ES2059817T3 - Procedimiento para la preparacion de hidroxiacidos. - Google Patents

Procedimiento para la preparacion de hidroxiacidos.

Info

Publication number
ES2059817T3
ES2059817T3 ES89810403T ES89810403T ES2059817T3 ES 2059817 T3 ES2059817 T3 ES 2059817T3 ES 89810403 T ES89810403 T ES 89810403T ES 89810403 T ES89810403 T ES 89810403T ES 2059817 T3 ES2059817 T3 ES 2059817T3
Authority
ES
Spain
Prior art keywords
preparation
phenylbutyric acid
dehydrogenase
enzyme
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89810403T
Other languages
English (en)
Inventor
Oreste Dr Ghisalba
Daniel Dr Gygax
Rene Dr Lattmann
Hans-Peter Dr Schar
Elke Dr Schmidt
Gottfried Dr Sedelmeier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Application granted granted Critical
Publication of ES2059817T3 publication Critical patent/ES2059817T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/52—Propionic acid; Butyric acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/367—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic

Abstract

LA PATENTE AFECTA A UN PROCESO, PREFERENTEMENTE CONTINUO, DE OBTENCION DE ACIDO R - O S - 2 - HIDROXI - 4 - FENIL - BUTIRICO EN UNIDAD ENANTIOMERA MUY ALTA. EL PROCESO SE CARACTERIZA POR REDUCIR EL ACIDO 2 - OXO - 4 - FENILBUTIRICO CON ELL ENZIMA D LACTATODEHIDROGENASA DE STAPHILOCOCCUS EPIDERMIDIS, O CON EL ENZIMA L - LACTATODEHIDROGENASA PROCEDENTE DEL CORAZON VACUNO EN PRESENCIA DE NAD(H) ASI COMO DE FORMIATO O ETANOL Y FORMIATO- O ALCOHOLDEHIDROGENASA. EL ACIDO R - 2 - HIDROXI - 4 - FENILBUTIRICO ES UN PRODUCTO INTERMEDIO VALIOSO EN LA OBTENCION DE INHIBIDORES ACE O DE SUS NIVELES PREVIOS.
ES89810403T 1988-06-06 1989-05-30 Procedimiento para la preparacion de hidroxiacidos. Expired - Lifetime ES2059817T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH213888 1988-06-06

Publications (1)

Publication Number Publication Date
ES2059817T3 true ES2059817T3 (es) 1994-11-16

Family

ID=4226761

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89810403T Expired - Lifetime ES2059817T3 (es) 1988-06-06 1989-05-30 Procedimiento para la preparacion de hidroxiacidos.

Country Status (14)

Country Link
US (1) US5098841A (es)
EP (1) EP0347374B1 (es)
JP (1) JP2873236B2 (es)
KR (1) KR0165102B1 (es)
AT (1) ATE98697T1 (es)
CA (1) CA1336081C (es)
DE (1) DE58906409D1 (es)
DK (1) DK172667B1 (es)
ES (1) ES2059817T3 (es)
FI (1) FI95047C (es)
IE (1) IE63497B1 (es)
IL (1) IL90527A (es)
MX (1) MX170725B (es)
PT (1) PT90747B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5256552A (en) * 1988-02-08 1993-10-26 Daicel Chemical Industries, Ltd. Process for the production of optically active 2-hydroxy-4-phenylbutyric acid
JP2752754B2 (ja) * 1988-02-08 1998-05-18 ダイセル化学工業株式会社 光学活性２―ヒドロキシ―４―フェニル酪酸の製造法
US5371014A (en) * 1988-02-12 1994-12-06 Daicel Chemical Industries, Ltd. Process for the production of optically active 2-hydroxy acid esters using microbes to reduce the 2-oxo precursor
ATE195145T1 (de) * 1991-12-23 2000-08-15 Genzyme Ltd Synthese von homochiralen 2-hydroxysäuren
US5770410A (en) * 1992-01-30 1998-06-23 Genzyme Corporation Chiral synthesis with modified enzymes
GB9413710D0 (en) * 1994-07-07 1994-08-24 Genzyme Ltd Chiral synthesis
RU2278612C2 (ru) * 2000-07-14 2006-06-27 Лайфскен, Инк. Иммуносенсор
JP2004511249A (ja) * 2000-10-17 2004-04-15 ピーシービーユー　サービシイズ，　インコーポレイテッド 組合せる酵素システムを使用するα−ヒドロキシカルボン酸の製造
JP2008542494A (ja) * 2005-06-01 2008-11-27 イッサム リサーチ ディベロップメント カンパニー オブ ザ ヘブリュー ユニバーシティー オブ エルサレム 所定のキラリティーを有する生分解性ポリマー
KR101408128B1 (ko) * 2006-09-29 2014-06-16 카운실 오브 사이언티픽 엔드 인더스트리얼 리서치 유무기 하이브리드 키랄 흡수제 및 그 제조방법
CN101302503B (zh) * 2007-05-08 2011-04-06 上海医药工业研究院 突变的植物乳杆菌d-乳酸脱氢酶及其基因、重组酶和应用
WO2011009849A2 (en) 2009-07-21 2011-01-27 Basf Se Method for preparing optically active hydroxy acid esters
CN109234325A (zh) * 2017-07-11 2019-01-18 上海弈柯莱生物医药科技有限公司 一种乳酸脱氢酶在不对称合成手性羟基化合物中的应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH628009A5 (de) * 1977-07-26 1982-02-15 Hoffmann La Roche Verfahren zur herstellung von optisch aktiven alpha-hydroxycarbonsaeuren.
DE2930087A1 (de) * 1979-07-25 1981-02-26 Biotechnolog Forschung Gmbh Verfahren zur kontinuierlichen enzymatischen umwandlung von wasserloeslichen alpha -ketocarbonsaeuren in die entsprechenden alpha -hydroxycarbonsaeuren
US4785089A (en) * 1985-06-13 1988-11-15 Ciba-Geigy Corporation Novel sulfonic acid esters and their preparation

Also Published As

Publication number Publication date
MX170725B (es) 1993-09-09
EP0347374A1 (de) 1989-12-20
DE58906409D1 (de) 1994-01-27
ATE98697T1 (de) 1994-01-15
JP2873236B2 (ja) 1999-03-24
DK172667B1 (da) 1999-05-10
IE891821L (en) 1989-12-06
US5098841A (en) 1992-03-24
IL90527A (en) 1993-05-13
FI95047C (fi) 1995-12-11
PT90747A (pt) 1989-12-29
PT90747B (pt) 1994-10-31
KR0165102B1 (ko) 1999-01-15
IL90527A0 (en) 1990-01-18
FI95047B (fi) 1995-08-31
JPH0239893A (ja) 1990-02-08
FI892702A0 (fi) 1989-06-02
DK271289A (da) 1989-12-07
KR910001065A (ko) 1991-01-30
DK271289D0 (da) 1989-06-02
IE63497B1 (en) 1995-05-03
CA1336081C (en) 1995-06-27
EP0347374B1 (de) 1993-12-15
FI892702A (fi) 1989-12-07

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