ES2085940T3 - 4-amino-3-piridinoles sustituidos, un procedimiento para su preparacion y su uso como medicamentos. - Google Patents
4-amino-3-piridinoles sustituidos, un procedimiento para su preparacion y su uso como medicamentos.Info
- Publication number
- ES2085940T3 ES2085940T3 ES91116336T ES91116336T ES2085940T3 ES 2085940 T3 ES2085940 T3 ES 2085940T3 ES 91116336 T ES91116336 T ES 91116336T ES 91116336 T ES91116336 T ES 91116336T ES 2085940 T3 ES2085940 T3 ES 2085940T3
- Authority
- ES
- Spain
- Prior art keywords
- sub
- hydrogen
- preparation
- rent
- piridinoles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000003814 drug Substances 0.000 title 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- 150000001875 compounds Chemical class 0.000 abstract 3
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical class [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 230000001713 cholinergic effect Effects 0.000 abstract 1
- 230000006735 deficit Effects 0.000 abstract 1
- 230000004064 dysfunction Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/26—Radicals substituted by halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Surface Treatment Of Glass (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58911390A | 1990-09-27 | 1990-09-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2085940T3 true ES2085940T3 (es) | 1996-06-16 |
Family
ID=24356648
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES91116336T Expired - Lifetime ES2085940T3 (es) | 1990-09-27 | 1991-09-25 | 4-amino-3-piridinoles sustituidos, un procedimiento para su preparacion y su uso como medicamentos. |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US5821239A (Direct) |
| EP (1) | EP0477903B1 (Direct) |
| JP (1) | JP3090511B2 (Direct) |
| KR (1) | KR100215357B1 (Direct) |
| AT (1) | ATE136297T1 (Direct) |
| AU (1) | AU637720B2 (Direct) |
| CA (1) | CA2052433C (Direct) |
| CZ (1) | CZ282002B6 (Direct) |
| DE (1) | DE69118470T2 (Direct) |
| DK (1) | DK0477903T3 (Direct) |
| ES (1) | ES2085940T3 (Direct) |
| FI (1) | FI914504A7 (Direct) |
| GR (1) | GR3019742T3 (Direct) |
| HU (1) | HUT60247A (Direct) |
| IE (1) | IE73874B1 (Direct) |
| IL (1) | IL99581A (Direct) |
| NO (1) | NO913778L (Direct) |
| NZ (1) | NZ239935A (Direct) |
| PT (1) | PT99073B (Direct) |
| TW (1) | TW200462B (Direct) |
| YU (1) | YU158591A (Direct) |
| ZA (1) | ZA917692B (Direct) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6218383B1 (en) | 1998-08-07 | 2001-04-17 | Targacept, Inc. | Pharmaceutical compositions for the prevention and treatment of central nervous system disorders |
| FR2813891B1 (fr) * | 2000-09-14 | 2005-01-14 | Immunotech Sa | Reactif multifonctionnel pour erythrocytes mettant en jeu des carbamates et applications |
| DE10102791B4 (de) * | 2001-01-22 | 2004-04-15 | Ifm Electronic Gmbh | Elektrischer Meßumformer |
| US7279470B2 (en) * | 2001-12-14 | 2007-10-09 | Novo Nordisk A/S | Compounds and uses thereof for decreasing activity of hormone-sensitive lipase |
| KR100443983B1 (ko) | 2002-01-15 | 2004-08-09 | 삼성전자주식회사 | 냉장고 |
| US8007826B2 (en) | 2003-12-11 | 2011-08-30 | Acorda Therapeutics, Inc. | Sustained release aminopyridine composition |
| US8354437B2 (en) | 2004-04-09 | 2013-01-15 | Acorda Therapeutics, Inc. | Method of using sustained release aminopyridine compositions |
| CA2598294C (en) * | 2005-02-17 | 2011-10-18 | Astellas Pharma Inc. | Pyridyl non-aromatic nitrogen-containing heterocyclic-1-carboxylate derivative |
| BRPI0903914A2 (pt) * | 2008-09-10 | 2015-07-21 | Acorda Therapeutics Inc | Uso de um composto, método para analisar a eficácia de uma composição de liberação prolongada, e, composição farmacêutica. |
| JP6082250B2 (ja) | 2010-02-09 | 2017-02-15 | ザ・ジョンズ・ホプキンス・ユニバーシティー | 認知機能を改善するための方法および組成物 |
| CA2891122C (en) | 2012-11-14 | 2021-07-20 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
| RS56949B1 (sr) | 2012-12-13 | 2018-05-31 | H Lundbeck As | Kompozicije koje obuhvataju vortioksetin i donepezil |
| EP2968220B1 (en) | 2013-03-15 | 2021-05-05 | Agenebio, Inc. | Methods and compositions for improving cognitive function |
| EP3827820A1 (en) | 2013-03-15 | 2021-06-02 | The Johns Hopkins University | Brivaracetam for improving cognitive function |
| CN107810002B (zh) | 2015-05-22 | 2021-01-05 | 艾吉因生物股份有限公司 | 左乙拉西坦的延时释放药物组合物 |
| JP6899120B2 (ja) * | 2016-10-12 | 2021-07-07 | 株式会社ナノエッグ | アセチルコリンエステラーゼ（ＡＣｈＥ）阻害剤 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4179563A (en) * | 1978-05-19 | 1979-12-18 | Warner-Lambert Company | 3-Aryloxy-substituted-aminopyridines and methods for their production |
| US4734275A (en) * | 1983-08-19 | 1988-03-29 | Research Corporation | Anti-curare agents |
| DE3514073A1 (de) * | 1985-04-18 | 1986-10-23 | Hoechst Ag, 6230 Frankfurt | Mehrfach substituierte pyridin-1-oxide, verfahren zu ihrer herstellung, die sie enthaltenden arzneimittel und ihre verwendung |
| US4735958A (en) * | 1986-12-22 | 1988-04-05 | Warner-Lambert Company | Trans-6-[2-[2-(substituted-phenyl)-3- (or 4-) heteroaryl-5-substituted-1H-pyrrol-1-yl]-ethyl]tetrahydro-4-hydroxy-2H-pyran-2-one inhibitors of cholesterol biosynthesis |
| US4831044A (en) * | 1987-10-29 | 1989-05-16 | Ici Americas Inc. | Fungicidal pyridyl cyclopropane carboxamidines |
| US4994473A (en) * | 1987-11-17 | 1991-02-19 | Ici Americas Inc. | Pyridyl containing insecticides |
| US5019574A (en) * | 1988-09-30 | 1991-05-28 | Chugai Seiyaku Kabushiki Kaisha | 3,4-diaminoquinoline and 3,4-diamino-5,6,7,8-tetrahydroquinoline compounds useful for improving psychoneural function |
| FI90417C (fi) * | 1988-11-16 | 1994-02-10 | Hoechst Marion Roussel Inc | Menetelmä terapeuttisesti aktiivisten hydroksi-1,2,3,4-tetrahydroaminoakridiinien valmistamiseksi |
| US4931457B1 (en) * | 1989-06-28 | 1993-11-16 | Hoechst-Roussel Pharmaceuticals Incorporated | Naphthylamino-and naphthyloxy-pyridineamin compounds useful as topical antiinflammatory agents for the treatment of skin disorders |
-
1991
- 1991-08-31 TW TW080106907A patent/TW200462B/zh active
- 1991-09-25 AT AT91116336T patent/ATE136297T1/de not_active IP Right Cessation
- 1991-09-25 ES ES91116336T patent/ES2085940T3/es not_active Expired - Lifetime
- 1991-09-25 DE DE69118470T patent/DE69118470T2/de not_active Expired - Fee Related
- 1991-09-25 CZ CS912936A patent/CZ282002B6/cs not_active IP Right Cessation
- 1991-09-25 DK DK91116336.8T patent/DK0477903T3/da active
- 1991-09-25 FI FI914504A patent/FI914504A7/fi not_active Application Discontinuation
- 1991-09-25 NZ NZ239935A patent/NZ239935A/en unknown
- 1991-09-25 EP EP91116336A patent/EP0477903B1/en not_active Expired - Lifetime
- 1991-09-26 CA CA002052433A patent/CA2052433C/en not_active Expired - Fee Related
- 1991-09-26 JP JP03273439A patent/JP3090511B2/ja not_active Expired - Fee Related
- 1991-09-26 AU AU84756/91A patent/AU637720B2/en not_active Expired - Fee Related
- 1991-09-26 PT PT99073A patent/PT99073B/pt not_active IP Right Cessation
- 1991-09-26 ZA ZA917692A patent/ZA917692B/xx unknown
- 1991-09-26 HU HU913075A patent/HUT60247A/hu unknown
- 1991-09-26 YU YU158591A patent/YU158591A/sh unknown
- 1991-09-26 IL IL9958191A patent/IL99581A/en not_active IP Right Cessation
- 1991-09-26 NO NO91913778A patent/NO913778L/no unknown
- 1991-09-26 IE IE338991A patent/IE73874B1/en not_active IP Right Cessation
- 1991-09-27 KR KR1019910016850A patent/KR100215357B1/ko not_active Expired - Fee Related
-
1996
- 1996-02-16 US US08/602,693 patent/US5821239A/en not_active Expired - Fee Related
- 1996-04-24 GR GR960401135T patent/GR3019742T3/el unknown
-
1998
- 1998-06-02 US US09/088,926 patent/US5866565A/en not_active Expired - Fee Related
- 1998-06-02 US US09/088,928 patent/US5869480A/en not_active Expired - Fee Related
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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