CA2055827A1 - Solutions for the perfusion, preservation and reperfusion of organs - Google Patents

Solutions for the perfusion, preservation and reperfusion of organs

Info

Publication number
CA2055827A1
CA2055827A1 CA2055827A CA2055827A CA2055827A1 CA 2055827 A1 CA2055827 A1 CA 2055827A1 CA 2055827 A CA2055827 A CA 2055827A CA 2055827 A CA2055827 A CA 2055827A CA 2055827 A1 CA2055827 A1 CA 2055827A1
Authority
CA
Canada
Prior art keywords
solutions
perfusion
preservation
reperfusion
oxygen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2055827A
Other languages
French (fr)
Other versions
CA2055827C (en
Inventor
Philippe Menasche
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imtix Sangstat
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9014424A external-priority patent/FR2669189B1/en
Priority claimed from FR9109027A external-priority patent/FR2679107B1/en
Application filed by Individual filed Critical Individual
Publication of CA2055827A1 publication Critical patent/CA2055827A1/en
Application granted granted Critical
Publication of CA2055827C publication Critical patent/CA2055827C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
    • A01N1/0226—Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A61K31/175—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine having the group, >N—C(O)—N=N— or, e.g. carbonohydrazides, carbazones, semicarbazides, semicarbazones; Thioanalogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A61K38/063—Glutathione

Abstract

Perfusion and preservation and/or reperfusion solutions for surgery and organ transplantation, including that of the heart, a feature of which solutions is the inclusion of at least one antioxidant compound, such as a trapping agent for free oxygen radicals, in particular glutathione in the reduced state or N-acetylcysteine, said solutions possessing a zero or greatly reduced partial pressure of oxygen which is maintained substantially at this value up to the time of use. The solution is preferably presented in flexible bags impermeable to oxygen.
CA002055827A 1990-11-20 1991-11-19 Solutions for the perfusion, preservation and reperfusion of organs Expired - Lifetime CA2055827C (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR9014424A FR2669189B1 (en) 1990-11-20 1990-11-20 PERFUSION AND STORAGE SOLUTIONS FOR CARDIAC TRANSPLANTATIONS.
FR9014424 1990-11-20
FR9109027A FR2679107B1 (en) 1991-07-17 1991-07-17 ORGANIC PERFUSION, PRESERVATION AND REPERFUSION SOLUTIONS.
FR9109027 1991-07-17

Publications (2)

Publication Number Publication Date
CA2055827A1 true CA2055827A1 (en) 1992-05-21
CA2055827C CA2055827C (en) 1999-06-15

Family

ID=26228338

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002055827A Expired - Lifetime CA2055827C (en) 1990-11-20 1991-11-19 Solutions for the perfusion, preservation and reperfusion of organs

Country Status (8)

Country Link
AT (1) AT399440B (en)
BE (1) BE1006834A3 (en)
CA (1) CA2055827C (en)
CH (1) CH683485A5 (en)
DE (1) DE4138040A1 (en)
ES (1) ES2050580B1 (en)
GB (1) GB2249937B (en)
IT (1) IT1251995B (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE1007500A3 (en) * 1992-09-18 1995-07-18 Pasteur Merieux Serums Vacc Solution infusion, conservation and organ reperfusion.
WO1994026103A1 (en) * 1993-05-07 1994-11-24 Chugai Seiyaku Kabushiki Kaisha Organ preservative
DE4325547C2 (en) * 1993-07-29 1997-11-27 Max Planck Gesellschaft Use of thiol compounds for the therapy of hepatitis-virus-induced diseases
JPH07215801A (en) * 1994-01-28 1995-08-15 Senju Pharmaceut Co Ltd Preservative for lung and method for preserving lung
JPH07330501A (en) * 1994-06-14 1995-12-19 Senju Pharmaceut Co Ltd Liver-preserving agent and liver preserving method
DE4439477C2 (en) * 1994-11-08 1999-10-21 Asta Medica Ag Use of R, S - (+/-) - alpha-lipoic acid, R - (+) - alpha-lipoic acid, S - (-) - alpha-lipoic acid in reduced or oxidized form or the metabolites and their salts, esters, amides for the treatment of diabetic microangiopathy
DE19706111C2 (en) * 1997-02-17 1999-02-18 Fresenius Medical Care De Gmbh Solution for storage of organs
US5990153A (en) * 1997-05-05 1999-11-23 Wood; John G. Ultrasonicated α-lipoic acid solutions for attenuating microvascular injury
US6045990A (en) * 1998-07-09 2000-04-04 Baust; John M. Inclusion of apoptotic regulators in solutions for cell storage at low temperature
DE19834087C1 (en) * 1998-07-29 2000-03-30 Mirzaie Sedaposhteh Massoud Aqueous preservative solution for storage of animal tissue, especially porcine heart valves, contains sodium, potassium, magnesium and calcium salts, glucose and chelate former
GB0028414D0 (en) 2000-11-22 2001-01-03 Univ Leeds Flush preservation solution
DE102007026392A1 (en) 2007-06-06 2008-12-11 Bayer Healthcare Ag Solutions for the perfusion and preservation of organs and tissues
GR20180100514A (en) * 2018-11-07 2020-06-15 Πανεπιστημιο Πατρων Pharmaceutical combinations and kits for the prevention or therapy of pain and other complications of orthopedic or vascular surgery and multiple trauma

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4186253A (en) * 1978-10-10 1980-01-29 The Green Cross Corporation Perfusate for preserving organ to be transplanted and preserving method
US4473552A (en) * 1981-03-16 1984-09-25 Jost Leonora I Anaerobic method for preserving whole blood, tissue and components containing living mammalian cells
US4423600A (en) * 1982-12-10 1984-01-03 Mckenna Joan J Method for preservation of living organic tissue by freezing
SE8403912D0 (en) * 1984-07-30 1984-07-30 Pharmacia Ab PHARMACEUTICAL KIT OR COMPOSITION
DE3581407D1 (en) * 1985-09-06 1991-02-21 Nestle Sa STORAGE OF LIVING TISSUE.
US4879283A (en) * 1985-10-03 1989-11-07 Wisconsin Alumni Research Foundation Solution for the preservation of organs
US4798824A (en) * 1985-10-03 1989-01-17 Wisconsin Alumni Research Foundation Perfusate for the preservation of organs
ES2007994A6 (en) * 1988-08-16 1989-07-01 Grino Boira Jose Maria Liquid medium for infusion and preservation of organs.
US4920044A (en) * 1988-11-08 1990-04-24 The Cleveland Clinic Foundation Intracellular flush solution for preserving organs
US4938961A (en) * 1989-04-28 1990-07-03 Geoffrey Collins Organ preservation solution containing pokyethylene gycol and method of performing cardioplegia

Also Published As

Publication number Publication date
ITMI912991A1 (en) 1993-05-11
ITMI912991A0 (en) 1991-11-11
CA2055827C (en) 1999-06-15
BE1006834A3 (en) 1995-01-03
GB2249937A (en) 1992-05-27
AT399440B (en) 1995-05-26
GB2249937B (en) 1994-02-16
DE4138040A1 (en) 1992-05-21
ES2050580B1 (en) 1994-12-16
CH683485A5 (en) 1994-03-31
IT1251995B (en) 1995-05-27
GB9124488D0 (en) 1992-01-08
ES2050580A1 (en) 1994-05-16
ATA228791A (en) 1994-10-15

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