ES2050580A1 - Soluciones de perfusion, de conservacion y/o de reperfusion de organos. - Google Patents

Soluciones de perfusion, de conservacion y/o de reperfusion de organos.

Info

Publication number
ES2050580A1
ES2050580A1 ES09102549A ES9102549A ES2050580A1 ES 2050580 A1 ES2050580 A1 ES 2050580A1 ES 09102549 A ES09102549 A ES 09102549A ES 9102549 A ES9102549 A ES 9102549A ES 2050580 A1 ES2050580 A1 ES 2050580A1
Authority
ES
Spain
Prior art keywords
solutions
perfusion
reperfusion
oxygen
organs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09102549A
Other languages
English (en)
Other versions
ES2050580B1 (es
Inventor
Philippe Menasche
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Pasteur SA
Original Assignee
Pasteur Merieux Serum et Vaccines SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9014424A external-priority patent/FR2669189B1/fr
Priority claimed from FR9109027A external-priority patent/FR2679107B1/fr
Application filed by Pasteur Merieux Serum et Vaccines SA filed Critical Pasteur Merieux Serum et Vaccines SA
Publication of ES2050580A1 publication Critical patent/ES2050580A1/es
Application granted granted Critical
Publication of ES2050580B1 publication Critical patent/ES2050580B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
    • A01N1/0226—Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A61K31/175—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine having the group, >N—C(O)—N=N— or, e.g. carbonohydrazides, carbazones, semicarbazides, semicarbazones; Thioanalogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A61K38/063—Glutathione

Abstract

SOLUCIONES DE PERFUSION DE CONSERVACION Y/O DE REPERFUSION DE ORGANOS PARA LA CIRUGIA Y LOS TRASPLANTES DE ORGANOS COMPRENDIDO EL ORGANO CARDIACO, QUE INCLUYEN POR LO MENOS UN COMPUESTO ANTIOXIDANTE TAL COMO UN CAZADOR DE RADICALES LIBRES DEL OXIGENO EN PARTICULAR EL GLUTATION EN ESTADO REDUCIDO O LA N-ACETILCISTEINA PRESENTANDO DICHAS SOLUCIONES UNA PRESION PARCIAL DE OXIGENO NULA O MUY REBAJADA Y MANTENIENDOSE SENSIBLEMENTE A ESTE VALOR HASTA LA UTILIZACION. LA SOLUCION SE PRESENTA PREFERENTEMENTE EN BOLSAS FLEXIBLES IMPERMEABLES AL OXIGENO.
ES09102549A 1990-11-20 1991-11-18 Soluciones de perfusion, de conservacion y/o de reperfusion de organos. Expired - Fee Related ES2050580B1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9014424A FR2669189B1 (fr) 1990-11-20 1990-11-20 Solutions de perfusion et de stockage pour transplantations cardiaques.
FR9109027A FR2679107B1 (fr) 1991-07-17 1991-07-17 Solutions de perfusion, de conservation et de reperfusion d'organes.

Publications (2)

Publication Number Publication Date
ES2050580A1 true ES2050580A1 (es) 1994-05-16
ES2050580B1 ES2050580B1 (es) 1994-12-16

Family

ID=26228338

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09102549A Expired - Fee Related ES2050580B1 (es) 1990-11-20 1991-11-18 Soluciones de perfusion, de conservacion y/o de reperfusion de organos.

Country Status (8)

Country Link
AT (1) AT399440B (es)
BE (1) BE1006834A3 (es)
CA (1) CA2055827C (es)
CH (1) CH683485A5 (es)
DE (1) DE4138040A1 (es)
ES (1) ES2050580B1 (es)
GB (1) GB2249937B (es)
IT (1) IT1251995B (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2070089A1 (es) * 1992-09-18 1995-05-16 Pasteur Merieux Serums Vacc Solucion de perfusion, conservacion y reperfusion de organos.

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994026103A1 (en) * 1993-05-07 1994-11-24 Chugai Seiyaku Kabushiki Kaisha Organ preservative
DE4325547C2 (de) * 1993-07-29 1997-11-27 Max Planck Gesellschaft Verwendung von Thiolverbindungen zur Therapie von Hepatitis-_Viren-induzierten Erkrankungen
JPH07215801A (ja) * 1994-01-28 1995-08-15 Senju Pharmaceut Co Ltd 肺保存剤および肺保存方法
JPH07330501A (ja) * 1994-06-14 1995-12-19 Senju Pharmaceut Co Ltd 肝保存剤および肝保存方法
DE4439477C2 (de) * 1994-11-08 1999-10-21 Asta Medica Ag Verwendung von R,S-(+/-)-alpha-Liponsäure, R-(+)-alpha-Liponäure, S-(-)-alpha-Liponsäure in reduzierter oder oxidierter Form oder der Metabolite sowie deren Salze, Ester, Amide zur Behandlung der diabetischen Mikroangiopathie
DE19706111C2 (de) * 1997-02-17 1999-02-18 Fresenius Medical Care De Gmbh Lösung zur Aufbewahrung von Organen
US5990153A (en) * 1997-05-05 1999-11-23 Wood; John G. Ultrasonicated α-lipoic acid solutions for attenuating microvascular injury
US6045990A (en) * 1998-07-09 2000-04-04 Baust; John M. Inclusion of apoptotic regulators in solutions for cell storage at low temperature
DE19834087C1 (de) * 1998-07-29 2000-03-30 Mirzaie Sedaposhteh Massoud Wäßrige Konservierungslösung und Verfahren zur Aufbewahrung tierischen Gewebes
GB0028414D0 (en) 2000-11-22 2001-01-03 Univ Leeds Flush preservation solution
DE102007026392A1 (de) 2007-06-06 2008-12-11 Bayer Healthcare Ag Lösungen für die Perfusion und Konservierung von Organen und Geweben
GR20180100514A (el) * 2018-11-07 2020-06-15 Πανεπιστημιο Πατρων Φαρμακευτικοι συνδυασμοι και κιτ για την προληψη ή την θεραπεια του πονου και αλλων επιπλοκων της ορθοπαιδικης ή αγγειακης χειρουργικης και του πολλαπλου τραυματος

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986000812A1 (en) * 1984-07-30 1986-02-13 Pharmacia Ab A drug kit or drug composition for use in preventing and treating ischaemic cell damage and preparation thereof
WO1987001940A1 (en) * 1985-10-03 1987-04-09 Wisconsin Alumni Research Foundation Perfusate for the preservation of organs
ES2007994A6 (es) * 1988-08-16 1989-07-01 Grino Boira Jose Maria Medio liquido para perfusion y preservacion de organos.
US4920044A (en) * 1988-11-08 1990-04-24 The Cleveland Clinic Foundation Intracellular flush solution for preserving organs

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4186253A (en) * 1978-10-10 1980-01-29 The Green Cross Corporation Perfusate for preserving organ to be transplanted and preserving method
US4473552A (en) * 1981-03-16 1984-09-25 Jost Leonora I Anaerobic method for preserving whole blood, tissue and components containing living mammalian cells
US4423600A (en) * 1982-12-10 1984-01-03 Mckenna Joan J Method for preservation of living organic tissue by freezing
DE3581407D1 (de) * 1985-09-06 1991-02-21 Nestle Sa Bewahrung lebender gewebe.
US4879283A (en) * 1985-10-03 1989-11-07 Wisconsin Alumni Research Foundation Solution for the preservation of organs
US4938961A (en) * 1989-04-28 1990-07-03 Geoffrey Collins Organ preservation solution containing pokyethylene gycol and method of performing cardioplegia

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986000812A1 (en) * 1984-07-30 1986-02-13 Pharmacia Ab A drug kit or drug composition for use in preventing and treating ischaemic cell damage and preparation thereof
WO1987001940A1 (en) * 1985-10-03 1987-04-09 Wisconsin Alumni Research Foundation Perfusate for the preservation of organs
ES2007994A6 (es) * 1988-08-16 1989-07-01 Grino Boira Jose Maria Medio liquido para perfusion y preservacion de organos.
US4920044A (en) * 1988-11-08 1990-04-24 The Cleveland Clinic Foundation Intracellular flush solution for preserving organs

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2070089A1 (es) * 1992-09-18 1995-05-16 Pasteur Merieux Serums Vacc Solucion de perfusion, conservacion y reperfusion de organos.

Also Published As

Publication number Publication date
CH683485A5 (fr) 1994-03-31
DE4138040A1 (de) 1992-05-21
AT399440B (de) 1995-05-26
BE1006834A3 (fr) 1995-01-03
CA2055827C (en) 1999-06-15
CA2055827A1 (en) 1992-05-21
ATA228791A (de) 1994-10-15
IT1251995B (it) 1995-05-27
GB2249937A (en) 1992-05-27
ITMI912991A1 (it) 1993-05-11
ES2050580B1 (es) 1994-12-16
ITMI912991A0 (it) 1991-11-11
GB9124488D0 (en) 1992-01-08
GB2249937B (en) 1994-02-16

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Legal Events

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PC2A Transfer of patent
FD2A Announcement of lapse in spain

Effective date: 20141120