EP4218412A1 - Irradiation de globules rouges et stockage anaérobie - Google Patents

Irradiation de globules rouges et stockage anaérobie Download PDF

Info

Publication number
EP4218412A1
EP4218412A1 EP23162955.1A EP23162955A EP4218412A1 EP 4218412 A1 EP4218412 A1 EP 4218412A1 EP 23162955 A EP23162955 A EP 23162955A EP 4218412 A1 EP4218412 A1 EP 4218412A1
Authority
EP
European Patent Office
Prior art keywords
oxygen
carbon dioxide
storage system
red blood
blood
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP23162955.1A
Other languages
German (de)
English (en)
Inventor
Tatsuro Yoshida
Paul Vernucci
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hemanext Inc
Original Assignee
Hemanext Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hemanext Inc filed Critical Hemanext Inc
Publication of EP4218412A1 publication Critical patent/EP4218412A1/fr
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0236—Mechanical aspects
    • A01N1/0242—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0236—Mechanical aspects
    • A01N1/0263—Non-refrigerated containers specially adapted for transporting or storing living parts whilst preserving, e.g. cool boxes, blood bags or "straws" for cryopreservation
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0278—Physical preservation processes
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0278—Physical preservation processes
    • A01N1/0294—Electromagnetic, i.e. using electromagnetic radiation or electromagnetic fields
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/18—Erythrocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/10—Bag-type containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/08—Radiation
    • A61L2/081—Gamma radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/08—Radiation
    • A61L2/082—X-rays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
    • A61L2202/10—Apparatus features
    • A61L2202/18—Aseptic storing means
    • A61L2202/181—Flexible packaging means, e.g. permeable membranes, paper
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
    • A61L2202/20—Targets to be treated
    • A61L2202/22—Blood or products thereof

Definitions

  • the present disclosure relates to a storage blood system having an oxygen/carbon dioxide depletion device and a blood storage bag for the long-term storage of red blood cells (RBCs). More particularly, the present disclosure relates to a blood storage system that is capable of removing oxygen and carbon dioxide from the red blood cells prior to storage and gamma and/or X-ray irradiating red blood cells either pre- or post-anaerobic treatment, as well as maintaining oxygen or oxygen and carbon dioxide depleted states during storage, thereby prolonging the storage life and minimizing deterioration of the deoxygenated red blood cells.
  • red blood cells red blood cells
  • Adequate blood supply and the storage thereof is a problem facing every major hospital and health organization around the world. Often, the amount of blood supply in storage is considerably smaller than the need therefore. This is especially true during crisis periods such as natural catastrophes, war and the like, when the blood supply is often perilously close to running out. It is at critical times such as these that the cry for more donations of fresh blood is often heard. However, unfortunately, even when there is no crisis period, the blood supply and that kept in storage must be constantly monitored and replenished, because stored blood does not maintain its viability for long.
  • Hb hemoglobin
  • RBCs red blood cells
  • transfusion-associated graft-versus-host disease TA-GVHD
  • TA-GVHD transfusion-associated graft-versus-host disease
  • anaerobically stored RBC must be compatible with gamma- or X-ray irradiation treatment so that anaerobically stored blood can be transfused to patients requiring irradiated RBC.
  • Gamma-irradiation abrogates proliferation of T-lymphocytes by damaging the DNA directly and via reactive oxygen species (ROS), namely hydroxyl radicals produced during gamma-radiolysis of water.
  • ROS reactive oxygen species
  • the major damage observed includes: i) increased hemolysis; ii) increased K+ leak; iii) reduction in post-transfusion survival; and iv) reduced deformability. Such damage is similar to, but an exaggerated form of storage-induced damage of RBC.
  • the compromised status of RBC is well known to the physicians who administer such compromised RBC.
  • the FDA mandates restricted use of such RBC in terms of shortened shelf life after gamma-irradiation (14 days) and/or 28 days total shelf life for irradiated units.
  • irradiation of blood components has received increased attention due to increasing categories of patients eligible to receive such blood to prevent transfusion-associated graft versus host disease.
  • irradiation leads to enhancement of storage lesions, which could have deleterious effects when such blood is transfused. It is well known in the field that the main deleterious side-effect of radiation on RBC is oxidative damage caused by ROS.
  • Radiation damage to RBC in the presence of oxygen can occur in two ways;
  • red blood cell red blood cell
  • RBC red blood cell
  • studies have shown that irradiated red blood cells that are oxygen and oxygen and carbon dioxide depleted are equivalent or healthier (in terms of K+ leakage, hemolysis and oxidized proteins/lipids) in comparison to non-irradiated and non-oxygen and carbon dioxide depleted blood and non-oxygen and carbon dioxide depleted irradiated blood.
  • the higher concentration of potassium in RBC storage media was at levels that indicated red blood cell damage.
  • the present disclosure applies the finding of compatibility of gamma-irradiation with anaerobically stored blood, as well as the protective effects of anaerobic conditions in enhancing ATP, DPG and in reducing oxidative damage during refrigerated storage, to substantially reduce the negative or deleterious effect of gamma- and X-ray irradiation of RBCs in the presence of oxygen.
  • U.S. Patent No. US Patent 5,362,442 to Kent describes adding a scavenger to bind free radicals such as ethanol.
  • U.S. Patent No. 61875572 to Platz et al. describes adding chemical sensitizers;
  • U.S. Patent No. 6,403,124, also to Dottori describe adding L-carnitine or an alkanoul derivative to reduce RBC cell membrane damage induced by irradiation. These additives are not required to prevent the deleterious effects of irradiation on RBCs when treated anaeorobically.
  • a method and system for removing plasma with or without platelets adding an additive solution (e.g., nutrient and/or metabolic supplements) to the concentrated RBC, filtering out leukocytes and/or platelets via a leuko reduction filter, removing oxygen and/or CO 2 from the filtered RBC, and gamma irradiating or X-ray irradiating the oxygen and/or CO 2 filtered RBC either prior to or during storage thereof.
  • an additive solution e.g., nutrient and/or metabolic supplements
  • the preferred range of gamma irradiation is a minimum of between about 25 Gy to 50 Gy.
  • Gamma or X-ray irradiating RBC under anaerobic or anaerobic and CO 2 conditions (ambient to 1°C) defined as less than 20% SO 2 (oxygen-saturation of hemoglobin), more preferably less than 5%, and most preferably less than 3%.
  • Gamma or x-ray irradiating RBC under anaerobic or anaerobic and CO 2 depleted conditions (ambient to 1°C) defined as less than 20% SO 2 (oxygen-saturation of hemoglobin), more preferably SO 2 ⁇ 5%, and most preferably SO 2 ⁇ 3% and pCO 2 ⁇ 10mmHg; pCO 2 ⁇ 5mmHg; pCO 2 ⁇ 1mmHg.
  • Gamma or x-ray irradiating RBC under aerobic conditions ambient to 1°C and then removing oxygen or oxygen and carbon dioxide from the irradiated RBC to levels defined as less than 20% SO 2 (oxygen-saturation of hemoglobin), more preferably SO 2 ⁇ 5%, and most preferably SO 2 ⁇ 3% and pCO 2 ⁇ 10mmHg; pCO 2 ⁇ 5mmHg; pCO 2 ⁇ 1mmHg.
  • SO 2 oxygen-saturation of hemoglobin
  • the gamma or x-ray irradiation under aerobic conditions and removal of oxygen or oxygen and carbon dioxide can be performed before placing blood for extended storage, or within 24 hr of blood collection, between 1 through 7 days after blood collection or beyond 7 days.
  • older blood defined as blood stored for more than one week, and exposing such blood to gamma or x-ray irradiating RBC under aerobic conditions (ambient to 1°C) and then removing oxygen or oxygen and carbon dioxide from the irradiated RBC to levels defined as less than 20% SO 2 (oxygen-saturation of hemoglobin), more preferably SO 2 ⁇ 5%, and most preferably SO 2 ⁇ 3% and pCO 2 ⁇ 10mmHg; pCO 2 ⁇ 5mmHg; pCO 2 ⁇ 1mmHg.
  • SO 2 oxygen-saturation of hemoglobin
  • older blood defined as blood stored for more than one week
  • oxygen or oxygen and carbon dioxide from such older blood and exposing such blood to Gamma or x-ray irradiation at wherein the levels of oxygen and carbon dioxide are levels defined as less than 20% SO 2 (oxygen-saturation of hemoglobin), more preferably SO 2 ⁇ 5%, and most preferably SO 2 ⁇ 3% and pCO 2 ⁇ 10mmHg; pCO 2 ⁇ 5mmHg; pCO 2 ⁇ 1mmHg.
  • RBC Storing gamma or X-ray irradiated or pre-irradiated RBC (either under anaerobic conditions with or without CO 2 depletion) RBC for extended time at 1-6°C under anaerobic or anaerobic and CO 2 depleted condition defined as less than 20% SO 2 (oxygen-saturation of hemoglobin), more preferably less than 5%, and most preferably 3% and less than pCO 2 ⁇ 10mmHg; pCO 2 ⁇ 5mmHg; pCO 2 ⁇ 1mmHg.
  • a preferred embodiment includes a blood storage system comprising: a collection vessel for red blood cells; an oxygen or oxygen/carbon dioxide depletion device; tubing connecting the collection vessel to the oxygen or oxygen/carbon dioxide depletion device and the storage vessel for red blood cells that can be gamma or X-ray irradiated and stored under anaerobic or anaerobic and CO 2 depleted condition for extended time.
  • the anaerobic or anaerobic and CO 2 condition is measured as an oxygen-saturation of hemoglobin of less than 20% SO 2 , preferably about 5% or less, and most preferably about 3% or less.
  • the oxygen or oxygen/carbon dioxide depletion device comprises: a cartridge; a plurality of gas permeable hollow fibers or sheets extending within the cartridge from an entrance to an exit thereof, wherein the hollow fibers or gas-permeable films are adapted to receiving and conveying red blood cells; and an amount of an oxygen scavenger or both oxygen scavenger and a carbon dioxide scavenger packed within the cartridge and contiguous to and in between the plurality of hollow fibers.
  • the oxygen or oxygen/carbon dioxide depletion device comprises: a cartridge; a plurality of hollow fibers or gas-permeable films extending within the cartridge from an entrance to an exit thereof, wherein the hollow fibers or gas-permeable films are adapted to receiving and conveying red blood cells; and a low oxygen or a low oxygen and carbon dioxide environment is created outside the hollow fibers by flowing an inert gas in-between the hollow fibers.
  • the blood storage system further comprising a leuko reduction filter disposed between the collection vessel and the oxygen/carbon dioxide depletion device.
  • the blood storage system further comprising an additive solution vessel in communication with the collection vessel.
  • the blood storage system further comprising a plasma vessel in communication with the collection vessel.
  • a method for storing red blood cells comprising: removing oxygen or oxygen and carbon dioxide from red blood cells to produce anaerobic red blood cells; and storing irradiated RBC with either gamma- or X-ray, thereby producing irradiated anaerobic red blood cells; and storing the irradiated anaerobic or anaerobic and CO 2 depleted red blood cells.
  • the irradiated anaerobic or irradiated anaerobic and CO 2 depleted red blood cells are preferably stored at a temperature from between about 1°C to about 6°C under anaerobic conditions.
  • the present disclosure also provides for a device and method of removing carbon dioxide (CO 2 ) in addition to oxygen (O 2 ) prior to or at the onset of anaerobic or anaerobic and CO 2 depleted storage and/or gamma or X-ray irradiation.
  • CO 2 carbon dioxide
  • O 2 oxygen
  • the present disclosure provides for a blood collection system that incorporates an oxygen or oxygen/carbon dioxide depletion device having an oxygen or oxygen and carbon dioxide sorbent in combination with a filter or membrane to strip oxygen or oxygen and carbon dioxide from the blood during transport to the storage bag, wherein the oxygen/carbon dioxide depleted blood is gamma or X-ray irradiated either prior to or during storage.
  • the present disclosure further provides for a system to deplete the oxygen or oxygen and carbon dioxide from collected red blood cells that includes an (optional additive solution), an oxygen or oxygen and carbon dioxide depletion device, and a blood storage bag that maintains the red blood cells in an oxygen or oxygen and carbon dioxide depleted state after gamma- or X-ray irradiation.
  • a system to deplete the oxygen or oxygen and carbon dioxide from collected red blood cells that includes an (optional additive solution), an oxygen or oxygen and carbon dioxide depletion device, and a blood storage bag that maintains the red blood cells in an oxygen or oxygen and carbon dioxide depleted state after gamma- or X-ray irradiation.
  • RBCs do not require oxygen for their own survival. It was shown previously that when RBCs were stored in blood bank refrigerator (1-6°C) under anaerobic or anaerobic and CO 2 depleted conditions, they demonstrated significantly improved post-transfusion recovery after 6-week storage compared to the conventionally stored controls. The mechanisms of reduction in storage lesions under anaerobic or anaerobic/CO 2 depleted conditions have been described and direct evidences demonstrated. It is, at least in part, due to reduction in oxidative damages in the presence of O 2 caused by ROS during refrigerated storage.
  • gamma- or X-ray irradiation exacerbate oxidative damage on treated RBC
  • storing irradiated RBC under anaerobic and, optionally, CO 2 depleted condition is not expected to intensify the damage; it is also expected to prevent damage resulting from ROS generated during irradiation by depriving O 2 that fuels those reactions.
  • Effectiveness of gamma- or X-ray irradiation is not dependent on the presence of oxygen. In contrast, anaerobic condition is shown to be more effective in causing damage to DNA (and thus inhibiting proliferation of lymphocytes). Furthermore, absence of O 2 during and/or immediately after gamma- or X-ray irradiation will reduce O 2 -fueld oxidative damages to RBC induced by hydroxyl radicals and ROS produced by radiolysis of water with gamma- or X-rays.
  • a disposable blood anaerobic storage system is shown and referenced using reference numeral 10.
  • the blood storage system includes an oxygen/carbon dioxide depletion device 100 (OCDD 100), an anaerobic blood storage bag 200 and an additive solution bag 300.
  • OCDD 100 removes oxygen and/or carbon dioxide from red blood cells traveling through it.
  • the system also contains a leuko reduction filter 400.
  • Components conventionally associated with the process of blood collection are a phlebotomy needle 410, a blood collection bag 420 containing an anti-coagulant and a bag 430 containing plasma.
  • Tubing can connect the various components of the blood storage system 10 in various configurations (one embodiment shown).
  • Tube 440 connects collection bag 420 with leuko reduction filter 400.
  • Tube 441 connects additive solution bag 300 with collection bag 420.
  • Tube 442 connects plasma bag 430 with collection bag 420.
  • Tube 443 connects leukoreduction filter 400 with OCDD 100.
  • Tube 414 connects OCDD 100 with blood storage bag 200.
  • Blood storage system 10 is preferably a single-use, disposable, low cost system. As filtered and oxygen or oxygen and carbon dioxide depleted blood passes from OCDD 100 to blood storage bag 200. Blood stored in bag 200 will be gamma and/or X-ray irradiated during storage via device 453.
  • Bag 200 containing oxygen depleted or oxygen and carbon dioxide depleted RBC is placed into device 453 and exposed to gamma and/or X-ray radiation.
  • pre-anaerobic blood stored in collection bag 421 can be gamma and/or X-ray irradiated via device 445 before passing through OCDD 100 and stored in bag 200, as shown in Fig. 1b .
  • bag 420 could also be gamma and/or X-ray irradiated in an irradiating device 445 prior to passing through leukoreduction filter 400.
  • Oxygen or oxygen/carbon dioxide depletion device 100 removes the oxygen from collected RBCs prior to the RBCs being stored in blood storage bag 200.
  • the oxygen content in RBCs must be depleted from oxy-hemoglobin because more than 99% of such oxygen is hemoglobin-bound in venous blood.
  • the degree of oxygen saturation is to be reduced to less than 4% within 48 hours of blood collection.
  • the oxygen depletion is preferably accomplished at room temperature.
  • the affinity of oxygen to hemoglobin is highly dependent on the temperature, with a p50 of 26 mmHg at 37° C dropping to ⁇ 4 mmHg at 4° C.
  • carbon dioxide depletion has the beneficial effect of elevating DPG levels in red blood cells.
  • Carbon dioxide exists inside RBCs and in plasma in equilibrium with HCO 3 - ion (carbonic acid). Carbon dioxide is mainly dissolved in RBC/plasma mixture as carbonic acid and rapid equilibrium between CO 2 and carbonic acid is maintained by carbonic anhydrase inside RBC. Carbon dioxide is freely permeable through RBC membrane, while HCO 3 - inside RBC and plasma is rapidly equilibrated by anion exchanger (band 3) protein.
  • band 3 anion exchanger
  • the anaerobic conversion system includes an oxygen or oxygen/carbon dioxide depletion device 515 (OCDD) and an anaerobic blood storage bag 528.
  • OCDD 515 removes oxygen or oxygen and carbon dioxide from red blood cells traveling through it.
  • Tubing connects the various components of the blood storage system 500.
  • Tube 512 connects to RBC concentrate prepared by using an additive solution (e.g., AS1, AS3, AS5, SAGM, MAPS, etc.) and storing in bag 528 by passing aforementioned RBC concentrate from collection bag 510 through OCDD 515.
  • an additive solution e.g., AS1, AS3, AS5, SAGM, MAPS, etc.
  • Tubes 518 and 520 connect OCDD 515 with blood storage bag 528.
  • Blood storage system 500 is preferably a single-use, disposable, low cost system. Oxygen and/or carbon dioxide depleted blood is gamma and/or X-ray in blood storage bag 528 via device 553 and subsequently stored for later transfusion.
  • blood in collection bag 510 may be gamma- or X-ray irradiated via device 551 prior to oxygen or oxygen and carbon dioxide depletion and low temperature storage, as shown in Fig. 2b.
  • Fig. 2b applies to the scenario in which blood bag 510 contains older, for example 2 day old blood, that is then irradiated and depleted of oxygen or oxygen and or carbon dioxide, and stored.
  • an oxygen or oxygen/carbon dioxide depletion device (OCDD) 101 contains an oxygen sorbent 110.
  • OCDD 101 is a disposable cartridge 105 containing oxygen sorbent 110 and a series of hollow fibers 115.
  • Oxygen sorbent 110 is a mixture of non-toxic inorganic and/or organic salts and ferrous iron or other materials with high reactivity toward oxygen.
  • Oxygen sorbent 110 is made from particles that have significant absorbing capacity for O 2 (more than 5 ml O 2 /g) and can maintain the inside of cartridge 105 to less than 0.01% which corresponds to PO 2 less than 0.08 mmHg.
  • Oxygen sorbent 110 is either free or contained in an oxygen permeable envelope.
  • OCDD 101 of the present disclosure must deplete approximately 100 mL of oxygen from a unit of blood.
  • RBCs are stored in a blood storage bag 200.
  • the oxygen content of RBC suspended in additive solution 300 must be reduced to equal to or less than 4% SO 2 before placing them in refrigerated storage. Further, oxygen depleted RBC must be kept in an anaerobic state and low carbon dioxide state throughout entire storage duration.
  • RBCs pass through an oxygen permeable film or membrane, that may be formed as hollow fibers 115 of Fig. 3 .
  • the membrane or films may be constructed in a flat sheet or hollow fiber form.
  • the oxygen permeable films can be non porous materials that are capable of high oxygen permeability rates (polyolefins, silicones, epoxies, polyesters, etc.) and oxygen permeable membranes are hydrophobic porous structures. These may be constructed of polymers (e.g., polyolefins, Teflon, PVDF, or polysulfone) or inorganic materials (e.g., ceramics). Oxygen depletion takes place as RBC pass through hollow fibers 115.
  • Oxygen permeable films or oxygen permeable membranes may be extruded into sheets or hollow fibers 15. Accordingly, hollow fibers 115 and sheets may be used interchangeably.
  • OCDD provides a simple structure having a large surface area to remove oxygen and maintain constant flow of blood therethrough. The oxygen depletion or removal is accomplished by irreversible reaction of ferrous ion in oxygen sorbent 110 with ambient oxygen to form ferric oxide.
  • OCDD 101 does not need agitation for oxygen removal and can be manufactured easily to withstand centrifugation as part of a blood collection system as necessary.
  • the depletion devices function to deplete, O 2 and CO 2 , or O 2 alone, or O 2 with specific levels of CO 2 by supplying appropriate composition of flushing gas.
  • Gases appropriate for depletion devices are, for example, Ar, He, N 2 , Ar/CO 2 , or N 2 /CO 2 .
  • Figs. 9a through 9c and 10a through 910c also disclose scavenging depletion devices.
  • Depletion takes place with the use of scavengers or sorbents and without the use of external gases.
  • carbon dioxide depletion in conjunction with oxygen depletion is effective to enhance DPG and ATP, respectively, prior to storage in blood storage bags.
  • Depletion device 20 includes a plurality of fibers 25, approximately 5000 in number, through which red blood cells flow. Plurality of fibers 25 are surrounded by a plastic cylinder 30. Plastic cylinder or cartridge 30 contains a gas inlet 35 and a gas outlet 40 through which a flushing gas or a combination of flushing gases, such as those mentioned above, are supplied to remove carbon and/or oxygen from blood. Specifications for depletion device 20 are shown in Table 1 below at second column.
  • Depletion device 45 like device 20 of Figs. 7a to 7c , includes a plurality of fibers 50, approximately 5000 in number, through which red blood cells flow. Plurality of fibers 50 are surrounded by a plastic cylinder 55. Plastic cylinder 55 contains a gas inlet 60 and a gas outlet 65 through which a gas or a combination of gases, such as those mentioned above are supplied to remove oxygen or oxygen and carbon dioxide from blood. Specifications for depletion device 45 are shown in Table 1 above in the third column. The active surface area of depletion of device 45 is twice that of device 20 because device 45 is twice as long as device 20.
  • Figs. 9a through 9c disclose a depletion device 70 having a core 75 containing scavenging materials for either O 2 , or both O 2 and CO 2 .
  • Core 75 is packed by a gas permeable film with very low liquid permeability.
  • Hollow fibers 80 are wound around core 75, and a plastic cylinder 82 contains and envelopes hollow fibers 80.
  • the active surface area for depletion is approximately 0.8796m 2 as shown in Table 2 below at the second column.
  • Figs. 10a through 10c disclose a depletion device 85 containing fiber bundles 87 enclosed in gas permeable film with very low liquid permeability. Fiber bundles 87 are surrounded by scavenger materials 89 for either O 2 or both O 2 and CO 2 . Fiber bundles 87 and scavenger materials 89 are contained within a plastic cylinder 90.
  • the active surface area for depletion is approximately 0.8796m 2 as shown in Table 2 above at the third column.
  • Fig. 11 is a plot of the performance of flushing depletion devices 20 and 45 and scavenging depletion devices 70 and 85.
  • the data of Fig. 11 was plotted using the following conditions: Hematocrit, 62% (pooled 3 units of pRBC), and 21°C at various head heights to produce different flow rates.
  • Oxygen/carbon dioxide scavenger Multisorb Technologies, Buffalo, NY was activated with adding 5% and 12% w/w water vapor for device 79 and device 85, respectively.
  • Data are plotted with flow rate (g RBC suspension per min) vs. pO 2 (mmHg).
  • a plurality of gas permeable films/membranes may be substituted for the plurality of hollow fibers.
  • the films and fibers may be packed in any suitable configuration within the cartridge, such as linear or longitudinal, spiral, or coil, so long as they can receive and convey red blood cells.
  • Fig. 11 shows that lowest oxygen saturation is achieved using devices 45 and 85.
  • Device 45 exhibits a larger active surface area exposed to gases along length of fibers 50.
  • Device 85 also has a long surface area of exposure to scavenging materials.
  • Device 85 has bundles 87 surrounded by scavenging materials 89. The space occupied by scavenging materials 89 between bundles 87 promotes dispersion of oxygen and carbon dioxide from red blood cells contained in fiber bundles 87, thus aiding scavenging of oxygen and carbon dioxide from red blood cells.
  • a further use of the depletion devices is to add back oxygen and or carbon dioxide prior to transfusion by flushing with pure oxygen or air. This use is for special cases, such as massive transfusions, where the capacity of the lung to re-oxygenate transfused blood is not adequate, or sickle cell anemia.
  • depletion devices can be used to obtain intermediate levels or states of depletion of oxygen and carbon dioxide depending needs of the patient to obtain optimal levels in the transfused blood depending upon the patients needs.
  • Blood bag 200 has an inner blood-compatible bag 250 (preferably polyvinyl chloride (PVC)), and an outer barrier film bag 255.
  • the material of bag 250 is compatible with RBCs.
  • Disposed between inner bag 250 and outer oxygen barrier film bag 255 is a pocket that contains an oxygen/carbon dioxide sorbent 110.
  • Barrier film bag 255 is laminated to the entire surface of inner bag 250.
  • Sorbent 110 is contained in a sachet 260, which is alternately referred to as a pouch or pocket. Sorbent 110 is optimally located between tubing 440 that leads into and from bag 200, specifically between inner bag and outer oxygen barrier film bag 255.
  • Oxygen sorbent is ideally located in a pouch or pocket 260 and not in contact with RBCs. Oxygen sorbent may also be combined with CO 2 scavengers or sorbents, enabling sorbent 110 to deplete both oxygen and carbon dioxide at the same time.
  • blood storage bags 201 and 202 are configured to store RBCs for extended storage periods of time.
  • Inner blood storage bags 205 are preferably made from DEHP-plasticized PVC and are in contact with RBCs.
  • DEHP-plasticized PVC is approximately 200 fold less permeable to oxygen compared to silicone.
  • PVC is insufficient as an oxygen barrier to maintain the anaerobic state of RBCs throughout the storage duration. Therefore, blood storage bags 201 and 202 are fabricated with outer transparent oxygen barrier film 206 (e.g., nylon polymer) laminated to the outer surface inner blood bag 205.
  • outer transparent oxygen barrier film 206 e.g., nylon polymer
  • a small sachet 210 containing oxygen/carbon dioxide sorbent 110 enveloped in oxygen-permeable, RBC compatible membrane is enclosed inside of laminated PVC bag 205 and in contact with RBCs.
  • Small sachet envelope 210 is preferably made from a silicone or siloxane material with high oxygen permeability of biocompatible material.
  • Sachet envelope 210 has a wall thickness of less than 0.13 mm thickness ensures that O 2 permeability ceases to become the rate-limiting step.
  • PVC bag 205 may also contain carbon dioxide scavengers.
  • bag 202 has a similar configuration to bag 201 of Fig. 4a. However, bag 202 has a large sorbent 215 enclosed inside of PVC bag 205. Large sorbent 215 preferably has a comb-like configuration to rapidly absorb oxygen during extended storage.
  • the benefit of laminated bags of Figs. 4a and 4b is that once RBCs are anaerobically stored in bags, no further special handling is required.
  • bag 202 may contain carbon dioxide scavenger to provide carbon dioxide-scavenging in addition to oxygen-scavenging capability.
  • RBCs are stored in secondary bags 301 and 302, respectively, in order to maintain an anaerobic storage environment for RBC storage.
  • Secondary bags 301 and 302 are transparent oxygen barrier films (e.g., nylon polymer) that compensate for the inability of PVC blood bags 305 and 320, respectively, to operate as a sufficient oxygen barrier to maintain RBCs in an anaerobic state.
  • Secondary bags 301 and 302 are made with an oxygen barrier film, preferably a nylon polymer or other transparent, flexible film with low oxygen permeability.
  • a small oxygen/carbon dioxide sorbent 310 is disposed between a PVC barrier bag 305 and secondary bag 306 to remove slowly diffusing oxygen.
  • Fig. 6a is similar to the preferred embodiment of the blood bag of Fig. 4 except that secondary bag 306 is separate from and not bonded to bag 305 in this embodiment.
  • PVC bag 305 including ports are enclosed in secondary barrier bag 305.
  • Oxygen sorbent 310 may optionally contain carbon dioxide scavengers to provide both oxygen and carbon dioxide scavenging capability.
  • a secondary bag 302 contains a large sachet 325 inside of PVC bag 320.
  • Sachet 325 is filled with either oxygen or oxygen/carbon dioxide sorbent 110.
  • Sachet 325 is a molded element with surface texture to increase the surface area.
  • Sachet 325 has a comb-like geometry for rapid oxygen or oxygen/carbon dioxide depletion.
  • Sachet 325 acts rapidly to strip oxygen or oxygen/carbon dioxide from RBCs prior to refrigeration and storage of RBCs in place of OCDD of Fig. 3 .
  • agitation is necessary, therefore sachet 325 must possess a large surface area, high oxygen or oxygen/carbon dioxide permeability and mechanical strength to withstand centrifugation step during component preparation and the prolonged storage.
  • Sachet 325 is preferably made from materials such as 0.15 mm thick silicone membrane with surface texture to increase the surface area.
  • Sachet 325 may be made from materials such as PTFE or other fluoropolymer.
  • Sachet 325 may have a rectangular shape such, such as, for example, a 4" X 6" rectangle, although other sizes are possible, for the anaerobic maintenance.
  • Sachet 325 may contain carbon dioxide scavengers in addition to oxygen scavengers to provide oxygen and carbon dioxide scavenging capability.
  • Figs. 6a and 6b are easily made from off-shelf components except for sachet 325 of Fig. 6b .
  • secondary bags 301 and 302 In order to access RBCs for any testing, secondary bags 301 and 302 must be opened. Unless the unit is transfused within short time, RBC must be re-sealed with fresh sorbent for further storage. (1 day air exposure of storage bag would not oxygenate blood to appreciable degree, since PVC plasticized with DEHP has relatively low permeability to oxygen).
  • the PVC bag is preferably formed with the oxygen barrier film, such as a SiO 2 layer formed with the sol-gel method.
  • the oxygen barrier film such as a SiO 2 layer formed with the sol-gel method.
  • a portion of the sheet material will be sealed on standard heat sealing equipment, such as radiofrequency sealers. Materials options may be obtained in extruded sheets and each tested for oxygen barrier, lamination integrity, and seal strength/integrity.
  • an additive solution from bag 300 is provided prior to stripping oxygen and carbon dioxide from the RBCs is used.
  • the additive solution 300 preferably contains the following composition adenine 2mmol/L; glucose 110 mmol/L; mannitol 55 mmol/L; NaCl 26mmol/L; Na 2 HPO 4 12mmol/L citric acid and a pH of 6.5.
  • Additive solution 300 is preferably an acidic additive solution OFAS3, although other similar additive solutions could also be used that are shown to enhance oxygen/carbon dioxide -depleted storage. OFAS3 has shown enhanced ATP levels and good in vivo recovery as disclosed herein. While OFAS3 is a preferred additive solution, other solutions that offer similar functionality could also be used.
  • additive solutions used currently in the field such as AS1, AS3, AS5, SAGM, and MAPS can also be used. Additive solutions help to prevent rapid deterioration of RBCs during storage and are typically added prior to RBCs being made anaerobic.
  • OCDD and storage bags 100 and 200 can be manufactured independent of other components of the disposable, anaerobic blood storage system (i.e., every item upstream of and including leuko reduction filter 400 in Fig. 1a ).
  • oxygen scavenger is a material that irreversibly binds to or combines with oxygen under the conditions of use.
  • oxygen can chemically react with some component of the material and be converted into another compound. Any material where the off-rate of bound oxygen is zero can serve as an oxygen scavenger.
  • oxygen scavengers include iron powders and organic compounds.
  • oxygen sorbent may be used interchangeably herein with oxygen scavenger.
  • carbon dioxide scavenger is a material that irreversibly binds to or combines with carbon dioxide under the conditions of use.
  • the carbon dioxide can chemically react with some component of the material and be converted into another compound. Any material where the off-rate of bound carbon dioxide is zero can serve as a carbon dioxide scavenger.
  • carbon dioxide sorbent may be used interchangeably herein with carbon dioxide scavenger.
  • oxygen scavengers and carbon dioxide scavengers are provided by Multisorb Technologies (Buffalo, NY) or Mitsubishi Gas Chemical Co (Tokyo, Japan). Oxygen scavengers may exhibit a secondary functionality of carbon dioxide scavenging. Such materials can be blended to a desired ratio to achieve desired results.
  • Carbon dioxide scavengers include metal oxides and metal hydroxides. Metal oxides react with water to produce metal hydroxides. The metal hydroxide reacts with carbon dioxide to form water and a metal carbonate. For example, if calcium oxide is used, the calcium oxide will react with water that is added to the sorbent to produce calcium hydroxide CaO + H 2 O ⁇ Ca(OH) 2
  • the calcium hydroxide will react with carbon dioxide to form calcium carbonate and water.
  • scavengers can be incorporated into storage receptacles and bags in any known form, such as in sachets, patches, coatings, pockets, and packets.
  • oxygen removal is completed prior to introduction of the RBCs to the blood storage device, then it can be accomplished by any method known in the art.
  • a suspension of RBCs can be repeatedly flushed with an inert gas (with or without a defined concentration of carbon dioxide), with or without gentle mixing, until the desired oxygen and or carbon dioxide content is reached or until substantially all of the oxygen and carbon dioxide has been removed.
  • the inert gas can be argon, helium, nitrogen, mixtures thereof, or any other gas that does not bind to the hememoiety of hemoglobin.
  • OCDD 101 of Fig. 3 can be used with blood bag of Fig. 4 , 201 of Fig. 5a or 301 of Fig. 6a .
  • oxygen is depleted by in-bag sachet 215 of Fig. 6b , it can be stored as in Fig. 6b or oxygen/carbon dioxide -depleted content transferred to the final storage bag such as Fig. 4 , Fig. 5a or Fig. 6a for extended storage.
  • Other combinations and configurations are fully within the scope of the present disclosure.
  • the present disclosure also provides another embodiment of a blood storage device.
  • the device is a sealed receptacle adapted to retain and store red blood cells.
  • the receptacle has walls formed from a laminate.
  • the laminate has (a) an outer layer of a material substantially impermeable to oxygen or oxygen and carbon dioxide, (b) an inner layer of a material compatible with red blood cells, and (c) an interstitial layer between the outer layer and the inner layer.
  • the interstitial layer is of a material having admixed therein an amount of an oxygen scavenger or an oxygen/carbon dioxide scavenger.
  • the layers preferably take the form of polymers.
  • a preferred polymer for the outer layer is nylon.
  • a preferred polymer for inner layer is PVC.
  • the polymer of the interstitial layer should provide effective adhesion between the inner and outer layers and provide effective admixture of oxygen scavengers or oxygen/carbon dioxide scavengers therein.
  • Useful polymers for the interstitial layer include, for example, olefin polymers, such as ethylene and propylene homopolymers and copolymers, and acrylic polymers.
  • the present disclosure also provides another embodiment of a blood storage system.
  • the system has a collection bag for red blood cells; a unitary device for depleting oxygen or oxygen and carbon dioxide and reducing leukocytes and/or platelets from red blood cells; a storage bag for red blood cells; and tubing connecting the collection bag to the unitary device and the unitary device to the storage bag.
  • a feature of this embodiment is that the functions of depleting oxygen or oxygen and carbon dioxide and reducing leukocytes and/or platelets from red blood cells are combined into a single, unitary device rather than require separate devices.
  • unitary device can take the form of a single cartridge. Leukocyte and/or platelet reduction is typically carried out by passing red blood cells through a mesh.
  • a mesh can be incorporated into either the flushing or the scavenging oxygen or oxygen/carbon dioxide depletion device disclosed herein.
  • the mesh is preferably located within the device so that leukocyte and/or platelet reduction takes place prior to the onset of flushing or scavenging.
  • Figs. 12a through 12h show the results of a 3-arm study showing: a control (aerobic OFAS3 with no O 2 or CO 2 depletion), anaerobic OFAS3 (both O 2 and CO 2 depleted with pure Ar), and O 2 only depleted with 95% Ar and 5% CO 2 (CO 2 is not depleted).
  • Figs. 12a , 12c , 12e and 12g use the additive solution OFAS3 (200mL; experimental, proprietary) and the plots of Figs 12b , 12d , 12f and 12h , use the AS-3 additive solution. Comparing additive solutions, effects of CO 2 depletion on DPG levels were similar. OFAS3 showed higher ATP when oxygen was depleted ( ⁇ CO 2 ), and O 2 depletion alone showed significant enhancement of ATP compared to aerobic control. AS-3 additive exhibited no significant enhancement of ATP when O 2 alone was depleted.
  • Figs. 12a and 12b DPG levels during storage. DPG levels were maintained for over 2 weeks, when CO 2 was removed in addition to oxygen.
  • Fig. 12c ATP levels during storage with OFAS3. Highest ATP levels were achieved with OFAS3 RBC when O 2 only was depleted. For O 2 /CO 2 depletion, intermediate levels of ATP were observed compared to the control while very high DPG levels were attained during first 2.5 weeks. Very high levels of ATP may suggest higher rate of 24-hour post transfusion recovery. Therefore, extent of carbon dioxide and oxygen depletion levels may be adjusted to meet the specific requirement of the recipient. DPG levels can be maintained very high (at the expense of ATP) for purposes of meeting acute oxygen demand of recipient.
  • ATP levels may allow higher 24-hour recovery rate (lower fraction of non-viable RBC upon transfusion) thereby reducing the quantity of blood needed to be transfused (up to 25% of RBC are non-viable). More importantly, this would benefit chronically transfused patients who may not demand highest oxygen transport efficiency immediately after transfusion (DPG level recovers in body after 8-48 hours) who suffers from toxic iron overloading caused by non-viable RBCs.
  • Fig. 12d ATP levels during storage with AS3. Highest ATP levels were achieved with AS3 RBC when O 2 only was depleted. No significant differences in ATP levels where observed with control and O 2 depletion alone.
  • Figs. 12e and 12f pH of RBC cytosol (in) and suspending medium (ex). Immediately after gas exchange (day 0), significant rise in pH (in and ex) was observed only when CO 2 was depleted together with O 2 . Rapid rates of pH decline observed with CO 2 /O 2 depleted samples were caused by higher rates of lactate production ( Figs. 12g and 12h ).
  • Figs. 12g and 12h Normalized (to hemoglobin) glucose and lactate levels during storage with OFAS3 and AS3. Higher rates of glucose depletion and lactate productions correspond to high DPG levels observed in panels A and B. Legends for symbols/lines are same for both panels. OFAS3 additive contains similar glucose concentration with x2 volume resulting in higher normalized glucose levels.
  • Figs. 12a and 12c taken together suggest that extent of increases (compared to control) of ATP and DPG levels may be adjusted by controlling level of CO 2 depletion, when O 2 is depleted. Higher glucose utilization and lactate production were observed with enhanced DPG production ( Fig. 12g ). This may be also effective with AS3 additive, since similar trend in glucose utilization and lactate production were observed ( Fig. 12h ).
  • Fig. 13 shows a graph comparing the effect of gamma irradiation on aerobic and anaerobic RBC.
  • Fig. 13 shows an control unit, RBC that are aerobic and not gamma-irradiated (Unit A, black filled solid line), aerobic RBC that are gamma-irradiated (Unit B; control plus gamma irradiation indicated by a filled circle with dotted line) and an anaerobically depleted RBC unit that has been gamma-irradiated (Unit C; Anaerobic + ⁇ , open circle and solid line).
  • Unit B and Unit C are irradiated and Unit A is non-irradiated and aerobic RBC.
  • the constituent of the blood that is being measured is potassium.
  • the amount of leakage of potassium (K+) from RBC that is measured in the storage media is an indicator of health of the RBC. Therefore, in the context of the present application, a greater level of concentration of potassium in RBC storage media, is indicative of a greater level of RBC damage relative to a lower level of concentration of potassium in RBC storage media.
  • Fig. 13 indicates that gamma irradiation induced a high rate of K+ leakage during the first week for Unit B and Unit C. K+ leakage rates after days eight and fifteen, were similar for all units. Significantly, the difference between K+ leakage between Unit B and Unit C increases beyond the twenty-second day of storage. The results indicate that this trend could exist for several more days. Accordingly, the use of anaerobic depletion and gamma irradiation may permit the extension of current FDA storage limit of twenty-eight days for anaerobically depleted and gamma irradiated blood prepared after component separation.
  • Irradiating RBC for immuno-compromised individuals is a necessity.
  • the present results show that irradiated RBC that were also oxygen depleted did not increase K+ leakage rates, an indicator of RBC damage.
  • the benefits of oxygen depleted RBC including increased levels of ATP and DPG-2,3 are not negatively impacted by the irradiation.
EP23162955.1A 2010-11-05 2011-11-04 Irradiation de globules rouges et stockage anaérobie Pending EP4218412A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US41068410P 2010-11-05 2010-11-05
PCT/US2011/059372 WO2012061731A1 (fr) 2010-11-05 2011-11-04 Irradiation des globules rouges et conservation anaérobie
EP11838889.1A EP2635114B1 (fr) 2010-11-05 2011-11-04 Irradiation des globules rouges et conservation anaérobie
EP19158815.1A EP3539381B1 (fr) 2010-11-05 2011-11-04 Irradiation de globules rouges et stockage anaérobie

Related Parent Applications (3)

Application Number Title Priority Date Filing Date
EP19158815.1A Division EP3539381B1 (fr) 2010-11-05 2011-11-04 Irradiation de globules rouges et stockage anaérobie
EP19158815.1A Division-Into EP3539381B1 (fr) 2010-11-05 2011-11-04 Irradiation de globules rouges et stockage anaérobie
EP11838889.1A Division EP2635114B1 (fr) 2010-11-05 2011-11-04 Irradiation des globules rouges et conservation anaérobie

Publications (1)

Publication Number Publication Date
EP4218412A1 true EP4218412A1 (fr) 2023-08-02

Family

ID=46019976

Family Applications (3)

Application Number Title Priority Date Filing Date
EP23162955.1A Pending EP4218412A1 (fr) 2010-11-05 2011-11-04 Irradiation de globules rouges et stockage anaérobie
EP11838889.1A Active EP2635114B1 (fr) 2010-11-05 2011-11-04 Irradiation des globules rouges et conservation anaérobie
EP19158815.1A Active EP3539381B1 (fr) 2010-11-05 2011-11-04 Irradiation de globules rouges et stockage anaérobie

Family Applications After (2)

Application Number Title Priority Date Filing Date
EP11838889.1A Active EP2635114B1 (fr) 2010-11-05 2011-11-04 Irradiation des globules rouges et conservation anaérobie
EP19158815.1A Active EP3539381B1 (fr) 2010-11-05 2011-11-04 Irradiation de globules rouges et stockage anaérobie

Country Status (7)

Country Link
US (1) US10136635B2 (fr)
EP (3) EP4218412A1 (fr)
JP (1) JP5859558B2 (fr)
CA (1) CA2817106C (fr)
ES (2) ES2793484T3 (fr)
PT (2) PT3539381T (fr)
WO (1) WO2012061731A1 (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011046963A1 (fr) 2009-10-12 2011-04-21 New Health Sciences, Inc. Dispositifs d'appauvrissement en oxygène et procédés pour retirer l'oxygène de globules rouges
WO2011046841A1 (fr) 2009-10-12 2011-04-21 New Health Sciences, Inc. Système de sac de stockage de sang et dispositifs d'épuisement avec capacités d'épuisement en dioxyde de carbone et en oxygène
US11284616B2 (en) 2010-05-05 2022-03-29 Hemanext Inc. Irradiation of red blood cells and anaerobic storage
US9199016B2 (en) 2009-10-12 2015-12-01 New Health Sciences, Inc. System for extended storage of red blood cells and methods of use
EP4091645A1 (fr) 2010-08-25 2022-11-23 Hemanext Inc. Procédé d'amélioration de la qualité et de la survie des globules rouges pendant le stockage
EP4218412A1 (fr) 2010-11-05 2023-08-02 Hemanext Inc. Irradiation de globules rouges et stockage anaérobie
WO2012125955A2 (fr) 2011-03-16 2012-09-20 Mayo Foundation For Medical Education And Research Procédés et matériaux pour prolonger le stockage utile des préparations d'hématies et des préparations de plaquettes
US9067004B2 (en) 2011-03-28 2015-06-30 New Health Sciences, Inc. Method and system for removing oxygen and carbon dioxide during red cell blood processing using an inert carrier gas and manifold assembly
JP2014518283A (ja) * 2011-07-05 2014-07-28 ニュー・ヘルス・サイエンシーズ・インコーポレイテッド 赤血球の長期保存システムおよび使用方法
EP4074395B1 (fr) 2011-08-10 2024-01-24 Hemanext Inc. Dispositif de filtre de séparation intégré de plasma et de leucocytes à appauvrissement en oxygène et/ou en co2
CA2902061C (fr) 2013-02-28 2023-08-08 New Health Sciences, Inc. Dispositifs d'appauvrissement de gaz et d'addition de gaz pour traitement sanguin
US10376627B2 (en) 2014-03-24 2019-08-13 Fenwal, Inc. Flexible biological fluid filters
US9782707B2 (en) 2014-03-24 2017-10-10 Fenwal, Inc. Biological fluid filters having flexible walls and methods for making such filters
US9968738B2 (en) 2014-03-24 2018-05-15 Fenwal, Inc. Biological fluid filters with molded frame and methods for making such filters
US10159778B2 (en) 2014-03-24 2018-12-25 Fenwal, Inc. Biological fluid filters having flexible walls and methods for making such filters
US9796166B2 (en) 2014-03-24 2017-10-24 Fenwal, Inc. Flexible biological fluid filters
PT3268015T (pt) * 2015-03-10 2022-01-06 Hemanext Inc Kits descartáveis de redução de oxigénio, dispositivos e métodos de utilização dos mesmos
EP3285711A4 (fr) * 2015-04-23 2018-11-07 New Health Sciences, Inc. Récipients de stockage de sang anaérobie
CN114748503A (zh) 2015-05-18 2022-07-15 希玛奈克斯特股份有限公司 储存全血的方法及其组合物
AU2017271545C1 (en) * 2016-05-27 2023-06-15 Hemanext Inc. Anaerobic blood storage and pathogen inactivation method
RU2019130972A (ru) * 2017-03-03 2021-04-05 РИЧ ТЕКНОЛОДЖИЗ ХОЛДИНГ КОМПАНИ, ЭлЭлСи Устройство для консервирования препаратов крови и клеточных культур в газовой среде под давлением
WO2022210224A1 (fr) * 2021-03-29 2022-10-06 国立大学法人新潟大学 Procédé de production de préparation cellulaire et récipient de stimulation hypoxique utilisé à cet effet

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5362442A (en) 1993-07-22 1994-11-08 2920913 Canada Inc. Method for sterilizing products with gamma radiation
WO1998051147A1 (fr) * 1997-05-15 1998-11-19 The Regents Of The University Of California Stockage prolonge a froid de globules rouges par elimination d'oxygene et utilisation d'additif
US6162396A (en) * 1997-04-26 2000-12-19 The Regents Of The University Of California Blood storage device and method for oxygen removal
US6403124B1 (en) 1997-04-16 2002-06-11 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Storage and maintenance of blood products including red blood cells and platelets
US6482585B2 (en) 1997-04-16 2002-11-19 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Storage and maintenance of blood products including red blood cells and platelets
WO2003043571A2 (fr) * 2001-11-16 2003-05-30 Hollinger Digital, Inc. Procede pour allonger la duree de conservation utile de globules rouges refrigeres par un supplement nutritif
WO2003086577A1 (fr) * 2002-04-08 2003-10-23 Teva Medical Ltd. Preparation d'un filtre a leucocytes et procede d'utilisation de ce filtre
WO2003103390A1 (fr) * 2002-06-07 2003-12-18 Promethean Lifesciences, Inc. Sterilisation, stabilisation et conservation de matiere vivante
WO2008034476A1 (fr) * 2006-09-19 2008-03-27 Maco Pharma S.A. Systeme de sacs de sang et procede d'inactivation d'agents pathogenes dans des concentres de plaquettes au moyen de ce systeme

Family Cites Families (297)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3064647A (en) 1957-06-13 1962-11-20 Baxter Laboratories Inc Blood component separation method and apparatus
US3361041A (en) 1964-01-13 1968-01-02 Equitable Paper Bag Co Method and apparatus for making gusseted header bags
FR1455087A (fr) 1964-05-08 1966-04-01 Schwarz Biores Procédé de conservation du sang
US3942529A (en) 1967-02-01 1976-03-09 Investrop A.G. Package and method for storing blood
US3668837A (en) 1970-02-13 1972-06-13 Pall Corp Separator of the semipermeable membrane type
US3668838A (en) 1970-12-07 1972-06-13 Dalph C Mcneil Flash economizer
US3803810A (en) 1972-05-01 1974-04-16 Pall Corp Liquid-gas separator and filter
US3910841A (en) 1974-04-02 1975-10-07 William G Esmond Stacked exchange device
US4131200A (en) 1976-07-06 1978-12-26 Union Carbide Corporation Thermoplastic blood bag
US4082509A (en) 1976-08-05 1978-04-04 Dow Corning Corporation Method of storing blood and a blood storage bag therefor
US4086924A (en) 1976-10-06 1978-05-02 Haemonetics Corporation Plasmapheresis apparatus
SE421999B (sv) 1977-10-17 1982-02-15 Gambro Dialysatoren Anordning for diffusion och/eller filtration av emnen mellan tva fluider via semipermeabla membran vilken anordning innefattar parallellkopplade banor innehallande seriekopplade kamrar
US4370160A (en) 1978-06-27 1983-01-25 Dow Corning Corporation Process for preparing silicone microparticles
US6447987B1 (en) 1978-09-09 2002-09-10 The United States Of America As Represented By The Secretary Of The Army Prolonged storage of red blood cells
US6150085A (en) 1998-09-16 2000-11-21 The United States Of America As Represented By The Secretary Of The Army Prolonged storage of red blood cells and composition
US4222379A (en) 1978-10-26 1980-09-16 Baxter Travenol Laboratories, Inc. Multiple blood bag having plasticizer-free portions and a high blood component survival rate
GB2035093B (en) * 1978-10-26 1983-01-12 Baxter Travenol Lab Medical articles made of blood compatible polymers
US4228032A (en) 1978-11-06 1980-10-14 Dow Corning Corporation Method of storing blood and a blood storage bag therefore
US4342723A (en) 1978-11-24 1982-08-03 Shin-Etsu Polymer Co., Ltd. Gas-exchange sheet members
US4256692A (en) 1979-02-01 1981-03-17 C. R. Bard, Inc. Membrane oxygenator
US4253458A (en) 1979-03-08 1981-03-03 Baxter Travenol Laboratories, Inc. Method and apparatus for collecting blood plasma
US4262581A (en) 1979-05-04 1981-04-21 Kcl Corporation Method and apparatus for making printed gusset bags
US4398642A (en) 1979-11-02 1983-08-16 Toyo Boseki Kabushiki Kaisha Multi-ply vessel and method for production thereof
US4381775A (en) 1980-02-05 1983-05-03 Takeda Chemical Industries, Ltd. Method for low pressure filtration of plasma from blood
US4267269A (en) 1980-02-05 1981-05-12 Baxter Travenol Laboratories, Inc. Red cell storage solution
CA1156641A (fr) 1980-03-17 1983-11-08 Takanari Nawata Agent absorbant l'oxygene et le gaz carbonique et procede de conservation du cafe a l'aide de cet agent
US4314480A (en) 1980-07-14 1982-02-09 Baxter Travenol Laboratories, Inc. Venous pressure isolator
US5382526A (en) 1980-10-31 1995-01-17 Baxter International Inc. Blood storage container and material
US4440815A (en) 1981-06-29 1984-04-03 Abbott Laboratories Clear, autoclavable plastic formulation for medical liquid containers
US4455299A (en) 1981-11-20 1984-06-19 Baxter Travenol Laboratories, Inc. Storage of blood platelets
US4386069A (en) 1981-12-02 1983-05-31 Baxter Travenol Laboratories, Inc. Additive solution and method for preserving normal red cell morphology in whole blood during storage
EP0093381B1 (fr) 1982-04-27 1986-07-23 The Wellcome Foundation Limited Composés tricycliques, leur préparation, leur utilisation et des produits intermédiaires
JPS58194879A (ja) 1982-04-27 1983-11-12 ザ・ウエルカム・フアウンデ−シヨン・リミテツド 三環式化合物
US5310674A (en) 1982-05-10 1994-05-10 Bar-Ilan University Apertured cell carrier
DE3225408A1 (de) 1982-07-07 1984-01-12 Biotest-Serum-Institut Gmbh, 6000 Frankfurt Waessrige loesung zum suspendieren und lagern von zellen, insbesondere erythrozyten
BE898469A (fr) 1982-12-20 1984-03-30 El Paso Polyolefins Compositions polyoléfiniques stérilisables à la chaleur et articles fabriqués à partir de ces compositions.
US4670013A (en) 1982-12-27 1987-06-02 Miles Laboratories, Inc. Container for blood and blood components
KR890005278B1 (ko) 1983-01-28 1989-12-20 미쓰비시가스가가꾸 가부시끼 가이샤 탈산소제 포장체
US4540416A (en) 1983-08-18 1985-09-10 El Paso Polyolefins Company Heat-sterilizable polyolefin compositions and articles manufactured therefrom
US4859360A (en) 1983-10-27 1989-08-22 Biosynergy, Inc. Cholesteric liquid crystal formulations and time/temperature monitoring means
US4701267B1 (en) 1984-03-15 1996-03-12 Asahi Medical Co Method for removing leukocytes
US5417986A (en) 1984-03-16 1995-05-23 The United States Of America As Represented By The Secretary Of The Army Vaccines against diseases caused by enteropathogenic organisms using antigens encapsulated within biodegradable-biocompatible microspheres
US4831012A (en) 1984-03-23 1989-05-16 Baxter International Inc. Purified hemoglobin solutions and method for making same
EP0168755B1 (fr) 1984-07-16 1991-04-17 Sumitomo Bakelite Company Limited Récipient et méthode pour la conservation de sang
US4585735A (en) 1984-07-19 1986-04-29 American National Red Cross Prolonged storage of red blood cells
US4654053A (en) 1984-07-27 1987-03-31 University Patents, Inc. Oxygen sorbent
US4629544A (en) 1984-09-24 1986-12-16 Aquanautics Corporation Apparatus and method for reversibly removing ligands from carriers
US4568328A (en) 1984-10-29 1986-02-04 Extracorporeal Medical Specialties, Inc. Automated photophoresis blood portion control methods and apparatus
US4748121A (en) 1984-11-30 1988-05-31 Ppg Industries, Inc. Porous glass fibers with immobilized biochemically active material
US4713176A (en) 1985-04-12 1987-12-15 Hemascience Laboratories, Inc. Plasmapheresis system and method
FR2581289A1 (fr) 1985-05-06 1986-11-07 Rgl Transfusion Sanguine Centr Solution synthetique pour la conservation prolongee de concentres erythrocytaires
KR890002855B1 (ko) 1985-06-26 1989-08-05 미쯔비시 가스 가가구 가부시기가이샤 시이트상 탈산소제 및 그 제조방법
SE448444B (sv) 1985-07-08 1987-02-23 Alfa Laval Food & Dairy Eng Forslutbar pase samt anvendning av denna
IT1218450B (it) 1985-09-24 1990-04-19 Teresa Borgione Perfezionamenti agli ossigenatori per il sangue, a fibre cave
US4961928A (en) 1986-03-19 1990-10-09 American Red Cross Synthetic, plasma-free, transfusible storage medium for red blood cells and platelets
JPS62157385U (fr) 1986-03-26 1987-10-06
US4769318A (en) 1986-06-03 1988-09-06 Ube Industries, Ltd. Additive solution for blood preservation and activation
JPS6363616A (ja) 1986-09-04 1988-03-22 Showa Denko Kk 赤血球濃厚液の保存剤及び保存方法
JPH0326882Y2 (fr) 1986-12-12 1991-06-11
US4880786A (en) 1987-01-14 1989-11-14 Ube Industries, Ltd. Additive solution for blood preservation and activation
US5000848A (en) 1987-01-28 1991-03-19 Membrex, Inc. Rotary filtration device with hyperphilic membrane
JP2700170B2 (ja) 1987-07-11 1998-01-19 大日本インキ化学工業株式会社 膜型人工肺
US5192320A (en) 1987-07-11 1993-03-09 Dainippon Ink And Chemicals Inc. Artificial lung and method of using it
CA1323271C (fr) 1987-07-11 1993-10-19 Takanori Anazawa Poumon artificiel a membrane et mode d'utilisation
JPH07121340B2 (ja) 1987-07-11 1995-12-25 大日本インキ化学工業株式会社 中空繊維膜
DE3722984A1 (de) 1987-07-11 1989-01-19 Biotest Pharma Gmbh Waessrige loesung zum suspendieren und lagern von zellen, insbesondere erythrozyten
US4925572A (en) 1987-10-20 1990-05-15 Pall Corporation Device and method for depletion of the leukocyte content of blood and blood components
US4861867A (en) 1988-02-03 1989-08-29 Baxter International, Inc. Purified hemoglobin solutions and method for making same
US4880548A (en) 1988-02-17 1989-11-14 Pall Corporation Device and method for separating leucocytes from platelet concentrate
JP2685544B2 (ja) 1988-11-11 1997-12-03 株式会社日立製作所 血液フィルタおよび血液検査方法並びに血液検査装置
US4998990A (en) 1988-12-20 1991-03-12 The Coca-Cola Company Collapsible bag with evacuation passageway and method for making the same
US5229012A (en) 1989-05-09 1993-07-20 Pall Corporation Method for depletion of the leucocyte content of blood and blood components
US5120659A (en) 1989-06-26 1992-06-09 Mine Safety Appliances Company Deuterated water test method
DK0413378T3 (da) 1989-08-18 1995-05-15 Akzo Nobel Nv Escherichia coli vaccine
US5152905A (en) 1989-09-12 1992-10-06 Pall Corporation Method for processing blood for human transfusion
US5037419A (en) 1989-09-21 1991-08-06 Eastman Kodak Company Blood bag system containing vitamin E
IL95912A (en) 1989-10-06 1998-08-16 American Nat Red Cross A method for extending the shelf life of blood cells
US5386014A (en) 1989-11-22 1995-01-31 Enzon, Inc. Chemically modified hemoglobin as an effective, stable, non-immunogenic red blood cell substitute
US5139668A (en) * 1989-12-27 1992-08-18 Alberta Research Corporation Hollow fiber bundle element
SU1718766A1 (ru) 1990-01-30 1992-03-15 Ленинградский научно-исследовательский институт гематологии и переливания крови Способ консервировани эритроцитов крови
JP2888590B2 (ja) 1990-03-30 1999-05-10 テルモ株式会社 血漿および濃厚赤血球採取用器具
US6187572B1 (en) 1990-04-16 2001-02-13 Baxter International Inc. Method of inactivation of viral and bacterial blood contaminants
CA2040993C (fr) 1990-04-25 2001-08-07 Yoshiaki Inoue Composition qui absorbe l'oxygene et methode de conservation d'un article grace a cette composition
US6077659A (en) 1990-05-15 2000-06-20 New York Blood Center, Inc. Vitamin E and derivatives thereof prevent potassium ion leakage and other types of damage in red cells that are virus sterilized by phthalocyanines and light
US5194158A (en) 1990-06-15 1993-03-16 Matson Stephen L Radon removal system and process
JP2953753B2 (ja) 1990-06-28 1999-09-27 テルモ株式会社 血漿採取装置
JPH0474515A (ja) 1990-07-13 1992-03-09 Toray Ind Inc 酸素吸収体
US5368808A (en) 1990-10-26 1994-11-29 Kyoraku Co., Ltd. Blowbag manufacturing method
DE69126861T2 (de) 1990-11-07 1998-02-26 Baxter Int Lösung zur aufbewahrung roter blutzellen
US5208335A (en) 1991-03-19 1993-05-04 Air Products And Chemicals, Inc. Reversible oxygen sorbent compositions
US5789152A (en) 1991-04-30 1998-08-04 Basil T. Hone Composition and method for detecting HIV with baculovirus derived vesicles
CA2089005C (fr) 1991-06-21 1999-01-19 John Chapman Methode d'inactivation des agents pathogenes dans les liquides organiques
US5443743A (en) 1991-09-11 1995-08-22 Pall Corporation Gas plasma treated porous medium and method of separation using same
US5353793A (en) 1991-11-25 1994-10-11 Oishi-Kogyo Company Sensor apparatus
JP3461360B2 (ja) * 1991-11-30 2003-10-27 旭メディカル株式会社 白血球除去用フィルター材料
JP3337232B2 (ja) 1991-12-26 2002-10-21 東レ・ダウコーニング・シリコーン株式会社 シリコーン硬化物微粒子と無機質微粒子からなる粉体混合物の製造方法
US5356375A (en) 1992-04-06 1994-10-18 Namic U.S.A. Corporation Positive pressure fluid delivery and waste removal system
JP3177713B2 (ja) * 1992-04-30 2001-06-18 科学技術振興事業団 輸血用血液または血液製剤の保存方法
US5304487A (en) 1992-05-01 1994-04-19 Trustees Of The University Of Pennsylvania Fluid handling in mesoscale analytical devices
JPH05317413A (ja) 1992-05-20 1993-12-03 Asahi Medical Co Ltd 白血球除去血液成分採取装置
US6248690B1 (en) 1992-05-26 2001-06-19 Multisorb Technologies, Inc. Oxygen absorber
US5529821A (en) 1992-06-29 1996-06-25 Terumo Kabushiki Kaisha Container for storing blood or blood component
DE4229325C2 (de) 1992-09-02 1995-12-21 Heraeus Instr Gmbh Kulturgefäß für Zellkulturen
US5328268A (en) 1992-10-30 1994-07-12 Custom Packaging Systems, Inc. Bulk bag with restrainer
SE9301581D0 (sv) 1993-05-07 1993-05-07 Kabi Pharmacia Ab Protein formulation
US5427663A (en) 1993-06-08 1995-06-27 British Technology Group Usa Inc. Microlithographic array for macromolecule and cell fractionation
US5744056A (en) * 1993-07-16 1998-04-28 Amoco Corporation Oxygen-scavenging compositions and articles
IT1260685B (it) 1993-09-29 1996-04-22 Sorin Biomedica Spa Dispositivo per il contenimento di sangue
GB2283015B (en) 1993-10-22 1998-05-13 Chemitreat Pte Ltd Membrane reactor for the removal of dissolved oxygen from water
US20010037978A1 (en) 1999-04-20 2001-11-08 Daryl R. Calhoun Filter assembly having a flexible housing and method of making same
CA2143365A1 (fr) 1994-03-14 1995-09-15 Hugh V. Cottingham Methode et appareil pour l'amplification de l'acide nucleique
WO1995029662A2 (fr) 1994-04-20 1995-11-09 U.S. Department Of The Army Vaccin contre les infections par des bacteries gram-negatives
US5617873A (en) 1994-08-25 1997-04-08 The United States Of America As Represented By The Administrator, Of The National Aeronautics And Space Administration Non-invasive method and apparatus for monitoring intracranial pressure and pressure volume index in humans
US6156231A (en) 1994-09-08 2000-12-05 Multisorb Technologies, Inc. Oxygen absorbing composition with cover layer
US5476764A (en) 1994-09-16 1995-12-19 The Regents Of The University Of California Method using CO for extending the useful shelf-life of refrigerated red blood cells
US6045701A (en) 1994-10-17 2000-04-04 Baxter International Inc. Method of filtering a fluid suspension with a membrane having a particular coating
DE4446270C1 (de) 1994-12-23 1996-02-29 Hewlett Packard Gmbh Basisstruktur für einen Flüssigkeitschromatographie-Entgaser
US5730989A (en) 1995-02-16 1998-03-24 Novavax, Inc. Oral vaccine against gram negative bacterial infection
US6610832B1 (en) * 1995-03-23 2003-08-26 Biopure Corporation Preserving a hemoglobin blood substitute with a transparent overwrap
US6288027B1 (en) 1995-03-23 2001-09-11 Biopure Corporation Preserving a hemoglobin blood substitute with a transparent overwrap
US5605934A (en) 1995-03-23 1997-02-25 Baxter International Inc. Method of manufacturing and storing solutions
US5895810A (en) 1995-03-23 1999-04-20 Biopure Corporation Stable polymerized hemoglobin and use thereof
DK0815138T3 (da) 1995-03-23 2002-12-23 Biopure Corp Stabil polymeriseret hæmoglobin-blod-erstatning
US5691452A (en) 1995-03-23 1997-11-25 Biopure Corporation Method for preserving a hemoglobin blood substitute
WO1996029864A1 (fr) 1995-03-24 1996-10-03 Organ, Inc. Methode de rajeunissement de globules rouges perimes
EP0869835B1 (fr) 1995-04-13 2005-06-08 Travenol Laboratories (Israel) Ltd. Procede et appareil de filtrage des leucocytes
US5624794A (en) 1995-06-05 1997-04-29 The Regents Of The University Of California Method for extending the useful shelf-life of refrigerated red blood cells by flushing with inert gas
US5716852A (en) 1996-03-29 1998-02-10 University Of Washington Microfabricated diffusion-based chemical sensor
US6527957B1 (en) 1995-08-09 2003-03-04 Baxter International Inc. Methods for separating, collecting and storing red blood cells
US5709472A (en) 1995-10-23 1998-01-20 Lifelines Technology, Inc. Time-temperature indicator device and method of manufacture
US6042264A (en) 1995-10-23 2000-03-28 Lifelines Technology, Inc. Time-temperature indicator device and method of manufacture
US5846427A (en) 1995-10-23 1998-12-08 Hemasure, Inc. Extra-lumenal crossflow plasmapheresis devices and method of use thereof
US5686304A (en) 1995-12-15 1997-11-11 Avecor Cardiovascular, Inc. Cell culture apparatus and method
US5693230A (en) 1996-01-25 1997-12-02 Gas Research Institute Hollow fiber contactor and process
US5863460A (en) * 1996-04-01 1999-01-26 Chiron Diagnostics Corporation Oxygen sensing membranes and methods of making same
US5698250A (en) 1996-04-03 1997-12-16 Tenneco Packaging Inc. Modifield atmosphere package for cut of raw meat
SE9601348D0 (sv) * 1996-04-10 1996-04-10 Pharmacia Ab Improved containers for parenteral fluids
US5906285A (en) 1996-05-10 1999-05-25 Plastipak Packaging, Inc. Plastic blow molded container
IT1285393B1 (it) * 1996-06-04 1998-06-03 Hospal Dasco Spa Formulazione di polivinile cloruro plastificato per la realizzazione di componenti in materiale biocompatibile, in particolare di linee
US6148536A (en) 1996-06-10 2000-11-21 Nippon Telegraph And Telephone Corporation Two-fluid nozzle and device employing the same nozzle for freezing and drying liquid containing biological substances
US6808675B1 (en) 1996-06-25 2004-10-26 Thermogenesis Corp. Freezing and thawing bag, mold, apparatus and method
JP3915126B2 (ja) 1996-07-09 2007-05-16 ポール・コーポレーション 多要素フィルター
US6254628B1 (en) 1996-12-09 2001-07-03 Micro Therapeutics, Inc. Intracranial stent
US5876604A (en) 1996-10-24 1999-03-02 Compact Membrane Systems, Inc Method of gasifying or degasifying a liquid
US6358678B1 (en) 1998-02-11 2002-03-19 The United States Of America As Represented By The Secretary Of The Navy Applications of reversible crosslinking and co-treatment in stabilization and viral inactivations of erythrocytes
EP0969897B1 (fr) 1997-03-17 2010-08-18 Adidas AG Systeme de retour de l'information concernant des signes physiologiques
US6164821A (en) 1997-05-09 2000-12-26 The Procter & Gamble Company Flexible, self-supporting storage bag with hinged, framed closure
DE69839047T2 (de) 1997-05-20 2009-01-15 Zymequest, Inc., Beverly Flüssigkeitsüberwachungssystem
IT1293309B1 (it) 1997-07-09 1999-02-16 Sis Ter Spa Apparecchiatura per il trattamento del sangue con dispositivo di scambio a membrana
US6368871B1 (en) 1997-08-13 2002-04-09 Cepheid Non-planar microstructures for manipulation of fluid samples
US6022477A (en) 1997-11-14 2000-02-08 New Jersey Institute Of Technology Method and apparatus for isolation purification of biomolecules
DE19754573A1 (de) 1997-12-09 1999-06-10 Bayer Ag Pharmazeutische Zusammensetzung zur Behandlung von Schlaganfall und Schädel-Hirn-Trauma
JP2003521552A (ja) 1998-03-25 2003-07-15 シェブロン フィリップス ケミカル カンパニー エルピー プラスチックフィルムそして飲料および食品の容器で使用するための酸化生成物が減少する酸素スカベンジャー
US6027623A (en) 1998-04-22 2000-02-22 Toyo Technologies, Inc. Device and method for electrophoretic fraction
US5937617A (en) 1998-05-01 1999-08-17 Innoflex Incorporated Pouch with pre-inserted straw
US6090062A (en) 1998-05-29 2000-07-18 Wayne State University Programmable antisiphon shunt system
US6908553B1 (en) 1998-07-08 2005-06-21 Baxter International Inc. Composite membrane with particulate matter substantially immobilized therein
US20070099170A1 (en) 1998-07-21 2007-05-03 Navigant Biotechnologies, Inc. Method for treatment and storage of blood and blood products using endogenous alloxazines and acetate
US20030215784A1 (en) * 1998-07-21 2003-11-20 Dumont Larry Joe Method and apparatus for inactivation of biological contaminants using photosensitizers
CA2341614C (fr) 1998-08-31 2008-11-18 Walter Reed Army Institute Of Research Stockage prolonge de globules rouges
US6695803B1 (en) 1998-10-16 2004-02-24 Mission Medical, Inc. Blood processing system
AUPP676898A0 (en) 1998-10-26 1998-11-19 Noble House Group Pty Ltd Sampling first in blood collection
US6413713B1 (en) 1998-10-30 2002-07-02 Hyperbaric Systems Method for preserving blood platelets
CA2287768C (fr) 1998-11-02 2004-01-13 Ahmed Abdoh Methode de collecte, d'analyse et de rapport automatises de donnees
WO2001054584A1 (fr) 1999-01-27 2001-08-02 The Government Of The United States As Represented By The Administrator Of The National Aeronautics And Space Administration Appareil ultrasonore et technique de mesure des changements de pression intracranienne
US6582496B1 (en) 2000-01-28 2003-06-24 Mykrolis Corporation Hollow fiber membrane contactor
US6337026B1 (en) 1999-03-08 2002-01-08 Whatman Hemasure, Inc. Leukocyte reduction filtration media
US6945411B1 (en) 1999-03-16 2005-09-20 Pall Corporation Biological fluid filter and system
US6097293A (en) 1999-04-15 2000-08-01 Industrial Technology, Inc. Passive electrical marker for underground use and method of making thereof
US6210601B1 (en) 1999-04-21 2001-04-03 Larry A. Hottle Method of making an oxygen scavenging sealant composition
US6455311B1 (en) 1999-04-30 2002-09-24 The General Hospital Corporation Fabrication of vascularized tissue
US6387461B1 (en) 1999-05-06 2002-05-14 Cryovac, Inc. Oxygen scavenger compositions
US6629919B2 (en) 1999-06-03 2003-10-07 Haemonetics Corporation Core for blood processing apparatus
US6610772B1 (en) 1999-08-10 2003-08-26 Eastman Chemical Company Platelet particle polymer composite with oxygen scavenging organic cations
US6287284B1 (en) 1999-09-27 2001-09-11 Npt, Inc. Silicone bag assembly
US6703492B1 (en) 1999-11-09 2004-03-09 Smithkline Beecham Corporation Staphylococcus epidermidis nucleic acids and proteins
DE60033520T2 (de) 1999-12-08 2007-06-21 Baxter International Inc. (A Delaware Corporation), Deerfield Verfahren zur herstellung einer mikroporösen filtermembran
US6315815B1 (en) 1999-12-16 2001-11-13 United Technologies Corporation Membrane based fuel deoxygenator
EP1289630B1 (fr) 2000-03-07 2008-03-05 MAT Adsorption Technologies GmbH & Co. KG Module a elements de membrane pour ecoulement partiel et ecoulement total
US20010037078A1 (en) 2000-03-31 2001-11-01 Daniel Lynn Systems and methods for collecting leukocyte-reduced blood components, including plasma that is free or virtually free of cellular blood species
US6468732B1 (en) 2000-04-04 2002-10-22 Bayer Corporation Method and long-term stable bicarbonate-containing diluent composition, and storage means therefor, for reducing or reversing aeration induced cell shrinkage and storage induced cell swelling of a whole blood sample
ES2257315T3 (es) 2000-04-21 2006-08-01 Kuraray Co., Ltd. Tubo multicapa y dispositivo medico que comprende el tubo multicapa.
US6402818B1 (en) 2000-06-02 2002-06-11 Celgard Inc. Degassing a liquid with a membrane contactor
US6558571B1 (en) 2000-08-11 2003-05-06 Multisorb Technologies, Inc. Oxygen-absorbing composition and method
US7904313B2 (en) 2000-08-24 2011-03-08 Quintiles, Inc. Recruiting a patient into a clinical trial
US20080027368A1 (en) 2000-09-27 2008-01-31 Sorin Group Usa, Inc. Disposable cartridge for a blood perfusion system
EP1328312A4 (fr) 2000-09-27 2007-08-01 Cobe Cardiovascular Inc Systeme de perfusion sanguine
WO2002026114A2 (fr) 2000-09-27 2002-04-04 Bitensky Mark W Jeux d'echantillons de diagnostic cellulaire, methodes d'utilisation et procedes de fabrication
US7104958B2 (en) 2001-10-01 2006-09-12 New Health Sciences, Inc. Systems and methods for investigating intracranial pressure
WO2002026118A2 (fr) 2000-09-29 2002-04-04 New Health Sciences, Inc. Systemes et methodes d'evaluation de l'effet d'un traitement
US6955648B2 (en) 2000-09-29 2005-10-18 New Health Sciences, Inc. Precision brain blood flow assessment remotely in real time using nanotechnology ultrasound
US7604599B2 (en) 2000-09-29 2009-10-20 New Health Sciences, Inc. Systems and methods for using dynamic vascular assessment to improve vascular stent placement, application, design and marketing
US6494909B2 (en) 2000-12-01 2002-12-17 Prodesco, Inc. Endovascular valve
US6770434B2 (en) 2000-12-29 2004-08-03 The Provost, Fellows And Scholars Of The College Of The Holy & Undivided Trinity Of Queen Elizabeth Near Dublin Biological assay method
AU2002239810A1 (en) 2001-01-02 2002-07-16 The Charles Stark Draper Laboratory, Inc. Tissue engineering of three-dimensional vascularized using microfabricated polymer assembly technology
US6773670B2 (en) 2001-02-09 2004-08-10 Cardiovention, Inc. C/O The Brenner Group, Inc. Blood filter having a sensor for active gas removal and methods of use
JP2002253936A (ja) 2001-02-28 2002-09-10 Japan Gore Tex Inc 分離膜チューブ及び分離膜モジュール
US6613280B2 (en) 2001-03-20 2003-09-02 Therox, Inc. Disposable cartridge for producing gas-enriched fluids
US6974447B2 (en) 2001-04-17 2005-12-13 Baxter International Inc. High gas barrier receptacle and closure assembly
CN2502700Y (zh) 2001-05-10 2002-07-31 张明礼 血液收集装置
US6697667B1 (en) 2001-05-31 2004-02-24 Advanced Cardiovascular Systems, Inc. Apparatus and method for locating coronary sinus
ES2320424T3 (es) 2001-07-31 2009-05-22 Asahi Kasei Medical Co., Ltd. Filtro de eliminacion de leucocitos que comprende un recubrimiento polimerico.
US7909788B2 (en) 2001-08-01 2011-03-22 Battelle Memorial Institute Carbon dioxide removal from whole blood by photolytic activation
US6682698B2 (en) 2001-08-23 2004-01-27 Michigan Critical Care Consultants, Inc. Apparatus for exchanging gases in a liquid
DE10151343A1 (de) 2001-10-22 2003-05-08 Vita 34 Ag Beutelsystem für die Kryokonservierung von Körperflüssigkeiten
CA2467087A1 (fr) 2001-11-16 2003-05-30 Hemanext, Llc Solution d'additif pour la conservation de sang
EP1455860B1 (fr) 2001-12-10 2011-08-31 CaridianBCT, Inc. Procedes de leucoreduction de globules rouges
EP1470686A1 (fr) 2002-01-31 2004-10-27 Telefonaktiebolaget LM Ericsson (publ) Procede pour generer des flux multiples de supports sdp dans un contexte pop unique
US6761695B2 (en) 2002-03-07 2004-07-13 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Method and apparatus for non-invasive measurement of changes in intracranial pressure
AU2003213758A1 (en) 2002-03-14 2003-09-29 Fenwal, Inc. Compound removal device
CN1642628B (zh) 2002-03-19 2010-06-16 安格斯公司 中空纤维膜接触装置及方法
US20030183801A1 (en) 2002-03-28 2003-10-02 Hu Yang Porous oxygen scavenging material
US6773407B2 (en) 2002-04-08 2004-08-10 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Non-invasive method of determining absolute intracranial pressure
US20030190272A1 (en) 2002-04-08 2003-10-09 Dennis Raine Sterilization containers and methods for radiation sterilization of liquid products
JP4376635B2 (ja) 2002-04-16 2009-12-02 カリディアンビーシーティー、インコーポレーテッド 血液成分処理システム、装置、および方法
US7183045B2 (en) 2002-04-24 2007-02-27 Gambro Inc. Removal of adenine during a pathogen reduction process in whole blood or red blood cell by dilution
US6899743B2 (en) 2002-06-12 2005-05-31 Membrane Technology And Research, Inc. Separation of organic mixtures using gas separation or pervaporation and dephlegmation
US6878335B2 (en) 2002-06-21 2005-04-12 Vital Signs, Inc. Process of manufacturing a breathing bag and breathing bag manufactured by such process
US6817979B2 (en) 2002-06-28 2004-11-16 Nokia Corporation System and method for interacting with a user's virtual physiological model via a mobile terminal
JP2004089495A (ja) 2002-08-30 2004-03-25 Terumo Corp バッグ連結体
US20080160107A1 (en) 2002-09-10 2008-07-03 Nitric Biotherapeutics, Inc. Use of nitric oxide gas to treat blood and blood products
AU2003290677B2 (en) 2002-11-08 2009-09-17 The Brigham And Women's Hospital, Inc. Compositions and methods for prolonging survival of platelets
US6899822B2 (en) 2002-11-18 2005-05-31 Multisorb Technologies, Inc. Oxygen-absorbing composition
DE10327988B4 (de) 2002-12-18 2009-05-14 Alpha Plan Gmbh Filtermodul zur Aufbereitung von Flüssigkeiten
ITTO20030039A1 (it) 2003-01-24 2004-07-25 Fresenius Hemocare Italia Srl Filtro per separare leucociti da sangue intero e/o da preparati derivati dal sangue, procedimento per la fabbricazione del filtro, dispositivo e utilizzazione.
US8828226B2 (en) 2003-03-01 2014-09-09 The Trustees Of Boston University System for assessing the efficacy of stored red blood cells using microvascular networks
US7517453B2 (en) 2003-03-01 2009-04-14 The Trustees Of Boston University Microvascular network device
US20040254560A1 (en) 2003-06-11 2004-12-16 Coelho Philip H. Rupture resistant blow molded freezer bag for containing blood products
US7078100B2 (en) 2003-08-28 2006-07-18 Cryovac, Inc. Oxygen scavenger compositions derived from isophthalic acid and/or terephthalic acid monomer or derivatives thereof
US7754798B2 (en) 2003-08-28 2010-07-13 Cryovac, Inc. Oxygen scavenger block copolymers and compositions
US8070952B2 (en) 2003-10-03 2011-12-06 Medical Service S.R.L. Apparatus and method for the treatment of blood
US7097690B2 (en) 2003-10-10 2006-08-29 Scimed Life Systems, Inc. Apparatus and method for removing gasses from a liquid
US20050085785A1 (en) 2003-10-17 2005-04-21 Sherwin Shang High impact strength film and non-pvc containing container and pouch and overpouch
CN1878582B (zh) 2003-11-24 2011-05-25 甘布罗伦迪亚股份公司 脱气设备以及具有这种脱气设备的过滤器的端盖组件
US20050137517A1 (en) 2003-12-19 2005-06-23 Baxter International Inc. Processing systems and methods for providing leukocyte-reduced blood components conditioned for pathogen inactivation
US7347887B2 (en) 2003-12-22 2008-03-25 The Boc Group, Inc. Oxygen sorbent compositions and methods of using same
US20050139806A1 (en) 2003-12-24 2005-06-30 Havens Marvin R. Oxygen scavenger compositions
US7125498B2 (en) 2004-02-04 2006-10-24 Multisorb Technologies, Inc. Oxygen-absorbing compositions and method
US9314014B2 (en) 2004-02-18 2016-04-19 University Of Maryland, Baltimore Compositions and methods for the storage of red blood cells
JP4579569B2 (ja) 2004-04-16 2010-11-10 株式会社クレハ 多層二軸延伸ブローボトル及びその製造方法
WO2006031385A2 (fr) 2004-08-24 2006-03-23 The General Hospital Corporation Dispositifs, systemes et procedes de separation de particules
US20060081524A1 (en) 2004-10-15 2006-04-20 Amitava Sengupta Membrane contactor and method of making the same
KR100721054B1 (ko) 2004-11-23 2007-05-25 주식회사 뉴하트바이오 혈액정화 및/또는 혈액산화용 필터모듈, 그를 이용한혈액정화 및 혈액산화 방법 그리고 그를 포함하는혈액정화 장치
CA2592432A1 (fr) 2004-12-23 2006-07-06 Hospira, Inc. Systeme de fermeture d'orifices pour recipient de fluide intraveineux
US20100221697A1 (en) 2005-01-12 2010-09-02 BioVec Transfusions, LLC Composition for preserving platelets and method of using and storing the same
EP1683579A1 (fr) 2005-01-25 2006-07-26 Jean-Denis Rochat Dispositif jetable pour la séparation en continu par centrifugation d'un liquide physiologique
US7465335B2 (en) 2005-02-02 2008-12-16 United Technologies Corporation Fuel deoxygenation system with textured oxygen permeable membrane
BRPI0520102A2 (pt) 2005-02-17 2009-04-22 Univ Cincinnati composiÇço aquosa para armazenagem de hemÁcias suspensço de hemÁcias, mÉtodo de preservaÇço de hemÁcias ou glàbulos vermelhos do sangue ("red blood cells" - rbc`s) durante um perÍodo de armazenagem, mÉtodo para aperfeiÇoamento da manutenÇço de membrana de hemÁcias ou glàbulos vermelhos do sangue ("red blood cells" - rbc) e supressço de apoptose de rbc`s durante um perÍodo de armazenagem, mÉtodo para reduÇço de fragilidade de hemÁcias (rbc`s) e supressço de hemàlise de rbc`s durante um perÍodo de armazenagem, mÉtodo para aumentar a viabilidade de hemÁcias (rbc`s), mÉtodo de preservaÇço de hamÁcias (rbc`s) durante um perÍodo de armazenagem, combinaÇço, e composiÇço aquosa
JP3772909B1 (ja) 2005-04-04 2006-05-10 東洋紡績株式会社 血液浄化器
US20060226087A1 (en) 2005-04-08 2006-10-12 Mission Medical, Inc. Method and apparatus for blood separations
CN2780207Y (zh) 2005-04-12 2006-05-17 浙江科锐生物科技有限公司 一次性使用的活性炭血液灌流器
AU2006236150A1 (en) 2005-04-20 2006-10-26 Fred Hutchinson Cancer Research Center Methods, compositions and articles of manufacture for enhancing survivability of cells, tissues, organs, and organisms
JP4584018B2 (ja) 2005-05-09 2010-11-17 日東電工株式会社 脱気装置
US7465336B2 (en) 2005-06-09 2008-12-16 United Technologies Corporation Fuel deoxygenation system with non-planar plate members
CN2894710Y (zh) 2006-03-31 2007-05-02 天津市海河医院 医用血气交换器
US7763097B2 (en) 2006-06-08 2010-07-27 University of Pittsburgh—of the Commonwealth System of Higher Education Devices, systems and methods for reducing the concentration of a chemical entity in fluids
US7517146B2 (en) 2006-08-30 2009-04-14 Temptime Corporation Color-retaining excess-temperature exposure indicator
US7713614B2 (en) 2006-09-19 2010-05-11 Kuraray Co., Ltd. Resin composition and multilayer structure
BRPI0717293A2 (pt) 2006-09-25 2013-10-15 Nipro Corp Recipiente de plástico moldado a sopro para infusão
US20080098894A1 (en) 2006-11-01 2008-05-01 Sabatino Daniel R Acoustic degassing heat exchanger
WO2008089337A1 (fr) 2007-01-19 2008-07-24 The Regents Of The University Of Michigan Compositions et méthodes destinées à la conservation d'érythrocytes
JP2008253452A (ja) 2007-04-03 2008-10-23 Sekisui Chem Co Ltd 真空採血管
US8398743B2 (en) 2007-05-08 2013-03-19 General Electric Company Methods and systems for reducing carbon dioxide in combustion flue gases
KR101071402B1 (ko) 2007-09-11 2011-10-07 (주) 비에이치케이 혈액 정화장치
EP2252362A1 (fr) 2008-02-07 2010-11-24 University of Pittsburgh - Of the Commonwealth System of Higher Education Dispositifs, systèmes et procédés d échange de gaz intracorporel
EP2113266A1 (fr) 2008-04-30 2009-11-04 Gambro Lundia AB Dispositif de dégazage
EP2274083A1 (fr) 2008-04-30 2011-01-19 Gambro Lundia AB Membrane hydrophobe de désaération
JP5560459B2 (ja) 2008-10-17 2014-07-30 三菱マテリアル株式会社 金属ナノ粒子の合成方法
US8177884B2 (en) 2009-05-20 2012-05-15 United Technologies Corporation Fuel deoxygenator with porous support plate
US8377172B2 (en) 2009-06-11 2013-02-19 Georgia Tech Research Corporation Fiber sorbents
AU2010278768A1 (en) 2009-07-31 2012-03-15 New Health Sciences, Inc. Removal of oxygen from biological fluids
US9044880B2 (en) 2009-08-04 2015-06-02 Mitsubishi Gas Chemical Company, Inc. Method for producing container
WO2011046841A1 (fr) * 2009-10-12 2011-04-21 New Health Sciences, Inc. Système de sac de stockage de sang et dispositifs d'épuisement avec capacités d'épuisement en dioxyde de carbone et en oxygène
WO2011046963A1 (fr) 2009-10-12 2011-04-21 New Health Sciences, Inc. Dispositifs d'appauvrissement en oxygène et procédés pour retirer l'oxygène de globules rouges
US9199016B2 (en) 2009-10-12 2015-12-01 New Health Sciences, Inc. System for extended storage of red blood cells and methods of use
JP2011092905A (ja) 2009-10-30 2011-05-12 Japan Gore Tex Inc 脱気膜の製造方法、封筒状物、および該封筒状物を用いた脱気装置
WO2011068897A1 (fr) 2009-12-01 2011-06-09 Exthera Medical, Llc Procédé d'élimination de cytokines du sang par des polysaccharides immobilisés en surface
US20130197420A1 (en) 2010-01-19 2013-08-01 William H. Fissell, IV Nanoporous membranes, devices, and methods for respiratory gas exchange
EP4091645A1 (fr) 2010-08-25 2022-11-23 Hemanext Inc. Procédé d'amélioration de la qualité et de la survie des globules rouges pendant le stockage
EP4218412A1 (fr) 2010-11-05 2023-08-02 Hemanext Inc. Irradiation de globules rouges et stockage anaérobie
US20120219633A1 (en) 2011-02-28 2012-08-30 Pall Corporation Removal of immunoglobulins and leukocytes from biological fluids
EP2684551B1 (fr) 2011-03-09 2021-10-06 Terumo Kabushiki Kaisha Système pour distribuer un transporteur d'oxygène, dispositif d'oxygénation pour transporteur d'oxygène, et boîtier pour transporteur d'oxygène
AU2012294890B2 (en) 2011-03-28 2017-05-18 Hemanext Inc. Method and system for removing oxygen and carbon dioxide during red cell blood processing using an inert carrier gas and manifold assembly
US9067004B2 (en) 2011-03-28 2015-06-30 New Health Sciences, Inc. Method and system for removing oxygen and carbon dioxide during red cell blood processing using an inert carrier gas and manifold assembly
JP2014518283A (ja) 2011-07-05 2014-07-28 ニュー・ヘルス・サイエンシーズ・インコーポレイテッド 赤血球の長期保存システムおよび使用方法
EP4074395B1 (fr) 2011-08-10 2024-01-24 Hemanext Inc. Dispositif de filtre de séparation intégré de plasma et de leucocytes à appauvrissement en oxygène et/ou en co2
US9742735B2 (en) 2012-04-13 2017-08-22 Ologn Technologies Ag Secure zone for digital communications
EP2852461B1 (fr) 2012-05-22 2022-06-15 Hemanext Inc. Systèmes à réseau capillaire et leurs procédés d'utilisation
US9083010B2 (en) 2012-07-18 2015-07-14 Nthdegree Technologies Worldwide Inc. Diatomaceous energy storage devices
US9057901B2 (en) 2012-11-29 2015-06-16 Shenzhen China Star Optoelectronics Technology Co., Ltd Plastic frame, backlight module and liquid crystal display device
US20140158604A1 (en) 2012-12-12 2014-06-12 Jacques Chammas Platelet Storage Container
CA2902061C (fr) 2013-02-28 2023-08-08 New Health Sciences, Inc. Dispositifs d'appauvrissement de gaz et d'addition de gaz pour traitement sanguin
US20140248005A1 (en) 2013-03-01 2014-09-04 Stokely-Van Camp, Inc. Stand-Up Pouch
US9174771B2 (en) 2013-03-15 2015-11-03 Sangart, Inc. Packaging system for preserving a nonoxygenated hemoglobin based oxygen therapeutic product
WO2014194931A1 (fr) 2013-06-03 2014-12-11 Onderzoeks- En Ontwikkelingsfonds Rode Kruis-Vlaanderen Traitement de réduction d'agent pathogène
PT3268015T (pt) 2015-03-10 2022-01-06 Hemanext Inc Kits descartáveis de redução de oxigénio, dispositivos e métodos de utilização dos mesmos
EP3285711A4 (fr) 2015-04-23 2018-11-07 New Health Sciences, Inc. Récipients de stockage de sang anaérobie

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5362442A (en) 1993-07-22 1994-11-08 2920913 Canada Inc. Method for sterilizing products with gamma radiation
US6403124B1 (en) 1997-04-16 2002-06-11 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Storage and maintenance of blood products including red blood cells and platelets
US6482585B2 (en) 1997-04-16 2002-11-19 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Storage and maintenance of blood products including red blood cells and platelets
US6162396A (en) * 1997-04-26 2000-12-19 The Regents Of The University Of California Blood storage device and method for oxygen removal
WO1998051147A1 (fr) * 1997-05-15 1998-11-19 The Regents Of The University Of California Stockage prolonge a froid de globules rouges par elimination d'oxygene et utilisation d'additif
WO2003043571A2 (fr) * 2001-11-16 2003-05-30 Hollinger Digital, Inc. Procede pour allonger la duree de conservation utile de globules rouges refrigeres par un supplement nutritif
WO2003086577A1 (fr) * 2002-04-08 2003-10-23 Teva Medical Ltd. Preparation d'un filtre a leucocytes et procede d'utilisation de ce filtre
WO2003103390A1 (fr) * 2002-06-07 2003-12-18 Promethean Lifesciences, Inc. Sterilisation, stabilisation et conservation de matiere vivante
WO2008034476A1 (fr) * 2006-09-19 2008-03-27 Maco Pharma S.A. Systeme de sacs de sang et procede d'inactivation d'agents pathogenes dans des concentres de plaquettes au moyen de ce systeme

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
HOLME ET AL: "Current issues related to the quality of stored RBCs", TRANSFUSION AND APHERESIS SCIENCE, ELSEVIER SCIENCE, LONDON, GB, vol. 33, no. 1, 1 August 2005 (2005-08-01), pages 55 - 61, XP027724754, ISSN: 1473-0502, [retrieved on 20050801] *
P ; AGARWAL ET AL: "Effect of pre-storage gamma irradiation on red blood cells", INDIAN JOURNAL OF MEDICAL RESEARCH NOV, vol. 122, no. 5, 1 January 2005 (2005-01-01), pages 385, XP055464831 *
TATSURO YOSHIDA ET AL: "Anaerobic storage of red blood cells", BLOOD TRANSFUSION, vol. 8, 1 January 2010 (2010-01-01), pages 220 - 36, XP055090172, DOI: 10.2450/2010.0022-10 *

Also Published As

Publication number Publication date
PT3539381T (pt) 2023-09-26
JP2014501501A (ja) 2014-01-23
US20160242410A9 (en) 2016-08-25
JP5859558B2 (ja) 2016-02-10
EP3539381B1 (fr) 2023-05-24
CA2817106A1 (fr) 2012-05-10
CA2817106C (fr) 2020-08-25
ES2793484T3 (es) 2020-11-16
EP2635114B1 (fr) 2020-04-29
US20120115124A1 (en) 2012-05-10
WO2012061731A1 (fr) 2012-05-10
EP3539381A1 (fr) 2019-09-18
EP2635114A1 (fr) 2013-09-11
EP2635114A4 (fr) 2014-12-03
PT2635114T (pt) 2020-06-16
US10136635B2 (en) 2018-11-27
ES2957338T3 (es) 2024-01-17

Similar Documents

Publication Publication Date Title
EP2635114B1 (fr) Irradiation des globules rouges et conservation anaérobie
US8535421B2 (en) Blood storage bag system and depletion devices with oxygen and carbon dioxide depletion capabilities
US8569052B2 (en) Oxygen depletion devices and methods for removing oxygen from red blood cells
CA2840901C (fr) Systeme pour le stockage prolonge des erythrocytes et procedes d'utilisation
US11284616B2 (en) Irradiation of red blood cells and anaerobic storage
EP4091645A1 (fr) Procédé d'amélioration de la qualité et de la survie des globules rouges pendant le stockage
US20220211030A1 (en) Irradiation of Red Blood Cells and Anaerobic Storage

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION HAS BEEN PUBLISHED

AC Divisional application: reference to earlier application

Ref document number: 2635114

Country of ref document: EP

Kind code of ref document: P

Ref document number: 3539381

Country of ref document: EP

Kind code of ref document: P

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20240202

RBV Designated contracting states (corrected)

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR