ES2108595B1 - Derivados de la 3(2h)-piridacinona y procedimiento para su preparacion. - Google Patents
Derivados de la 3(2h)-piridacinona y procedimiento para su preparacion.Info
- Publication number
- ES2108595B1 ES2108595B1 ES09202568A ES9202568A ES2108595B1 ES 2108595 B1 ES2108595 B1 ES 2108595B1 ES 09202568 A ES09202568 A ES 09202568A ES 9202568 A ES9202568 A ES 9202568A ES 2108595 B1 ES2108595 B1 ES 2108595B1
- Authority
- ES
- Spain
- Prior art keywords
- group
- hydrogen
- optionally substituted
- formula
- piridacinone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- -1 PHENYL GROUP Chemical group 0.000 abstract 2
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 230000003288 anthiarrhythmic effect Effects 0.000 abstract 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/14—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU914057A HU214320B (hu) | 1991-12-20 | 1991-12-20 | Eljárás új 3(2H)-piridazinon-származékok és ezeket tartalmazó gyógyszerkészítmények előállítására |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2108595A1 ES2108595A1 (es) | 1997-12-16 |
| ES2108595B1 true ES2108595B1 (es) | 1998-08-16 |
Family
ID=10966710
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES09202568A Expired - Fee Related ES2108595B1 (es) | 1991-12-20 | 1992-12-18 | Derivados de la 3(2h)-piridacinona y procedimiento para su preparacion. |
Country Status (22)
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5935945A (en) * | 1996-10-31 | 1999-08-10 | Merck & Co., Inc. | Methods of treating or preventing cardiac arrhythmia |
| US5969017A (en) * | 1996-10-31 | 1999-10-19 | Merck & Co., Inc. | Methods of treating or preventing cardiac arrhythmia |
| KR20010052598A (ko) * | 1998-06-05 | 2001-06-25 | 사바 키스 ; 아틸라 만디 야노스 템페 ; 기울라 시미그 | 3(2ｈ)-피리다지논-4-치환된 아미노-5-클로로-유도체의제조 방법 |
| RU2211217C2 (ru) * | 1998-06-05 | 2003-08-27 | Эгиш Дьёдьсердьяр Рт. | Способ получения 5-хлор-4-аминозамещенного производного 3(2н)-пиридазинона |
| ES2162731B1 (es) * | 1999-06-04 | 2003-02-16 | Faes Fabrica Espanola De Produ | Nuevas arilpiperacilnilalquil-3(2h)-piridacinonas. |
| WO2001034151A1 (en) * | 1999-11-11 | 2001-05-17 | Fred Hutchinson Cancer Research Center | Novel topoisomerase poisons for the treatment of proliferative disorders |
| US7173063B1 (en) | 2000-11-10 | 2007-02-06 | Fred Hutchinson Cancer Research Center | Topoisomerase poisons for the treatment of proliferative disorders |
| HUP0103064A3 (en) * | 2001-07-26 | 2005-06-28 | Egis Gyogyszergyar Nyilvanosan | Polymorphic form of 5-chloro-4-(3-{[2-(3,4-dimethoxy-phenyl)-ethyl]-methyl-amino]-propylamino)-3-(2h)-piridazinone fumarate, its use, process for its preparation and pharmaceutical compositions containing it |
| HU227237B1 (en) * | 2001-09-27 | 2010-12-28 | Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag | Substituted alkylpyridazinone derivatives, process for their preparation, pharmaceutical compositions containing them |
| EP1470112A1 (en) * | 2002-01-18 | 2004-10-27 | Pharmacia Corporation | Substituted pyridazinones as inhibitors of p38 |
| HU227181B1 (en) * | 2002-09-11 | 2010-09-28 | Egis Gyogyszergyar Nyilvanosan | Use of 5-chloro-4-[3-[n-[2-(3,4-dimethoxyphenyl)ethyl)]-n-methylamino]-propylamino]-3-(2h)-pyridazinone for producing pharmaceutical compositions having metabolic modulator effect |
| WO2011062437A2 (ko) | 2009-11-20 | 2011-05-26 | 에스케이케미칼주식회사 | 고나도트로핀 방출 호르몬 수용체 길항제, 이의 제조방법 및 이를 함유하는 약제학적 조성물 |
| AU2011213621A1 (en) * | 2010-02-08 | 2012-08-30 | Allergan, Inc. | Pyridazine derivatives useful as cannabinoid - 2 agonists |
| FR2969606B1 (fr) * | 2010-12-22 | 2013-01-11 | Pf Medicament | Derives de diarylpyridazinones, leur preparation et leur application en therapeutique humaine |
| RU2455004C1 (ru) * | 2011-04-01 | 2012-07-10 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Ярославский государственный технический университет" (ФГБОУ ВПО "ЯГТУ") | Способ получения сульфохлоридов ряда 6-арилпиридазин-3(2н)-онов |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1285235A (fr) * | 1960-01-21 | 1962-02-23 | Ciba Geigy | Procédé de préparation de nouvelles diazines, notamment de 1-aryl-3-r-5-r'pyridazones-(6) dans lesquelles r représente un hydroxyle aliphatiquement éthérifié et r' représente un groupe n-(beta-aryl-éthyl)-pipérazino |
| FR2124164A1 (en) | 1971-02-10 | 1972-09-22 | Ferlux | Phenyl pyridazonyl piperazines - analgesics hypotensives sedatives and antibacterials |
| US4088764A (en) * | 1973-12-27 | 1978-05-09 | Cassella Farbwerke Mainkur Aktiengesellschaft | Pharmaceutically active derivatives of 1-phenoxy-3-amino-propan-2-ol |
| DE3048487A1 (de) * | 1980-12-22 | 1982-07-29 | Cassella Ag, 6000 Frankfurt | Basisch substituierte pyridazine, ihre herstellung und ihre verwendung |
| JPH0641454B2 (ja) * | 1985-02-27 | 1994-06-01 | 日産化学工業株式会社 | ピリダジノン誘導体 |
| EP0201765B1 (en) * | 1985-04-27 | 1991-09-18 | Nissan Chemical Industries Ltd. | 3(2h)pyridazinone, process for its preparation and anti-allergic agent containing it |
| MY104343A (en) * | 1987-11-23 | 1994-03-31 | Janssen Pharmaceutica Nv | Novel pyridizinamine deravatives |
| US4992433A (en) * | 1987-11-23 | 1991-02-12 | Janssen Pharmaceutica N.V. | Novel pyridazinamine derivatives |
| EP0363486A1 (de) * | 1988-03-17 | 1990-04-18 | Vsesojuzny Nauchno-Issledovatelsky Inst. Selskokhozyaistv. Biotekh. Vsesojuznoi Ak. Selskokhozyaistv. Nauk Imeni V.I. Lenina | Verfahren zur Sterilisation der Staubbeutel von Pflanzen |
| IE62890B1 (en) * | 1988-12-06 | 1995-03-08 | Hafslund Nycomed Pharma | New piperazinylalkyl-3(2h)-pyridazinones process for the preparation thereof and the use thereof as agents lowering blood pressure |
| DE3902316A1 (de) * | 1989-01-26 | 1990-08-02 | Lentia Gmbh | Neue piperazinylalkyl-3(2h)-pyridazinone, verfahren zu ihrer herstellung und ihre verwendung als blutdrucksenkende mittel |
-
1991
- 1991-12-20 HU HU914057A patent/HU214320B/hu not_active IP Right Cessation
-
1992
- 1992-12-18 RU RU92016234A patent/RU2130019C1/ru not_active IP Right Cessation
- 1992-12-18 BE BE9201106A patent/BE1006223A4/fr not_active IP Right Cessation
- 1992-12-18 YU YU109292A patent/YU48973B/sh unknown
- 1992-12-18 CA CA002085796A patent/CA2085796C/en not_active Expired - Fee Related
- 1992-12-18 FR FR9215297A patent/FR2685329B1/fr not_active Expired - Fee Related
- 1992-12-18 CN CN92113725A patent/CN1088578A/zh active Pending
- 1992-12-18 CH CH3869/92A patent/CH684754A5/de not_active IP Right Cessation
- 1992-12-18 ES ES09202568A patent/ES2108595B1/es not_active Expired - Fee Related
- 1992-12-18 PL PL92297070A patent/PL172933B1/pl not_active IP Right Cessation
- 1992-12-21 CZ CS923809A patent/CZ286039B6/cs not_active IP Right Cessation
- 1992-12-21 JP JP35639792A patent/JP3165935B2/ja not_active Expired - Fee Related
- 1992-12-21 GR GR920100570A patent/GR1002281B/el not_active IP Right Cessation
- 1992-12-21 DE DE4243381A patent/DE4243381B4/de not_active Expired - Fee Related
- 1992-12-21 DK DK152892A patent/DK152892A/da unknown
- 1992-12-21 NL NL9202210A patent/NL194966C/nl not_active IP Right Cessation
- 1992-12-21 US US07/995,295 patent/US5395934A/en not_active Expired - Fee Related
- 1992-12-21 ZA ZA929903A patent/ZA929903B/xx unknown
- 1992-12-21 FI FI925807A patent/FI106374B/fi not_active IP Right Cessation
- 1992-12-21 KR KR1019920024844A patent/KR100234596B1/ko not_active Expired - Fee Related
- 1992-12-21 GB GB9226601A patent/GB2262526B/en not_active Expired - Fee Related
- 1992-12-21 AT AT0253592A patent/AT403282B/de active
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20051219 |