GB2194886B - Medicaments containing tissue plasminogen activator. - Google Patents

Medicaments containing tissue plasminogen activator.

Info

Publication number
GB2194886B
GB2194886B GB8711058A GB8711058A GB2194886B GB 2194886 B GB2194886 B GB 2194886B GB 8711058 A GB8711058 A GB 8711058A GB 8711058 A GB8711058 A GB 8711058A GB 2194886 B GB2194886 B GB 2194886B
Authority
GB
United Kingdom
Prior art keywords
plasminogen activator
tissue plasminogen
tissue
containing tissue
medicaments containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
GB8711058A
Other versions
GB8711058D0 (en
GB2194886A (en
Inventor
Henry Berger
Crist John Frangakis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/862,057 external-priority patent/US4976959A/en
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Publication of GB8711058D0 publication Critical patent/GB8711058D0/en
Publication of GB2194886A publication Critical patent/GB2194886A/en
Application granted granted Critical
Publication of GB2194886B publication Critical patent/GB2194886B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44—Oxidoreductases (1)
    • A61K38/446—Superoxide dismutase (1.15)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21068—Tissue plasminogen activator (3.4.21.68), i.e. tPA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Tissue plasminogen activator (t-PA), optionally together with superoxide dismutase (SOD), is used to manufacture a medicament for use in the inhibition of damage to jeopardised tissue during blood reperfusion. The medicament is for preventing damage to tissue following ischaemic attack, e.g. in myocardial tissue, when blood supply is restored.
GB8711058A 1986-05-12 1987-05-11 Medicaments containing tissue plasminogen activator. Expired - Fee Related GB2194886B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86204686A 1986-05-12 1986-05-12
US06/862,057 US4976959A (en) 1986-05-12 1986-05-12 T-PA and SOD in limiting tissue damage

Publications (3)

Publication Number Publication Date
GB8711058D0 GB8711058D0 (en) 1987-06-17
GB2194886A GB2194886A (en) 1988-03-23
GB2194886B true GB2194886B (en) 1990-04-25

Family

ID=27127662

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8711058A Expired - Fee Related GB2194886B (en) 1986-05-12 1987-05-11 Medicaments containing tissue plasminogen activator.

Country Status (13)

Country Link
JP (1) JPH0680015B2 (en)
AU (1) AU600724B2 (en)
BE (1) BE1001425A4 (en)
CH (1) CH672989A5 (en)
DE (1) DE3715662A1 (en)
DK (1) DK237187A (en)
FR (1) FR2600895B1 (en)
GB (1) GB2194886B (en)
IE (1) IE59895B1 (en)
LU (1) LU86875A1 (en)
NL (1) NL8701113A (en)
NZ (1) NZ220260A (en)
SE (1) SE8701921L (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0780784B2 (en) * 1987-10-23 1995-08-30 宇部興産株式会社 Myocardial ischemic injury therapeutic agent based on microcirculatory disorder
NZ230808A (en) * 1988-10-24 1993-04-28 Squibb & Sons Inc Pharmaceutical compositions and combinations containing an angiotensin-converting enzyme inhibitor and a thrombolytic agent
DE4038563A1 (en) * 1990-12-04 1992-06-11 Gruenenthal Gmbh USE OF SUPEROXIDE DISMUTASES FOR PROPHYLAXIS AND / OR TREATMENT OF ORGAN FAILURE IN RISK PATIENTS WITH POLYTRAUMA
DE19518625C2 (en) * 1995-05-24 1997-08-07 Buescher Pebueso Beton Process for sealing concrete pipes and a concrete pipe suitable for carrying out the process
US6844315B2 (en) 1998-05-20 2005-01-18 Erasmus Universiteit Rotterdam Immunoregulator
US20030220258A1 (en) 2001-12-21 2003-11-27 Robbert Benner Treatment of ischemic events
US6921751B1 (en) 1998-05-20 2005-07-26 Erasmus Universiteit Rotterdam Immunoregulator
US8680059B2 (en) 1998-05-20 2014-03-25 Biotempt B.V. Oligopeptide acetate and formulations thereof
EP1138692A1 (en) 2000-03-29 2001-10-04 Erasmus Universiteit Rotterdam Fragments of human chorionic gonadotropin (hcg) as immunoregulator
US7175679B2 (en) 2001-03-29 2007-02-13 Biotempt B.V. Oligopeptide treatment of NF-κB mediated inflammation
US7358330B2 (en) 2001-03-29 2008-04-15 Biotempt B.V. Immunoregulatory compositions
USRE43279E1 (en) 2000-03-29 2012-03-27 Biotemp B.V. Compositions capable of reducing elevated blood urea concentration
US7576174B2 (en) 2000-03-29 2009-08-18 Biotempt B.V. Compositions capable of reducing elevated blood urea concentration
EP1300418A1 (en) 2001-10-04 2003-04-09 Erasmus Universiteit Rotterdam Gene regulation by oligopeptides
US7501391B2 (en) 2001-12-21 2009-03-10 Biotempt B.V. Treatment of transplant survival
US7786084B2 (en) 2001-12-21 2010-08-31 Biotempt B.V. Treatment of burns
US7517529B2 (en) 2003-04-08 2009-04-14 Biotempt B.V. Treatment of type I diabetes
KR20080033331A (en) 2005-07-05 2008-04-16 바이오템프트, 비.브이. Treatment of tumors
EP1864692A1 (en) 2006-06-07 2007-12-12 Biotempt B.V. Use of peptides for the control of radiation injury
US8652476B2 (en) 2009-07-27 2014-02-18 Niigata University Pharmaceutical composition for treating ischemic events
WO2011013668A1 (en) * 2009-07-27 2011-02-03 国立大学法人新潟大学 Pharmaceutical composition for treatment of ischemic events

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8003402A (en) * 1980-06-11 1982-01-04 Leuven Res & Dev Vzw NEW PLASMINOGEN ACTIVATOR AND PHARMACEUTICAL PREPARATION WITH THROMBOLYTIC ACTION.
DE3382389D1 (en) * 1982-12-14 1991-10-02 South African Inventions PLASMINOGEN ACTIVATOR.
JPS59196824A (en) * 1983-04-21 1984-11-08 Kowa Co Adsorption inhibitor
AU569429B2 (en) * 1985-05-28 1988-01-28 Wellcome Foundation Limited, The Aqueous acidic tissue plasminogen activator parenternal formulation
US4929444A (en) * 1985-05-28 1990-05-29 Burroughs Wellcome Co. Low pH pharmaceutical formulation containing t-PA
WO1987006831A1 (en) * 1986-05-15 1987-11-19 Emory University Composition and method for treating a thrombus and embolus

Also Published As

Publication number Publication date
JPH0680015B2 (en) 1994-10-12
AU600724B2 (en) 1990-08-23
IE871210L (en) 1987-11-12
FR2600895B1 (en) 1993-12-24
SE8701921L (en) 1987-11-13
FR2600895A1 (en) 1988-01-08
GB8711058D0 (en) 1987-06-17
NZ220260A (en) 1990-07-26
DE3715662A1 (en) 1987-11-19
LU86875A1 (en) 1988-01-20
DK237187A (en) 1987-11-13
AU7270487A (en) 1987-11-19
BE1001425A4 (en) 1989-10-31
JPS6322026A (en) 1988-01-29
SE8701921D0 (en) 1987-05-11
IE59895B1 (en) 1994-04-20
NL8701113A (en) 1987-12-01
CH672989A5 (en) 1990-01-31
GB2194886A (en) 1988-03-23
DK237187D0 (en) 1987-05-11

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19960511

732E Amendments to the register in respect of changes of name or changes affecting rights (sect. 32/1977)