fr) | 1995-05-24 |
EP0773806A1 (fr) | 1997-05-21 |
DK0773806T3 (da) | 1999-03-29 |
CA2155575C (fr) | 1999-07-27 |
WO1994017846A1 (fr) | 1994-08-18 |
DE69411039T2 (de) | 1998-10-08 |
FR2701211A1 (fr) | 1994-08-12 |
EP0773806B1 (fr) | 1998-06-10 |
CA2155575A1 (fr) | 1994-08-18 |
ATE167065T1 (de) | 1998-06-15 |
US5807346A (en) | 1998-09-15 |
DE69411039D1 (de) | 1998-07-16 |
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