KR900007420A - 폴린산의 분할방법 - Google Patents

폴린산의 분할방법 Download PDF

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Publication number
KR900007420A
KR900007420A KR1019890016278A KR890016278A KR900007420A KR 900007420 A KR900007420 A KR 900007420A KR 1019890016278 A KR1019890016278 A KR 1019890016278A KR 890016278 A KR890016278 A KR 890016278A KR 900007420 A KR900007420 A KR 900007420A
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KR
South Korea
Prior art keywords
polynate
alkaline earth
water
earth metal
ammonium
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KR1019890016278A
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English (en)
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KR920005744B1 (ko
Inventor
루돌프 뮬러 한스
울만 마틴
콘티 요세프
뮤르델 귄터
Original Assignee
에이치. 알. 뮬러. 에이치. 쥬터
에프로바 아크티엔 게젤샤프트
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 에이치. 알. 뮬러. 에이치. 쥬터, 에프로바 아크티엔 게젤샤프트 filed Critical 에이치. 알. 뮬러. 에이치. 쥬터
Publication of KR900007420A publication Critical patent/KR900007420A/ko
Application granted granted Critical
Publication of KR920005744B1 publication Critical patent/KR920005744B1/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Investigation Of Foundation Soil And Reinforcement Of Foundation Soil By Compacting Or Drainage (AREA)
  • Mechanical Treatment Of Semiconductor (AREA)
  • Saccharide Compounds (AREA)

Abstract

내용 없음

Description

폴린산의 분할방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (7)

  1. 무기 또는 유기산의 수-가용성 알카리 금속, 암모늄 또는 알카리 토금속염을 (6R,S)-폴린산 수용액에 첨가하고, 분리된 (6R)-폴리네이트를 여과해 낸 후, 여액으로부터(6S)-포리네이트를 분리시키는 것으로 이루어지는 (6R,S)-폴리네이트의 분할방법.
  2. 제1항에 있어서, (6S)-폴리네이트는 수-혼화성 유기용매및/또는 바람직하기는 수-가용성 알카리 토금속염을 첨가하여 여액에서 분리하고, 여과해 낸다음, 필요에 따라, 재결정시키는 (6R, S)-폴리네이트의 분할방법.
  3. 제1항에 있어서, (6R)-폴린산의 알카리 토금속 염의 제거는 대략 중성의 pH에서 수행하는 (6R,S)-폴리네이트의 분할방법.
  4. 제1항에 있어서, 나트륨 또는 특히 칼슘 또는 마그네슘 염을(6R,S)-폴린산의 알카리 금속 또는 알카리 토금속염으로서 사용하는 (6R,S)-폴리네이트의 분할방법
  5. 제1항에 있어서, 나트륨, 칼륨 또는 암모늄 할라이드, 특히 요드화 나트륨, 브롬화나트륨, 염화 나트륨, 요드화 칼륨, 브롬화 암모늄 및/또는 염화 암모늄을 무기산의 수-가용성 알카리 금속 또는 암모늄 염으로서 사용하는 (6R,S)-폴리네이트의 분할방법.
  6. 제1항 또는 제2항에 있어서, 유기용매로서 저급 알콜 또는 저급 케톤을 사용하는 (6R,S)-폴리네이트의 분할방법.
  7. 제1항, 제2항 또는 제6항에 있어서, 칼슘 또는 마그네슘 힐라이드를 (6S)-폴리네이트를 분리하기 위한 수-가용성 알카리 토금속 염으로서 사용하는 (6R,S)-폴리네이트의 분할방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890016278A 1988-11-11 1989-11-10 폴린산의 분할방법 KR920005744B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH04181/88-3 1988-11-11
CH4182/88A CH676981A5 (ko) 1988-11-11 1988-11-11
CH04182 1988-11-11

Publications (2)

Publication Number Publication Date
KR900007420A true KR900007420A (ko) 1990-06-01
KR920005744B1 KR920005744B1 (ko) 1992-07-18

Family

ID=4271318

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890016278A KR920005744B1 (ko) 1988-11-11 1989-11-10 폴린산의 분할방법

Country Status (21)

Country Link
US (1) US5010194A (ko)
EP (1) EP0367902B1 (ko)
JP (1) JPH0645621B2 (ko)
KR (1) KR920005744B1 (ko)
CN (1) CN1029956C (ko)
AR (1) AR245130A1 (ko)
AT (1) ATE102201T1 (ko)
AU (1) AU607641B2 (ko)
CA (1) CA2002430C (ko)
CH (1) CH676981A5 (ko)
DD (1) DD284879A5 (ko)
DE (1) DE58907088D1 (ko)
DK (1) DK173425B1 (ko)
ES (1) ES2061804T3 (ko)
FI (1) FI91157C (ko)
HU (1) HU201777B (ko)
IE (1) IE63929B1 (ko)
NO (1) NO170334C (ko)
NZ (1) NZ231193A (ko)
PT (1) PT92232B (ko)
ZA (1) ZA897284B (ko)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5124452A (en) * 1978-07-10 1992-06-23 Bioresearch S.P.A. Process for producing d,1-5-methyltetrahydrofolic acid and its salts
GB8621268D0 (en) * 1986-09-03 1986-10-08 Univ Strathclyde Separation of substances
CH673459A5 (ko) * 1987-05-15 1990-03-15 Eprova Ag
FR2643081B1 (fr) * 1989-02-14 1991-06-07 Panmedica Sa Folates de magnesium, procede de preparation et compositions pharmaceutiques
CH680731A5 (ko) * 1990-04-12 1992-10-30 Sapec Fine Chemicals
CH681303A5 (ko) * 1991-01-16 1993-02-26 Eprova Ag
ZA917406B (en) † 1991-03-29 1993-03-17 Lilly Co Eli Therapeutic method.
US5217974A (en) * 1991-03-29 1993-06-08 Eli Lilly And Company Method for treating gar-transformylase tumors in mammals and reducing mammalian toxicity
CH684270A5 (de) * 1991-10-04 1994-08-15 Sapec Fine Chemicals Verfahren zur Herstellung von Erdalkalimetallsalzen von (6R)-N(10)-Formyl-5,6,7,8-tetrahydrofolsäure.
DE4136921A1 (de) * 1991-11-11 1993-05-13 Knoll Ag Verfahren zur trennung von 5-methyl-tetrahydrofolsaeure
CH683262A5 (it) * 1992-01-22 1994-02-15 Applied Pharma Res Procedimento per la separazione dei diastereomeri del sale di calcio dell'acido (6(R,S)-N-formiltetraidrofolico).
IT1254635B (it) * 1992-02-20 1995-09-28 Bracco Spa Processo per la separazione degli stereoisomeri dell'acido folinico
US5599931A (en) * 1992-02-20 1997-02-04 Bracco S.P.A. Process for separating stereoisomers of folinic acid
US5198547A (en) * 1992-03-16 1993-03-30 South Alabama Medical Science Foundation, Usa Process for N5-formylating tetrahydropteridines
US5441960A (en) * 1992-04-16 1995-08-15 Zeneca Limited 1-pyrimidinylacetamide human leukocyte elastate inhibitors
US5698693A (en) * 1992-11-16 1997-12-16 The United States Of America As Represented By The Department Of Health And Human Services Process of separating the diastereomers of (6R,6S) -5,6,7,8-tetrahydrofolic acid derivatives
CH686672A5 (de) * 1992-12-01 1996-05-31 Cerbios Pharma Sa Verfahren zur Herstellung von (6S)-5,6,7,8-Tetrahydrofolsaeure.
US5710271A (en) * 1994-06-08 1998-01-20 Dibra S.P.A. Process for the preparation and separation of diastereomeric salts of folinic acid
US7721732B2 (en) * 2002-04-04 2010-05-25 Qxtec, Inc. Respiratory heat exchanger
CN101792444B (zh) * 2009-02-02 2011-10-12 天津康鸿医药科技发展有限公司 左亚叶酸钠及其制备方法及药物组合物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2688018A (en) * 1952-06-28 1954-08-31 American Cyanamid Co Method of preparing alkaline earth metal salts of 1-leucovorin
US4500711A (en) * 1977-03-21 1985-02-19 Burroughs Wellcome Co. Synthesis of leucovorin
US4148999A (en) * 1977-08-22 1979-04-10 The Government Of The United States Of America Preparation and purification of citrovorum factor
CH649550A5 (en) * 1984-02-09 1985-05-31 Eprova Ag Process for the preparation of alkaline earth metal salts of 5-methyltetrahydrofolic acid
GB8621268D0 (en) * 1986-09-03 1986-10-08 Univ Strathclyde Separation of substances
CH673459A5 (ko) * 1987-05-15 1990-03-15 Eprova Ag

Also Published As

Publication number Publication date
HUT51648A (en) 1990-05-28
AR245130A1 (es) 1993-12-30
JPH02178284A (ja) 1990-07-11
FI91157C (fi) 1994-05-25
EP0367902A2 (de) 1990-05-16
NO170334C (no) 1992-10-07
IE63929B1 (en) 1995-06-28
NZ231193A (en) 1991-03-26
FI91157B (fi) 1994-02-15
EP0367902A3 (de) 1991-04-03
CH676981A5 (ko) 1991-03-28
JPH0645621B2 (ja) 1994-06-15
CN1042541A (zh) 1990-05-30
CA2002430A1 (en) 1990-05-11
NO894499L (no) 1990-05-14
ES2061804T3 (es) 1994-12-16
DE58907088D1 (de) 1994-04-07
KR920005744B1 (ko) 1992-07-18
FI895380A0 (fi) 1989-11-10
CN1029956C (zh) 1995-10-11
NO170334B (no) 1992-06-29
US5010194A (en) 1991-04-23
PT92232A (pt) 1991-04-18
PT92232B (pt) 1995-07-06
NO894499D0 (no) 1989-11-10
DK515789A (da) 1990-05-12
HU895859D0 (en) 1990-02-28
DD284879A5 (de) 1990-11-28
CA2002430C (en) 1997-03-04
ZA897284B (en) 1991-04-24
DK173425B1 (da) 2000-10-09
IE893623L (en) 1990-05-11
HU201777B (en) 1990-12-28
EP0367902B1 (de) 1994-03-02
DK515789D0 (da) 1989-10-17
ATE102201T1 (de) 1994-03-15
AU4392489A (en) 1990-05-17
AU607641B2 (en) 1991-03-07

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