PT90747A - Processo para a preparacao de acido r- ou s-2-hidroxi-4-fenilbutirico - Google Patents

Processo para a preparacao de acido r- ou s-2-hidroxi-4-fenilbutirico

Info

Publication number
PT90747A
PT90747A PT90747A PT9074789A PT90747A PT 90747 A PT90747 A PT 90747A PT 90747 A PT90747 A PT 90747A PT 9074789 A PT9074789 A PT 9074789A PT 90747 A PT90747 A PT 90747A
Authority
PT
Portugal
Prior art keywords
preparation
phenylbutyric acid
hydroxy
dehydrogenase
enzyme
Prior art date
Application number
PT90747A
Other languages
English (en)
Other versions
PT90747B (pt
Inventor
Oreste Ghisalba
Gottfried Sedelmeier
Daniel Gygax
Rene Lattmann
Hans-Peter Schar
Elke Schmidt
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of PT90747A publication Critical patent/PT90747A/pt
Publication of PT90747B publication Critical patent/PT90747B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/52—Propionic acid; Butyric acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/367—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PT90747A 1988-06-06 1989-06-05 Processo para a preparacao de acido r- ou s-2-hidroxi-4-fenilbutirico PT90747B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH213888 1988-06-06

Publications (2)

Publication Number Publication Date
PT90747A true PT90747A (pt) 1989-12-29
PT90747B PT90747B (pt) 1994-10-31

Family

ID=4226761

Family Applications (1)

Application Number Title Priority Date Filing Date
PT90747A PT90747B (pt) 1988-06-06 1989-06-05 Processo para a preparacao de acido r- ou s-2-hidroxi-4-fenilbutirico

Country Status (14)

Country Link
US (1) US5098841A (pt)
EP (1) EP0347374B1 (pt)
JP (1) JP2873236B2 (pt)
KR (1) KR0165102B1 (pt)
AT (1) ATE98697T1 (pt)
CA (1) CA1336081C (pt)
DE (1) DE58906409D1 (pt)
DK (1) DK172667B1 (pt)
ES (1) ES2059817T3 (pt)
FI (1) FI95047C (pt)
IE (1) IE63497B1 (pt)
IL (1) IL90527A (pt)
MX (1) MX170725B (pt)
PT (1) PT90747B (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0394448B1 (en) * 1988-02-08 1996-05-01 Daicel Chemical Industries, Ltd. Process for preparing optically active 2-hydroxy-4-phenylbutyric acids
US5256552A (en) * 1988-02-08 1993-10-26 Daicel Chemical Industries, Ltd. Process for the production of optically active 2-hydroxy-4-phenylbutyric acid
US5371014A (en) * 1988-02-12 1994-12-06 Daicel Chemical Industries, Ltd. Process for the production of optically active 2-hydroxy acid esters using microbes to reduce the 2-oxo precursor
CA2117340C (en) * 1991-12-23 2003-06-10 Genzyme Limited Synthesis of homochiral 2-hydroxy acids
US5770410A (en) * 1992-01-30 1998-06-23 Genzyme Corporation Chiral synthesis with modified enzymes
GB9413710D0 (en) * 1994-07-07 1994-08-24 Genzyme Ltd Chiral synthesis
RU2278612C2 (ru) * 2000-07-14 2006-06-27 Лайфскен, Инк. Иммуносенсор
US20040053382A1 (en) * 2000-10-17 2004-03-18 Senkpeil Richard F. Production of alpha-hydroxy-carboxylic acids using a coupled enzyme system
US8067398B2 (en) * 2005-06-01 2011-11-29 Yissum Research Development Company Of The Hebrew University Of Jerusalem Biodegradable polymers having a pre-determined chirality
CA2664855C (en) * 2006-09-29 2014-04-29 Council Of Scientific & Industrial Research Organic-inorganic hybrid chiral sorbent and process for the preparation thereof
CN101302503B (zh) * 2007-05-08 2011-04-06 上海医药工业研究院 突变的植物乳杆菌d-乳酸脱氢酶及其基因、重组酶和应用
WO2011009849A2 (en) 2009-07-21 2011-01-27 Basf Se Method for preparing optically active hydroxy acid esters
KR102485620B1 (ko) * 2017-03-03 2023-01-09 길리애드 사이언시즈, 인코포레이티드 Acc 억제제 및 그의 고체 형태를 제조하는 방법
CN109234325A (zh) * 2017-07-11 2019-01-18 上海弈柯莱生物医药科技有限公司 一种乳酸脱氢酶在不对称合成手性羟基化合物中的应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH628009A5 (de) * 1977-07-26 1982-02-15 Hoffmann La Roche Verfahren zur herstellung von optisch aktiven alpha-hydroxycarbonsaeuren.
DE2930087A1 (de) * 1979-07-25 1981-02-26 Biotechnolog Forschung Gmbh Verfahren zur kontinuierlichen enzymatischen umwandlung von wasserloeslichen alpha -ketocarbonsaeuren in die entsprechenden alpha -hydroxycarbonsaeuren
US4785089A (en) * 1985-06-13 1988-11-15 Ciba-Geigy Corporation Novel sulfonic acid esters and their preparation

Also Published As

Publication number Publication date
CA1336081C (en) 1995-06-27
EP0347374B1 (de) 1993-12-15
PT90747B (pt) 1994-10-31
JPH0239893A (ja) 1990-02-08
FI892702A (fi) 1989-12-07
KR910001065A (ko) 1991-01-30
IE891821L (en) 1989-12-06
DK271289D0 (da) 1989-06-02
IL90527A0 (en) 1990-01-18
ATE98697T1 (de) 1994-01-15
US5098841A (en) 1992-03-24
DK172667B1 (da) 1999-05-10
JP2873236B2 (ja) 1999-03-24
FI95047C (fi) 1995-12-11
IL90527A (en) 1993-05-13
KR0165102B1 (ko) 1999-01-15
DK271289A (da) 1989-12-07
FI892702A0 (fi) 1989-06-02
DE58906409D1 (de) 1994-01-27
IE63497B1 (en) 1995-05-03
ES2059817T3 (es) 1994-11-16
MX170725B (es) 1993-09-09
EP0347374A1 (de) 1989-12-20
FI95047B (fi) 1995-08-31

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Legal Events

Date Code Title Description
FG3A Patent granted, date of granting

Effective date: 19940412

PC3A Transfer or assignment

Free format text: 970604 NOVARTIS AG CH

MM4A Annulment/lapse due to non-payment of fees, searched and examined patent

Free format text: MAXIMUM VALIDITY LIMIT REACHED

Effective date: 20090605