ES2052387T3 - Utilizacion de derivados de pirimidina-3-oxido para frenar la caida de los cabellos y composiciones topicas empleadas. - Google Patents
Utilizacion de derivados de pirimidina-3-oxido para frenar la caida de los cabellos y composiciones topicas empleadas.Info
- Publication number
- ES2052387T3 ES2052387T3 ES91913941T ES91913941T ES2052387T3 ES 2052387 T3 ES2052387 T3 ES 2052387T3 ES 91913941 T ES91913941 T ES 91913941T ES 91913941 T ES91913941 T ES 91913941T ES 2052387 T3 ES2052387 T3 ES 2052387T3
- Authority
- ES
- Spain
- Prior art keywords
- group
- designates
- hydrogen
- rent
- hair loss
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/32—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups
- C07C65/40—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups containing singly bound oxygen-containing groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Birds (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
LA INVENCION SE REFIERE A UNA COMPOSICION DESTINADA AL TRATAMIENTO DELA CAIDA DEL CABELLO QUE CONTIENE EN UN MEDIO FISIOLOGICAMENTE ACEPTABLE APROPIADO PARA UNA APLICACION TOPICA AL MENOS UN COMPUESTO QUE RESPONDE A LA FORMULA (I), EN LA QUE: R1 DESIGNA UN GRUPO METILO O NHR4 EN EL QUE R4 DESIGNA UN GRUPO ALQUILO EN C1-C4 O HIDROGENO; R2 DESIGNA HIDROGENO O UN GRUPO NHR4 EN EL QUE R4 TIENE LA MISMA SIGNIFICACION QUE ANTERIORMENTE; R2 PUEDE TAMBIEN DESIGNAR METILO CUANDO R1 DESIGNA METILO; CUANDO R1 DESIGNA NH2, R2 NO PUEDE SER HIDROGENO;M R3 PUEDE DESIGNAR UN ATOMO DE HIDROGENO, UN GRUPO ALQUILO EN C1-C4 QUE PUEDE EVENTUALMENTE LLEVAR: UN GRUPO OR5 EN EL QUE R5 DESIGNA UN GRUPO ALQUILO EN C1-C4, UN NUCLEO BENCENICO EVENTUALMENTE SUSTITUIDO POR UNO O VARIOS GRUPOS ALCOXI EN C1-C4, R3 PUEDE TAMBIEN REPRESENTAR UN ATOMO DE HALOGENO O UN GRUPO NITRO O AMINO, Y LAS SALES DE ADICION DE ACIDOS FISIOLOGICAMENTE ACEPTABLES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
LU87766A LU87766A1 (fr) | 1990-07-20 | 1990-07-20 | Utilisation de derives de pyrimidine 3-oxyde pour freiner la chute des cheveux et compositions topiques mises en oeuvre |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2052387T3 true ES2052387T3 (es) | 1994-07-01 |
Family
ID=19731245
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES91913941T Expired - Lifetime ES2052387T3 (es) | 1990-07-20 | 1991-07-19 | Utilizacion de derivados de pirimidina-3-oxido para frenar la caida de los cabellos y composiciones topicas empleadas. |
Country Status (7)
Country | Link |
---|---|
US (1) | US5328914A (es) |
EP (1) | EP0540629B1 (es) |
JP (1) | JP3040164B2 (es) |
DE (1) | DE69101922T2 (es) |
ES (1) | ES2052387T3 (es) |
LU (1) | LU87766A1 (es) |
WO (1) | WO1992001437A1 (es) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
LU87766A1 (fr) * | 1990-07-20 | 1992-03-11 | Oreal | Utilisation de derives de pyrimidine 3-oxyde pour freiner la chute des cheveux et compositions topiques mises en oeuvre |
FR2724561B1 (fr) * | 1994-09-19 | 1996-12-13 | Oreal | Utilisation du 2,4-diamino pyrimidine 3-oxyde ou de l'un de ses sels dans le traitement des desordres de la maturation et de la structuration du collagene |
AU760046B2 (en) | 1998-02-27 | 2003-05-08 | United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Disubstituted lavendustin a analogs and pharmaceutical compositions comprising the analogs |
FR2781481B1 (fr) | 1998-07-24 | 2000-09-15 | Oreal | Nouveaux 2-amino, 4-alkylamino pyrimidine 3-oxydes et composition les comprenant |
ATE352306T1 (de) * | 1998-07-31 | 2007-02-15 | Meir S Sacks | Ein präkursor der harnsäure und ein antioxidationsmittel enthaltende zusammensetzung und deren verwendung zur behandlung von neurodegenerativen erkrankungen |
DE19845202A1 (de) * | 1998-10-01 | 2000-04-06 | Wella Ag | Haarwuchsmittel |
FR2785802B1 (fr) * | 1998-11-12 | 2002-10-31 | Oreal | 2-amino, 4-alkylamino pyrimidine 3-oxydes comme anti-inflammatoires |
JP3523829B2 (ja) * | 1999-09-01 | 2004-04-26 | 甫 鳥本 | 芝生の病害虫防除剤、その製造方法及び防除方法 |
FR2798855B1 (fr) * | 1999-09-28 | 2003-04-25 | Oreal | Utilisation de complexes inorganiques-organiques dans une composition a usage topique |
US7763587B2 (en) * | 2002-06-13 | 2010-07-27 | L'oreal S.A. | Derivative of glucose and of vitamin F, compositions comprising it, uses and preparation process |
CA2494061C (en) * | 2002-07-31 | 2011-06-14 | Wayne R. Danter | Protein tyrosine kinase inhibitors |
WO2004033446A1 (en) * | 2002-10-09 | 2004-04-22 | Danter Wayne R | Protein tyrosine kinase inhibitors |
FR2852847B1 (fr) * | 2003-03-28 | 2006-09-08 | Isocell | Composition renfermant une superoxyde dismutase et un inhibiteur de la 5-lipoxygenase selectionne et applications |
US7326717B2 (en) * | 2003-05-06 | 2008-02-05 | L'oreal | Pyrimidine n-oxide compounds for stimulating the growth of keratin fibers and/or reducing loss thereof |
FR2854630B1 (fr) * | 2003-05-06 | 2005-06-10 | Oreal | Composition capilaire contenant un derive de pyrimidine n-oxydase, son utilisation pour stimuler la pousse des fibres keratiniques et/ou freiner leur chute |
FR2863878B1 (fr) * | 2003-12-22 | 2006-06-30 | Oreal | Utilisation d'ecdysteroides pour la preparation de compositions dermathologiques ou cosmetiques anti-chute de cheveux. |
US7238375B1 (en) * | 2004-12-20 | 2007-07-03 | Perry Stephen C | Composition and method to promote human hair growth |
EP1863431A1 (en) * | 2005-03-18 | 2007-12-12 | L'Oréal | Hair and/or eyelash care composition containing aminexil in combination with an agent for promoting the no production and uses thereof |
FR2883167B1 (fr) * | 2005-03-18 | 2009-07-10 | Oreal | Composition de soin capillaire et/ou des cils contenant de l'aminexil en association avec un vasodilatateur, destinee a stimuler la croissance des cheveux et/ou des cils et/ou freiner leur chute, ses utilisations |
WO2007101357A2 (de) * | 2006-03-07 | 2007-09-13 | Pelloni, Claudio | Haarwuchsmittel zur behandlung von menschlichen keratinfasern und verfahren zu dessen herstellung |
EP1897533A1 (en) * | 2006-09-08 | 2008-03-12 | Revotar Biopharmaceuticals AG | Use of 1,6-Bis [3-(3-carboxymethylphenyl)-4-(2-alpha -D-mannopyranosyl-oxy)-phenyl] hexane for the preparation of cosmetic compositions |
CA2673683C (en) | 2007-01-11 | 2014-07-29 | Critical Outcome Technologies, Inc. | Compounds and method for treatment of cancer |
EP1946756A1 (en) * | 2007-01-17 | 2008-07-23 | Revotar Biopharmaceuticals AG | Use of entacapone in cosmetic, dermatological and pharmaceutical compositions |
CA2710039C (en) * | 2007-12-26 | 2018-07-03 | Critical Outcome Technologies, Inc. | Semicarbazones, thiosemicarbazones and related compounds and methods for treatment of cancer |
FR2929117B1 (fr) * | 2008-03-28 | 2010-05-07 | Oreal | Utilisation de l'association du 2,4-diaminopyrimidine 3-n-oxyde et du madecassosside et/ou du terminoloside pour induire et/ou stimuler la croissance de ces fibres keratiniques humaines et/ou freiner leur chute |
EP3023426A1 (en) | 2008-07-17 | 2016-05-25 | Critical Outcome Technologies, Inc. | Thiosemicarbazone inhibitor compounds and cancer treatment methods |
FR2941150B1 (fr) | 2009-01-16 | 2013-01-11 | Oreal | Produit pour la prevention ou le traitement du blanchissement des cheveux. |
FR2953722B1 (fr) | 2009-12-16 | 2012-03-09 | Expanscience Lab | Composition comprenant au moins un sucre en c7 pour le traitement de l'alopecie, pour le traitement cosmetique des phaneres, et pour le soin des cheveux, cils ou ongles |
CA2999435A1 (en) | 2010-04-01 | 2011-10-06 | Critical Outcome Technologies Inc. | Compounds and method for treatment of hiv |
JP2013532720A (ja) * | 2010-08-05 | 2013-08-19 | レガシー ヘルスケア ホールディング リミテッド | 毛髪成長刺激方法 |
CN104058987B (zh) * | 2014-06-25 | 2016-04-20 | 齐鲁工业大学 | 一种连续式制备辣椒碱类物质的方法 |
CN104058988B (zh) * | 2014-06-25 | 2016-01-20 | 齐鲁工业大学 | 利用双相萃取技术从辣椒精中提取辣椒碱的方法 |
CN107970128B (zh) * | 2017-12-06 | 2021-01-15 | 彭氏(惠州)实业发展有限公司 | 一种含有二氨基嘧啶氧化物的生发液配方与生产工艺 |
FR3130153A1 (fr) * | 2021-12-15 | 2023-06-16 | L'oreal | Utilisation d’au moins un dérivé de pyrimidine 3-oxyde pour renforcer la fonction barrière de la peau |
CN114315738B (zh) * | 2022-01-15 | 2023-08-18 | 重庆东寰科技开发有限公司 | 一种2,4-二氨基嘧啶-3-氧化物的制备方法 |
CN114213340B (zh) * | 2022-02-22 | 2022-06-07 | 北京蓝晶微生物科技有限公司 | 2,4-二氨基嘧啶氧化物的制备方法 |
CN116143706B (zh) * | 2023-03-06 | 2023-09-19 | 珠海市柏瑞医药科技有限公司 | 一种二氨基嘧啶氧化物的合成方法 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1477048A (fr) * | 1965-04-23 | 1967-04-14 | Oreal | Nouveaux agents tensio-actifs non ioniques et leur procédé de préparation |
LU60900A1 (es) * | 1970-05-12 | 1972-02-10 | ||
BE791534A (es) * | 1971-11-18 | 1973-05-17 | Oreal | |
LU73633A1 (es) * | 1975-10-23 | 1977-05-31 | ||
FR2504535B1 (fr) * | 1981-04-28 | 1987-08-14 | Choay Sa | Disaccharides derives d'un acide uronique et d'une glucosamine et compositions pharmaceutiques les contenant pour le controle de la coagulation sanguine |
FR2574786B1 (fr) * | 1984-12-17 | 1988-06-10 | Oreal | Procede de preparation d'agents de surface non ioniques a partir de la monochlorhydrine du glycerol, produits obtenus et composition les contenant |
FR2581542B1 (fr) * | 1985-05-07 | 1988-02-19 | Oreal | Compositions topiques destinees au traitement de la peau a base de derives de l'acide salicylique |
GB8519416D0 (en) * | 1985-08-01 | 1985-09-04 | Unilever Plc | Oligosaccharides |
GB8630721D0 (en) * | 1986-12-23 | 1987-02-04 | Unilever Plc | Cosmetic compositions |
WO1989007595A1 (en) * | 1988-02-17 | 1989-08-24 | Bazzano Gail S | Spiroaza derivatives of heterocyclic n-oxides and their use in hair growth promotion |
GB8806892D0 (en) * | 1988-03-23 | 1988-04-27 | Unilever Plc | Lactams their synthesis & use in cosmetic compositions |
LU87308A1 (fr) * | 1988-08-01 | 1990-03-13 | Oreal | Nouveaux derives de diamino-2,4 pyrimidine oxyde-3 et leur utilisation pour le traitement et la prevention de la chute des cheveux |
GB8830019D0 (en) * | 1988-12-22 | 1989-02-15 | Unilever Plc | Cosmetic composition |
GB8913708D0 (en) * | 1989-06-14 | 1989-08-02 | Unilever Plc | Cosmetic composition |
LU87766A1 (fr) * | 1990-07-20 | 1992-03-11 | Oreal | Utilisation de derives de pyrimidine 3-oxyde pour freiner la chute des cheveux et compositions topiques mises en oeuvre |
-
1990
- 1990-07-20 LU LU87766A patent/LU87766A1/fr unknown
-
1991
- 1991-07-19 JP JP03513195A patent/JP3040164B2/ja not_active Expired - Lifetime
- 1991-07-19 DE DE69101922T patent/DE69101922T2/de not_active Expired - Lifetime
- 1991-07-19 US US07/956,507 patent/US5328914A/en not_active Expired - Lifetime
- 1991-07-19 EP EP91913941A patent/EP0540629B1/fr not_active Expired - Lifetime
- 1991-07-19 ES ES91913941T patent/ES2052387T3/es not_active Expired - Lifetime
- 1991-07-19 WO PCT/FR1991/000596 patent/WO1992001437A1/fr active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
EP0540629B1 (fr) | 1994-05-04 |
JP3040164B2 (ja) | 2000-05-08 |
LU87766A1 (fr) | 1992-03-11 |
US5328914A (en) | 1994-07-12 |
WO1992001437A1 (fr) | 1992-02-06 |
DE69101922T2 (de) | 1994-08-25 |
JPH05509099A (ja) | 1993-12-16 |
DE69101922D1 (de) | 1994-06-09 |
EP0540629A1 (fr) | 1993-05-12 |
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