CH683485A5 - Solutions de perfusion, de conservation et de reperfusion d'organes. - Google Patents
Solutions de perfusion, de conservation et de reperfusion d'organes. Download PDFInfo
- Publication number
- CH683485A5 CH683485A5 CH3224/91A CH322491A CH683485A5 CH 683485 A5 CH683485 A5 CH 683485A5 CH 3224/91 A CH3224/91 A CH 3224/91A CH 322491 A CH322491 A CH 322491A CH 683485 A5 CH683485 A5 CH 683485A5
- Authority
- CH
- Switzerland
- Prior art keywords
- mmol
- liter
- solution
- reperfusion
- solutions
- Prior art date
Links
- 210000000056 organ Anatomy 0.000 title claims description 20
- 230000010412 perfusion Effects 0.000 title claims description 10
- 239000003978 infusion fluid Substances 0.000 title claims description 8
- 238000004321 preservation Methods 0.000 title claims description 8
- 239000000243 solution Substances 0.000 claims description 83
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 claims description 47
- 230000010410 reperfusion Effects 0.000 claims description 36
- 238000001802 infusion Methods 0.000 claims description 25
- 229960003180 glutathione Drugs 0.000 claims description 21
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- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 2
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- LMBWSYZSUOEYSN-UHFFFAOYSA-N diethyldithiocarbamic acid Chemical compound CCN(CC)C(S)=S LMBWSYZSUOEYSN-UHFFFAOYSA-N 0.000 claims description 2
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Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0205—Chemical aspects
- A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
- A01N1/0226—Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
- A61K31/175—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine having the group, >N—C(O)—N=N— or, e.g. carbonohydrazides, carbazones, semicarbazides, semicarbazones; Thioanalogues thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
- A61K38/063—Glutathione
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9014424A FR2669189B1 (fr) | 1990-11-20 | 1990-11-20 | Solutions de perfusion et de stockage pour transplantations cardiaques. |
| FR9109027A FR2679107B1 (fr) | 1991-07-17 | 1991-07-17 | Solutions de perfusion, de conservation et de reperfusion d'organes. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH683485A5 true CH683485A5 (fr) | 1994-03-31 |
Family
ID=26228338
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH3224/91A CH683485A5 (fr) | 1990-11-20 | 1991-11-05 | Solutions de perfusion, de conservation et de reperfusion d'organes. |
Country Status (8)
| Country | Link |
|---|---|
| AT (1) | AT399440B (es) |
| BE (1) | BE1006834A3 (es) |
| CA (1) | CA2055827C (es) |
| CH (1) | CH683485A5 (es) |
| DE (1) | DE4138040A1 (es) |
| ES (1) | ES2050580B1 (es) |
| GB (1) | GB2249937B (es) |
| IT (1) | IT1251995B (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE1007500A3 (fr) * | 1992-09-18 | 1995-07-18 | Pasteur Merieux Serums Vacc | Solution de perfusion, de conservation et de reperfusion d'organes. |
| WO1994026103A1 (en) * | 1993-05-07 | 1994-11-24 | Chugai Seiyaku Kabushiki Kaisha | Organ preservative |
| DE4325547C2 (de) * | 1993-07-29 | 1997-11-27 | Max Planck Gesellschaft | Verwendung von Thiolverbindungen zur Therapie von Hepatitis-_Viren-induzierten Erkrankungen |
| JPH07215801A (ja) * | 1994-01-28 | 1995-08-15 | Senju Pharmaceut Co Ltd | 肺保存剤および肺保存方法 |
| JPH07330501A (ja) * | 1994-06-14 | 1995-12-19 | Senju Pharmaceut Co Ltd | 肝保存剤および肝保存方法 |
| DE4439477C2 (de) * | 1994-11-08 | 1999-10-21 | Asta Medica Ag | Verwendung von R,S-(+/-)-alpha-Liponsäure, R-(+)-alpha-Liponäure, S-(-)-alpha-Liponsäure in reduzierter oder oxidierter Form oder der Metabolite sowie deren Salze, Ester, Amide zur Behandlung der diabetischen Mikroangiopathie |
| DE19706111C2 (de) * | 1997-02-17 | 1999-02-18 | Fresenius Medical Care De Gmbh | Lösung zur Aufbewahrung von Organen |
| US5990153A (en) * | 1997-05-05 | 1999-11-23 | Wood; John G. | Ultrasonicated α-lipoic acid solutions for attenuating microvascular injury |
| US6045990A (en) * | 1998-07-09 | 2000-04-04 | Baust; John M. | Inclusion of apoptotic regulators in solutions for cell storage at low temperature |
| DE19834087C1 (de) * | 1998-07-29 | 2000-03-30 | Mirzaie Sedaposhteh Massoud | Wäßrige Konservierungslösung und Verfahren zur Aufbewahrung tierischen Gewebes |
| GB0028414D0 (en) | 2000-11-22 | 2001-01-03 | Univ Leeds | Flush preservation solution |
| DE102007026392A1 (de) | 2007-06-06 | 2008-12-11 | Bayer Healthcare Ag | Lösungen für die Perfusion und Konservierung von Organen und Geweben |
| GR20180100514A (el) * | 2018-11-07 | 2020-06-15 | Πανεπιστημιο Πατρων | Φαρμακευτικοι συνδυασμοι και κιτ για την προληψη ή την θεραπεια του πονου και αλλων επιπλοκων της ορθοπαιδικης ή αγγειακης χειρουργικης και του πολλαπλου τραυματος |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4186253A (en) * | 1978-10-10 | 1980-01-29 | The Green Cross Corporation | Perfusate for preserving organ to be transplanted and preserving method |
| US4473552A (en) * | 1981-03-16 | 1984-09-25 | Jost Leonora I | Anaerobic method for preserving whole blood, tissue and components containing living mammalian cells |
| US4423600A (en) * | 1982-12-10 | 1984-01-03 | Mckenna Joan J | Method for preservation of living organic tissue by freezing |
| SE8403912D0 (sv) * | 1984-07-30 | 1984-07-30 | Pharmacia Ab | Lekemedelssats eller -komposition |
| DE3581407D1 (de) * | 1985-09-06 | 1991-02-21 | Nestle Sa | Bewahrung lebender gewebe. |
| US4879283A (en) * | 1985-10-03 | 1989-11-07 | Wisconsin Alumni Research Foundation | Solution for the preservation of organs |
| US4798824A (en) * | 1985-10-03 | 1989-01-17 | Wisconsin Alumni Research Foundation | Perfusate for the preservation of organs |
| ES2007994A6 (es) * | 1988-08-16 | 1989-07-01 | Grino Boira Jose Maria | Medio liquido para perfusion y preservacion de organos. |
| US4920044A (en) * | 1988-11-08 | 1990-04-24 | The Cleveland Clinic Foundation | Intracellular flush solution for preserving organs |
| US4938961A (en) * | 1989-04-28 | 1990-07-03 | Geoffrey Collins | Organ preservation solution containing pokyethylene gycol and method of performing cardioplegia |
-
1991
- 1991-11-05 CH CH3224/91A patent/CH683485A5/fr not_active IP Right Cessation
- 1991-11-11 IT ITMI912991A patent/IT1251995B/it active IP Right Grant
- 1991-11-18 GB GB9124488A patent/GB2249937B/en not_active Expired - Lifetime
- 1991-11-18 AT AT0228791A patent/AT399440B/de not_active IP Right Cessation
- 1991-11-18 ES ES09102549A patent/ES2050580B1/es not_active Expired - Fee Related
- 1991-11-19 DE DE4138040A patent/DE4138040A1/de not_active Withdrawn
- 1991-11-19 CA CA002055827A patent/CA2055827C/en not_active Expired - Lifetime
- 1991-11-19 BE BE9101067A patent/BE1006834A3/fr not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ITMI912991A1 (it) | 1993-05-11 |
| ITMI912991A0 (it) | 1991-11-11 |
| CA2055827C (en) | 1999-06-15 |
| BE1006834A3 (fr) | 1995-01-03 |
| GB2249937A (en) | 1992-05-27 |
| AT399440B (de) | 1995-05-26 |
| GB2249937B (en) | 1994-02-16 |
| DE4138040A1 (de) | 1992-05-21 |
| ES2050580B1 (es) | 1994-12-16 |
| IT1251995B (it) | 1995-05-27 |
| CA2055827A1 (en) | 1992-05-21 |
| GB9124488D0 (en) | 1992-01-08 |
| ES2050580A1 (es) | 1994-05-16 |
| ATA228791A (de) | 1994-10-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PUE | Assignment |
Owner name: PASTEUR MERIEUX SERUMS ET VACCINS TRANSFER- IMTIX- |
|
| PL | Patent ceased |