CO5560569A2 - Productos de combinacion de derivados de propanolamina arilo sustituidos con otros ingredientes activos y su uso - Google Patents
Productos de combinacion de derivados de propanolamina arilo sustituidos con otros ingredientes activos y su usoInfo
- Publication number
- CO5560569A2 CO5560569A2 CO04014409A CO04014409A CO5560569A2 CO 5560569 A2 CO5560569 A2 CO 5560569A2 CO 04014409 A CO04014409 A CO 04014409A CO 04014409 A CO04014409 A CO 04014409A CO 5560569 A2 CO5560569 A2 CO 5560569A2
- Authority
- CO
- Colombia
- Prior art keywords
- alkyl
- residue
- amino acid
- cho
- phenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
Abstract
1.- Una composición de materia que comprende compuestos de la fórmula I: en la cualR1 es fenilo, heteroarilo, no sustituidos u opcionalmente sustituidos por uno a tres radicales mutuamente independientes, donde el sistema aromático o heteroaromático puede sustituirse uno a tres veces por flúor, cloro, bromo, iodo, OH, CF3, -NO2, CN, (C1-C8)- alcoxi, (C1-C8)alquil, -NH2, -NH-R9, -N(R9)R10, CHO, -COOR11, -(C=O)R12, (C1-C6)-alquil-OH, (C1-C6)-alquil(-OH)-fenil, (C1-C6)-alquil-CF3, (C1-C6)-alquil-NO2, (C1-C6)-alquil-CN, (C1-C6)alquil-NH2, (C1-C6)-alquil-NH-R9, (C1-C6)-alquil-N(R9)R10, (C1-C6)-alquil-CHO, (C1-C6)-alquil-COOH, (C1-C6)-alquil-COOR11, (C1-C6)-alquil-C(C=O)-R12, -O-(C1-C6)-alquil-OH, -O-(C1-C6)-alquil-CF3, -O-(C1-C6)-alquil-NO2, -O-(C1-C6)-alquil-CN, -O-(C1-C6)-alquil-NH2, -O-(C1-C6)-alquil-NH-R9, -O-(C1-C6)-alquil-(R9)R10, -O-(C1-C6)-alquil-CHO, -O-(C1-C6)-alquil-COOH, -O-(C1-C6)-alquil-COOR11, -O-(C1-C6)-alquil-(C=O)R12, -N-SO3H, -SO2-CH3, -O-(C1-C6)-alquil-O-(C1-C6)-alquil-fenil, (C1-C6)-alquiltio, piridil, siendo posible para uno o más átomo(s) de hidrógeno en los radicales alquil ser reemplazados por flúor, y siendo posible para fenil y piridil en turno ser mono sustituidos por metil, metoxi o halógeno;R2 es H, OH, CH2OH, OMe, CHO, NH2;R3 es residuo sacárido, residuo disacárido, residuo trisacárido, residuo tetrasacárido, donde el residuo sacárido, el residuo disacárido, el residuo trisacárido, o residuo tetrasacárido es opcionalmente sustituido una o más veces por uno de los grupos protectores de sacáridos, HO-SO2, (HO)2-PO-;R4 es H, metil, F, OMe;R9 a R12 son, independientemente el uno del otro, H, C1-C6-alquil;Z es -NH-C0-C16-alquil-C=O-, -O-C0-C16-alquil-C=O-, -(C=O)m-C1-C16-alquil-(C=O)n, residuo amino ácido, residuo di-amino ácido, donde el residuo amino ácido o el residuo di-amino ácido es opcionalmente sustituido una o más veces por un grupo protector amino ácido, un enlace covalente;m es 0 o 1;las sales farmacéuticamente aceptables o sus derivados fisiológicamente funcionales, y otros ingredientes activos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10140170A DE10140170A1 (de) | 2001-08-22 | 2001-08-22 | Kombinationspräparate von arylsubstituierten Propanolaminderivaten mit weiteren Wirkstoffen und deren Verwendung |
| DE2001142455 DE10142455A1 (de) | 2001-08-31 | 2001-08-31 | Kombinationspräparate von arylsubstituierten Propanolderivaten mit weiteren Wirkstoffen und deren Verwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5560569A2 true CO5560569A2 (es) | 2005-09-30 |
Family
ID=26009945
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO04014409A CO5560569A2 (es) | 2001-08-22 | 2004-02-19 | Productos de combinacion de derivados de propanolamina arilo sustituidos con otros ingredientes activos y su uso |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US20030158094A1 (es) |
| EP (1) | EP1420826A2 (es) |
| JP (1) | JP2005505538A (es) |
| KR (1) | KR20040027963A (es) |
| CN (1) | CN1638801A (es) |
| AR (1) | AR035284A1 (es) |
| BR (1) | BR0211995A (es) |
| CA (1) | CA2457974A1 (es) |
| CO (1) | CO5560569A2 (es) |
| HR (1) | HRP20040172A2 (es) |
| HU (1) | HUP0401908A2 (es) |
| IL (1) | IL160475A0 (es) |
| MX (1) | MXPA04001256A (es) |
| NO (1) | NO20040726L (es) |
| NZ (1) | NZ531292A (es) |
| PA (1) | PA8553101A1 (es) |
| PE (1) | PE20030358A1 (es) |
| PL (1) | PL366855A1 (es) |
| RU (1) | RU2004108120A (es) |
| UY (1) | UY27418A1 (es) |
| WO (1) | WO2003018059A2 (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2425392T3 (es) | 2002-03-20 | 2013-10-15 | Mannkind Corporation | Cartucho para un aparato de inhalación |
| ATE486064T1 (de) | 2004-08-20 | 2010-11-15 | Mannkind Corp | Katalyse der diketopiperazinsynthese |
| PL1791542T3 (pl) | 2004-08-23 | 2015-11-30 | Mannkind Corp | Sole diketopiperazyny do dostarczania leków |
| AU2006290870B2 (en) | 2005-09-14 | 2013-02-28 | Mannkind Corporation | Method of drug formulation based on increasing the affinity of active agents for crystalline microparticle surfaces |
| EP2497484A3 (en) | 2006-02-22 | 2012-11-07 | MannKind Corporation | A method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent |
| US8485180B2 (en) | 2008-06-13 | 2013-07-16 | Mannkind Corporation | Dry powder drug delivery system |
| DK2570147T3 (da) | 2008-06-13 | 2018-01-29 | Mannkind Corp | Tørpulverinhalator og system til lægemiddelindgivelse |
| KR101628410B1 (ko) | 2008-06-20 | 2016-06-08 | 맨카인드 코포레이션 | 흡입 활동에 관한 실시간 프로파일링을 위한 대화형 장치 및 방법 |
| TWI532497B (zh) | 2008-08-11 | 2016-05-11 | 曼凱公司 | 超快起作用胰島素之用途 |
| US8314106B2 (en) | 2008-12-29 | 2012-11-20 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
| RU2531455C2 (ru) | 2010-06-21 | 2014-10-20 | Маннкайнд Корпорейшн | Системы и способы доставки сухих порошковых лекарств |
| MY180552A (en) | 2011-04-01 | 2020-12-02 | Mannkind Corp | Blister package for pharmaceutical cartridges |
| WO2012174472A1 (en) | 2011-06-17 | 2012-12-20 | Mannkind Corporation | High capacity diketopiperazine microparticles |
| WO2013063160A1 (en) | 2011-10-24 | 2013-05-02 | Mannkind Corporation | Methods and compositions for treating pain |
| CA2878457C (en) | 2012-07-12 | 2021-01-19 | Mannkind Corporation | Dry powder drug delivery systems and methods |
| CN114848614A (zh) | 2013-07-18 | 2022-08-05 | 曼金德公司 | 热稳定性干粉药物组合物和方法 |
| US10307464B2 (en) | 2014-03-28 | 2019-06-04 | Mannkind Corporation | Use of ultrarapid acting insulin |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5023245A (en) * | 1987-11-10 | 1991-06-11 | Hauser-Kuhrts, Inc. | Improved niacin formulation |
| DK0869121T3 (da) * | 1997-04-04 | 2004-09-20 | Aventis Pharma Gmbh | Hypolipidæmiske propanolaminderivater |
| DE19845402B4 (de) * | 1998-10-02 | 2005-04-07 | Aventis Pharma Deutschland Gmbh | Mit Heterocyclen substituierte Propanolaminderivate, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung |
| DE19845406C2 (de) * | 1998-10-02 | 2001-10-18 | Aventis Pharma Gmbh | Substituierte 1,3-Diaryl-2-pyridin-2-yl-3-(pyridin-2-ylamino)- propanolderivate, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung |
| DE19845405C2 (de) * | 1998-10-02 | 2000-07-13 | Aventis Pharma Gmbh | Arylsubstituierte Propanolaminderivate und deren Verwendung |
| IL143944A0 (en) * | 1998-12-23 | 2002-04-21 | Searle Llc | Combinations for cardiovascular indications |
-
2002
- 2002-08-09 NZ NZ531292A patent/NZ531292A/en unknown
- 2002-08-09 IL IL16047502A patent/IL160475A0/xx unknown
- 2002-08-09 MX MXPA04001256A patent/MXPA04001256A/es unknown
- 2002-08-09 BR BR0211995-1A patent/BR0211995A/pt not_active IP Right Cessation
- 2002-08-09 CA CA002457974A patent/CA2457974A1/en not_active Abandoned
- 2002-08-09 CN CNA028163532A patent/CN1638801A/zh active Pending
- 2002-08-09 PL PL02366855A patent/PL366855A1/xx not_active Application Discontinuation
- 2002-08-09 EP EP02796212A patent/EP1420826A2/de not_active Withdrawn
- 2002-08-09 JP JP2003522574A patent/JP2005505538A/ja active Pending
- 2002-08-09 KR KR10-2004-7002542A patent/KR20040027963A/ko not_active Application Discontinuation
- 2002-08-09 WO PCT/EP2002/008907 patent/WO2003018059A2/de active IP Right Grant
- 2002-08-09 HU HU0401908A patent/HUP0401908A2/hu unknown
- 2002-08-09 RU RU2004108120/15A patent/RU2004108120A/ru not_active Application Discontinuation
- 2002-08-16 PE PE2002000744A patent/PE20030358A1/es not_active Application Discontinuation
- 2002-08-20 UY UY27418A patent/UY27418A1/es unknown
- 2002-08-20 AR ARP020103123A patent/AR035284A1/es not_active Application Discontinuation
- 2002-08-20 PA PA20028553101A patent/PA8553101A1/es unknown
- 2002-08-22 US US10/225,802 patent/US20030158094A1/en not_active Abandoned
-
2004
- 2004-02-19 NO NO20040726A patent/NO20040726L/no not_active Application Discontinuation
- 2004-02-19 CO CO04014409A patent/CO5560569A2/es not_active Application Discontinuation
- 2004-02-20 HR HR20040172A patent/HRP20040172A2/hr not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| PE20030358A1 (es) | 2003-04-23 |
| WO2003018059A2 (de) | 2003-03-06 |
| US20030158094A1 (en) | 2003-08-21 |
| IL160475A0 (en) | 2004-07-25 |
| NZ531292A (en) | 2005-08-26 |
| PL366855A1 (en) | 2005-02-07 |
| AR035284A1 (es) | 2004-05-05 |
| NO20040726L (no) | 2004-02-19 |
| UY27418A1 (es) | 2002-11-29 |
| KR20040027963A (ko) | 2004-04-01 |
| MXPA04001256A (es) | 2004-05-27 |
| WO2003018059A3 (de) | 2003-11-13 |
| CA2457974A1 (en) | 2003-03-06 |
| JP2005505538A (ja) | 2005-02-24 |
| PA8553101A1 (es) | 2003-06-30 |
| EP1420826A2 (de) | 2004-05-26 |
| HRP20040172A2 (en) | 2004-10-31 |
| CN1638801A (zh) | 2005-07-13 |
| BR0211995A (pt) | 2004-09-28 |
| HUP0401908A2 (hu) | 2005-01-28 |
| RU2004108120A (ru) | 2005-04-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CO5560569A2 (es) | Productos de combinacion de derivados de propanolamina arilo sustituidos con otros ingredientes activos y su uso | |
| NO20062135L (no) | Fenylderivater som PPAR-agonister | |
| BR0108893B1 (pt) | composiÇço farmacÊutica contendo derivados de azetidina, composto derivado de azetidina, e, processo para a preparaÇço de compostos. | |
| AR062683A1 (es) | Compuestos derivados de piridin-4-ilo, composicion farmaceutica que los contiene, y uso de los mismos en la preparacion de medicamentos | |
| AR035631A1 (es) | Compuestos quimicos | |
| ES2052387T3 (es) | Utilizacion de derivados de pirimidina-3-oxido para frenar la caida de los cabellos y composiciones topicas empleadas. | |
| AR039778A1 (es) | Moduladores alostericos positivos del receptor nicotinico de la acetilcolina | |
| AR035320A1 (es) | Compuestos activadores de hppardelta, composicion farmaceutica, su uso en la preparacion de medicamentos, metodo para el tratamiento de enfermedades mediadas por hppardelta | |
| NO20054787D0 (no) | Indenderivater som farmasotiske midler | |
| ES2187983T3 (es) | Derivados 1,2,3,4-tetrahidronaftaleno sustituidos. | |
| AR063988A1 (es) | Derivados heterociclicos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen | |
| AR041297A1 (es) | Derivados de 4-pirrolidino- fenil- bencil eter | |
| AR020032A1 (es) | Derivados de 1,3 -metil eritromicina. | |
| ATE372995T1 (de) | Benzo(b)(1,4)dioxepinderivate | |
| AR032607A1 (es) | Composiciones farmaceuticas que contienen sales de hidroxieicosatetraenoato, y el uso de las mismas para la manufactura de un medicamento para el tratamiento de desordenes del ojo seco | |
| AR039651A1 (es) | Derivados de isoquinolina | |
| UY29739A1 (es) | Derivados de amidas o sales farmacéuticamente aceptables de los mismos, procesos de preparaciones farmacéuticas conteniéndolos y aplicaciones | |
| AR064488A1 (es) | DERIVADOS DE4-(1-AMINO-ETIL)-CICLOHEXILAMINA, UNA COMPOSICION FARMACEUTICA QUE LO CONTIENE Y EL USO DE LOS MISMOS PARA LA PREPARACION DE UN MEDICAMENTO PARA EL TRATAMIENTO O PREVENCIoN DE UNA INFECCION BACTERIANA | |
| AR039935A1 (es) | Formulacion farmaceutica de liberacion inmediata | |
| AR068372A1 (es) | Derivados de n-fenilacetamida, inhibidores de la enzima soat1, y composiciones farmaceuticas y cosmeticas que los contienen | |
| HUP0203187A2 (hu) | Izoxazolszármazékok mint foszfodiészteráz VII inhibitorok és ezeket tartalmazó gyógyszerkészítmények | |
| ATE432262T1 (de) | Pyrazolphenylderivate als ppar-aktivatoren | |
| AR029001A1 (es) | Derivados de bencil-3,4-metilendioxicinamico y el uso de los mismos para la manufactura de un medicamento | |
| AR047409A1 (es) | Derivados ciclicos de fenilalanina, proceso de obtencion y composiciones farmaceuticas. | |
| AR044320A1 (es) | Derivados 3-decladinosilo de la clase de 9a - n-carbamoil - y 9a-ntiocarbamoil- 9 dihidro-9a aza- 9a - homoeritromicina a |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Application withdrawn |