ES2029003T3 - Un procedimiento para la preparacion de nuevos derivados de heteroaril 3-oxo-propanamida. - Google Patents
Un procedimiento para la preparacion de nuevos derivados de heteroaril 3-oxo-propanamida.Info
- Publication number
- ES2029003T3 ES2029003T3 ES198888300115T ES88300115T ES2029003T3 ES 2029003 T3 ES2029003 T3 ES 2029003T3 ES 198888300115 T ES198888300115 T ES 198888300115T ES 88300115 T ES88300115 T ES 88300115T ES 2029003 T3 ES2029003 T3 ES 2029003T3
- Authority
- ES
- Spain
- Prior art keywords
- alcoxi
- alkyl
- hydrogen
- halogen
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- OFZFFIDUIUEPIB-UHFFFAOYSA-N 3-oxopropanamide Chemical compound NC(=O)CC=O OFZFFIDUIUEPIB-UHFFFAOYSA-N 0.000 title 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 2
- -1 AMINO Chemical class 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical class O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- 208000037581 Persistent Infection Diseases 0.000 abstract 1
- 230000001154 acute effect Effects 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- ORTFAQDWJHRMNX-UHFFFAOYSA-N hydroxidooxidocarbon(.) Chemical class O[C]=O ORTFAQDWJHRMNX-UHFFFAOYSA-N 0.000 abstract 1
- LGROKZMEHJZWDU-UHFFFAOYSA-N n-amino-n-phenylnitramide Chemical compound [O-][N+](=O)N(N)C1=CC=CC=C1 LGROKZMEHJZWDU-UHFFFAOYSA-N 0.000 abstract 1
- 230000001613 neoplastic effect Effects 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyridine Compounds (AREA)
Abstract
LA INVENCION SE REFIERE A COMPUESTOS QUE TIENEN LA FORMULA GENERAL (I), EN LA QUE X REPRESENTA UN ATOMO DE OXIGENO O UN GRUPO -S(O)N, DONDE N ES 0, 1 O 2; R1 REPRESENTA ALQUILO C1-C6, BENCILO, PIRIDILO O FENILO, ESTANDO EL FENILO SIN SUSTITUIR O SUSTITUIDO POR 1 O 2 SUSTITUYENTES ELEGIDOS INDEPENDIENTEMENTE ENTRE HALOGENO, TRIFLUOROMETILO, ALQUILO C1-C6, ALCOXI C1-C6, NITRO, AMINO, FORMILAMINO Y ALCANOILAMINO C2-C8; CADA UNO DE R2 Y R3 ES INDEPENDIENTEMENTE: A) HIDROGENO, HALOGENO O ALQUILO C1-C6; B) HIDROGENO, ALCOXI C1-C6 O ALQUENILOXI C3-C4; O C) NITRO, AMINO, FENILAMINO A ALCANOILAMINO C2-C8; R4 REPRESENTA HIDROGENO O ALQUILO C1-C6; Y Q REPRESENTA HIDROGENO, CARBOXI, CONH2, ALCOXICARBONILO C2-C7 O UN GRUPO -CONRA(RB) O -CSNRA(RB), DONDE RA REPRESENTA HIDROGENO O ALQUILO C1-C20 Y RB REPRESENTA ALQUILO C1-C20 O UN GRUPO -(CH2)M-R5, DONDE M ES 0, 1 O 2 Y R5 ES A'') CICLOALQUILO C5-C8; B'') PIRIDILO, NO SUSTITUIDO O SUSTITUIDO POR 1 O 2 SUSTITUYENTES ELEGIDOS INDEPENDIENTEMENTE DE HALOGENO, ALQUILO C1-C6 Y ALCOXI C1-C6; O C'') FENILO, NO SUSTITUIDO O SUSTITUIDO POR 1 O 2 SUSTITUYENTES ELEGIDOS INDEPENDIENTEMENTE DE HALOGENO, CF3, ALQUILO C1-C6, ALCOXI C1-C6, AMINO, NITRO, FORMILAMINO, FORMILOXI Y ALCANOILOXI C2-C8, Y SUS SALES FARMACOLOGICAMENTE ACEPTABLES, QUE POSEEN ACTIVIDAD INMUNODULANTE Y SON UTILES, POR EJEMPLO, EN EL TRATAMIENTO DE ENFERMEDADES NEOPLASTICAS E INFECCIONES AGUDAS Y CRONICAS DE ORIGEN BACTERIANO Y VIRICO EN MAMIFEROS.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB878700477A GB8700477D0 (en) | 1987-01-09 | 1987-01-09 | Heteroaryl 2-cyano-3-oxo-propanamide derivatives |
| GB878717282A GB8717282D0 (en) | 1987-07-22 | 1987-07-22 | Heteroaryl 3-oxo-propanenitrile derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2029003T3 true ES2029003T3 (es) | 1992-07-16 |
Family
ID=26291768
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES198888300115T Expired - Lifetime ES2029003T3 (es) | 1987-01-09 | 1988-01-08 | Un procedimiento para la preparacion de nuevos derivados de heteroaril 3-oxo-propanamida. |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US4816467A (es) |
| EP (1) | EP0274443B1 (es) |
| JP (1) | JP2672312B2 (es) |
| KR (1) | KR960002852B1 (es) |
| CN (1) | CN1025500C (es) |
| AU (1) | AU598893B2 (es) |
| CA (1) | CA1310647C (es) |
| CZ (1) | CZ277972B6 (es) |
| DE (1) | DE3862937D1 (es) |
| DK (1) | DK8088A (es) |
| ES (1) | ES2029003T3 (es) |
| FI (1) | FI89489C (es) |
| GR (1) | GR3002032T3 (es) |
| HU (1) | HU198722B (es) |
| IE (1) | IE60620B1 (es) |
| IL (1) | IL85004A (es) |
| MY (1) | MY103348A (es) |
| NO (1) | NO165841C (es) |
| NZ (1) | NZ223113A (es) |
| PH (1) | PH27000A (es) |
| PT (1) | PT86516B (es) |
| SU (1) | SU1695826A3 (es) |
| YU (2) | YU46787B (es) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0286346B1 (en) * | 1987-04-09 | 1994-04-06 | E.I. Du Pont De Nemours And Company | Insecticidal substituted indazoles |
| GB8814586D0 (en) * | 1988-06-20 | 1988-07-27 | Erba Carlo Spa | Tricyclic 3-oxo-propanenitrile derivatives & process for their preparation |
| GB8814587D0 (en) * | 1988-06-20 | 1988-07-27 | Erba Carlo Spa | Condensed pyrazole 3-oxo-propanenitrile derivatives & process for their preparation |
| GB2227741B (en) * | 1989-02-06 | 1992-08-05 | Erba Carlo Spa | Condensed 3-oxo-propanenitrile derivatives and process for their preparation |
| GB8907799D0 (en) * | 1989-04-06 | 1989-05-17 | Erba Carlo Spa | Heteroaryl-3-oxo-propanenitrile derivatives useful in the treatment of rheumatoid arthritis and other autoimmune diseases |
| US5260328A (en) * | 1989-04-06 | 1993-11-09 | Farmitalia Carlo Erba Srl | Phenyl-indenopurazol 3-oxo-propanamide derivatives useful in the treatment of rheumatoid arthritis |
| GB8916290D0 (en) * | 1989-07-17 | 1989-08-31 | Erba Carlo Spa | Heteroaryl-3-oxo-propanenitrile derivatives useful in stimulating myelopoiesis |
| DK0527736T3 (da) * | 1990-05-18 | 1997-10-20 | Hoechst Ag | Isoxazol-4-carboxylsyreamider og hydroxyalkyliden-cyanoacetamider, lægemidler indeholdende disse forbindelser og anvendelsen af disse lægemidler. |
| US5547975A (en) * | 1994-09-20 | 1996-08-20 | Talley; John J. | Benzopyranopyrazolyl derivatives for the treatment of inflammation |
| US5886016A (en) * | 1995-09-15 | 1999-03-23 | G.D. Searle & Co. | Benzopyranopyrazolyl derivatives for the treatment of inflammation |
| GB9720899D0 (en) * | 1997-10-01 | 1997-12-03 | Pharmacia & Upjohn Spa | Condensed heterocyclic compounds |
| DK2857516T3 (en) * | 2000-04-11 | 2017-08-07 | Genentech Inc | Multivalent antibodies and uses thereof |
| ES2286275T3 (es) * | 2001-09-19 | 2007-12-01 | Pharmacia Corporation | Compuestos de pirazolo sustituidos para el tratamiento de la inflamacion. |
| CA2534426A1 (en) * | 2003-08-08 | 2005-02-17 | Barnes-Jewish Hospital | Emulsion particles for imaging and therapy and methods of use thereof |
| US20060035242A1 (en) | 2004-08-13 | 2006-02-16 | Michelitsch Melissa D | Prion-specific peptide reagents |
| CA2650574A1 (en) * | 2006-04-27 | 2007-11-08 | Barnes-Jewish Hospital | Detection and imaging of target tissue |
| CA2778174C (en) * | 2009-11-13 | 2018-02-20 | Merck Serono S.A. | Tricyclic pyrazol amine derivatives as pi3k inhibitors |
| CN102086212B (zh) * | 2009-12-03 | 2013-06-12 | 沈阳药科大学 | 抗真菌剂-2，3，4，5-四氢-4H-苯并[b]噻喃并[4，3-c]吡唑-2-甲酰胺衍生物 |
| WO2018075564A1 (en) | 2016-10-17 | 2018-04-26 | University Of Maryland, College Park | Multispecific antibodies targeting human immunodeficiency virus and methods of using the same |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4268516A (en) * | 1978-10-11 | 1981-05-19 | Pfizer Inc. | [1]Benzothiopyrano[4,3-c]pyrazoles as immunoregulatory agents |
| EP0022446A1 (de) * | 1979-04-06 | 1981-01-21 | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft | Verfahren zur Herstellung von Biotinestern und von Biotin |
| EP0057932A1 (en) * | 1981-02-11 | 1982-08-18 | E.I. Du Pont De Nemours And Company | Antiinflammatory and/or analgesic 3,4-dihydro(or 1,4-dihydro)-2-((substituted)thiol)-(1)-benzopyrano(3,4-d)imidazoles and their corresponding sulfoxides and sulfones |
| PH21213A (en) * | 1984-10-26 | 1987-08-21 | Fujisawa Pharmaceutical Co | Benzene- and pyrazole- fused heterocyclic compound and pharmaceutical composition comprising the same |
-
1987
- 1987-12-31 US US07/140,221 patent/US4816467A/en not_active Expired - Fee Related
-
1988
- 1988-01-01 IL IL85004A patent/IL85004A/xx not_active IP Right Cessation
- 1988-01-04 PH PH36319A patent/PH27000A/en unknown
- 1988-01-04 IE IE288A patent/IE60620B1/en not_active IP Right Cessation
- 1988-01-05 AU AU10037/88A patent/AU598893B2/en not_active Ceased
- 1988-01-06 YU YU1088A patent/YU46787B/sh unknown
- 1988-01-07 NZ NZ223113A patent/NZ223113A/xx unknown
- 1988-01-07 CN CN88100153A patent/CN1025500C/zh not_active Expired - Fee Related
- 1988-01-07 CA CA000556010A patent/CA1310647C/en not_active Expired - Fee Related
- 1988-01-07 CZ CS88179A patent/CZ277972B6/cs not_active IP Right Cessation
- 1988-01-08 PT PT86516A patent/PT86516B/pt not_active IP Right Cessation
- 1988-01-08 DK DK008088A patent/DK8088A/da not_active Application Discontinuation
- 1988-01-08 EP EP88300115A patent/EP0274443B1/en not_active Expired - Lifetime
- 1988-01-08 HU HU8858A patent/HU198722B/hu not_active IP Right Cessation
- 1988-01-08 DE DE8888300115T patent/DE3862937D1/de not_active Expired - Fee Related
- 1988-01-08 NO NO880068A patent/NO165841C/no unknown
- 1988-01-08 SU SU884355070A patent/SU1695826A3/ru active
- 1988-01-08 ES ES198888300115T patent/ES2029003T3/es not_active Expired - Lifetime
- 1988-01-08 JP JP63002374A patent/JP2672312B2/ja not_active Expired - Lifetime
- 1988-01-08 MY MYPI88000014A patent/MY103348A/en unknown
- 1988-01-08 FI FI880078A patent/FI89489C/fi not_active IP Right Cessation
- 1988-01-08 KR KR1019880000056A patent/KR960002852B1/ko active IP Right Grant
-
1989
- 1989-04-18 YU YU00794/89A patent/YU79489A/xx unknown
-
1991
- 1991-05-30 GR GR91400684T patent/GR3002032T3/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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