ES2075861T3 - Metodo y aparato para ensayos de quimioluminiscencia heterogeneos. - Google Patents

Metodo y aparato para ensayos de quimioluminiscencia heterogeneos.

Info

Publication number
ES2075861T3
ES2075861T3 ES90116380T ES90116380T ES2075861T3 ES 2075861 T3 ES2075861 T3 ES 2075861T3 ES 90116380 T ES90116380 T ES 90116380T ES 90116380 T ES90116380 T ES 90116380T ES 2075861 T3 ES2075861 T3 ES 2075861T3
Authority
ES
Spain
Prior art keywords
chemiluminescent reaction
porous element
solid
chemioluminescence
heterogeneous
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90116380T
Other languages
English (en)
Inventor
Omar S Khalil
Thomas F Zurek
Kevin R Genger
Curtis J Pepe
Yi-Her Jou
Stephen M Cotter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Application granted granted Critical
Publication of ES2075861T3 publication Critical patent/ES2075861T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54346—Nanoparticles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • G01N33/521—Single-layer analytical elements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • G01N33/525—Multi-layer analytical elements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54386—Analytical elements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
    • G01N33/5761—Hepatitis B
    • G01N33/5764—Hepatitis B surface antigen
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76—Chemiluminescence; Bioluminescence

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Communicable Diseases (AREA)
  • Nanotechnology (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)

Abstract

APARATO Y METODO PARA LLEVAR A CABO UN ENSAYO DE QUIMIOLUMINISCENCIA QUE INCLUYE LA INMOVILIZACION DE UN COMPLEJO DE REACCION QUIMIOLUMINISCENTE EN UN ELEMENTO SOLIDO Y POROSO. EL ELEMENTO SOLIDO Y POROSO SE TRATA PREFERIBLEMENTE PARA SUMINISTRAR UNA INTERACCION DE INMOVILIZACION CON EL COMPLEJO DE REACCION QUIMIOLUMINISCENTE, EN LA QUE EL COMPLEJO DE REACCION QUIMIOLUMINISCENTE ES ASI INMOVILIZADO EN UN ELEMENTO SOLIDO Y POROSO. LA ACTIVACION Y LECTURA DE LA REACCION QUIMIOLUMINISCENTE ACTIVADORA QUIMIOLUMINISCENTE CONCENTRADA PARA FORMAR UN SEDIMENTO EN LA SUPERFICIE DEL ELEMENTO POROSO EN EL QUE EL COMPLEJO DE REACCION QUIMIOLUMINISCENTE SE INMOVILIZA.
ES90116380T 1989-10-23 1990-08-27 Metodo y aparato para ensayos de quimioluminiscencia heterogeneos. Expired - Lifetime ES2075861T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/425,643 US5089424A (en) 1988-06-14 1989-10-23 Method and apparatus for heterogeneous chemiluminescence assay

Publications (1)

Publication Number Publication Date
ES2075861T3 true ES2075861T3 (es) 1995-10-16

Family

ID=23687434

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90116380T Expired - Lifetime ES2075861T3 (es) 1989-10-23 1990-08-27 Metodo y aparato para ensayos de quimioluminiscencia heterogeneos.

Country Status (9)

Country Link
US (1) US5089424A (es)
EP (1) EP0424634B1 (es)
JP (1) JP2664279B2 (es)
KR (1) KR910008409A (es)
AT (1) ATE123878T1 (es)
AU (1) AU635549B2 (es)
CA (1) CA2021586C (es)
DE (1) DE69020094T2 (es)
ES (1) ES2075861T3 (es)

Families Citing this family (197)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060013729A1 (en) * 1991-02-14 2006-01-19 Glen Carey Fluid handling apparatus for an automated analyzer
US6436349B1 (en) 1991-03-04 2002-08-20 Bayer Corporation Fluid handling apparatus for an automated analyzer
US6498037B1 (en) * 1991-03-04 2002-12-24 Bayer Corporation Method of handling reagents in a random access protocol
CA2384529C (en) * 1991-03-04 2007-01-02 Bayer Corporation Automated analyzer
DE4123818C2 (de) * 1991-07-18 1994-05-19 Berthold Lab Prof Dr Vorrichtung zur Messung der Chemilumineszenz einer in einem Probengefäß befindlichen Probe
DK0584343T3 (da) * 1992-03-10 1999-09-13 Jolla Cancer Res Found Rekombinant alkalisk phosphatase fra kalvetarme
EP1380842A3 (en) 1992-03-27 2009-12-30 Abbott Laboratories Test sample container assembly
US6399397B1 (en) * 1992-09-14 2002-06-04 Sri International Up-converting reporters for biological and other assays using laser excitation techniques
EP0628823A4 (en) * 1992-11-20 1996-05-08 Dainabot Co Ltd AUTOMATIC MULTI-CHANNEL IMMUNOTEST SYSTEM.
US5441894A (en) * 1993-04-30 1995-08-15 Abbott Laboratories Device containing a light absorbing element for automated chemiluminescent immunoassays
EP0651253A1 (en) * 1993-11-02 1995-05-03 Abbott Laboratories Immunoassay for the detection of human autoantibodies
US5468649A (en) * 1994-02-15 1995-11-21 Abbott Laboratories Process for labeling acridinium to microparticles and application in an instrument
US20010055581A1 (en) * 1994-03-18 2001-12-27 Lawrence Tamarkin Composition and method for delivery of biologically-active factors
US5599501A (en) * 1994-11-10 1997-02-04 Ciba Corning Diagnostics Corp. Incubation chamber
JPH08136546A (ja) * 1994-11-15 1996-05-31 Bio Sensor Kenkyusho:Kk 物質分析法
ES2220982T3 (es) * 1995-06-07 2004-12-16 Abbott Laboratories Peptidos destinados a la deteccion del vih-1.
US5686046A (en) * 1995-07-13 1997-11-11 Chiron Diagnostics Corporation Luminometer
US5720377A (en) * 1995-07-14 1998-02-24 Chiron Diagnostics Corporation Magnetic conveyor system
US5735387A (en) * 1995-07-14 1998-04-07 Chiron Diagnostics Corporation Specimen rack handling system
US6501549B1 (en) 1995-12-05 2002-12-31 University Of Utah Research Foundation Method of measuring chemical concentration based on spatial separation and resolution of luminescence
US20050202499A1 (en) 1996-10-31 2005-09-15 Billing-Medel Patricia A. Reagents and methods useful for detecting diseases of the breast
US6056923A (en) * 1997-06-25 2000-05-02 Clmp, Inc. Dual injector for chemiluminescence immunoanalyzing system
US6846905B2 (en) 1997-08-15 2005-01-25 Abbott Laboratories Antigen constructs useful in the detection and differentiation of antibodies to HIV
US7229841B2 (en) 2001-04-30 2007-06-12 Cytimmune Sciences, Inc. Colloidal metal compositions and methods
US6203974B1 (en) 1998-09-03 2001-03-20 Abbott Laboratories Chemiluminescent immunoassay for detection of antibodies to various viruses
US6794156B2 (en) * 1999-05-10 2004-09-21 Applera Corporation Cell growth, induction and lysis in an antibody-coated microplate for use in an ELISA
US6686171B2 (en) * 1999-05-10 2004-02-03 Tropix, Inc. Competitive chemiluminescent assay for cyclic nucleotide monophosphates
ES2165320B1 (es) * 2000-05-03 2003-06-16 Dentaid S L Dispositivo optico para la cuantificacion de compuestos volatiles de azufre (cvs) a traves de medidas de absorcion/reflectancia.
AU2002231736A1 (en) 2000-12-22 2002-07-08 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Use of repulsive guidance molecule (rgm) and its modulators
DE10136865B4 (de) * 2001-07-28 2007-11-15 Berthold Technologies Gmbh & Co. Kg Vorrichtung zur Messung der Chemilumineszenz
US20040024193A1 (en) 2002-07-26 2004-02-05 Williams Gregg T. Method of detecting and quantifying hepatitis C virus
DE60330877D1 (de) 2002-07-26 2010-02-25 Abbott Lab Verfahren zum nachweis und zur quantifizierung von hepatitis-c-virus
US7920906B2 (en) 2005-03-10 2011-04-05 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
US9247900B2 (en) 2004-07-13 2016-02-02 Dexcom, Inc. Analyte sensor
CN1960825A (zh) * 2004-01-28 2007-05-09 细胞免疫科学公司 官能化胶态金属组合物和方法
US20060020192A1 (en) 2004-07-13 2006-01-26 Dexcom, Inc. Transcutaneous analyte sensor
WO2006127694A2 (en) 2004-07-13 2006-11-30 Dexcom, Inc. Analyte sensor
US20070037232A1 (en) 2005-03-31 2007-02-15 Barasch Jonathan M Detection of NGAL in chronic renal disease
US8624027B2 (en) 2005-05-12 2014-01-07 Abbvie Inc. Combination therapy for treating cancer and diagnostic assays for use therein
ES2542501T3 (es) * 2005-09-30 2015-08-06 Abbvie Deutschland Gmbh & Co Kg Dominios de unión de proteínas de la familia de proteínas de moléculas de orientación repulsiva (RGM) y fragmentos funcionales de las mismas, así como su uso
US20080220448A1 (en) * 2006-09-01 2008-09-11 Blincko Stuart J Antigenic protein conjugates and process for preparing same
US8865398B2 (en) 2006-09-01 2014-10-21 Abbott Laboratories Combination hepatitis C virus antigen and antibody detection method
US7776605B2 (en) 2006-10-26 2010-08-17 Abbott Laboratories Assay for cardiac troponin autoantibodies
US20080305512A1 (en) * 2006-10-26 2008-12-11 Mattingly Phillip G Assay for cardiac troponin autoantibodies
MX2009004460A (es) * 2006-10-26 2009-07-09 Abbott Lab Inmunoensayo de analitos en muestras que contienen anticuerpos anti-analito endogenos.
KR100824388B1 (ko) * 2006-12-06 2008-04-22 한국타이어 주식회사 화학발광을 이용한 타이어 부위 별 노화측정방법
US7858924B2 (en) 2006-12-12 2010-12-28 Abbott Laboratories, Inc. Device for use in normalizing readings on a testing machine
US7914999B2 (en) 2006-12-29 2011-03-29 Abbott Laboratories Non-denaturing lysis reagent
JP5026849B2 (ja) * 2007-04-20 2012-09-19 株式会社日立製作所 化学発光計測装置
US20080280377A1 (en) 2007-05-08 2008-11-13 Abbott Laboratories Human b-type natriuretic peptide assay having reduced cross-reactivity with other peptide forms
ATE535813T1 (de) * 2007-05-24 2011-12-15 Abbott Lab Reduzierte kreuzreaktivität mit hydrophoben arzneistoffanalyt-stoffwechselprodukten zeigende immuntestverfahren
US20090053736A1 (en) * 2007-08-21 2009-02-26 Mattingly Phillip G Homogeneous Chemiluminescent Immunoassay for Analysis of Iron Metalloproteins
US7608361B2 (en) * 2007-08-22 2009-10-27 Stauffer John E Alkali metal battery
US20090068635A1 (en) * 2007-09-06 2009-03-12 Muerhoff Anthony S Indirectly labelled assay conjugates and methods of preparing and using same
EP2033971A1 (de) * 2007-09-06 2009-03-11 Abbott GmbH & Co. KG Bone Morphogenetic Protein (BMP)-bindende Domänen von Proteinen der Repulsive Guidance Molecule (RGM) Proteinfamilie und funktionale Fragmente davon sowie deren Verwendung
US20100136520A1 (en) * 2007-09-13 2010-06-03 Abbott Laboratories Detecting hepatitis b virus
US8138318B2 (en) 2007-09-13 2012-03-20 Abbott Laboratories Hepatitis B pre-S2 nucleic acid
US20090098531A1 (en) * 2007-09-13 2009-04-16 Abbott Laboratories Detecting hepatitis b virus
US20110014118A1 (en) * 2007-09-21 2011-01-20 Lawrence Tamarkin Nanotherapeutic colloidal metal compositions and methods
JP2011520769A (ja) * 2007-09-21 2011-07-21 サイトイミューン サイエンシズ インコーポレイテッド ナノ治療コロイド金属組成物および方法
WO2009052392A1 (en) 2007-10-19 2009-04-23 Abbott Laboratories Immunoassays and kits for the detection of ngal
US20100267055A1 (en) * 2007-10-21 2010-10-21 Abbott Laboratories One-step immunoassays exhibiting increased sensitivity and specificity
US8283124B2 (en) * 2007-10-25 2012-10-09 Abbott Laboratories Compositions for detecting antibodies to Babesia microti and methods of uses thereof
WO2009078875A1 (en) 2007-12-19 2009-06-25 Abbott Laboratories Immunosuppressant drug extraction reagent for immunoassays
CN101387650B (zh) * 2007-12-20 2012-06-27 北京科美生物技术有限公司 全自动板式发光仪及其发光检测方法
DE202008009859U1 (de) * 2007-12-21 2009-03-05 Berthold Technologies Gmbh & Co. Kg Vorrichtung zur wahlweisen Messung von insbesondere Lumineszenz- und/oder Fluoreszenzstrahlung
US20090203038A1 (en) * 2007-12-27 2009-08-13 Abbott Laboratories Negative Mimic Antibody For Use as a Blocking Reagent In BNP Immunoassays
WO2009086398A2 (en) * 2007-12-27 2009-07-09 Abbott Laboratories Anti-t. cruzi antibodies and methods of use
US8962803B2 (en) 2008-02-29 2015-02-24 AbbVie Deutschland GmbH & Co. KG Antibodies against the RGM A protein and uses thereof
US8268981B2 (en) * 2008-03-06 2012-09-18 Abbott Laboratories Plasmodium malariae and plasmodium ovale genes and uses thereof
US8030471B2 (en) * 2008-03-06 2011-10-04 Abbott Laboratories Plasmodium malariae and Plasmodium ovale genes and uses thereof
US9029508B2 (en) 2008-04-29 2015-05-12 Abbvie Inc. Dual variable domain immunoglobulins and uses thereof
US20090286329A1 (en) * 2008-05-19 2009-11-19 Abbott Laboratoires Isolated human autoantibodies to natriuretic peptides and methods and kits for detecting human autoantibodies to natriuretic peptides
US20090286256A1 (en) * 2008-05-19 2009-11-19 Abbott Laboratories Isolated human autoantibodies to natriuretic peptides and methods and kits for detecting human autoantibodies to natriuretic peptides
EP3002299A1 (en) 2008-06-03 2016-04-06 AbbVie Inc. Dual variable domain immunoglobulins and uses thereof
US20100015655A1 (en) * 2008-07-17 2010-01-21 Abbott Laboratories Methods and Kits for Detecting and Quantifying Damage Caused by a Parasite
WO2010028014A1 (en) 2008-09-03 2010-03-11 Abbott Laboratories Assays and kits for determining hiv-1 tropism
US20100105150A1 (en) * 2008-10-24 2010-04-29 Abbott Laboratories Isolated human autoantibodies to neutrophil gelatinase-associated lipocalin (ngal) and methods and kits for the detection of human autoantibodies to ngal
US8168165B2 (en) 2008-12-23 2012-05-01 Abbott Laboratories Alkylated interleukin-18 compositions
US8349325B2 (en) 2008-12-23 2013-01-08 Abbott Laboratories Soluble FMS-like tyrosine kinase-1 (sFLT-1) antibody and related composition, kit, methods of using, and materials and method for making
US8241915B2 (en) * 2009-01-14 2012-08-14 Abbott Laboratories Methods and kits for detecting hemoglobin in test samples
WO2010088470A1 (en) 2009-01-31 2010-08-05 Abbott Laboratories Markers to predict and monitor response to aurora kinase b inhibitor therapy
CA2751293A1 (en) * 2009-02-11 2010-08-19 Abbott Laboratories Methods and compositions for identifying, classifying and monitoring subject having bcl-2 family inhibitor-resistant tumors and cancers
US8030026B2 (en) 2009-02-24 2011-10-04 Abbott Laboratories Antibodies to troponin I and methods of use thereof
EP2810652A3 (en) 2009-03-05 2015-03-11 AbbVie Inc. IL-17 binding proteins
US8283162B2 (en) 2009-03-10 2012-10-09 Abbott Laboratories Antibodies relating to PIVKAII and uses thereof
US8063193B2 (en) 2009-03-27 2011-11-22 Abbott Laboratories Nucleotide and amino acid sequences encoding an exported protein 1 derived from Plasmodium vivax and uses thereof
CN201404734Y (zh) * 2009-04-28 2010-02-17 厦门市毕恩生物技术有限公司 底部控制式标本过滤容器
US20100291709A1 (en) * 2009-05-13 2010-11-18 Abbott Laboratories Human nt-pro b-type natriuretic peptide assay having reduced cross-reactivity with other peptide forms
JP2012531926A (ja) 2009-06-30 2012-12-13 アボット ラボラトリーズ Ｘｍｒｖ感染のマーカーとその使用
US8623358B2 (en) 2009-08-29 2014-01-07 Abbvie Inc. Therapeutic DLL4 binding proteins
US8501420B2 (en) * 2009-08-31 2013-08-06 Abbott Laboratories Biomarkers for prediction of major adverse cardiac events and uses thereof
JP5205354B2 (ja) * 2009-09-30 2013-06-05 富士フイルム株式会社 クロマトグラフ測定装置
US8455212B2 (en) * 2009-11-21 2013-06-04 Abbott Laboratories Assays for human NT-pro B-type natriuretic peptide, human pro B-type natriuretic peptide and human B-type natriuretic peptide
US8835120B2 (en) * 2009-12-02 2014-09-16 Abbott Laboratories Assay for cardiac troponin-T (cTnT)
US8652788B2 (en) * 2009-12-02 2014-02-18 Abbott Laboratories Assay for diagnosis of cardiac myocyte damage
US8183002B2 (en) * 2009-12-03 2012-05-22 Abbott Laboratories Autoantibody enhanced immunoassays and kits
US20110136141A1 (en) 2009-12-03 2011-06-09 Abbott Laboratories Peptide reagents and method for inhibiting autoantibody antigen binding
SG181563A1 (en) * 2009-12-08 2012-07-30 Abbott Gmbh & Co Kg Monoclonal antibodies against the rgm a protein for use in the treatment of retinal nerve fiber layer degeneration
EP2542582A4 (en) 2010-03-02 2013-12-04 Abbvie Inc THERAPEUTIC PROTEINS LINKING TO DLL4
US20110229921A1 (en) * 2010-03-18 2011-09-22 Abbott Laboratories METHODS OF ASSAYING URINARY NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN (uNGAL) IN THE PROGNOSIS OF CADAVERIC KIDNEY TRANSPLANT FUNCTION IN A PATIENT, INCLUDING A PATIENT DIAGNOSED WITH DELAYED GRAFT FUNCTION (DGF), A METHOD OF ASSAYING uNGAL IN THE ASSESSMENT OF RISK OF DGF IN A PATIENT DIAGNOSED WITH EARLY GRAFT FUNCTION (EGF), AND RELATED KITS
WO2011129382A1 (en) 2010-04-16 2011-10-20 Abbott Japan Co. Ltd. Methods and reagents for diagnosing rheumatoid arthritis
JP5524698B2 (ja) * 2010-04-27 2014-06-18 株式会社日立ハイテクノロジーズ 自動分析装置
CN102236013A (zh) * 2010-04-28 2011-11-09 上海捷瑞医用试剂有限公司 化学发光免疫分析仪用浓缩缓冲液及其制备方法
WO2011140234A1 (en) 2010-05-07 2011-11-10 Abbott Laboratories Methods for predicting sensitivity to treatment with a targeted tyrosine kinase inhibitor
US20120190563A1 (en) 2010-05-07 2012-07-26 Abbott Laboratories Methods for predicting sensitivity to treatment with a targeted tyrosine kinase inhibitor
AU2011252883B2 (en) 2010-05-14 2015-09-10 Abbvie Inc. IL-1 binding proteins
US9551714B2 (en) 2010-06-25 2017-01-24 Abbott Laboratories Materials and methods for assay of anti-hepatitis C virus (HCV) antibodies
WO2012006500A2 (en) 2010-07-08 2012-01-12 Abbott Laboratories Monoclonal antibodies against hepatitis c virus core protein
UY33492A (es) 2010-07-09 2012-01-31 Abbott Lab Inmunoglobulinas con dominio variable dual y usos de las mismas
US9120862B2 (en) 2010-07-26 2015-09-01 Abbott Laboratories Antibodies relating to PIVKA-II and uses thereof
CN103298834A (zh) 2010-08-03 2013-09-11 Abbvie公司 双重可变结构域免疫球蛋白及其用途
WO2012024513A2 (en) 2010-08-18 2012-02-23 Abbott Laboratories Molecular detection of xmrv infection
WO2012024518A1 (en) 2010-08-18 2012-02-23 Abbott Laboratories Molecular detection of xmrv infection
BR112013004581A2 (pt) 2010-08-26 2017-06-27 Abbvie Inc imunoglobulinas de domínio variável dual e seus usos
US20120115244A1 (en) 2010-11-09 2012-05-10 Abbott Laboratories Materials and methods for immunoassay of pterins
KR20130133247A (ko) 2010-12-21 2013-12-06 애브비 인코포레이티드 Ｉｌ-1-알파 및 -베타 이특이적 이원 가변 도메인 면역글로불린 및 이의 용도
SG10201600531TA (en) 2011-01-24 2016-02-26 Univ Singapore Pathogenic mycobacteria-derived mannose-capped lipoarabinomannan antigen binding proteins
AU2012229156A1 (en) 2011-03-11 2013-10-31 Board Of Regents Of The University Of Nebraska Biomarker for coronary artery disease
CN103620409B (zh) 2011-05-20 2017-04-12 阿波特日本有限公司 用于减少非特异性结合的免疫检验方法和试剂
US10641768B2 (en) 2011-07-08 2020-05-05 Abbott Japan Co. Ltd. Methods and kits for decreasing interferences from leukocytes in specific binding assays
WO2013009705A2 (en) 2011-07-09 2013-01-17 The Trustees Of Columbia University In The City Of New York Biomarkers, methods, and compositions for inhibiting a multi-cancer mesenchymal transition mechanism
AU2012328917B2 (en) 2011-10-24 2017-05-25 Abbvie Inc. Bispecific immunobinders directed against TNF and IL-17
WO2013063095A1 (en) 2011-10-24 2013-05-02 Abbvie Inc. Immunobinders directed against sclerostin
CA2855840C (en) 2011-12-14 2023-08-29 AbbVie Deutschland GmbH & Co. KG Composition and method for the diagnosis and treatment of iron-related disorders
EP2791175A2 (en) 2011-12-14 2014-10-22 Abbvie Deutschland GmbH & Co. KG Composition and method for the diagnosis and treatment of iron-related disorders
AR090047A1 (es) 2011-12-30 2014-10-15 Abbvie Inc Dominio variable dual de inmunoglobulinas y sus usos
AR089529A1 (es) 2011-12-30 2014-08-27 Abbvie Inc Proteinas de union especificas duales dirigidas contra il-13 y/o il-17
US8993248B2 (en) 2011-12-31 2015-03-31 Abbott Laboratories Truncated human vitamin D binding protein and mutation and fusion thereof and related materials and methods of use
RU2644337C2 (ru) 2012-01-27 2018-02-08 Эббви Дойчланд Гмбх Унд Ко. Кг Композиции и способы диагностики и лечения заболеваний, ассоциированных с дегенерацией нейритов
WO2014011955A2 (en) 2012-07-12 2014-01-16 Abbvie, Inc. Il-1 binding proteins
WO2014031327A2 (en) * 2012-08-20 2014-02-27 Siemens Healthcare Diagnostics Inc. Clam-shell luminometer
CN102798718A (zh) * 2012-08-31 2012-11-28 福建省洪诚生物药业有限公司 乙肝病毒前s1抗原检测试剂盒及其制备方法
PE20151179A1 (es) 2012-11-01 2015-09-12 Abbvie Inc Inmunoglobulinas de dominio variable dual anti-vegf/dll4 y usos de las mismas
WO2014089209A2 (en) 2012-12-04 2014-06-12 Abbvie, Inc. Blood-brain barrier (bbb) penetrating dual specific binding proteins
WO2014106001A2 (en) 2012-12-28 2014-07-03 Abbvie, Inc. Dual specific binding proteins having a receptor sequence
US9856319B2 (en) 2012-12-28 2018-01-02 Abbvie Inc. Monovalent binding proteins
EP2948475A2 (en) 2013-01-23 2015-12-02 AbbVie Inc. Methods and compositions for modulating an immune response
US9488663B2 (en) 2013-03-14 2016-11-08 Abbott Point Of Care Inc. Electrochemical methods and devices for amending urine samples for immunosensor detection
US9194873B2 (en) 2013-03-14 2015-11-24 Abbott Laboratories HCV antigen-antibody combination assay and methods and compositions for use therein
US9651547B2 (en) 2013-03-14 2017-05-16 Abbott Point Of Care Inc. Electrochemical methods and devices for amending urine samples for immunosensor detection
US9790478B2 (en) 2013-03-14 2017-10-17 Abbott Laboratories HCV NS3 recombinant antigens and mutants thereof for improved antibody detection
CN105378099B (zh) 2013-03-14 2021-05-11 雅培制药有限公司 Hcv核心脂质结合结构域单克隆抗体
US20140271453A1 (en) 2013-03-14 2014-09-18 Abbott Laboratories Methods for the early detection of lung cancer
BR112015023797A2 (pt) 2013-03-15 2017-10-24 Abbvie Inc proteínas de ligação de especificidade dupla dirigidas contra il-1b e/ou il-17
US9005901B2 (en) 2013-03-15 2015-04-14 Abbott Laboratories Assay with internal calibration
US9469686B2 (en) 2013-03-15 2016-10-18 Abbott Laboratories Anti-GP73 monoclonal antibodies and methods of obtaining the same
US9157910B2 (en) 2013-03-15 2015-10-13 Abbott Laboratories Assay with increased dynamic range
TW201446800A (zh) 2013-03-15 2014-12-16 Abbvie Inc 針對ＴＮＦα之雙特異性結合蛋白
WO2015031626A1 (en) 2013-08-28 2015-03-05 Abbvie Inc. Soluble cmet assay
BR112016007592A2 (pt) 2013-10-06 2018-01-23 Abbvie Inc proteína de ligação biespecífica que se liga a pelo menos dois alvos, conjugado de proteína de ligação biespecífica, composição farmacêutica, ácido nucleico isolado, vetor, célula hospedeira, método para produzir uma proteína de ligação biespecífica, método para determinar a reatividade de um paciente a um agente terapêutico que tem capacidade para modular a atividade de um tlr, método para ativar ou inibir células responsivas a tlr9, método para tratar um paciente que precisa de ativação de tlr9 ou inibição de tlr e método para identificar um inibidor ou estimulador de sinalização de tlr
KR102056963B1 (ko) 2013-12-30 2019-12-17 에피맙 바이오테라퓨틱스 인코포레이티드 Fabs-인-탠덤 면역글로불린 및 이의 용도
WO2015191934A2 (en) 2014-06-11 2015-12-17 Abbvie Inc. Blood-brain barrier (bbb) penetrating dual specific binding proteins for treating brain and neurological diseases
JP2017521654A (ja) 2014-06-27 2017-08-03 アボット・ラボラトリーズＡｂｂｏｔｔ Ｌａｂｏｒａｔｏｒｉｅｓ ヒトペギウイルス２（ＨＰｇＶ−２）を検出するための組成物および方法
WO2016069762A2 (en) 2014-10-29 2016-05-06 Abbott Laboratories Subject anti-hcv antibody detection assays employing ns3 capture peptides
WO2016094881A2 (en) 2014-12-11 2016-06-16 Abbvie Inc. Lrp-8 binding proteins
WO2016160976A2 (en) 2015-03-30 2016-10-06 Abbvie Inc. Monovalent tnf binding proteins
TW201710286A (zh) 2015-06-15 2017-03-16 艾伯維有限公司 抗ｖｅｇｆ、ｐｄｇｆ及／或其受體之結合蛋白
US20170089905A1 (en) 2015-09-28 2017-03-30 Abbott Japan Co., Ltd. Methods of diagnosing hepatocellular carcinoma and pancreatic cancer
CA3011746A1 (en) 2016-02-06 2017-08-10 Epimab Biotherapeutics, Inc. Fabs-in-tandem immunoglobulin and uses thereof
US20170363620A1 (en) 2016-06-17 2017-12-21 Abbott Laboratories BIOMARKERS TO PREDICT NEW ONSET HEART FAILURE WITH PRESERVED EJECTION FRACTION (HFpEF)
MX2019001134A (es) * 2016-07-29 2019-04-11 Inst Tecnologico Estudios Superiores Monterrey Sistemas y metodos para la deteccion de reacciones quimioluminiscentes.
EP3279667A1 (en) 2016-08-02 2018-02-07 Abbott Laboratories Cardiac troponin i and copeptin as biomarkers for short-term mortality in acute exacerbation of chronic obstructive pulmonary disease (aecopd)
US10722882B2 (en) * 2016-08-03 2020-07-28 Pierce Biotechnology, Inc. Chemiluminescent and fluorescent substrate pads and uses thereof
US20180106800A1 (en) 2016-10-03 2018-04-19 Abbott Laboratories Methods of assessing uch-l1 status in patient samples
CA3052513A1 (en) 2017-03-23 2018-09-27 Abbott Laboratories Methods for aiding in the diagnosis and determination of the extent of traumatic brain injury in a human subject using the early biomarker ubiquitin carboxy-terminal hydrolase l1
CN106980024A (zh) * 2017-03-28 2017-07-25 杭州凯坤科技有限公司 一种全自动光激化学发光检测仪
EP3610268A1 (en) 2017-04-15 2020-02-19 Abbott Laboratories Methods for aiding in the hyperacute diagnosis and determination of traumatic brain injury in a human subject using early biomarkers
JP7080899B2 (ja) 2017-04-28 2022-06-06 アボット・ラボラトリーズ 同じヒト対象に由来する少なくとも２つの試料に対して早期バイオマーカーを使用する、外傷性脳損傷の超急性の診断及び決定の一助となるための方法
CA3078725A1 (en) 2017-05-25 2018-11-29 Abbott Laboratories Methods for aiding in the determination of whether to perform imaging on a human subject who has sustained or may have sustained an injury to the head using early biomarkers
AU2018275236A1 (en) 2017-05-30 2019-10-31 Abbott Laboratories Methods for aiding in diagnosing and evaluating a mild traumatic brain injury in a human subject using cardiac troponin I
US11169159B2 (en) 2017-07-03 2021-11-09 Abbott Laboratories Methods for measuring ubiquitin carboxy-terminal hydrolase L1 levels in blood
AU2018378084A1 (en) 2017-12-09 2020-05-14 Abbott Laboratories Methods for aiding in diagnosing and evaluating a traumatic brain injury in a human subject using a combination of GFAP and UCH-L1
BR112019028254A2 (pt) 2017-12-09 2020-07-14 Abbott Laboratories métodos para ajudar no diagnóstico e avaliação de um paciente que sofreu uma lesão ortopédica e que sofreu ou pode ter sofrido uma lesão na cabeça, tal como uma lesão cerebral traumática (lct) leve, usando a proteína ácida fibrilar glial (gfap) e/ou a hidrolase carbóxi-terminal da ubiquitina l1 (uch-l1)
EP3732489A1 (en) 2017-12-29 2020-11-04 Abbott Laboratories Novel biomarkers and methods for diagnosing and evaluating traumatic brain injury
WO2019151468A1 (ja) * 2018-02-02 2019-08-08 日本ケミファ株式会社 生化学反応用基体及び分析装置
AR114436A1 (es) 2018-04-30 2020-09-02 Takeda Pharmaceuticals Co Proteínas de unión al receptor de cannabinoides tipo 1 (cb1) y usos de las mismas
WO2019213619A1 (en) 2018-05-04 2019-11-07 Abbott Laboratories Hbv diagnostic, prognostic, and therapeutic methods and products
EP3931573A1 (en) 2019-03-01 2022-01-05 Abbott Laboratories Methods for predicting major adverse cardiovascular events in subjects with coronary artery disease
EP4010707A1 (en) 2019-08-07 2022-06-15 Abbott Laboratories Methods for detecting assay interferents and increasing dynamic range
EP4136459A1 (en) 2020-04-13 2023-02-22 Abbott Laboratories Methods, complexes and kits for detecting or determining an amount of a ss-coronavirus antibody in a sample
CN111693514B (zh) * 2020-05-07 2022-07-05 四川轻化工大学 一种利用在线式液气转换的在线检测装置及方法
WO2022031804A1 (en) 2020-08-04 2022-02-10 Abbott Laboratories Improved methods and kits for detecting sars-cov-2 protein in a sample
US20220170948A1 (en) 2020-12-01 2022-06-02 Abbott Laboratories Use of one or more biomarkers to determine traumatic brain injury (tbi) in a human subject having received a head computerized tomography scan that is negative for a tbi
WO2023102384A1 (en) 2021-11-30 2023-06-08 Abbott Laboratories Use of one or more biomarkers to determine traumatic brain injury (tbi) in a subject having received a head computerized tomography scan that is negative for a tbi
WO2022147147A1 (en) 2020-12-30 2022-07-07 Abbott Laboratories Methods for determining sars-cov-2 antigen and anti-sars-cov-2 antibody in a sample
WO2022147178A1 (en) 2020-12-30 2022-07-07 Abbott Laboratories Improved methods, reagents and kits for detergent-based inactivation of betacoronavirus prior to and/or while assessing a biological sample for sars-cov-2 antigen or antibody
BR112023024169A2 (pt) 2021-05-18 2024-02-06 Abbott Lab Métodos para avaliar lesão cerebral em um indivíduo pediátrico
EP4356129A1 (en) 2021-06-14 2024-04-24 Abbott Laboratories Methods of diagnosing or aiding in diagnosis of brain injury caused by acoustic energy, electromagnetic energy, an over pressurization wave, and/or blast wind
WO2023028186A1 (en) 2021-08-27 2023-03-02 Abbott Laboratories Methods for detecting immunoglobulin g, subclass 4 (igg4) in a biological sample
WO2023034777A1 (en) 2021-08-31 2023-03-09 Abbott Laboratories Methods and systems of diagnosing brain injury
CA3232176A1 (en) 2021-09-30 2023-04-06 Beth MCQUISTON Methods and systems of diagnosing brain injury
US20230213536A1 (en) 2021-12-28 2023-07-06 Abbott Laboratories Use of biomarkers to determine sub-acute traumatic brain injury (tbi) in a subject having received a head computerized tomography (ct) scan that is negative for a tbi or no head ct scan
WO2024044288A1 (en) 2022-08-26 2024-02-29 Abbott Laboratories Use of cardiac troponin and galectin-3 to differentiate myocardial infarction type i and type ii
WO2024059692A1 (en) 2022-09-15 2024-03-21 Abbott Laboratories Hbv diagnostic, prognostic, and therapeutic methods and products
WO2024059708A1 (en) 2022-09-15 2024-03-21 Abbott Laboratories Biomarkers and methods for differentiating between mild and supermild traumatic brain injury
WO2024102383A1 (en) 2022-11-10 2024-05-16 Abbott Laboratories Methods of identifying macrotroponin in biological samples

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7112927A (es) * 1971-09-21 1973-03-23
US3992158A (en) * 1973-08-16 1976-11-16 Eastman Kodak Company Integral analytical element
US4104026A (en) * 1976-03-12 1978-08-01 University Of Virginia Immunoassay separation technique
EP0025350A3 (en) * 1979-09-05 1981-06-10 Dynatech Ag Apparatus for detecting luminescent reactions
US4363874A (en) * 1981-08-07 1982-12-14 Miles Laboratories, Inc. Multilayer analytical element having an impermeable radiation nondiffusing reflecting layer
JPS5832166A (ja) * 1981-08-21 1983-02-25 Hitachi Ltd 免疫定量用分析要素
JPS5929751U (ja) * 1982-08-19 1984-02-24 コニカ株式会社 血液の簡易型分析装置
JPS59170768A (ja) * 1983-03-17 1984-09-27 Fuji Photo Film Co Ltd 非アイソト−プアツセイ用多層分析要素およびそれを用いるアツセイ方法
US4652533A (en) * 1983-04-28 1987-03-24 Pandex Laboratories, Inc. Method of solid phase immunoassay incorporating a luminescent label
US4704255A (en) * 1983-07-15 1987-11-03 Pandex Laboratories, Inc. Assay cartridge
US4552839A (en) * 1983-08-01 1985-11-12 Syntex (U.S.A.) Inc. Determination of analytes in particle-containing medium
JPS60149950A (ja) * 1984-01-17 1985-08-07 Hitachi Ltd ケミルミネツセントの検出法
US4632901A (en) * 1984-05-11 1986-12-30 Hybritech Incorporated Method and apparatus for immunoassays
CA1272127A (en) * 1985-04-04 1990-07-31 Hybritech Incorporated Solid phase system for use in ligand-receptor assays
US4623461A (en) * 1985-05-31 1986-11-18 Murex Corporation Transverse flow diagnostic device
JPS61275656A (ja) * 1985-05-31 1986-12-05 Hitachi Ltd リン光イムノアツセイ装置
JPS62103542A (ja) * 1985-07-22 1987-05-14 Fuji Photo Film Co Ltd 一体型多層分析要素
US4923680A (en) * 1987-09-18 1990-05-08 Eastman Kodak Company Test device containing an immunoassay filter with a flow-delaying polymer
AU609241B2 (en) * 1988-01-29 1991-04-26 Abbott Laboratories Ion-capture assays and devices
US5244630A (en) 1988-04-22 1993-09-14 Abbott Laboratories Device for performing solid-phase diagnostic assay

Also Published As

Publication number Publication date
ATE123878T1 (de) 1995-06-15
DE69020094D1 (de) 1995-07-20
AU635549B2 (en) 1993-03-25
EP0424634A2 (en) 1991-05-02
US5089424A (en) 1992-02-18
AU5984790A (en) 1991-04-26
EP0424634A3 (en) 1992-03-04
JPH03154853A (ja) 1991-07-02
CA2021586C (en) 2002-09-03
CA2021586A1 (en) 1991-04-24
DE69020094T2 (de) 1996-03-07
EP0424634B1 (en) 1995-06-14
KR910008409A (ko) 1991-05-31
JP2664279B2 (ja) 1997-10-15

Similar Documents

Publication Publication Date Title
ES2075861T3 (es) Metodo y aparato para ensayos de quimioluminiscencia heterogeneos.
DE58908351D1 (de) Mit Reagenz ablösbar imprägnierte Trägermatrix.
DE60040794D1 (de) Verfahren zur Immobilisierung von Oligonukleotiden auf festem Trägermaterial
ATE89255T1 (de) Verfahren zur isomerisierung von gesaettigten fluorkohlenwasserstoffen.
DE3650432T2 (de) Verfahren und Verwendung für ortspezifische Aktivierung von Substanzen.
ATE10208T1 (de) Stabilisierte, waessrige loesung von co-enzymen zur verwendung in klinischen analysen; verfahren zur stabilisierung eines labilen co-enzyms in einer waessrigen loesung fuer die klinische analyse und regenzsatz fuer diese klinische analyse.
PT98564A (pt) Processo para a realizacao de processos catalizados por enzimas com cristais reticulados como forma de imobilizacao de enzimas e dispositivos que os contem
ATE185816T1 (de) In sol-gel immobilizierte lipase bearbeitet hydrophoben substanzen
DE3584796D1 (de) Verfahren und vorrichtung zur durchfuehrung analytischer bestimmungen.
DE59203610D1 (de) Reaktor zur Durchführung biologischer Reaktionen mittels Biokatalysatoren.
ES2121750T3 (es) Ensayo de adn amplificado.
ES2180543T3 (es) Seleccion basada en reacciones para la expresion de, y la concentracion de, restos cataliticos.
SE8300553D0 (sv) Sett och anordning vid biospecifika affinitetsreaktioner
JPS5266682A (en) Immobilization of enzyme or microbial fungus
EP0334966A4 (en) Process for synthesizing optically active compounds
DE3851725D1 (de) Diagnostisches System mit Anwendung eines einheitlichen Substrates für die Immobilisierung von Mikrosphären.
ES8206038A1 (es) Sistema fisico-bioquimico para la deteccion de sustancias deactividad antigenica.
BR7805506A (pt) Processo para purificacao de aguas de despejo,carregadas de substancias organicas,contendo calcio
IT8722389A0 (it) Procedimento per la immobilizzazione chimica di sostanze biologicamente attive su silice.
DE3872888D1 (de) Immunassay unter benutzung der mikropartikelneutralisierung.
DK85791A (da) Partikelformet lipasepraeparat, fremgangsmaade til fremstilling deraf og anvendelse deraf
ATE93491T1 (de) Verfahren zur regenerierung von aktivkohle.
ATE58641T1 (de) Verfahren zur dehalogenierung von halogenierten kohlenwasserstoffen.
JPS53115879A (en) Immobilized organic catalysts
ATE98682T1 (de) Verfahren zur immobilisierung von lipasen.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 424634

Country of ref document: ES