ES2114524T3 - Agentes con accion selectiva sobre receptores de adenosina. - Google Patents
Agentes con accion selectiva sobre receptores de adenosina.Info
- Publication number
- ES2114524T3 ES2114524T3 ES90105920T ES90105920T ES2114524T3 ES 2114524 T3 ES2114524 T3 ES 2114524T3 ES 90105920 T ES90105920 T ES 90105920T ES 90105920 T ES90105920 T ES 90105920T ES 2114524 T3 ES2114524 T3 ES 2114524T3
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- adenosine
- hydrogen
- proviso
- beta
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Genetics & Genomics (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Vascular Medicine (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
SON DESCUBIERTAS ADENOSINAS QUE ACTUAN SELECTIVAMENTE EN RECEPTORES DE ADENOSINA Y QUE ACTUAN EN GENERAL COMO ANTAGONISTAS DE ADENOSINA. DE LOS ESTUDIOS IN VITRO ES CONOCIDO QUE LOS EFECTOS FISIOLOGICOS ESPECIFICOS PUEDEN SER DISTINGUIDOS COMO RESULTADO DE ESTA SELECTIVIDAD Y QUE LA ACTIVIDAD DEL RECEPTOR DE ADENOSINA IN VITRO SE CORRELACIONA CON LA ACTIVIDAD DEL RECEPTOR DE ADENOSINA IN VIVO. LAS PREPARACIONES FARMACEUTICAS DE LOS COMPONENTES SOMETIDOS PUEDEN SER PREPARADOS EN LAS BASES DE LA ACTIVIDAD ENLAZANTE SELECTIVA DE LOS COMPONENTES DESCUBIERTOS AQUI, QUE INCREMENTARAN CIERTOS EFECTOS FISIOLOGICOS MIENTRAS SE MINIMIZAN OTROS, TALES COMO DISMINUIR LA PRESION SANGUINEA SIN DISMINUIR EL RITMO DEL CORAZON.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US32991989A | 1989-03-29 | 1989-03-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2114524T3 true ES2114524T3 (es) | 1998-06-01 |
Family
ID=23287579
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90105920T Expired - Lifetime ES2114524T3 (es) | 1989-03-29 | 1990-03-28 | Agentes con accion selectiva sobre receptores de adenosina. |
Country Status (18)
Country | Link |
---|---|
EP (1) | EP0390112B1 (es) |
JP (1) | JP2954971B2 (es) |
KR (1) | KR0168647B1 (es) |
CN (1) | CN1034575C (es) |
AT (1) | ATE162791T1 (es) |
AU (1) | AU630439B2 (es) |
CA (1) | CA2013380C (es) |
DE (1) | DE69031989T2 (es) |
DK (1) | DK0390112T3 (es) |
ES (1) | ES2114524T3 (es) |
FI (1) | FI95910C (es) |
GR (1) | GR3026173T3 (es) |
HU (1) | HU206354B (es) |
IL (1) | IL93892A (es) |
NO (1) | NO173996C (es) |
NZ (1) | NZ233078A (es) |
PT (1) | PT93588B (es) |
ZA (1) | ZA902280B (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9022644D0 (en) * | 1990-10-18 | 1990-11-28 | Ici Plc | Heterocyclic compounds |
IT1254915B (it) * | 1992-04-24 | 1995-10-11 | Gloria Cristalli | Derivati di adenosina ad attivita' a2 agonista |
JPH08500967A (ja) * | 1992-06-12 | 1996-02-06 | ガーヴァン インスティチュート オブ メディカル リサーチ | ヒトA1,A2aおよびA2bアデノシン受容体をエンコードするDNA配列 |
FR2741881B1 (fr) * | 1995-12-01 | 1999-07-30 | Centre Nat Rech Scient | Nouveaux derives de purine possedant notamment des prorietes anti-proliferatives et leurs applications biologiques |
GB9613021D0 (en) * | 1996-06-21 | 1996-08-28 | Pharmacia Spa | Bicyclic 4-aralkylaminopyrimidine derivatives as tyrosine kinase inhibitors |
WO2000063703A1 (en) | 1999-04-16 | 2000-10-26 | Schering Corporation | Use of azetidinone compounds |
GB0100621D0 (en) * | 2001-01-10 | 2001-02-21 | Vernalis Res Ltd | Chemical compounds VI |
KR100468352B1 (ko) * | 2002-09-24 | 2005-01-27 | 한국과학기술연구원 | 신규 피라졸로피리미딘계 유도체, 그의 제조방법 및 이를 유효성분으로 하는 약학적 조성물 |
WO2004092170A2 (en) | 2003-04-09 | 2004-10-28 | Biogen Idec Ma Inc. | Triazolotriazines and pyrazolotriazines useful as a2a adenosine receptor antagon ists |
ATE418555T1 (de) | 2003-04-09 | 2009-01-15 | Biogen Idec Inc | A2a-adenosinrezeptorantagonisten |
EP1615931A1 (en) | 2003-04-09 | 2006-01-18 | Biogen Idec MA Inc. | Triazolopyrazines and methods of making and using the same |
JP2015172077A (ja) * | 2015-06-24 | 2015-10-01 | 中国医学科学院葯物研究所 | N6−置換アデノシン誘導体とn6−置換アデニン誘導体の鎮静、催眠、抗うつ、抗痙攣、抗てんかん、抗パーキンソン病と認知証予防・治療の用途 |
WO2018199236A1 (ja) * | 2017-04-27 | 2018-11-01 | 武田薬品工業株式会社 | 複素環化合物 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL262940A (es) * | 1960-03-31 | |||
NL283192A (es) * | 1961-09-14 | |||
NL128629C (es) * | 1966-05-07 | |||
DE1795828A1 (de) * | 1966-12-21 | 1975-11-27 | Boehringer Mannheim Gmbh | Adenosinderivate |
DE2139107A1 (de) * | 1971-08-04 | 1973-02-15 | Merck Patent Gmbh | Heterocyclisch substituierte adenosinverbindungen |
US3862189A (en) * | 1973-08-14 | 1975-01-21 | Warner Lambert Co | Aralkyl-substituted purines and pyrimidines as antianginal bronchodilator agents |
AU527013B2 (en) * | 1979-01-10 | 1983-02-10 | Imperial Chemical Industries Ltd. | Pure during derivatives and defoliation of cotton |
US4388308A (en) * | 1980-06-09 | 1983-06-14 | G.D. Searle & Co. | N6 -[(2-Hydroxypropyl)aryl]adenosines |
US4514405A (en) * | 1981-09-17 | 1985-04-30 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Use of adenosine derivatives as anticonvulsants |
EP0305643B1 (en) * | 1984-04-18 | 1994-01-05 | Whitby Research Incorporated | N-6 thienyl substituted adenosine derivatives as cardiac vasodilators |
AU575438B2 (en) * | 1984-10-26 | 1988-07-28 | Warner-Lambert Company | N6 - substituted deoxyribose analogues of adenosines |
DE3529497A1 (de) * | 1985-08-17 | 1987-02-26 | Boehringer Mannheim Gmbh | N(pfeil hoch)6(pfeil hoch)-disubstituierte purinderivate, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel |
DE3712735A1 (de) * | 1987-04-15 | 1988-11-10 | Boehringer Mannheim Gmbh | Neue pyrazolo(3,4-d)pyrimidine, verfahren zu ihrer herstellung und verwendung als arzneimittel |
KR910700253A (ko) * | 1989-01-31 | 1991-03-14 | 로버트 제이, 바란 | N_6-치환-9-메틸아데닌: 신규한 부류의 아데노신 수용체 길항질 |
-
1990
- 1990-03-23 ZA ZA902280A patent/ZA902280B/xx unknown
- 1990-03-26 NZ NZ233078A patent/NZ233078A/en unknown
- 1990-03-26 AU AU52215/90A patent/AU630439B2/en not_active Ceased
- 1990-03-26 IL IL9389290A patent/IL93892A/en not_active IP Right Cessation
- 1990-03-27 HU HU901856A patent/HU206354B/hu not_active IP Right Cessation
- 1990-03-28 DE DE69031989T patent/DE69031989T2/de not_active Expired - Fee Related
- 1990-03-28 CN CN90101711A patent/CN1034575C/zh not_active Expired - Fee Related
- 1990-03-28 EP EP90105920A patent/EP0390112B1/en not_active Expired - Lifetime
- 1990-03-28 DK DK90105920T patent/DK0390112T3/da active
- 1990-03-28 KR KR1019900004159A patent/KR0168647B1/ko not_active IP Right Cessation
- 1990-03-28 NO NO901423A patent/NO173996C/no not_active IP Right Cessation
- 1990-03-28 AT AT90105920T patent/ATE162791T1/de not_active IP Right Cessation
- 1990-03-28 ES ES90105920T patent/ES2114524T3/es not_active Expired - Lifetime
- 1990-03-28 FI FI901549A patent/FI95910C/fi not_active IP Right Cessation
- 1990-03-28 PT PT93588A patent/PT93588B/pt not_active IP Right Cessation
- 1990-03-29 CA CA002013380A patent/CA2013380C/en not_active Expired - Fee Related
- 1990-03-29 JP JP2079072A patent/JP2954971B2/ja not_active Expired - Fee Related
-
1998
- 1998-02-18 GR GR980400348T patent/GR3026173T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
ZA902280B (en) | 1990-12-28 |
PT93588A (pt) | 1990-11-20 |
EP0390112A2 (en) | 1990-10-03 |
KR0168647B1 (ko) | 1999-01-15 |
FI95910B (fi) | 1995-12-29 |
JPH02289570A (ja) | 1990-11-29 |
NO901423L (no) | 1990-10-01 |
DE69031989D1 (de) | 1998-03-05 |
HU901856D0 (en) | 1990-08-28 |
HUT53648A (en) | 1990-11-28 |
NO173996B (no) | 1993-11-22 |
DK0390112T3 (da) | 1998-09-23 |
EP0390112A3 (en) | 1992-02-12 |
KR900014389A (ko) | 1990-10-23 |
AU630439B2 (en) | 1992-10-29 |
CN1034575C (zh) | 1997-04-16 |
DE69031989T2 (de) | 1998-09-03 |
EP0390112B1 (en) | 1998-01-28 |
JP2954971B2 (ja) | 1999-09-27 |
NO901423D0 (no) | 1990-03-28 |
NO173996C (no) | 1994-03-02 |
IL93892A (en) | 1994-11-28 |
NZ233078A (en) | 1993-11-25 |
AU5221590A (en) | 1990-10-04 |
GR3026173T3 (en) | 1998-05-29 |
CA2013380C (en) | 2001-05-22 |
HU206354B (en) | 1992-10-28 |
CN1045973A (zh) | 1990-10-10 |
PT93588B (pt) | 1996-08-30 |
FI901549A0 (fi) | 1990-03-28 |
FI95910C (fi) | 1996-04-10 |
CA2013380A1 (en) | 1990-09-29 |
ATE162791T1 (de) | 1998-02-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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