DE69221252T2 - Lipophile Zusammensetzungen von Oligosaccharid-Antibiotikasalzen - Google Patents
Lipophile Zusammensetzungen von Oligosaccharid-AntibiotikasalzenInfo
- Publication number
- DE69221252T2 DE69221252T2 DE69221252T DE69221252T DE69221252T2 DE 69221252 T2 DE69221252 T2 DE 69221252T2 DE 69221252 T DE69221252 T DE 69221252T DE 69221252 T DE69221252 T DE 69221252T DE 69221252 T2 DE69221252 T2 DE 69221252T2
- Authority
- DE
- Germany
- Prior art keywords
- cyclodextrin
- hydroxypropyl
- formula
- compound
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
- A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
- C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
- C07H9/04—Cyclic acetals
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nanotechnology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77786491A | 1991-10-16 | 1991-10-16 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69221252D1 DE69221252D1 (de) | 1997-09-04 |
| DE69221252T2 true DE69221252T2 (de) | 1998-01-22 |
Family
ID=25111545
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69221252T Expired - Fee Related DE69221252T2 (de) | 1991-10-16 | 1992-10-14 | Lipophile Zusammensetzungen von Oligosaccharid-Antibiotikasalzen |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US5624914A (enExample) |
| EP (2) | EP0610295A1 (enExample) |
| JP (1) | JP2614407B2 (enExample) |
| KR (1) | KR100249584B1 (enExample) |
| CN (1) | CN1035923C (enExample) |
| AT (1) | ATE156019T1 (enExample) |
| AU (1) | AU678344B2 (enExample) |
| CA (1) | CA2121345C (enExample) |
| DE (1) | DE69221252T2 (enExample) |
| DK (1) | DK0538011T3 (enExample) |
| ES (1) | ES2104845T3 (enExample) |
| FI (1) | FI941723A7 (enExample) |
| GR (1) | GR3024800T3 (enExample) |
| HK (1) | HK1001085A1 (enExample) |
| HR (1) | HRP921069B1 (enExample) |
| HU (1) | HUT75157A (enExample) |
| IL (1) | IL103446A (enExample) |
| MX (1) | MX9205922A (enExample) |
| NO (1) | NO307326B1 (enExample) |
| NZ (1) | NZ244735A (enExample) |
| PH (1) | PH31675A (enExample) |
| PL (1) | PL170591B1 (enExample) |
| SI (1) | SI9200260A (enExample) |
| TW (1) | TW221378B (enExample) |
| WO (1) | WO1993007904A1 (enExample) |
| YU (1) | YU48722B (enExample) |
| ZA (1) | ZA927923B (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6380172B1 (en) | 1991-10-16 | 2002-04-30 | Schering Corporation | Monomeric lipophilic oligosaccharide antibiotic compositions |
| US5948688A (en) * | 1991-10-16 | 1999-09-07 | Schering Corporation | Method of determining monomeric drug content |
| US5652226A (en) * | 1995-12-22 | 1997-07-29 | Schering Corporation | Water soluble antibiotics |
| US5776912A (en) * | 1996-12-20 | 1998-07-07 | Schering Corporation | Lipophilic oligosaccharide antibiotic compositions |
| US5763600A (en) * | 1997-04-18 | 1998-06-09 | Schering Corporation | Oligosaccharide antibiotics and process for preparation thereof |
| JP2001518556A (ja) * | 1997-10-03 | 2001-10-16 | ガレニカ ファーマシューティカルズ， インコーポレイテッド | イミン形成ポリサッカライド、その調製、ならびにアジュバントおよび免疫刺激剤としてのその使用 |
| US6162910A (en) * | 1998-11-30 | 2000-12-19 | Schering Corporation | Process for preparing lipophilic oligosaccharide antibiotics |
| US6320044B1 (en) | 1998-12-18 | 2001-11-20 | Schering Corporation | Process for recovering lipophilic oligosaccharide antibiotics |
| CO5231233A1 (es) * | 1998-12-18 | 2002-12-27 | Cherinf Corp | Proceso para recuperar antibioticos oligosacaridos lipofilic lipofilicos |
| WO2001039573A2 (de) * | 1999-12-01 | 2001-06-07 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Verwendung von lungensurfactant zur behandlung von legionärskrankheit |
| US6861513B2 (en) | 2000-01-12 | 2005-03-01 | Schering Corporation | Everninomicin biosynthetic genes |
| DE60136926D1 (de) * | 2000-05-02 | 2009-01-22 | Theravance Inc | Zusammensetzung die eine zyklodextrin und ein glykopeptid-antibiotikum enthält |
| WO2002032459A2 (en) * | 2000-10-17 | 2002-04-25 | Massachusetts Institute Of Technology | Method of increasing the efficacy of antibiotics by complexing with cyclodextrins |
| DE10109166A1 (de) * | 2001-02-25 | 2002-09-12 | Combinature Biopharm Ag | Avilamycin-Derivate |
| EP1730163A4 (en) * | 2004-03-17 | 2009-12-30 | Panacos Pharmaceuticals Inc | Pharmaceutical salts of 3-O- (3,3-dimethylsuccinyl) betulinic acid |
| EP1666228B1 (en) * | 2004-12-01 | 2016-04-13 | Nitto Denko Corporation | Foam filling member |
| BRPI0610668A2 (pt) * | 2005-04-12 | 2010-07-13 | Panacos Pharmaceuticals Inc | polimorfas de di-n-metil-d-glucamina do ácido 3-o-(3',3'-dimetilsuccinil) betulìnico |
| AU2008299885C1 (en) * | 2007-09-14 | 2015-06-25 | Sanofi Pasteur Biologics, Llc | Pharmaceutical compositions containing clostridium difficile toxoids A and B |
| JP2010095454A (ja) * | 2008-10-14 | 2010-04-30 | Cyclochem:Kk | 抗菌組成物 |
| EP4324483A3 (en) * | 2011-01-14 | 2024-05-01 | Emory University | Oligosaccharide conjugates for targeting bacteria and uses related thereto |
| AU2016276774A1 (en) | 2015-06-10 | 2018-01-18 | Vtesse, Inc. | Hydroxypropyl beta-cyclodextrin compositions and methods |
| CN106317143B (zh) * | 2016-08-23 | 2020-10-30 | 河北圣雪大成制药有限责任公司 | 一种提取阿维拉霉素的方法 |
| JP2025506676A (ja) | 2022-02-18 | 2025-03-13 | ベレン セラピューティクス ピー．ビー．シー． | ヒドロキシプロピル－ベータ－シクロデキストリンの組成物及びその精製方法 |
| CN117024611B (zh) * | 2023-03-01 | 2024-05-17 | 中国科学院南海海洋研究所 | 寡糖类抗生素everninomicin高产菌株的构建及活性的应用 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR128F (enExample) * | 1962-04-02 | |||
| US3915956A (en) * | 1973-07-09 | 1975-10-28 | Schering Corp | Reduction products of everninomicins and methods for their manufacture |
| US3920629A (en) * | 1973-09-19 | 1975-11-18 | Schering Corp | Desevernitrose everninomicins and method for their manufacture |
| US4006225A (en) * | 1973-10-31 | 1977-02-01 | Schering Corporation | Method of using reduction products of everninomicins as antibacterial agents and pharmaceutical compositions useful therefor |
| US4027016A (en) * | 1976-01-19 | 1977-05-31 | Schering Corporation | Everninomicin antibacterial derivatives, electrochemical method for their manufacture, method for their use as antibacterial agents, and pharmaceutical compositions useful therefor |
| US3998708A (en) * | 1976-01-19 | 1976-12-21 | Schering Corporation | Electrochemical process for preparing hydroxylaminoeverninomicins |
| US4129720A (en) * | 1977-02-14 | 1978-12-12 | Schering Corporation | Aminoeverninomicin and derivatives thereof |
| US4597968A (en) * | 1982-08-06 | 1986-07-01 | Schering Corporation | Antibiotic 13-384 complex from Micromonospora carbonacea var africana |
| DE3346123A1 (de) * | 1983-12-21 | 1985-06-27 | Janssen Pharmaceutica, N.V., Beerse | Pharmazeutische praeparate von in wasser schwerloeslichen oder instabilen arzneistoffen und verfahren zu ihrer herstellung |
| US4727064A (en) * | 1984-04-25 | 1988-02-23 | The United States Of America As Represented By The Department Of Health And Human Services | Pharmaceutical preparations containing cyclodextrin derivatives |
| US4596795A (en) * | 1984-04-25 | 1986-06-24 | The United States Of America As Represented By The Secretary, Dept. Of Health & Human Services | Administration of sex hormones in the form of hydrophilic cyclodextrin derivatives |
| US4735903A (en) * | 1984-06-21 | 1988-04-05 | Schering Corporation | Micromonospora carbonacea var africana |
| US4870060A (en) * | 1985-03-15 | 1989-09-26 | Janssen Pharmaceutica | Derivatives of γ-cylodextrin |
| US4767748A (en) * | 1985-10-15 | 1988-07-30 | Schering Corporation | Substituted oligosaccharide antibodies |
| US4622314A (en) * | 1985-10-15 | 1986-11-11 | Schering Corporation | Substituted oligosaccharide antibiotics |
| US5017566A (en) * | 1987-12-30 | 1991-05-21 | University Of Florida | Redox systems for brain-targeted drug delivery |
| US5002935A (en) * | 1987-12-30 | 1991-03-26 | University Of Florida | Improvements in redox systems for brain-targeted drug delivery |
| KR0166088B1 (ko) * | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
-
1992
- 1992-10-14 WO PCT/US1992/008565 patent/WO1993007904A1/en not_active Ceased
- 1992-10-14 NZ NZ244735A patent/NZ244735A/en unknown
- 1992-10-14 AU AU27806/92A patent/AU678344B2/en not_active Ceased
- 1992-10-14 TW TW081108170A patent/TW221378B/zh active
- 1992-10-14 DK DK92309368.6T patent/DK0538011T3/da active
- 1992-10-14 YU YU92192A patent/YU48722B/sh unknown
- 1992-10-14 US US08/211,700 patent/US5624914A/en not_active Expired - Lifetime
- 1992-10-14 CA CA002121345A patent/CA2121345C/en not_active Expired - Fee Related
- 1992-10-14 HU HU9401104A patent/HUT75157A/hu unknown
- 1992-10-14 EP EP92921991A patent/EP0610295A1/en active Pending
- 1992-10-14 DE DE69221252T patent/DE69221252T2/de not_active Expired - Fee Related
- 1992-10-14 ZA ZA927923A patent/ZA927923B/xx unknown
- 1992-10-14 EP EP92309368A patent/EP0538011B1/en not_active Expired - Lifetime
- 1992-10-14 ES ES92309368T patent/ES2104845T3/es not_active Expired - Lifetime
- 1992-10-14 AT AT92309368T patent/ATE156019T1/de not_active IP Right Cessation
- 1992-10-14 PH PH45109A patent/PH31675A/en unknown
- 1992-10-14 PL PL92303189A patent/PL170591B1/pl unknown
- 1992-10-14 KR KR1019940701247A patent/KR100249584B1/ko not_active Expired - Fee Related
- 1992-10-14 JP JP5507719A patent/JP2614407B2/ja not_active Expired - Lifetime
- 1992-10-15 MX MX9205922A patent/MX9205922A/es not_active IP Right Cessation
- 1992-10-15 CN CN92112388A patent/CN1035923C/zh not_active Expired - Fee Related
- 1992-10-15 IL IL10344692A patent/IL103446A/xx not_active IP Right Cessation
- 1992-10-16 SI SI19929200260A patent/SI9200260A/sl unknown
- 1992-10-16 HR HR07/777,864A patent/HRP921069B1/xx not_active IP Right Cessation
-
1994
- 1994-04-08 NO NO941276A patent/NO307326B1/no not_active IP Right Cessation
- 1994-04-14 FI FI941723A patent/FI941723A7/fi unknown
-
1997
- 1997-09-19 GR GR970402434T patent/GR3024800T3/el unknown
-
1998
- 1998-01-09 HK HK98100167A patent/HK1001085A1/en not_active IP Right Cessation
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |