IT1251995B - Soluzioni di perfusione,di conservazione e di riperfusione d'organi - Google Patents

Soluzioni di perfusione,di conservazione e di riperfusione d'organi

Info

Publication number
IT1251995B
IT1251995B ITMI912991A ITMI912991A IT1251995B IT 1251995 B IT1251995 B IT 1251995B IT MI912991 A ITMI912991 A IT MI912991A IT MI912991 A ITMI912991 A IT MI912991A IT 1251995 B IT1251995 B IT 1251995B
Authority
IT
Italy
Prior art keywords
solutions
perfusion
oxygen
bodies
beginning
Prior art date
Application number
ITMI912991A
Other languages
English (en)
Inventor
Philippe Menasche
Original Assignee
Pasteur Merieux Serums Vacc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9014424A external-priority patent/FR2669189B1/fr
Priority claimed from FR9109027A external-priority patent/FR2679107B1/fr
Application filed by Pasteur Merieux Serums Vacc filed Critical Pasteur Merieux Serums Vacc
Publication of ITMI912991A0 publication Critical patent/ITMI912991A0/it
Publication of ITMI912991A1 publication Critical patent/ITMI912991A1/it
Application granted granted Critical
Publication of IT1251995B publication Critical patent/IT1251995B/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
    • A01N1/0226—Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A61K31/175—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine having the group, >N—C(O)—N=N— or, e.g. carbonohydrazides, carbazones, semicarbazides, semicarbazones; Thioanalogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A61K38/063—Glutathione

Abstract

Soluzioni di perfusione, di conservazione e/o di riperfusione per la chirurgia e i trapianti d'organo, ivi compreso l'organo cardiaco, caratterizzate dall'inclusione di almeno un composto antiossidante, come sequestrante dei radicali liberi di ossigeno, segnatamente il glutatione allo stato ridotto o la N-acetil-cisteina, dove le suddette soluzioni presentano una pressione parziale d'ossigeno nulla o molto abbassata e che si mantiene sensibilmente su questo valore fino all'utilizzazione. La soluzione viene di preferenza presentata in sacchetti flessibili impermeabili all'ossigeno.
ITMI912991A 1990-11-20 1991-11-11 Soluzioni di perfusione,di conservazione e di riperfusione d'organi IT1251995B (it)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9014424A FR2669189B1 (fr) 1990-11-20 1990-11-20 Solutions de perfusion et de stockage pour transplantations cardiaques.
FR9109027A FR2679107B1 (fr) 1991-07-17 1991-07-17 Solutions de perfusion, de conservation et de reperfusion d'organes.

Publications (3)

Publication Number Publication Date
ITMI912991A0 ITMI912991A0 (it) 1991-11-11
ITMI912991A1 ITMI912991A1 (it) 1993-05-11
IT1251995B true IT1251995B (it) 1995-05-27

Family

ID=26228338

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI912991A IT1251995B (it) 1990-11-20 1991-11-11 Soluzioni di perfusione,di conservazione e di riperfusione d'organi

Country Status (8)

Country Link
AT (1) AT399440B (it)
BE (1) BE1006834A3 (it)
CA (1) CA2055827C (it)
CH (1) CH683485A5 (it)
DE (1) DE4138040A1 (it)
ES (1) ES2050580B1 (it)
GB (1) GB2249937B (it)
IT (1) IT1251995B (it)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE1007500A3 (fr) * 1992-09-18 1995-07-18 Pasteur Merieux Serums Vacc Solution de perfusion, de conservation et de reperfusion d'organes.
WO1994026103A1 (en) * 1993-05-07 1994-11-24 Chugai Seiyaku Kabushiki Kaisha Organ preservative
DE4325547C2 (de) * 1993-07-29 1997-11-27 Max Planck Gesellschaft Verwendung von Thiolverbindungen zur Therapie von Hepatitis-_Viren-induzierten Erkrankungen
JPH07215801A (ja) * 1994-01-28 1995-08-15 Senju Pharmaceut Co Ltd 肺保存剤および肺保存方法
JPH07330501A (ja) * 1994-06-14 1995-12-19 Senju Pharmaceut Co Ltd 肝保存剤および肝保存方法
DE4439477C2 (de) * 1994-11-08 1999-10-21 Asta Medica Ag Verwendung von R,S-(+/-)-alpha-Liponsäure, R-(+)-alpha-Liponäure, S-(-)-alpha-Liponsäure in reduzierter oder oxidierter Form oder der Metabolite sowie deren Salze, Ester, Amide zur Behandlung der diabetischen Mikroangiopathie
DE19706111C2 (de) * 1997-02-17 1999-02-18 Fresenius Medical Care De Gmbh Lösung zur Aufbewahrung von Organen
US5990153A (en) * 1997-05-05 1999-11-23 Wood; John G. Ultrasonicated α-lipoic acid solutions for attenuating microvascular injury
US6045990A (en) * 1998-07-09 2000-04-04 Baust; John M. Inclusion of apoptotic regulators in solutions for cell storage at low temperature
DE19834087C1 (de) * 1998-07-29 2000-03-30 Mirzaie Sedaposhteh Massoud Wäßrige Konservierungslösung und Verfahren zur Aufbewahrung tierischen Gewebes
GB0028414D0 (en) 2000-11-22 2001-01-03 Univ Leeds Flush preservation solution
DE102007026392A1 (de) 2007-06-06 2008-12-11 Bayer Healthcare Ag Lösungen für die Perfusion und Konservierung von Organen und Geweben
GR20180100514A (el) * 2018-11-07 2020-06-15 Πανεπιστημιο Πατρων Φαρμακευτικοι συνδυασμοι και κιτ για την προληψη ή την θεραπεια του πονου και αλλων επιπλοκων της ορθοπαιδικης ή αγγειακης χειρουργικης και του πολλαπλου τραυματος

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4186253A (en) * 1978-10-10 1980-01-29 The Green Cross Corporation Perfusate for preserving organ to be transplanted and preserving method
US4473552A (en) * 1981-03-16 1984-09-25 Jost Leonora I Anaerobic method for preserving whole blood, tissue and components containing living mammalian cells
US4423600A (en) * 1982-12-10 1984-01-03 Mckenna Joan J Method for preservation of living organic tissue by freezing
SE8403912D0 (sv) * 1984-07-30 1984-07-30 Pharmacia Ab Lekemedelssats eller -komposition
DE3581407D1 (de) * 1985-09-06 1991-02-21 Nestle Sa Bewahrung lebender gewebe.
US4879283A (en) * 1985-10-03 1989-11-07 Wisconsin Alumni Research Foundation Solution for the preservation of organs
US4798824A (en) * 1985-10-03 1989-01-17 Wisconsin Alumni Research Foundation Perfusate for the preservation of organs
ES2007994A6 (es) * 1988-08-16 1989-07-01 Grino Boira Jose Maria Medio liquido para perfusion y preservacion de organos.
US4920044A (en) * 1988-11-08 1990-04-24 The Cleveland Clinic Foundation Intracellular flush solution for preserving organs
US4938961A (en) * 1989-04-28 1990-07-03 Geoffrey Collins Organ preservation solution containing pokyethylene gycol and method of performing cardioplegia

Also Published As

Publication number Publication date
ITMI912991A1 (it) 1993-05-11
ITMI912991A0 (it) 1991-11-11
CA2055827C (en) 1999-06-15
BE1006834A3 (fr) 1995-01-03
GB2249937A (en) 1992-05-27
AT399440B (de) 1995-05-26
GB2249937B (en) 1994-02-16
DE4138040A1 (de) 1992-05-21
ES2050580B1 (es) 1994-12-16
CH683485A5 (fr) 1994-03-31
CA2055827A1 (en) 1992-05-21
GB9124488D0 (en) 1992-01-08
ES2050580A1 (es) 1994-05-16
ATA228791A (de) 1994-10-15

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0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19990226