ES2050580B1 - Soluciones de perfusion, de conservacion y/o de reperfusion de organos. - Google Patents
Soluciones de perfusion, de conservacion y/o de reperfusion de organos.Info
- Publication number
- ES2050580B1 ES2050580B1 ES09102549A ES9102549A ES2050580B1 ES 2050580 B1 ES2050580 B1 ES 2050580B1 ES 09102549 A ES09102549 A ES 09102549A ES 9102549 A ES9102549 A ES 9102549A ES 2050580 B1 ES2050580 B1 ES 2050580B1
- Authority
- ES
- Spain
- Prior art keywords
- perfusion
- conservation
- solutions
- organ
- organs
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 210000000056 organ Anatomy 0.000 title abstract 4
- 230000010412 perfusion Effects 0.000 title abstract 2
- 230000010410 reperfusion Effects 0.000 title abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 239000003963 antioxidant agent Substances 0.000 abstract 1
- 230000003078 antioxidant effect Effects 0.000 abstract 1
- 230000000747 cardiac effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000001356 surgical procedure Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0205—Chemical aspects
- A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
- A01N1/0226—Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
- A61K31/175—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine having the group, >N—C(O)—N=N— or, e.g. carbonohydrazides, carbazones, semicarbazides, semicarbazones; Thioanalogues thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
- A61K38/063—Glutathione
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Environmental Sciences (AREA)
- Dentistry (AREA)
- Physiology (AREA)
- Biophysics (AREA)
- Inorganic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
SOLUCIONES DE PERFUSION DE CONSERVACION Y/O DE REPERFUSION DE ORGANOS PARA LA CIRUGIA Y LOS TRASPLANTES DE ORGANOS COMPRENDIDO EL ORGANO CARDIACO, QUE INCLUYEN POR LO MENOS UN COMPUESTO ANTIOXIDANTE TAL COMO UN CAZADOR DE RADICALES LIBRES DEL OXIGENO EN PARTICULAR EL GLUTATION EN ESTADO REDUCIDO O LA N-ACETILCISTEINA PRESENTANDO DICHAS SOLUCIONES UNA PRESION PARCIAL DE OXIGENO NULA O MUY REBAJADA Y MANTENIENDOSE SENSIBLEMENTE A ESTE VALOR HASTA LA UTILIZACION. LA SOLUCION SE PRESENTA PREFERENTEMENTE EN BOLSAS FLEXIBLES IMPERMEABLES AL OXIGENO.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9014424A FR2669189B1 (fr) | 1990-11-20 | 1990-11-20 | Solutions de perfusion et de stockage pour transplantations cardiaques. |
FR9109027A FR2679107B1 (fr) | 1991-07-17 | 1991-07-17 | Solutions de perfusion, de conservation et de reperfusion d'organes. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2050580A1 ES2050580A1 (es) | 1994-05-16 |
ES2050580B1 true ES2050580B1 (es) | 1994-12-16 |
Family
ID=26228338
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES09102549A Expired - Fee Related ES2050580B1 (es) | 1990-11-20 | 1991-11-18 | Soluciones de perfusion, de conservacion y/o de reperfusion de organos. |
Country Status (8)
Country | Link |
---|---|
AT (1) | AT399440B (es) |
BE (1) | BE1006834A3 (es) |
CA (1) | CA2055827C (es) |
CH (1) | CH683485A5 (es) |
DE (1) | DE4138040A1 (es) |
ES (1) | ES2050580B1 (es) |
GB (1) | GB2249937B (es) |
IT (1) | IT1251995B (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE1007500A3 (fr) * | 1992-09-18 | 1995-07-18 | Pasteur Merieux Serums Vacc | Solution de perfusion, de conservation et de reperfusion d'organes. |
WO1994026103A1 (en) * | 1993-05-07 | 1994-11-24 | Chugai Seiyaku Kabushiki Kaisha | Organ preservative |
DE4325547C2 (de) * | 1993-07-29 | 1997-11-27 | Max Planck Gesellschaft | Verwendung von Thiolverbindungen zur Therapie von Hepatitis-_Viren-induzierten Erkrankungen |
JPH07215801A (ja) * | 1994-01-28 | 1995-08-15 | Senju Pharmaceut Co Ltd | 肺保存剤および肺保存方法 |
JPH07330501A (ja) * | 1994-06-14 | 1995-12-19 | Senju Pharmaceut Co Ltd | 肝保存剤および肝保存方法 |
DE4439477C2 (de) * | 1994-11-08 | 1999-10-21 | Asta Medica Ag | Verwendung von R,S-(+/-)-alpha-Liponsäure, R-(+)-alpha-Liponäure, S-(-)-alpha-Liponsäure in reduzierter oder oxidierter Form oder der Metabolite sowie deren Salze, Ester, Amide zur Behandlung der diabetischen Mikroangiopathie |
DE19706111C2 (de) * | 1997-02-17 | 1999-02-18 | Fresenius Medical Care De Gmbh | Lösung zur Aufbewahrung von Organen |
US5990153A (en) * | 1997-05-05 | 1999-11-23 | Wood; John G. | Ultrasonicated α-lipoic acid solutions for attenuating microvascular injury |
US6045990A (en) * | 1998-07-09 | 2000-04-04 | Baust; John M. | Inclusion of apoptotic regulators in solutions for cell storage at low temperature |
DE19834087C1 (de) * | 1998-07-29 | 2000-03-30 | Mirzaie Sedaposhteh Massoud | Wäßrige Konservierungslösung und Verfahren zur Aufbewahrung tierischen Gewebes |
GB0028414D0 (en) | 2000-11-22 | 2001-01-03 | Univ Leeds | Flush preservation solution |
DE102007026392A1 (de) | 2007-06-06 | 2008-12-11 | Bayer Healthcare Ag | Lösungen für die Perfusion und Konservierung von Organen und Geweben |
GR20180100514A (el) * | 2018-11-07 | 2020-06-15 | Πανεπιστημιο Πατρων | Φαρμακευτικοι συνδυασμοι και κιτ για την προληψη ή την θεραπεια του πονου και αλλων επιπλοκων της ορθοπαιδικης ή αγγειακης χειρουργικης και του πολλαπλου τραυματος |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4186253A (en) * | 1978-10-10 | 1980-01-29 | The Green Cross Corporation | Perfusate for preserving organ to be transplanted and preserving method |
US4473552A (en) * | 1981-03-16 | 1984-09-25 | Jost Leonora I | Anaerobic method for preserving whole blood, tissue and components containing living mammalian cells |
US4423600A (en) * | 1982-12-10 | 1984-01-03 | Mckenna Joan J | Method for preservation of living organic tissue by freezing |
SE8403912D0 (sv) * | 1984-07-30 | 1984-07-30 | Pharmacia Ab | Lekemedelssats eller -komposition |
DE3581407D1 (de) * | 1985-09-06 | 1991-02-21 | Nestle Sa | Bewahrung lebender gewebe. |
US4879283A (en) * | 1985-10-03 | 1989-11-07 | Wisconsin Alumni Research Foundation | Solution for the preservation of organs |
US4798824A (en) * | 1985-10-03 | 1989-01-17 | Wisconsin Alumni Research Foundation | Perfusate for the preservation of organs |
ES2007994A6 (es) * | 1988-08-16 | 1989-07-01 | Grino Boira Jose Maria | Medio liquido para perfusion y preservacion de organos. |
US4920044A (en) * | 1988-11-08 | 1990-04-24 | The Cleveland Clinic Foundation | Intracellular flush solution for preserving organs |
US4938961A (en) * | 1989-04-28 | 1990-07-03 | Geoffrey Collins | Organ preservation solution containing pokyethylene gycol and method of performing cardioplegia |
-
1991
- 1991-11-05 CH CH3224/91A patent/CH683485A5/fr not_active IP Right Cessation
- 1991-11-11 IT ITMI912991A patent/IT1251995B/it active IP Right Grant
- 1991-11-18 GB GB9124488A patent/GB2249937B/en not_active Expired - Lifetime
- 1991-11-18 AT AT0228791A patent/AT399440B/de not_active IP Right Cessation
- 1991-11-18 ES ES09102549A patent/ES2050580B1/es not_active Expired - Fee Related
- 1991-11-19 DE DE4138040A patent/DE4138040A1/de not_active Withdrawn
- 1991-11-19 CA CA002055827A patent/CA2055827C/en not_active Expired - Lifetime
- 1991-11-19 BE BE9101067A patent/BE1006834A3/fr not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ITMI912991A1 (it) | 1993-05-11 |
ITMI912991A0 (it) | 1991-11-11 |
CA2055827C (en) | 1999-06-15 |
BE1006834A3 (fr) | 1995-01-03 |
GB2249937A (en) | 1992-05-27 |
AT399440B (de) | 1995-05-26 |
GB2249937B (en) | 1994-02-16 |
DE4138040A1 (de) | 1992-05-21 |
CH683485A5 (fr) | 1994-03-31 |
IT1251995B (it) | 1995-05-27 |
CA2055827A1 (en) | 1992-05-21 |
GB9124488D0 (en) | 1992-01-08 |
ES2050580A1 (es) | 1994-05-16 |
ATA228791A (de) | 1994-10-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC2A | Transfer of patent | ||
FD2A | Announcement of lapse in spain |
Effective date: 20141120 |