ES2060608T3 - 1h-imidazoles sustituidos. - Google Patents

1h-imidazoles sustituidos.

Info

Publication number
ES2060608T3
ES2060608T3 ES87870149T ES87870149T ES2060608T3 ES 2060608 T3 ES2060608 T3 ES 2060608T3 ES 87870149 T ES87870149 T ES 87870149T ES 87870149 T ES87870149 T ES 87870149T ES 2060608 T3 ES2060608 T3 ES 2060608T3
Authority
ES
Spain
Prior art keywords
alkyl
hydrogen
compounds
methyl
imidazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87870149T
Other languages
English (en)
Inventor
Eric Cossement
Jean-Pierre Geerts
Jean Gobert
Philippe Michel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UCB SA
Original Assignee
UCB SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UCB SA filed Critical UCB SA
Application granted granted Critical
Publication of ES2060608T3 publication Critical patent/ES2060608T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/58—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Epoxy Resins (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)

Abstract

NUEVOS 1-H IMIDAZOLES SUSTIUIDOS Y SUS SALE, SUS ROCEDIMIENTOS DE PREPARACION Y COMPOSICIONES TERAPEUTICAS. STOS COMPUESTOS RESPONDEN A LA FORMULA (I) EN LA UQE R1, 2, R3, R5 = HIDROGENO O ALQUILO EN C1-4; R4 = HIDROGENO, LQUILO EN C1-4 O ALCOXI EN C1-4; Y1 = HIDROGENO E Y2 = OZ2 LO INVERSO; Z1 = Z2 = HIDROGENO O ALQUILO EN C1-4 O Z1 Y 2 = -CH2- O -C(CH3)2-. ESTOS COMPUESTOS SON PREPARADOS SEA OR REDUCCION DE UN COMPUESRTO IMIDAZOLICO CORRESPONDIENTE IDROXILADO O ALCOXILADO SOBRE EL PUNTO METILO SITUADO ENTRE OS CICLOS IMIDAZOLE Y FENILO, SEA POR HIDROLISIS DE UN -[[2,2-DIMETIL-4H-1,3-BENZODIOXIN-6 (U 8)-YL] METIL]- 1HMIDAZOL, SEA TODAVIA POR REDUCCION DE UN 3-[(1H-IMIDAZOL-IL)METIL]-2-HIDROXIBENZOATO DE ALQUILO. ESTOS COMPUESTOS OSEEN ACTIVIDADES ANTIISQUEMICAS, CARDIACAS, CEREBRAL Y ISULAR.
ES87870149T 1986-11-04 1987-10-30 1h-imidazoles sustituidos. Expired - Lifetime ES2060608T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB868626287A GB8626287D0 (en) 1986-11-04 1986-11-04 Substituted 1h-imidazoles

Publications (1)

Publication Number Publication Date
ES2060608T3 true ES2060608T3 (es) 1994-12-01

Family

ID=10606751

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87870149T Expired - Lifetime ES2060608T3 (es) 1986-11-04 1987-10-30 1h-imidazoles sustituidos.

Country Status (24)

Country Link
US (1) US4814343A (es)
EP (1) EP0269599B1 (es)
JP (1) JP2632877B2 (es)
KR (1) KR910003116B1 (es)
AT (1) ATE98640T1 (es)
AU (1) AU592733B2 (es)
CA (1) CA1301174C (es)
CY (1) CY1845A (es)
DE (1) DE3788507T2 (es)
DK (1) DK166584B1 (es)
ES (1) ES2060608T3 (es)
FI (1) FI91858C (es)
GB (1) GB8626287D0 (es)
HK (1) HK78895A (es)
HU (1) HU206684B (es)
IE (1) IE61901B1 (es)
IL (1) IL84322A (es)
MY (1) MY102578A (es)
NO (1) NO169960C (es)
NZ (1) NZ222382A (es)
PL (3) PL155119B1 (es)
PT (1) PT86040B (es)
SU (4) SU1662349A3 (es)
ZA (1) ZA878170B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0249772A (ja) * 1988-04-07 1990-02-20 Glaxo Group Ltd イミダゾール誘導体
GB8810067D0 (en) * 1988-04-28 1988-06-02 Ucb Sa Substituted 1-(1h-imidazol-4-yl)alkyl-benzamides
JPH04252867A (ja) * 1991-01-25 1992-09-08 Nissan Motor Co Ltd 内燃機関の燃料供給装置
GB9310965D0 (en) * 1993-05-27 1993-07-14 Ucb Sa 2-hydroxy-3-(1h-imidazol-4-yl)alkyl)benzenecarboximidamides
HUT74386A (en) * 1993-11-15 1996-12-30 Schering Corp Phenyl-alkyl imidazoles as h3-receptor antagonists and pharmaceutical compositions containing them
GB9425211D0 (en) * 1994-12-14 1995-02-15 Ucb Sa Substituted 1H-imidazoles
GB9521680D0 (en) * 1995-10-23 1996-01-03 Orion Yhtymo Oy New use of imidazole derivatives
US7868020B2 (en) * 2007-01-12 2011-01-11 Allergan, Inc. Quinolynylmethylimidizoles as therapeutic agents
US8119807B2 (en) * 2007-01-12 2012-02-21 Allergan, Inc. Quinolynylmethylimidizoles as therapeutic agents
WO2008086131A1 (en) * 2007-01-12 2008-07-17 Allergan, Inc. Naphthylmethylimidizoles as therapeutic agents

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US29761A (en) * 1860-08-28 Improvements in telegraphic apparatus
US4062967A (en) 1974-02-07 1977-12-13 Smith Kline & French Laboratories Limited Bis-guanidino-alkane compounds
AU518569B2 (en) * 1979-08-07 1981-10-08 Farmos-Yhtyma Oy 4-benzyl- and 4-benzoyl imidazole derivatives
GB2092569B (en) * 1981-02-05 1984-09-19 Farmos Oy Substituted imidazole derivatives and their preparation and use
GB2101114B (en) * 1981-07-10 1985-05-22 Farmos Group Ltd Substituted imidazole derivatives and their preparation and use
DE4224020A1 (de) * 1992-07-22 1994-01-27 Deutsche Aerospace Verfahren zur Auslösung der Zündung eines Gefechtskopfes und Anordnung zum Durchführen des Verfahrens

Also Published As

Publication number Publication date
ATE98640T1 (de) 1994-01-15
CY1845A (en) 1996-03-08
NO874572L (no) 1988-05-05
FI874789A0 (fi) 1987-10-30
MY102578A (en) 1992-07-31
NO169960C (no) 1992-08-26
JP2632877B2 (ja) 1997-07-23
PT86040A (pt) 1987-11-01
AU592733B2 (en) 1990-01-18
HU206684B (en) 1992-12-28
PT86040B (pt) 1990-07-31
PL268558A1 (en) 1988-09-01
IE872963L (en) 1988-05-04
EP0269599B1 (fr) 1993-12-15
HK78895A (en) 1995-05-26
PL156482B1 (pl) 1992-03-31
NO169960B (no) 1992-05-18
AU8059387A (en) 1988-05-05
KR880006205A (ko) 1988-07-22
PL155119B1 (en) 1991-10-31
FI91858C (fi) 1994-08-25
DE3788507T2 (de) 1994-05-19
IL84322A0 (en) 1988-03-31
DK572987D0 (da) 1987-11-02
EP0269599A3 (en) 1990-03-14
KR910003116B1 (ko) 1991-05-18
ZA878170B (en) 1989-07-26
CA1301174C (en) 1992-05-19
SU1662349A3 (ru) 1991-07-07
IE61901B1 (en) 1994-11-30
GB8626287D0 (en) 1986-12-03
US4814343A (en) 1989-03-21
HUT56547A (en) 1991-09-30
DK572987A (da) 1988-05-05
NZ222382A (en) 1991-07-26
SU1635899A3 (ru) 1991-03-15
PL156483B1 (en) 1992-03-31
JPS63132876A (ja) 1988-06-04
SU1628857A3 (ru) 1991-02-15
SU1710558A1 (ru) 1992-02-07
EP0269599A2 (fr) 1988-06-01
FI874789A (fi) 1988-05-05
DE3788507D1 (de) 1994-01-27
FI91858B (fi) 1994-05-13
IL84322A (en) 1991-08-16
NO874572D0 (no) 1987-11-03
DK166584B1 (da) 1993-06-14

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