ES2061804T3 - Procedimiento para la separacion del acido folinico. - Google Patents
Procedimiento para la separacion del acido folinico.Info
- Publication number
- ES2061804T3 ES2061804T3 ES89111820T ES89111820T ES2061804T3 ES 2061804 T3 ES2061804 T3 ES 2061804T3 ES 89111820 T ES89111820 T ES 89111820T ES 89111820 T ES89111820 T ES 89111820T ES 2061804 T3 ES2061804 T3 ES 2061804T3
- Authority
- ES
- Spain
- Prior art keywords
- salts
- folinate
- water
- alkaline
- suspension
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- VVIAGPKUTFNRDU-ABLWVSNPSA-N folinic acid Chemical compound C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-ABLWVSNPSA-N 0.000 title abstract 3
- VVIAGPKUTFNRDU-UHFFFAOYSA-N 6S-folinic acid Natural products C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-UHFFFAOYSA-N 0.000 title abstract 2
- MPJKWIXIYCLVCU-UHFFFAOYSA-N Folinic acid Natural products NC1=NC2=C(N(C=O)C(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)CC(=O)O)CN2)C(=O)N1 MPJKWIXIYCLVCU-UHFFFAOYSA-N 0.000 title abstract 2
- 235000008191 folinic acid Nutrition 0.000 title abstract 2
- 239000011672 folinic acid Substances 0.000 title abstract 2
- 229960001691 leucovorin Drugs 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 238000000926 separation method Methods 0.000 title abstract 2
- VVIAGPKUTFNRDU-STQMWFEESA-N (6S)-5-formyltetrahydrofolic acid Chemical class C([C@H]1CNC=2N=C(NC(=O)C=2N1C=O)N)NC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-STQMWFEESA-N 0.000 abstract 7
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 abstract 6
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 abstract 3
- 235000019152 folic acid Nutrition 0.000 abstract 3
- 239000011724 folic acid Substances 0.000 abstract 3
- 229960000304 folic acid Drugs 0.000 abstract 3
- 239000000725 suspension Substances 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- 150000001298 alcohols Chemical class 0.000 abstract 2
- 239000003960 organic solvent Substances 0.000 abstract 2
- 239000002244 precipitate Substances 0.000 abstract 2
- 238000011282 treatment Methods 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- 206010002065 Anaemia megaloblastic Diseases 0.000 abstract 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- 208000000682 Megaloblastic Anemia Diseases 0.000 abstract 1
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- 208000025747 Rheumatic disease Diseases 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 239000000729 antidote Substances 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
- 239000011575 calcium Substances 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 159000000011 group IA salts Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000002576 ketones Chemical class 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 231100001016 megaloblastic anemia Toxicity 0.000 abstract 1
- 230000003472 neutralizing effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000005728 strengthening Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
- C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Investigation Of Foundation Soil And Reinforcement Of Foundation Soil By Compacting Or Drainage (AREA)
- Mechanical Treatment Of Semiconductor (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Saccharide Compounds (AREA)
Abstract
EL INVENTO SE REFIERE A UN PROCEDIMIENTO PARA SEPARAR FOLINATOS (6R, 6S) EN SUS DIASTEROISOMEROS QUE CONSISTE EN: MEZCLAR UNA SOLUCION DE UNAS SALES DEL ACIDO (6R, 6S) FONILICO CON UNAS SALES SOLUBLES EN AGUA ALCONOTERREAS, AMONICAS O ALCALINAS DE UN ACIDO ORGANICO O INORGANICO, PARA FORMAR UNA SUSPENSION; FILTRAR LA SUSPENSION PARA RECOGER COMO PRECIPITADO LA SAL DE FOLINATO (6S) Y UN LIQUIDO DE FILTRACION QUE SE MEZCLA CON DISOLVENTES ORGANICOS MISCIBLES CON AGUA Y/O SALES ALCALINOTERREAS SOLUBLES EN AGUA PARA PRECIPITAR FOLINATO (6S) Y FORMAR UNA SUSPENSION; FILTRAR LA SUSPENSION PARA RECOGER UN PRECIPITADO Y CRISTALIZAR EL PRECIPITADO LIBRE DE FOLINATO (6R). LA SEPARACION DEL ACIDO FOLINICO (6R) DE SALES ALCALINOTERREAS SE REALIZAN NEUTRALIZANDO LA SOLUCION. EL FOLINATO (6S) OBTENIDO SE UTILIZA COMO MEDICAMENTO PARA EL TRATAMIENTO DE ANEMIAS MEGALOBLASTICA (CARENCIA DE ACIDO FOLICO) COMO ANTIDOTO PARA REFORZAR LA TOLERABILIDAD DE ANTAGONISTAS DE ACIDO FOLICO COM AMINOTERREA, METOHEXATO Y 5-FLUORARACIL EN LA TERAPIA DEL CANCER Y TRATAMIENTO DE ENFERMEDADES AUTOINMUNES COMO ARTRITIR REUMATICA, Y PSORIASIS Y REFORZAR LOS ANTIPARASITARIOS. SE EMPLEAN SALES MAGNESICAS, CALCICAS O SODICAS COMO SALES ALCALINOTERREAS, ALCALINA DEL ACIDO FOLICO (6R,S), SE UTILIZAN HALOGENOS SODICOS, POTASICOS O AMONICOS COMO SALES AMONICAS O ALCALINAS DE ACIDOS INORGANICOS; SE EMPLEAN ALCOHOLES O CETONAS DE BAJO PESO MOLECULAR COMO DISOLVENTE ORGANICOS PARA SEPARAR EL FRENATOR (6S) Y SE UTILIZAN SALES CALCALINOTERREAS SOLUBLES EN AGUA (HALOGENUROS DE CALCIO).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH4182/88A CH676981A5 (es) | 1988-11-11 | 1988-11-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2061804T3 true ES2061804T3 (es) | 1994-12-16 |
Family
ID=4271318
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES89111820T Expired - Lifetime ES2061804T3 (es) | 1988-11-11 | 1989-06-29 | Procedimiento para la separacion del acido folinico. |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5010194A (es) |
| EP (1) | EP0367902B1 (es) |
| JP (1) | JPH0645621B2 (es) |
| KR (1) | KR920005744B1 (es) |
| CN (1) | CN1029956C (es) |
| AR (1) | AR245130A1 (es) |
| AT (1) | ATE102201T1 (es) |
| AU (1) | AU607641B2 (es) |
| CA (1) | CA2002430C (es) |
| CH (1) | CH676981A5 (es) |
| DD (1) | DD284879A5 (es) |
| DE (1) | DE58907088D1 (es) |
| DK (1) | DK173425B1 (es) |
| ES (1) | ES2061804T3 (es) |
| FI (1) | FI91157C (es) |
| HU (1) | HU201777B (es) |
| IE (1) | IE63929B1 (es) |
| NO (1) | NO170334C (es) |
| NZ (1) | NZ231193A (es) |
| PT (1) | PT92232B (es) |
| ZA (1) | ZA897284B (es) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5124452A (en) * | 1978-07-10 | 1992-06-23 | Bioresearch S.P.A. | Process for producing d,1-5-methyltetrahydrofolic acid and its salts |
| GB8621268D0 (en) * | 1986-09-03 | 1986-10-08 | Univ Strathclyde | Separation of substances |
| CH673459A5 (es) * | 1987-05-15 | 1990-03-15 | Eprova Ag | |
| FR2643081B1 (fr) * | 1989-02-14 | 1991-06-07 | Panmedica Sa | Folates de magnesium, procede de preparation et compositions pharmaceutiques |
| CH680731A5 (es) * | 1990-04-12 | 1992-10-30 | Sapec Fine Chemicals | |
| CH681303A5 (es) * | 1991-01-16 | 1993-02-26 | Eprova Ag | |
| DK0505640T4 (da) † | 1991-03-29 | 2002-12-16 | Lilly Co Eli | Forbedret terapeutisk metode |
| US5217974A (en) * | 1991-03-29 | 1993-06-08 | Eli Lilly And Company | Method for treating gar-transformylase tumors in mammals and reducing mammalian toxicity |
| CH684270A5 (de) * | 1991-10-04 | 1994-08-15 | Sapec Fine Chemicals | Verfahren zur Herstellung von Erdalkalimetallsalzen von (6R)-N(10)-Formyl-5,6,7,8-tetrahydrofolsäure. |
| DE4136921A1 (de) * | 1991-11-11 | 1993-05-13 | Knoll Ag | Verfahren zur trennung von 5-methyl-tetrahydrofolsaeure |
| CH683262A5 (it) * | 1992-01-22 | 1994-02-15 | Applied Pharma Res | Procedimento per la separazione dei diastereomeri del sale di calcio dell'acido (6(R,S)-N-formiltetraidrofolico). |
| IT1254635B (it) * | 1992-02-20 | 1995-09-28 | Bracco Spa | Processo per la separazione degli stereoisomeri dell'acido folinico |
| US5599931A (en) * | 1992-02-20 | 1997-02-04 | Bracco S.P.A. | Process for separating stereoisomers of folinic acid |
| US5198547A (en) * | 1992-03-16 | 1993-03-30 | South Alabama Medical Science Foundation, Usa | Process for N5-formylating tetrahydropteridines |
| US5441960A (en) * | 1992-04-16 | 1995-08-15 | Zeneca Limited | 1-pyrimidinylacetamide human leukocyte elastate inhibitors |
| US5698693A (en) * | 1992-11-16 | 1997-12-16 | The United States Of America As Represented By The Department Of Health And Human Services | Process of separating the diastereomers of (6R,6S) -5,6,7,8-tetrahydrofolic acid derivatives |
| CH686672A5 (de) * | 1992-12-01 | 1996-05-31 | Cerbios Pharma Sa | Verfahren zur Herstellung von (6S)-5,6,7,8-Tetrahydrofolsaeure. |
| US5710271A (en) * | 1994-06-08 | 1998-01-20 | Dibra S.P.A. | Process for the preparation and separation of diastereomeric salts of folinic acid |
| US7721732B2 (en) * | 2002-04-04 | 2010-05-25 | Qxtec, Inc. | Respiratory heat exchanger |
| CN101792444B (zh) * | 2009-02-02 | 2011-10-12 | 天津康鸿医药科技发展有限公司 | 左亚叶酸钠及其制备方法及药物组合物 |
| CN117486884A (zh) * | 2023-09-26 | 2024-02-02 | 湖州展望药业有限公司 | 一种亚叶酸钙的纯化方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2688018A (en) * | 1952-06-28 | 1954-08-31 | American Cyanamid Co | Method of preparing alkaline earth metal salts of 1-leucovorin |
| US4500711A (en) * | 1977-03-21 | 1985-02-19 | Burroughs Wellcome Co. | Synthesis of leucovorin |
| US4148999A (en) * | 1977-08-22 | 1979-04-10 | The Government Of The United States Of America | Preparation and purification of citrovorum factor |
| CH649550A5 (en) * | 1984-02-09 | 1985-05-31 | Eprova Ag | Process for the preparation of alkaline earth metal salts of 5-methyltetrahydrofolic acid |
| GB8621268D0 (en) * | 1986-09-03 | 1986-10-08 | Univ Strathclyde | Separation of substances |
| CH673459A5 (es) * | 1987-05-15 | 1990-03-15 | Eprova Ag |
-
1988
- 1988-11-11 CH CH4182/88A patent/CH676981A5/de not_active IP Right Cessation
-
1989
- 1989-06-29 ES ES89111820T patent/ES2061804T3/es not_active Expired - Lifetime
- 1989-06-29 DE DE89111820T patent/DE58907088D1/de not_active Expired - Lifetime
- 1989-06-29 EP EP89111820A patent/EP0367902B1/de not_active Expired - Lifetime
- 1989-06-29 AT AT89111820T patent/ATE102201T1/de not_active IP Right Cessation
- 1989-09-25 ZA ZA897284A patent/ZA897284B/xx unknown
- 1989-10-17 DK DK198905157A patent/DK173425B1/da not_active IP Right Cessation
- 1989-10-30 NZ NZ231193A patent/NZ231193A/en unknown
- 1989-10-31 AU AU43924/89A patent/AU607641B2/en not_active Expired
- 1989-11-01 DD DD89334113A patent/DD284879A5/de unknown
- 1989-11-07 US US07/432,819 patent/US5010194A/en not_active Expired - Lifetime
- 1989-11-07 CA CA002002430A patent/CA2002430C/en not_active Expired - Lifetime
- 1989-11-08 AR AR89315393A patent/AR245130A1/es active
- 1989-11-08 PT PT92232A patent/PT92232B/pt not_active IP Right Cessation
- 1989-11-09 JP JP1290140A patent/JPH0645621B2/ja not_active Expired - Lifetime
- 1989-11-10 CN CN89109727A patent/CN1029956C/zh not_active Expired - Lifetime
- 1989-11-10 NO NO894499A patent/NO170334C/no not_active IP Right Cessation
- 1989-11-10 KR KR1019890016278A patent/KR920005744B1/ko not_active Expired
- 1989-11-10 IE IE362389A patent/IE63929B1/en not_active IP Right Cessation
- 1989-11-10 HU HU895859A patent/HU201777B/hu unknown
- 1989-11-10 FI FI895380A patent/FI91157C/fi active IP Right Grant
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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