ATE235813T1 - Verfahren zur vorbereitung von organen auf die kryokonservierung - Google Patents
Verfahren zur vorbereitung von organen auf die kryokonservierungInfo
- Publication number
- ATE235813T1 ATE235813T1 AT95928376T AT95928376T ATE235813T1 AT E235813 T1 ATE235813 T1 AT E235813T1 AT 95928376 T AT95928376 T AT 95928376T AT 95928376 T AT95928376 T AT 95928376T AT E235813 T1 ATE235813 T1 AT E235813T1
- Authority
- AT
- Austria
- Prior art keywords
- cryopreservation
- organ
- growth factor
- transforming growth
- factor beta
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0205—Chemical aspects
- A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
- A01N1/0221—Freeze-process protecting agents, i.e. substances protecting cells from effects of the physical process, e.g. cryoprotectants, osmolarity regulators like oncotic agents
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0236—Mechanical aspects
- A01N1/0242—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components
- A01N1/0247—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components for perfusion, i.e. for circulating fluid through organs, blood vessels or other living parts
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0236—Mechanical aspects
- A01N1/0242—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components
- A01N1/0252—Temperature controlling refrigerating apparatus, i.e. devices used to actively control the temperature of a designated internal volume, e.g. refrigerators, freeze-drying apparatus or liquid nitrogen baths
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Physics & Mathematics (AREA)
- Thermal Sciences (AREA)
- Mechanical Engineering (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/292,001 US5723282A (en) | 1991-07-08 | 1994-08-18 | Method of preparing organs for vitrification |
PCT/US1995/010223 WO1996005727A1 (en) | 1994-08-18 | 1995-08-11 | Methods of preparing organs for cryopreservation and subsequent transplantation |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE235813T1 true ATE235813T1 (de) | 2003-04-15 |
Family
ID=23122767
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT95928376T ATE235813T1 (de) | 1994-08-18 | 1995-08-11 | Verfahren zur vorbereitung von organen auf die kryokonservierung |
Country Status (9)
Country | Link |
---|---|
US (4) | US5723282A (de) |
EP (1) | EP0777413B1 (de) |
JP (1) | JPH10504568A (de) |
KR (1) | KR970705337A (de) |
AT (1) | ATE235813T1 (de) |
AU (1) | AU692292B2 (de) |
CA (1) | CA2197773A1 (de) |
DE (1) | DE69530212T2 (de) |
WO (1) | WO1996005727A1 (de) |
Families Citing this family (65)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5723282A (en) * | 1991-07-08 | 1998-03-03 | The American National Red Cross | Method of preparing organs for vitrification |
US5856081A (en) * | 1991-07-08 | 1999-01-05 | The American National Red Cross | Computer controlled cryoprotectant perfusion apparatus |
WO1997026894A1 (en) * | 1996-01-25 | 1997-07-31 | Weglicki William B | Intravenous magnesium gluconate for treatment of conditions caused by excessive oxidative stress due to free radical distribution |
JP3989574B2 (ja) * | 1996-07-11 | 2007-10-10 | ネオ製薬工業株式会社 | 歯牙保存液 |
WO1999008513A1 (en) * | 1997-08-20 | 1999-02-25 | Biopore, Inc. | Cryoprotectant removal method and apparatus |
CA2345018A1 (en) * | 1998-09-21 | 2000-03-30 | 21St Century Medicine, Inc. | Polyvinyl alcohol compounds for inhibition of ice growth |
US6673594B1 (en) | 1998-09-29 | 2004-01-06 | Organ Recovery Systems | Apparatus and method for maintaining and/or restoring viability of organs |
US6977140B1 (en) | 1998-09-29 | 2005-12-20 | Organ Recovery Systems, Inc. | Method for maintaining and/or restoring viability of organs |
US7749693B2 (en) * | 1998-09-29 | 2010-07-06 | Lifeline Scientific, Inc. | Method of determining that an organ is not suitable for transplantation and using it for testing substances |
US6567860B1 (en) | 1998-10-30 | 2003-05-20 | Computer Associates Think, Inc. | Method and apparatus for new device driver installation by an operating system |
US6194137B1 (en) | 1999-04-13 | 2001-02-27 | Organ Recovery Systems, Inc. | Method of cryopreservation of blood vessels by vitrification |
US20070048726A1 (en) * | 2000-01-14 | 2007-03-01 | Biolife Solutions, Inc. | Methods and Compositions for the Control of Molecular-Based Cell Death During Preservation of Cells, Tissues or Organs in a Gel-Like State |
US7250292B2 (en) * | 2000-01-26 | 2007-07-31 | 21St Century Medicine | Hypertonic reduction of chilling injury |
US6962814B2 (en) | 2000-08-16 | 2005-11-08 | Duke University | Decellularized tissue engineered constructs and tissues |
CA2426169A1 (en) * | 2000-10-19 | 2002-04-25 | Bijan S. Khirabadi | Method of cryopreservation of tissues or organs other than a blood vessel by vitrification |
US6916602B2 (en) * | 2001-05-29 | 2005-07-12 | Interface Multigrad Technology Ltd. | Methods of preserving functionality of an ovary, preserving fertility of a patient undergoing a treatment expected to cause sterility and assuring a supply of viable gametes for future use |
US8580487B2 (en) * | 2001-05-29 | 2013-11-12 | Core Dynamics Limited | Methods of preserving functionality of an organ, preserving fertility of a patient undergoing a treatment expected to cause sterility and assuring a supply of viable gametes for future use |
US20050053912A1 (en) * | 2001-06-11 | 2005-03-10 | Roth Mark B. | Methods for inducing reversible stasis |
US7488309B2 (en) | 2002-07-03 | 2009-02-10 | Bioanalytical Systems, Inc. | Device and method for drug delivery to animals |
DE60314154T2 (de) * | 2002-08-23 | 2008-01-24 | Organ Recovery Systems, Des Plaines | Verbindungsanordnungen, insbesondere für transplantationsorgane |
US7270946B2 (en) * | 2002-10-04 | 2007-09-18 | Organ Recovery Systems, Inc. | Method for treatment of cellular materials with sugars prior to preservation |
CA2446368C (en) | 2002-10-29 | 2014-10-14 | Bayer Healthcare Llc | Diffuse reflectance readhead |
US6921633B2 (en) * | 2002-11-18 | 2005-07-26 | Biolife Solutions Incorporated | Methods and compositions for the preservation of cells, tissues or organs in the vitreous state |
WO2004076647A2 (en) * | 2003-02-26 | 2004-09-10 | The Regents Of The University Of California | Use of steady-state oxygen gradients to modulate animal cell functions |
EP1613152B1 (de) * | 2003-04-04 | 2018-07-04 | Organ Recovery Systems, Inc. | Vorrichtung zur trennung von gasen von fliessenden flüssigkeiten |
US7678563B2 (en) | 2003-04-04 | 2010-03-16 | Organ Recovery Systems, Inc. | Method and apparatus for controlling air pressure in an organ or tissue container |
CA2474377A1 (en) * | 2003-07-18 | 2005-01-18 | Cordis Corporation | A minimally invasive isolated hepatic perfusion technique for treatment of liver metastases |
WO2005027633A2 (en) * | 2003-09-16 | 2005-03-31 | 21St Century Medicine, Inc. | Methods and compositions for the cryopreservation of organs |
EP1684580A2 (de) | 2003-10-22 | 2006-08-02 | Fred Hutchinson Cancer Research Center | Verfahren, zusammensetzungen und vorrichtungen zur induktion von stasen geweben und organen |
AU2004295702A1 (en) * | 2003-12-01 | 2005-06-16 | Vertex Pharmaceuticals Incorporated | Compositions comprising fetal liver cells and methods useful for HCV infection |
US7780712B2 (en) * | 2005-04-08 | 2010-08-24 | Jonathan Thomas | Laparoscopic kidney cooling device |
US20100233670A1 (en) * | 2006-02-13 | 2010-09-16 | Zohar Gavish | Frozen Viable Solid Organs and Method for Freezing Same |
PT2029740E (pt) * | 2006-05-31 | 2012-07-06 | Genzyme Corp | Utilização de polissacáridos para promoção de actividade enzimática |
CN101868259B (zh) * | 2007-09-14 | 2014-08-27 | 拜耳医疗保健公司 | 防止重力流的流体路径装置组 |
US9113624B2 (en) * | 2008-10-15 | 2015-08-25 | Covidien Lp | System and method for perfusing biological organs |
WO2010096821A2 (en) | 2009-02-23 | 2010-08-26 | Cell & Tissue Systems, Inc. | Method for ice-free cryopreservation of tissue |
US9834756B2 (en) | 2010-07-16 | 2017-12-05 | Lifeline Scientific, Inc. | Methods for increasing isolation yields of cellular products |
CN103429733B (zh) | 2010-10-22 | 2015-11-25 | 细胞与组织系统股份有限公司 | 培养的胰岛 |
WO2012078968A2 (en) | 2010-12-10 | 2012-06-14 | Lifeline Scientific, Inc. | Machine perfusion with complement inhibitors |
US8828034B2 (en) | 2011-04-29 | 2014-09-09 | Lifeline Scientific, Inc. | Cannula |
US9022978B2 (en) | 2011-04-29 | 2015-05-05 | Lifeline Scientific, Inc. | Universal sealring cannula |
US9642625B2 (en) | 2011-04-29 | 2017-05-09 | Lifeline Scientific, Inc. | Cannula for a donor organ with or without an aortic cuff or patch |
CA2850714C (en) * | 2011-10-03 | 2019-11-26 | Vivoline Medical Ab | Medical fluid comprising globulin and its use for preservation of harvested organs |
WO2013143822A1 (en) | 2012-03-26 | 2013-10-03 | Imax Discovery Gmbh | Adenosine as sweetness enhancer for certain sugars |
US10433538B2 (en) * | 2012-10-12 | 2019-10-08 | University of Pittsburgh—of the Commonwealth System of Higher Education | Compositions and methods for organ preservation |
EP2721930A1 (de) * | 2012-10-19 | 2014-04-23 | Serumwerk Bernburg AG | Kryokonservierungslösung, Verfahren zu ihrer Herstellung und Verwendung |
WO2015023972A1 (en) | 2013-08-16 | 2015-02-19 | Alexion Pharmaceuticals, Inc. | Treatment of graft rejection by administering a complement inhibitor to an organ prior to transplant |
US10765111B1 (en) | 2014-03-05 | 2020-09-08 | Akron Biotechnology, Llc | Cryosolutions and uses thereof |
CN104054697B (zh) * | 2014-07-07 | 2015-10-28 | 中国水产科学研究院长江水产研究所 | 一种达氏鲟精子冷冻保存液及制备方法和应用 |
GB2532499A (en) * | 2014-11-21 | 2016-05-25 | Virgin Health Bank Qstp-Llc | Improvements in tissue processing |
EP3288586A1 (de) | 2015-05-01 | 2018-03-07 | Alexion Pharmaceuticals, Inc. | Wirksamkeit eines anti-c5-antikörpers bei der prävention von antikörper-vermittelter abstossung bei sensibilisierten empfängern eines nierentransplantats |
US20180311345A1 (en) | 2015-10-30 | 2018-11-01 | Alexion Pharmaceuticals, Inc. | A method of inhibiting exacerbations of t cell-mediated allograft vasculopathy |
EP3487296A1 (de) | 2016-07-22 | 2019-05-29 | Tissue Testing Technologies LLC | Verbesserung der zellkryokonservierung mit glycolipiden |
US11849719B2 (en) | 2016-07-24 | 2023-12-26 | 21St Century Medicine, Inc. | Methods for introduction and prolonged washout by organ perfusion of maximally vitrifiable cryoprotectant solutions at elevated temperatures |
US11246308B2 (en) | 2016-12-20 | 2022-02-15 | Tissue Testing Technologies Llc | Ice-free preservation of large volume tissue samples for viable, functional tissue banking |
CN108728359B (zh) * | 2018-06-08 | 2022-03-11 | 天晴干细胞股份有限公司 | 一种空间站细胞培养瓶及其辅助装置的应用 |
JP2020002062A (ja) * | 2018-06-28 | 2020-01-09 | 株式会社Screenホールディングス | 灌流装置および灌流方法 |
WO2020263891A1 (en) * | 2019-06-27 | 2020-12-30 | Cook Medical Technologies Llc | System for passive permeation of a biological material and method of using same |
BR112022007399A2 (pt) | 2019-11-07 | 2022-07-05 | Tissue Testing Tech Llc | Vitrificação sem gelo e nanoaquecimento de grandes amostras de tecido |
US11856947B2 (en) | 2020-02-17 | 2024-01-02 | Cook Medical Technologies Llc | System for automated permeation of a biological material and method of using same |
JP2021151956A (ja) * | 2020-03-24 | 2021-09-30 | 株式会社Screenホールディングス | 液体容器封止蓋および当該蓋によって封止された容器を用いた灌流装置 |
AU2021365838B2 (en) | 2020-10-21 | 2024-09-19 | Tissue Testing Technologies Llc | Minimizing immunogenicity of decellularized tissues |
US20220354108A1 (en) | 2021-05-04 | 2022-11-10 | Tissue Testing Technologies Llc | Preservation methods using trehalose with other cryoprotectants being absent from the cryopreservation protocol |
US20230149919A1 (en) | 2021-11-15 | 2023-05-18 | Tissue Testing Technologies Llc | Cassette for preservation of natural and bioengineered tissues |
US20230148587A1 (en) | 2021-11-15 | 2023-05-18 | Tissue Testing Technologies Llc | Preservation of natural and bioengineered tissues and methods of storing and transport |
Family Cites Families (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3772153A (en) * | 1969-04-02 | 1973-11-13 | Air Liquide | Apparatus for the preservation of animal or human organs in living condition |
US3892628A (en) * | 1969-10-06 | 1975-07-01 | Baxter Laboratories Inc | Preservation of organs |
US3677024A (en) * | 1970-01-20 | 1972-07-18 | Paul E Segall | Preservation and storage of biologic materials |
US3639084A (en) * | 1970-04-06 | 1972-02-01 | Baxter Laboratories Inc | Mechanism for control pulsatile fluid flow |
US3753865A (en) * | 1971-03-12 | 1973-08-21 | Univ California | Method and apparatus for preserving human organs extracorporeally |
DE2241698C2 (de) * | 1971-09-02 | 1982-08-26 | Roland Dr.med. Zürich Doerig | Verfahren zur Organerhaltung sowie Vorrichtung zum Durchführen dieses Verfahrens |
US3843455A (en) * | 1972-09-13 | 1974-10-22 | M Bier | Apparatus and technique for preservation of isolated organs through perfusion |
US3995444A (en) * | 1974-11-08 | 1976-12-07 | American Hospital Supply Corporation | Organ perfusion system |
US3940943A (en) * | 1975-01-22 | 1976-03-02 | The Curators Of The University Of Missouri | Multistage freezing system for preservation of biological materials |
US4186565A (en) * | 1978-05-19 | 1980-02-05 | Henry Ford Hospital | Perfusion system for organ preservation |
US4629686A (en) * | 1982-02-19 | 1986-12-16 | Endotronics, Inc. | Apparatus for delivering a controlled dosage of a chemical substance |
CA1200507A (en) * | 1982-06-04 | 1986-02-11 | Nobuo Sakao | Method of preserving organ and apparatus for preserving the same |
US4559298A (en) * | 1982-11-23 | 1985-12-17 | American National Red Cross | Cryopreservation of biological materials in a non-frozen or vitreous state |
US4618586A (en) * | 1983-04-08 | 1986-10-21 | Endotronics, Inc. | Apparatus for administering a controlled dosage of a chemical substance having an improved culture chamber |
US4837390A (en) * | 1983-05-11 | 1989-06-06 | Keyes Offshore, Inc. | Hyperbaric organ preservation apparatus and method for preserving living organs |
US4471629A (en) * | 1983-05-31 | 1984-09-18 | Mount Carmel Research And Education Corporation | Method of freezing and transplant of kidneys and apparatus |
US4798824A (en) * | 1985-10-03 | 1989-01-17 | Wisconsin Alumni Research Foundation | Perfusate for the preservation of organs |
US4879283A (en) * | 1985-10-03 | 1989-11-07 | Wisconsin Alumni Research Foundation | Solution for the preservation of organs |
US4688387A (en) * | 1985-11-12 | 1987-08-25 | Vital Force, Inc. | Method for preservation and storage of viable biological materials at cryogenic temperatures |
US4704029A (en) * | 1985-12-26 | 1987-11-03 | Research Corporation | Blood glucose monitor |
US4745759A (en) * | 1986-12-23 | 1988-05-24 | Bauer Dan O | Kidney preservation machine |
WO1988005261A1 (en) * | 1987-01-16 | 1988-07-28 | Tops Systems, Inc. | Total organ perfusion system |
US5145769A (en) * | 1987-08-21 | 1992-09-08 | Cryolife Inc. | Method for cryopreserving blood vessels |
US5051352A (en) * | 1987-10-07 | 1991-09-24 | The Regents Of The University Of California | Apparatus and method of preserving the viability of animal organs |
ES2007994A6 (es) * | 1988-08-16 | 1989-07-01 | Grino Boira Jose Maria | Medio liquido para perfusion y preservacion de organos. |
JPH0653160B2 (ja) * | 1989-08-18 | 1994-07-20 | 呉羽化学工業株式会社 | 拍動発生方法及び装置 |
US5118512A (en) * | 1990-01-23 | 1992-06-02 | Osteotech, Inc. (A Delaware Corp.) | Process for cryopreserving biological materials and materials prepared thereby |
US5145770A (en) * | 1990-06-04 | 1992-09-08 | Biosurface Technology, Inc. | Cryopreservation of cultured epithelial sheets |
GB9021325D0 (en) * | 1990-10-01 | 1990-11-14 | Geistlich Soehne Ag | Chemical composition |
US5112110A (en) * | 1990-10-29 | 1992-05-12 | Ladd Furniture | Seating unit having lockable cushions |
US5157930A (en) * | 1991-04-22 | 1992-10-27 | Mcghee Samuel C | Organ preservation apparatus |
US5160313A (en) * | 1991-05-14 | 1992-11-03 | Cryolife, Inc. | Process for preparing tissue for transplantation |
US5217860A (en) * | 1991-07-08 | 1993-06-08 | The American National Red Cross | Method for preserving organs for transplantation by vitrification |
US5723282A (en) * | 1991-07-08 | 1998-03-03 | The American National Red Cross | Method of preparing organs for vitrification |
US5328821A (en) * | 1991-12-12 | 1994-07-12 | Robyn Fisher | Cold and cryo-preservation methods for human tissue slices |
US5518878A (en) * | 1993-09-15 | 1996-05-21 | Organogenesis Inc. | Cryopreservation of cultured skin or cornea equivalents with agitation |
-
1994
- 1994-08-18 US US08/292,001 patent/US5723282A/en not_active Expired - Lifetime
-
1995
- 1995-05-31 US US08/455,027 patent/US5821045A/en not_active Expired - Fee Related
- 1995-08-11 AT AT95928376T patent/ATE235813T1/de not_active IP Right Cessation
- 1995-08-11 DE DE69530212T patent/DE69530212T2/de not_active Expired - Fee Related
- 1995-08-11 JP JP8508140A patent/JPH10504568A/ja not_active Ceased
- 1995-08-11 EP EP95928376A patent/EP0777413B1/de not_active Expired - Lifetime
- 1995-08-11 WO PCT/US1995/010223 patent/WO1996005727A1/en active IP Right Grant
- 1995-08-11 AU AU32174/95A patent/AU692292B2/en not_active Ceased
- 1995-08-11 KR KR1019970701070A patent/KR970705337A/ko not_active Application Discontinuation
- 1995-08-11 CA CA002197773A patent/CA2197773A1/en not_active Abandoned
-
1998
- 1998-02-27 US US09/031,893 patent/US5962214A/en not_active Expired - Fee Related
- 1998-04-28 US US09/066,809 patent/US6187529B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AU692292B2 (en) | 1998-06-04 |
AU3217495A (en) | 1996-03-14 |
EP0777413A1 (de) | 1997-06-11 |
DE69530212T2 (de) | 2003-12-04 |
US5821045A (en) | 1998-10-13 |
US5723282A (en) | 1998-03-03 |
JPH10504568A (ja) | 1998-05-06 |
US5962214A (en) | 1999-10-05 |
US6187529B1 (en) | 2001-02-13 |
DE69530212D1 (de) | 2003-05-08 |
KR970705337A (ko) | 1997-10-09 |
WO1996005727A1 (en) | 1996-02-29 |
EP0777413B1 (de) | 2003-04-02 |
CA2197773A1 (en) | 1996-02-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |