EP3962605A1 - Composition de soins buccodentaires - Google Patents
Composition de soins buccodentairesInfo
- Publication number
- EP3962605A1 EP3962605A1 EP20798027.7A EP20798027A EP3962605A1 EP 3962605 A1 EP3962605 A1 EP 3962605A1 EP 20798027 A EP20798027 A EP 20798027A EP 3962605 A1 EP3962605 A1 EP 3962605A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- nisin
- oral care
- sodium bicarbonate
- weight
- care composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 82
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims abstract description 126
- NVNLLIYOARQCIX-MSHCCFNRSA-N Nisin Chemical compound N1C(=O)[C@@H](CC(C)C)NC(=O)C(=C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@@H](NC(=O)C(=C/C)/NC(=O)[C@H](N)[C@H](C)CC)CSC[C@@H]1C(=O)N[C@@H]1C(=O)N2CCC[C@@H]2C(=O)NCC(=O)N[C@@H](C(=O)N[C@H](CCCCN)C(=O)N[C@@H]2C(NCC(=O)N[C@H](C)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCSC)C(=O)NCC(=O)N[C@H](CS[C@@H]2C)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H](CCSC)C(=O)N[C@H](CCCCN)C(=O)N[C@@H]2C(N[C@H](C)C(=O)N[C@@H]3C(=O)N[C@@H](C(N[C@H](CC=4NC=NC=4)C(=O)N[C@H](CS[C@@H]3C)C(=O)N[C@H](CO)C(=O)N[C@H]([C@H](C)CC)C(=O)N[C@H](CC=3NC=NC=3)C(=O)N[C@H](C(C)C)C(=O)NC(=C)C(=O)N[C@H](CCCCN)C(O)=O)=O)CS[C@@H]2C)=O)=O)CS[C@@H]1C NVNLLIYOARQCIX-MSHCCFNRSA-N 0.000 claims abstract description 72
- 108010053775 Nisin Proteins 0.000 claims abstract description 72
- 239000004309 nisin Substances 0.000 claims abstract description 72
- 235000010297 nisin Nutrition 0.000 claims abstract description 72
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims abstract description 63
- 235000017557 sodium bicarbonate Nutrition 0.000 claims abstract description 63
- 238000009472 formulation Methods 0.000 claims abstract description 21
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims abstract description 4
- 238000000034 method Methods 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 239000003795 chemical substances by application Substances 0.000 claims description 5
- 239000003755 preservative agent Substances 0.000 claims description 4
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims description 3
- 239000003082 abrasive agent Substances 0.000 claims description 3
- 239000004599 antimicrobial Substances 0.000 claims description 3
- 239000011230 binding agent Substances 0.000 claims description 3
- 238000004140 cleaning Methods 0.000 claims description 3
- 239000003086 colorant Substances 0.000 claims description 3
- 239000003975 dentin desensitizing agent Substances 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000013355 food flavoring agent Nutrition 0.000 claims description 3
- 235000003599 food sweetener Nutrition 0.000 claims description 3
- 239000003906 humectant Substances 0.000 claims description 3
- 238000005498 polishing Methods 0.000 claims description 3
- 239000004094 surface-active agent Substances 0.000 claims description 3
- 239000003765 sweetening agent Substances 0.000 claims description 3
- 239000002562 thickening agent Substances 0.000 claims description 3
- 239000000463 material Substances 0.000 claims 2
- 238000002474 experimental method Methods 0.000 description 18
- 239000000243 solution Substances 0.000 description 11
- 239000012488 sample solution Substances 0.000 description 9
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 239000000606 toothpaste Substances 0.000 description 6
- 229940034610 toothpaste Drugs 0.000 description 6
- 239000000499 gel Substances 0.000 description 4
- 230000009467 reduction Effects 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- 239000002324 mouth wash Substances 0.000 description 3
- 229940051866 mouthwash Drugs 0.000 description 3
- 239000002953 phosphate buffered saline Substances 0.000 description 3
- 239000004793 Polystyrene Substances 0.000 description 2
- 241000194019 Streptococcus mutans Species 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 239000007621 bhi medium Substances 0.000 description 2
- 210000004556 brain Anatomy 0.000 description 2
- 229940112822 chewing gum Drugs 0.000 description 2
- 235000015218 chewing gum Nutrition 0.000 description 2
- 238000001802 infusion Methods 0.000 description 2
- 239000007937 lozenge Substances 0.000 description 2
- 239000002609 medium Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 229920002223 polystyrene Polymers 0.000 description 2
- 210000003296 saliva Anatomy 0.000 description 2
- 239000000523 sample Substances 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- 239000000253 Denture Cleanser Substances 0.000 description 1
- 208000003433 Gingival Pocket Diseases 0.000 description 1
- 230000003214 anti-biofilm Effects 0.000 description 1
- 230000002272 anti-calculus Effects 0.000 description 1
- 230000002882 anti-plaque Effects 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000032770 biofilm formation Effects 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 239000000551 dentifrice Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
- 239000007938 effervescent tablet Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000007935 oral tablet Substances 0.000 description 1
- 229940096978 oral tablet Drugs 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000005201 scrubbing Methods 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/92—Oral administration
Definitions
- the present invention relates to an oral care composition for at least toothpaste, mouthwash, gel, chewing gum, and lozenges.
- One embodiment discloses an oral care composition that aids in cleaning teeth including greater than 0.0% by weight sodium bicarbonate and greater than 0.0% by weight of nisin to more effectively remove biofilm from a tooth surface than either sodium bicarbonate or nisin alone.
- Another embodiment discloses a method of treating teeth including applying an oral care composition to a tooth surface.
- the composition includes greater than 0.0% by weight sodium bicarbonate and greater than 0.0% by weight of nisin to more effectively remove biofilm from a tooth surface than either sodium bicarbonate or nisin alone.
- Another embodiment discloses an oral care composition that aids in cleaning teeth, the oral care composition including at least 15% by weight sodium bicarbonate and at least 0.000375% by weight of nisin, wherein a ratio of sodium bicarbonate to nisin is at least 500 to 1 and does not exceed 200,000 to 1.
- Another embodiment discloses a method of treating teeth including applying an oral care composition to a tooth surface.
- the composition including at least 15% by weight sodium bicarbonate and at least 0.000375% by weight of nisin, wherein a ratio of sodium bicarbonate to nisin is at least 500 to 1 and does not exceed 200,000 to 1.
- An oral care composition including a base formulation, sodium bicarbonate, and nisin, wherein the oral care composition removes biofilm from a tooth surface more effectively than the base formulation with the sodium bicarbonate or the nisin alone.
- FIG. 1 graphically shows the results of Experiment 1.
- FIG. 2 graphically shows the results of Experiment 2 in which sample solution numbers 10-13 include 0.0% by weight nisin and varying concentrations of sodium bicarbonate.
- FIG. 3 graphically shows the results of Experiment 2 in which sample solution numbers 14-22 include varying concentrations of nisin and 0.0% by weight sodium bicarbonate.
- FIG. 4 graphically shows the results of Experiment 2 in which sample solution numbers 23-32 include varying concentrations of nisin and 15.0% by weight sodium bicarbonate.
- FIG. 5 graphically shows the results of Experiment 2 in which sample solution numbers 33-42 include varying concentrations of nisin and 51.0% by weight sodium bicarbonate.
- FIG. 6 graphically shows the results of Experiment 2 in which sample solution numbers 43-52 include varying concentrations of nisin and 75.0% by weight sodium bicarbonate.
- FIG. 7 graphically shows the results of Experiment 2 in which sample solution numbers 53-62 include varying concentrations of nisin and 90.0% by weight sodium bicarbonate.
- Biofilm can consist of multiple species of bacteria excreting a slimy glue-like substance that sticks to the surface of teeth.
- the most efficient measure to remove biofilm is mechanical scrubbing by a toothbrush.
- an oral composition e.g., a toothpaste, dentifrice, gel, mouthwash, lozenges, etc.
- sodium bicarbonate and nisin remove plaque effectively.
- Nisin has been used in oral care technology as a bactericide and has been used in food industry as a preservative for its antibacterial effect. Also, there are research reports to utilize Nisin in oral care to prevent or reduce biofilm. When used together in an oral care composition, sodium bicarbonate and nisin remove plaque more effectively than either of the two components alone.
- the oral care composition may optionally include surfactants, soothing or
- desensitizing agents flavoring agents, sweetening agents, humectant agents, coloring agents, additional polishing or abrasive materials, additional antimicrobial agents, binders or thickening agents, fluoride, preservatives, and water.
- the present disclosure provides an oral care composition
- a base formulation comprising a base formulation, sodium bicarbonate, and nisin, wherein the oral care composition removes biofilm from a tooth surface more effectively than the base formulation with the sodium bicarbonate or the nisin alone.
- base formulation refers to a formulation that includes at least one of the oral care ingredients described herein, but does not include sodium bicarbonate or nisin.
- the base formulation may have the same composition as the oral care composition, except that sodium bicarbonate and nisin are absent in the base formulation. Under the same testing conditions, the oral care composition as described herein can achieve higher efficacy in removing biofilm from a tooth surface than the base formulation, the base
- oral care compositions discussed herein may be prepared by any suitable method.
- S mutans streptococcus mutans
- BHI brain heart infusion
- the S mutans solution was diluted with the BHI medium with 0.5% sucrose to adjust the number of bacteria to 10 8 cfu/ml. This step ensures that the S mutans concentration is consistent for each sample.
- 200 pL of the resulting S mutans solution was injected into 96-well polystyrene microplates and cultured for 24 hours at 37 degrees Celsius under anaerobic conditions to form the biofilm.
- the biofilm in each of the wells was washed with phosphate-buffered saline (“PBS”) once. Then, the biofilms in each of the wells were exposed to respective sample solutions 1-9 listed below in Table 1 for 10 minutes, and then the exposed-biofilms were each washed with PBS three times. As shown in the table below, each of the samples has different concentrations of sodium bicarbonate and nisin. Finally, the wells of exposed-biofilm were dissolved with 200 pL IN NaOH, and the efficacy of each solution to remove the biofilm in the respective well was measured using UV-vis spectrophotometric optical density at a wavelength of 550 nm (OD550).
- PBS phosphate-buffered saline
- each of the samples has specified concentrations by weight of sodium bicarbonate and nisin.
- the percentage of biofilm removal represents the reduction of biofilm as a result of applying the samples to the biofilm.
- the results from Experiment 1 are presented in graphical form in FIG. 1, which shows that samples including both sodium bicarbonate and nisin are more effective at removing biofilm than the samples with only one of sodium bicarbonate and nisin.
- Experiment 1 was carried out using an aqueous solution having the concentrations reported in Table 1.
- the concentrations may vary according to the specific oral care product.
- the oral care composition is a toothpaste
- the concentrations of sodium bicarbonate and nisin reported in Table 1 may be increased because the toothpaste when used by a user will be diluted by saliva to about as much as 1/2 to 1/5.
- the oral care composition is a gel or mouthwash, it may not be diluted as much during use as a toothpaste so the concentrations of sodium bicarbonate and nisin may remain closer to the concentrations reported in Table 1.
- Experiment 2 also treated laboratory-created biofilms with different samples of the oral care solutions as noted in Tables 2-7.
- the experimental set up is the same as the experimental setup for Experiment 1, except for a few differences.
- a streptococcus mutans (“S mutans”) solution was cultured in a brain heart infusion (“BHI”) medium overnight at 37 degrees Celsius and under anaerobic conditions.
- BHI brain heart infusion
- the S mutans solution was diluted with the BHI medium with 0.5% sucrose to adjust the number of bacteria to 10 8 cfu/ml. This step ensures that the S mutans concentration is consistent for each sample.
- 200 pL of the resulting S mutans solution was injected into 96-well polystyrene microplates and cultured for 24 hours at 37 degrees Celsius under anaerobic conditions to form the biofilm.
- the biofilm in each of the wells was washed with deionized water (“DI”) once. Then, the sample solutions were diluted to 1/3 with DI water. This step mimics the dilution of the solution by a user’s saliva, when in use. Then, the biofilms in each of the wells were exposed to respective sample solutions listed below in Tables 2-7 for 10 minutes, and then the exposed-biofilms were each washed with DI water three times. As shown in the Tables 2-7 below, each of the samples 10-62 has different concentrations of sodium bicarbonate and nisin.
- each of the samples has specified concentrations by weight of sodium bicarbonate and nisin.
- the percentage of biofilm removal represents the reduction of biofilm as a result of applying the samples to the biofilm.
- the results from Experiment 2 are presented in graphical form in FIGS. 2-7.
- the samples including both sodium bicarbonate and nisin are more effective at removing biofilm than the samples with only one of sodium bicarbonate and nisin.
- nisin concentration ranges from 0.000375% and 0.03% by weight and the sodium bicarbonate concentration ranges from 15% to 90% by weight when the nisin concentration ranges 0.0015% and 0.015% by weight and the sodium bicarbonate concentration ranges from 15% to 75% by weight, and when the nisin concentration ranges from 0.003% and 0.015% by weight and the sodium bicarbonate concentration ranges from 15% to 75% by weight.
- the nisin concentration may be 0.003% by weight and the sodium bicarbonate concentration may be 51% by weight.
- Experiment 2 was carried out using an aqueous solution having the concentrations reported in Tables 2-7. In actual oral care products using the disclosed combination, the concentrations may vary according to the specific oral care product. Regardless of the type oral care composition, it is believed that the ratios between sodium bicarbonate and nisin will be similar to those shown in the experiment. That is, the ratio of sodium bicarbonate to nisin may range from a ratio of 500 to 1 (e.g., 15% by weight sodium bicarbonate to 0.03% by weight nisin) to a ratio of 200,000 to 1 (e.g., 75% by weight sodium bicarbonate to 0.000375% by weight nisin).
- the ratio of sodium bicarbonate to nisin may range from 1000 to 1 to 25000 to 1, from 2500 to 1 to 17000 to 1, or from 3400 to 1 to 17000 to 1. In one embodiment, for example, the ratio of sodium bicarbonate to nisin may be 5000 to 1. In another embodiment, for example, the ratio of sodium bicarbonate to nisin may be 3400 to 1.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Emergency Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Cosmetics (AREA)
Abstract
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962840229P | 2019-04-29 | 2019-04-29 | |
US16/704,911 US11304888B2 (en) | 2019-04-29 | 2019-12-05 | Oral care composition |
PCT/US2020/029363 WO2020223082A1 (fr) | 2019-04-29 | 2020-04-22 | Composition de soins buccodentaires |
Publications (2)
Publication Number | Publication Date |
---|---|
EP3962605A1 true EP3962605A1 (fr) | 2022-03-09 |
EP3962605A4 EP3962605A4 (fr) | 2023-05-10 |
Family
ID=72916929
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP20798027.7A Pending EP3962605A4 (fr) | 2019-04-29 | 2020-04-22 | Composition de soins buccodentaires |
Country Status (9)
Country | Link |
---|---|
US (1) | US11304888B2 (fr) |
EP (1) | EP3962605A4 (fr) |
JP (1) | JP2022530614A (fr) |
AR (1) | AR118806A1 (fr) |
BR (1) | BR112021021678B1 (fr) |
CA (1) | CA3131938A1 (fr) |
CO (1) | CO2021012300A2 (fr) |
MX (1) | MX2021013137A (fr) |
WO (1) | WO2020223082A1 (fr) |
Family Cites Families (127)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB551369A (en) | 1940-06-11 | 1943-02-19 | Conrad Lawrence Walsh | Improvements in the manufacture of toilette preparations and the like |
GB1209319A (en) | 1967-12-20 | 1970-10-21 | Anneliese Scheller | Improved toothpaste |
US3935304A (en) | 1972-10-04 | 1976-01-27 | Colgate-Palmolive Company | Dental creams |
CH593062A5 (fr) | 1972-10-04 | 1977-11-15 | Colgate Palmolive Co | |
ZA737238B (en) | 1972-10-04 | 1975-04-30 | Colgate Palmolive Co | Toothpaste |
ZA737237B (en) | 1972-10-04 | 1975-04-30 | Colgate Palmolive Co | Dental creams |
US3935305A (en) | 1972-10-04 | 1976-01-27 | Colgate-Palmolive Company | Toothpaste |
US3937321A (en) | 1972-10-04 | 1976-02-10 | Colgate-Palmolive Company | Toothpaste |
US3943240A (en) | 1973-08-20 | 1976-03-09 | Colgate-Palmolive Company | Toothpaste |
PH13727A (en) | 1974-05-30 | 1980-09-09 | Colgate Palmolive Co | Toothpaste |
US4160022A (en) | 1975-09-15 | 1979-07-03 | Colgate Palmolive Company | Toothpaste |
US4575457A (en) | 1984-05-24 | 1986-03-11 | American Home Products Corporation | Periodontal toothpaste with wound-healing properties |
US4690776A (en) | 1985-02-27 | 1987-09-01 | Smigel Irwin E | Method of manufacture of a toothpaste composition |
US4603045A (en) | 1985-02-27 | 1986-07-29 | Smigel Irwin E | Toothpaste for bonded (composite filling material) as well as natural teeth |
US4623536A (en) | 1985-06-13 | 1986-11-18 | Church & Dwight Co., Inc. | Sodium bicarbonate containing toothpaste |
US5004596A (en) | 1986-01-17 | 1991-04-02 | Cocherell Francis E | Anhydrous toothpaste or dental cream composition |
US4812306A (en) | 1986-01-17 | 1989-03-14 | Cocherell Francis E | Toothpaste or dental cream composition and method of preparing same |
US5180578A (en) | 1987-01-30 | 1993-01-19 | Colgate-Palmolive Company | Antibacterial antiplaque anticalculus oral composition |
JP2561829B2 (ja) | 1987-02-06 | 1996-12-11 | 日本ゼオラ株式会社 | 練歯磨 |
US5041280A (en) | 1987-10-01 | 1991-08-20 | Epilady Usa, Inc. | Toothpaste composition for stain removal |
US5304540A (en) | 1988-06-22 | 1994-04-19 | Applied Microbiology, Inc. | Pharmaceutical bacteriocin compositions and methods for using the same |
US5217950A (en) | 1988-06-22 | 1993-06-08 | Applied Microbiology, Inc. | Nisin compositions for use as enhanced, broad range bactericides |
US5135910A (en) | 1988-06-22 | 1992-08-04 | The Public Health Research Institute Of The City Of New York | Nisin compositions for use as enhanced, broad range bactericides |
US5334582A (en) | 1988-06-22 | 1994-08-02 | Applied Microbiology, Inc. | Pharmaceutical bacteriocin compositions and methods for using the same |
US5260271A (en) | 1988-06-22 | 1993-11-09 | Applied Microbiology, Inc. | Nisin compositions for use as enhanced broad range bactericides |
EP0545911B1 (fr) | 1988-06-22 | 1996-09-11 | Applied Microbiology, Inc. | Compositions de bactériocin à lanthionine utilisées en tant que bactéricides |
US4891211A (en) | 1988-06-29 | 1990-01-02 | Church & Dwight Co., Inc. | Stable hydrogen peroxide-releasing dentifice |
JPH02250816A (ja) | 1989-03-23 | 1990-10-08 | Kao Corp | 口腔用組成物 |
US5180576A (en) | 1991-08-30 | 1993-01-19 | Church & Dwight Co., Inc. | Anticalculus dentifrices |
GB9126686D0 (en) | 1991-12-17 | 1992-02-12 | Smithkline Beecham Plc | Novel compositions |
GB9224598D0 (en) | 1992-11-24 | 1993-01-13 | Smithkline Beecham Plc | Novel compositions |
IL107887A (en) | 1992-12-08 | 2003-07-06 | Ambi Inc | Stabilized lanthionine containing bacteriocin compositions |
US5368845A (en) | 1993-01-07 | 1994-11-29 | Colgate Palmolive Company | Oral composition |
US5376360A (en) | 1993-08-30 | 1994-12-27 | Church & Dwight Co., Inc. | Baking soda toothpaste containing soluble pyrophosphate salts |
WO1995006455A1 (fr) | 1993-08-30 | 1995-03-09 | Church & Dwight Co., Inc. | Dentifrice et gel a base de bicarbonate de sodium contenant des sels pyrophosphates solubles |
US5424060A (en) | 1993-10-25 | 1995-06-13 | Church & Dwight Co., Inc. | Dentifrice composition containing stabilized sodium percarbonate |
JP3195150B2 (ja) | 1994-01-25 | 2001-08-06 | 花王株式会社 | 口腔用組成物 |
EP0691124A1 (fr) | 1994-07-07 | 1996-01-10 | Sara Lee/DE N.V. | Produits d'hygiène buccale |
JP3241946B2 (ja) | 1994-10-04 | 2001-12-25 | 花王株式会社 | 口腔用組成物 |
IES70514B2 (en) | 1995-04-12 | 1996-12-11 | Teagasc Agric Food Dev Authori | Bacteriocins |
GB9510719D0 (en) | 1995-05-26 | 1995-07-19 | Smithkline Beecham Plc | Novel compositions |
WO1997010801A2 (fr) | 1995-09-20 | 1997-03-27 | Ambi Inc. | Compositions a base de nisine prevenant la formation de caries dentaires par suppression de la production d'acide a partir d'aliments par des bacteries buccales |
FR2749576B1 (fr) | 1996-06-06 | 1998-09-04 | Rhone Poulenc Chimie | Procede de preparation de silice susceptible d'etre utilisee dans les compositions dentifrices |
JP3667472B2 (ja) | 1996-11-22 | 2005-07-06 | 花王株式会社 | 口腔用組成物 |
JPH10167939A (ja) | 1996-12-09 | 1998-06-23 | Lion Corp | 口腔用組成物 |
US5980925A (en) | 1997-12-30 | 1999-11-09 | Ethicon, Inc. | High glycerin containing anti-microbial cleansers |
KR100555038B1 (ko) | 1998-12-10 | 2006-06-20 | 주식회사 엘지생활건강 | 나이신과 유지피 추출물을 함유한 구강위생증진용 조성물 |
KR100321821B1 (ko) | 1999-11-12 | 2002-01-31 | 허권 | 송염용액의 제조방법 및 송염용액을 이용한 송염과 송염연고제 그리고 송염 치약의 제조방법 |
US7387774B2 (en) | 1999-11-12 | 2008-06-17 | The Procter & Gamble Co. | Method of enhancing fluoridation and mineralization of teeth |
US6333024B1 (en) | 2000-01-20 | 2001-12-25 | Colgate-Palmolive Company | Effervescent dual component dentifrice having reduced sensory cues |
US8283135B2 (en) | 2000-06-30 | 2012-10-09 | The Procter & Gamble Company | Oral care compositions containing combinations of anti-bacterial and host-response modulating agents |
KR100446855B1 (ko) | 2000-12-08 | 2004-09-04 | 주식회사 엘지생활건강 | 미백제로서 과산화물과 중조를 사용하는 치약 조성물내에서 미백제 자극을 낮추고 향미를 증진시키기 위한향료 조성물 |
BG65539B1 (bg) | 2002-04-23 | 2008-11-28 | Недялка ИЗМИРОВА | Средства за хигиена на устната кухина, съдържащи модифициран клиноптилолит |
US20040018155A1 (en) | 2002-07-25 | 2004-01-29 | Ronald Hoagland | Toothpaste formulation |
RO121587B1 (ro) | 2003-04-22 | 2007-12-28 | Magdalena Mititelu | Pasta de dinti, cu propolis |
US7135163B2 (en) | 2003-10-16 | 2006-11-14 | Church & Dwight Co., Inc. | Prevention of crystal formation in toothpaste |
EP1701691A4 (fr) | 2003-12-22 | 2009-11-04 | Imrex Inc | Methodes et compositions d'hygiene buccale |
CN101437485A (zh) | 2006-05-09 | 2009-05-20 | 高露洁-棕榄公司 | 口腔护理方案 |
US8900558B2 (en) | 2006-06-30 | 2014-12-02 | Colgate-Palmolive Company | High fluoride ion oral care composition and method for maintaining anticaries activity |
CN1899261B (zh) | 2006-07-26 | 2010-05-12 | 广州立白企业集团有限公司 | 一种咸味小苏打牙膏 |
US20080241117A1 (en) | 2007-04-02 | 2008-10-02 | Abdul Gaffar | Oral Care Compositions Containing a Mixed Tocopherol Component |
US20080267891A1 (en) | 2007-04-30 | 2008-10-30 | Colgate-Palmolive Company | Oral Care Composition To Reduce Or Eliminate Dental Sensitivity |
US20090186090A1 (en) | 2007-04-30 | 2009-07-23 | Colgate-Palmolive | Oral Care Composition to Reduce or Eliminate Dental Sensitivity |
US20090053267A1 (en) | 2007-08-20 | 2009-02-26 | Depierro Karen | Dentifrice composition containing silicone oil beads |
US20090269288A1 (en) | 2008-04-24 | 2009-10-29 | Zoya Lavrova | Black pearl toothpaste |
AR076180A1 (es) | 2009-04-01 | 2011-05-26 | Colgate Palmolive Co | Composiciones de uso oral para el tratamiento de la sensibilidad dental y metodos para su produccion y utilizacion |
JP2011001352A (ja) | 2009-05-19 | 2011-01-06 | Adeka Clean Aid Co Ltd | ナイシンの殺菌上有効な使用方法 |
CN101647768B (zh) | 2009-09-08 | 2011-06-08 | 上海大学 | 含有龙血竭提取物的中草药牙膏的制备方法 |
CN102711661A (zh) | 2010-01-29 | 2012-10-03 | 高露洁-棕榄公司 | 用于口腔治疗给药的牙条 |
WO2011123121A1 (fr) | 2010-03-31 | 2011-10-06 | Colgate-Palmolive Company | Composition de soin buccal |
JP5694506B2 (ja) | 2010-03-31 | 2015-04-01 | コルゲート・パーモリブ・カンパニーColgate−Palmolive Company | 口腔ケア組成物 |
RO126742B1 (ro) | 2010-10-27 | 2014-06-30 | Ana-Corina Ioniţă | Compoziţie pentru pastă de dinţi |
CN103040659A (zh) | 2011-10-11 | 2013-04-17 | 涂波 | 一种多功能保健牙膏 |
KR101544896B1 (ko) | 2011-11-29 | 2015-08-17 | 박정숙 | 천년초 분말과 천년초 추출물을 유효성분으로 함유하는 치약 조성물 및 이의 제조방법. |
CN103156788A (zh) | 2011-12-09 | 2013-06-19 | 赵英 | 一种调理型养护牙膏 |
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EP2861202B1 (fr) | 2012-06-18 | 2018-07-18 | 3M Innovative Properties Company | Composition de poudre pour le polissage d'air de la surface de tissu dentaire dur |
CN102871902A (zh) | 2012-09-14 | 2013-01-16 | 启东乾朔电子有限公司 | 一种可预防口腔溃疡的牙膏 |
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JP5750552B2 (ja) | 2012-11-14 | 2015-07-22 | 株式会社優しい研究所 | 抗菌用組成物 |
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MD4453C1 (ro) | 2015-04-27 | 2017-07-31 | Институт Химии Академии Наук Молдовы | Pastă de dinţi şi procedeu de obţinere a acesteia |
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WO2017069227A1 (fr) | 2015-10-23 | 2017-04-27 | 株式会社優しい研究所 | Composition de soins de santé comprenant une bactériocine |
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US20200337975A1 (en) | 2020-10-29 |
EP3962605A4 (fr) | 2023-05-10 |
BR112021021678A2 (fr) | 2021-12-21 |
US11304888B2 (en) | 2022-04-19 |
BR112021021678B1 (pt) | 2023-11-07 |
WO2020223082A1 (fr) | 2020-11-05 |
MX2021013137A (es) | 2021-11-25 |
CO2021012300A2 (es) | 2021-10-20 |
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JP2022530614A (ja) | 2022-06-30 |
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