ES2104845T3 - Composiciones lipofilas de sales de antibioticos oligosacaridos. - Google Patents

Composiciones lipofilas de sales de antibioticos oligosacaridos.

Info

Publication number
ES2104845T3
ES2104845T3 ES92309368T ES92309368T ES2104845T3 ES 2104845 T3 ES2104845 T3 ES 2104845T3 ES 92309368 T ES92309368 T ES 92309368T ES 92309368 T ES92309368 T ES 92309368T ES 2104845 T3 ES2104845 T3 ES 2104845T3
Authority
ES
Spain
Prior art keywords
formula
antibiotic
amount
lipophyl
oligosaccharid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92309368T
Other languages
English (en)
Spanish (es)
Inventor
Mahesh Patel
Vincent P Gullo
Roberta Hare
David Loebenberg
James B Morton
George H Miller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp & Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of ES2104845T3 publication Critical patent/ES2104845T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
    • C07H9/04—Cyclic acetals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nanotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
ES92309368T 1991-10-16 1992-10-14 Composiciones lipofilas de sales de antibioticos oligosacaridos. Expired - Lifetime ES2104845T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US77786491A 1991-10-16 1991-10-16

Publications (1)

Publication Number Publication Date
ES2104845T3 true ES2104845T3 (es) 1997-10-16

Family

ID=25111545

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92309368T Expired - Lifetime ES2104845T3 (es) 1991-10-16 1992-10-14 Composiciones lipofilas de sales de antibioticos oligosacaridos.

Country Status (27)

Country Link
US (1) US5624914A (enExample)
EP (2) EP0610295A1 (enExample)
JP (1) JP2614407B2 (enExample)
KR (1) KR100249584B1 (enExample)
CN (1) CN1035923C (enExample)
AT (1) ATE156019T1 (enExample)
AU (1) AU678344B2 (enExample)
CA (1) CA2121345C (enExample)
DE (1) DE69221252T2 (enExample)
DK (1) DK0538011T3 (enExample)
ES (1) ES2104845T3 (enExample)
FI (1) FI941723A7 (enExample)
GR (1) GR3024800T3 (enExample)
HK (1) HK1001085A1 (enExample)
HR (1) HRP921069B1 (enExample)
HU (1) HUT75157A (enExample)
IL (1) IL103446A (enExample)
MX (1) MX9205922A (enExample)
NO (1) NO307326B1 (enExample)
NZ (1) NZ244735A (enExample)
PH (1) PH31675A (enExample)
PL (1) PL170591B1 (enExample)
SI (1) SI9200260A (enExample)
TW (1) TW221378B (enExample)
WO (1) WO1993007904A1 (enExample)
YU (1) YU48722B (enExample)
ZA (1) ZA927923B (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6380172B1 (en) 1991-10-16 2002-04-30 Schering Corporation Monomeric lipophilic oligosaccharide antibiotic compositions
US5948688A (en) * 1991-10-16 1999-09-07 Schering Corporation Method of determining monomeric drug content
US5652226A (en) * 1995-12-22 1997-07-29 Schering Corporation Water soluble antibiotics
US5776912A (en) * 1996-12-20 1998-07-07 Schering Corporation Lipophilic oligosaccharide antibiotic compositions
US5763600A (en) * 1997-04-18 1998-06-09 Schering Corporation Oligosaccharide antibiotics and process for preparation thereof
JP2001518556A (ja) * 1997-10-03 2001-10-16 ガレニカ ファーマシューティカルズ, インコーポレイテッド イミン形成ポリサッカライド、その調製、ならびにアジュバントおよび免疫刺激剤としてのその使用
US6162910A (en) * 1998-11-30 2000-12-19 Schering Corporation Process for preparing lipophilic oligosaccharide antibiotics
US6320044B1 (en) 1998-12-18 2001-11-20 Schering Corporation Process for recovering lipophilic oligosaccharide antibiotics
CO5231233A1 (es) * 1998-12-18 2002-12-27 Cherinf Corp Proceso para recuperar antibioticos oligosacaridos lipofilic lipofilicos
WO2001039573A2 (de) * 1999-12-01 2001-06-07 Byk Gulden Lomberg Chemische Fabrik Gmbh Verwendung von lungensurfactant zur behandlung von legionärskrankheit
US6861513B2 (en) 2000-01-12 2005-03-01 Schering Corporation Everninomicin biosynthetic genes
DE60136926D1 (de) * 2000-05-02 2009-01-22 Theravance Inc Zusammensetzung die eine zyklodextrin und ein glykopeptid-antibiotikum enthält
WO2002032459A2 (en) * 2000-10-17 2002-04-25 Massachusetts Institute Of Technology Method of increasing the efficacy of antibiotics by complexing with cyclodextrins
DE10109166A1 (de) * 2001-02-25 2002-09-12 Combinature Biopharm Ag Avilamycin-Derivate
EP1730163A4 (en) * 2004-03-17 2009-12-30 Panacos Pharmaceuticals Inc Pharmaceutical salts of 3-O- (3,3-dimethylsuccinyl) betulinic acid
EP1666228B1 (en) * 2004-12-01 2016-04-13 Nitto Denko Corporation Foam filling member
BRPI0610668A2 (pt) * 2005-04-12 2010-07-13 Panacos Pharmaceuticals Inc polimorfas de di-n-metil-d-glucamina do ácido 3-o-(3',3'-dimetilsuccinil) betulìnico
AU2008299885C1 (en) * 2007-09-14 2015-06-25 Sanofi Pasteur Biologics, Llc Pharmaceutical compositions containing clostridium difficile toxoids A and B
JP2010095454A (ja) * 2008-10-14 2010-04-30 Cyclochem:Kk 抗菌組成物
EP4324483A3 (en) * 2011-01-14 2024-05-01 Emory University Oligosaccharide conjugates for targeting bacteria and uses related thereto
AU2016276774A1 (en) 2015-06-10 2018-01-18 Vtesse, Inc. Hydroxypropyl beta-cyclodextrin compositions and methods
CN106317143B (zh) * 2016-08-23 2020-10-30 河北圣雪大成制药有限责任公司 一种提取阿维拉霉素的方法
JP2025506676A (ja) 2022-02-18 2025-03-13 ベレン セラピューティクス ピー.ビー.シー. ヒドロキシプロピル-ベータ-シクロデキストリンの組成物及びその精製方法
CN117024611B (zh) * 2023-03-01 2024-05-17 中国科学院南海海洋研究所 寡糖类抗生素everninomicin高产菌株的构建及活性的应用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR128F (enExample) * 1962-04-02
US3915956A (en) * 1973-07-09 1975-10-28 Schering Corp Reduction products of everninomicins and methods for their manufacture
US3920629A (en) * 1973-09-19 1975-11-18 Schering Corp Desevernitrose everninomicins and method for their manufacture
US4006225A (en) * 1973-10-31 1977-02-01 Schering Corporation Method of using reduction products of everninomicins as antibacterial agents and pharmaceutical compositions useful therefor
US4027016A (en) * 1976-01-19 1977-05-31 Schering Corporation Everninomicin antibacterial derivatives, electrochemical method for their manufacture, method for their use as antibacterial agents, and pharmaceutical compositions useful therefor
US3998708A (en) * 1976-01-19 1976-12-21 Schering Corporation Electrochemical process for preparing hydroxylaminoeverninomicins
US4129720A (en) * 1977-02-14 1978-12-12 Schering Corporation Aminoeverninomicin and derivatives thereof
US4597968A (en) * 1982-08-06 1986-07-01 Schering Corporation Antibiotic 13-384 complex from Micromonospora carbonacea var africana
DE3346123A1 (de) * 1983-12-21 1985-06-27 Janssen Pharmaceutica, N.V., Beerse Pharmazeutische praeparate von in wasser schwerloeslichen oder instabilen arzneistoffen und verfahren zu ihrer herstellung
US4727064A (en) * 1984-04-25 1988-02-23 The United States Of America As Represented By The Department Of Health And Human Services Pharmaceutical preparations containing cyclodextrin derivatives
US4596795A (en) * 1984-04-25 1986-06-24 The United States Of America As Represented By The Secretary, Dept. Of Health & Human Services Administration of sex hormones in the form of hydrophilic cyclodextrin derivatives
US4735903A (en) * 1984-06-21 1988-04-05 Schering Corporation Micromonospora carbonacea var africana
US4870060A (en) * 1985-03-15 1989-09-26 Janssen Pharmaceutica Derivatives of γ-cylodextrin
US4767748A (en) * 1985-10-15 1988-07-30 Schering Corporation Substituted oligosaccharide antibodies
US4622314A (en) * 1985-10-15 1986-11-11 Schering Corporation Substituted oligosaccharide antibiotics
US5017566A (en) * 1987-12-30 1991-05-21 University Of Florida Redox systems for brain-targeted drug delivery
US5002935A (en) * 1987-12-30 1991-03-26 University Of Florida Improvements in redox systems for brain-targeted drug delivery
KR0166088B1 (ko) * 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도

Also Published As

Publication number Publication date
YU48722B (sh) 1999-07-28
CN1035923C (zh) 1997-09-24
MX9205922A (es) 1994-08-31
CN1073359A (zh) 1993-06-23
EP0538011A1 (en) 1993-04-21
NO941276D0 (no) 1994-04-08
HRP921069A2 (en) 1994-12-31
DK0538011T3 (da) 1997-09-08
AU678344B2 (en) 1997-05-29
IL103446A (en) 1997-02-18
IL103446A0 (en) 1993-03-15
CA2121345C (en) 1998-08-25
ZA927923B (en) 1993-04-26
HK1001085A1 (en) 1998-05-22
HU9401104D0 (en) 1994-07-28
AU2780692A (en) 1993-05-21
EP0538011B1 (en) 1997-07-30
EP0610295A1 (en) 1994-08-17
JP2614407B2 (ja) 1997-05-28
GR3024800T3 (en) 1998-01-30
TW221378B (enExample) 1994-03-01
DE69221252D1 (de) 1997-09-04
HRP921069B1 (en) 1999-12-31
PL170591B1 (pl) 1997-01-31
PH31675A (en) 1999-01-18
SI9200260A (en) 1993-06-30
NO941276L (no) 1994-04-08
US5624914A (en) 1997-04-29
HUT75157A (en) 1997-04-28
NO307326B1 (no) 2000-03-20
KR100249584B1 (ko) 2000-04-01
YU92192A (sr) 1996-01-09
ATE156019T1 (de) 1997-08-15
JPH06510546A (ja) 1994-11-24
DE69221252T2 (de) 1998-01-22
FI941723A0 (fi) 1994-04-14
CA2121345A1 (en) 1993-04-29
WO1993007904A1 (en) 1993-04-29
FI941723A7 (fi) 1994-04-14
NZ244735A (en) 1995-12-21

Similar Documents

Publication Publication Date Title
YU48722B (sh) Postupak za dobijanje preparata soli lipofilnih oligosaharidnih antibiotika
KR950702431A (ko) 신규한 의약 조성물(novel pharmaceutical compositions)
KR950000728A (ko) 포스포네이트 뉴클레오티드 에스테르 유도체
CA2221190A1 (en) Novel substituted taxanes and pharmaceutical compositions containing them
MX9207169A (es) Composiciones orales para suprimir olores bucales.
ES2036580T3 (es) Composiciones quimicas y su uso como aditivos a combustibles.
ES8300678A1 (es) Procedimiento de preparacion de derivados de 1-fenil-1-hi- droxi-etilamina
DK0652773T3 (da) Anvendelse af nor- og homo-galdesyrederivater somabsorptionsfremmende bestanddele i lægemidler
UY26635A1 (es) Métodos sinérgicos y composiciones para el tratamiento del cáncer
PL315636A1 (en) Cosmetic or pharmaceutic compositions containing magnipherine or its derivatives
AR008540A1 (es) Composiciones antibioticas de oligosacaridos lipofilicos, composiciones farmaceuticas que los contienen y el uso de dichas composiciones para prepararmedicamentos.
ES346057A1 (es) Procedimiento para la obtencion de 3,4-dihidroxifenilalca- nolaminas.
AU624951B2 (en) New sulfonamides derived from benzocyclic or benzoheterocyclic acids, their preparation and application in thereapeutics
AR019190A1 (es) Derivados de 2-aminopiridinas, productos intermedios para su preparacion, medicamentos y composiciones farmaceuticas que los contienen y su uso para preparar medicamentos
SE8204918L (sv) Nya 3-amino-pregn-5-en-derivat, deras salter, sett for framstellning och anvendning derav som lekemedel och kompositioner innehallande dem
FI930974A0 (fi) Substituerade aminofosfonatderivat, foerfarande foer framstaellning av desamma och farmaceutiska kompositioner innehaollande desamma
AR030160A1 (es) Compuestos de acido hidroxamico , formulacion farmaceutica que lo comprende y uso de dicho compuesto para la fabricacion de dicha composicion
AR052853A1 (es) Composiciones orales que contienen compuestos antibacterianos de bifenol
ES2108240T3 (es) Derivados de tiosemicarbazona de 2-formilpiridina, su preparacion y su uso como agentes antitumor.
AR026726A1 (es) Nuevos compuestos antitromboticos y composiciones farmaceuticas que los contienen
RU2004119056A (ru) Составленные на основе воды фармацевтические композиции водорастворимых пролекарств пропофола
CO4771112A1 (es) Pasta/barra de platos transparente
FR2707089B1 (fr) Nouveaux dérivés d'acide phosphonique, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
SE8700250L (sv) 8alfa-acylaminoergoliner, deras framstellning och farmaceutiska kompositioner innehallande dem
ES2060592T3 (es) Un tioester y su uso en la preparacion de composiciones farmaceuticas para el tratamiento de los sindromes de isquemia y reperfusion.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 538011

Country of ref document: ES