EP3291786A1 - Système de prélèvement de contenu de récipient - Google Patents
Système de prélèvement de contenu de récipientInfo
- Publication number
- EP3291786A1 EP3291786A1 EP15721575.7A EP15721575A EP3291786A1 EP 3291786 A1 EP3291786 A1 EP 3291786A1 EP 15721575 A EP15721575 A EP 15721575A EP 3291786 A1 EP3291786 A1 EP 3291786A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- container
- locking
- removal
- movable
- disc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2089—Containers or vials which are to be joined to each other in order to mix their contents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2006—Piercing means
- A61J1/201—Piercing means having one piercing end
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2048—Connecting means
- A61J1/2051—Connecting means having tap means, e.g. tap means activated by sliding
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D55/00—Accessories for container closures not otherwise provided for
- B65D55/02—Locking devices; Means for discouraging or indicating unauthorised opening or removal of closure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2006—Piercing means
- A61J1/2013—Piercing means having two piercing ends
Definitions
- the invention relates to a container removal system having at least one first and at least one second container, which can be connected to one another in a media-carrying manner by means of a connection device which has a removal device which, by means of at least one locking device in a locked position, prevents a media exchange or at least allows an unlocked position in which the removal device for a removal operation is guided longitudinally movable in a receptacle of the connecting device, wherein the locking device can be converted by moving at least one of the container in an unlocked position.
- the perforable opening portion of the movable container engages the piercing mandrel and on further movement deforms the flexible plate of the withdrawing device to release the lock on the wall of the receptacle.
- the axial force acting on the locked catch depends on the perforation resistance at the opening area of the movable container. The reliability of the locking device therefore leaves something to be desired.
- the object of the invention is to provide a container removal system which is distinguished by improved functional reliability. According to the invention this object is achieved by a removal system having the features of claim 1 in its entirety.
- a key element having a physical coding is provided for forming an encryption, which is effective in the manner of a key-lock system, between the movable container and the connecting device as control means on the movable container, and as a lock the system is provided on the body of the blocking element with an opening with an internally provided physical coding such that, with suitable codes, the control means of the container can be introduced into the opening of the blocking element in order to bring it into the unlocked state.
- the coding of the key element may be formed on the cap portion of the movable container by circumferentially provided recesses or projections, in correspondence to the coding of the locking element provided by at the wall of its opening, with matching coding to the recesses and / or projections of the movable container complementary recesses and / or projections is formed.
- the arrangement may be such that at the periphery of the disc first Riegelgl members, through which the disc is releasably locked in a start position against an opening movement of the sleeve, and second latch members are provided which in their normal locking position, the locking element in hold locked state and are controllable from the locked position by contact with the introduced into the locking element control means of the movable container in an unlocked position in which they transfer the blocking element in the unlocked state.
- First and second latch members may be formed on mutually resiliently deflectable tongue parts, which are formed in the form of circumferentially distributed in the discs, raised from the disk plane tabs.
- FIG. 1 shows a perspective oblique view of an exemplary embodiment of the container removal system according to the invention
- Fig. 3 is a perspective oblique view of the vial of
- Partial view of the embodiment wherein the state is shown prior to insertion into the connection means of the sampling system; an oblique perspective view of forming part of the connecting device media removal device; an oblique perspective view of the locking element of the connecting device of the embodiment; an oblique perspective view of the cap portion of the movable vial, as seen on the free end face; in an exploded perspective oblique view, the encryption system operating according to the key-lock principle, wherein the cap member forming the key element of Figure 7 is before insertion into the locking element of Figure 6 serving as a lock of the system.
- FIG. 9 a schematically simplified drawn partial longitudinal section of the removal device containing connecting device and the associated opening portion of the movable vial, which is shown with its cap portion in a centering position prior to insertion into the locking element of the connecting device; in Fig. 9 corresponding depicting development another stage of the connection / removal process, wherein with appropriate coding of key element of the vial and serving as a lock locking element, the cap portion of the vial is partially inserted into the locking element and wherein the upper part in the drawing Fig.10 shows a comparison with Figure 9 rotated by 90 ° cutting plane;
- FIGS. 1 to 15 similar partial longitudinal sections to FIGS. 9 and 10, in which successive positions in the course of a connection
- FIG. 32 is a sketch of a cross-section of the removal device of the embodiment of FIG. 31; FIG.
- Fig. 33 is a FIGS. 30 and 31 similar sectional view of another embodiment.
- FIG. 34 shows a schematically simplified illustration of the blocking element of the exemplary embodiment of FIG. 33.
- the connecting device contains a removal device with a piercing hollow mandrel in the form of a cannula which passes through between perforation tips and is normally locked in an ineffective position, in which both perforation points of the puncturing mandrel are spaced apart from one perforable
- Opening portion 48 on the neck portion 1 1 of the vial 5 is aligned.
- a radiation-permeable film instead of the cover 1 5 is provided, a corresponding film with high-energy radiation, z. B. irradiate UV or beta radiation to kill possibly on the elastomer surface (perforation surface) existing germs.
- the coding of the cap part 1 3 ein Culturei ⁇ ger part of the vial 5 be.
- SSE caps 13 may also be part of known Herstü- ckigen plastic caps with encoding, such as those described in WO
- the outline of the cap part 1 3 has the shape of a Reuleaux triangle with rounded corners.
- the cap part 13 forms a physically coded key element with the outer circumference of the re-league triangle, wherein the coding on the cap part 1 3 is formed by recesses 21.
- the recesses 21 are in the form of circumferentially recessed grooves, the circumferential length of which is delimited by walls 23 defining radial planes with respect to the central opening 17, of which only some walls 23 are numbered in FIG.
- the axial depth of the recesses 21 is less than the thickness of the cap part 1 3, so that the recesses 21 on the visible in Fig. 7 end face is open and the main part of the vial 5 facing side of the cap part 1 3, which in Fig 8 is visible, is free from recesses 21.
- annular body 25 As a codable lock for the Sc-key lock system, an annular body 25 (see in particular Figures 6 and 8) is provided which forms a blocking element as part of the locking device of the removal device 27, which is separately dargestel in Fig. 5.
- the annular body 25 has for insertion of the key element formed by the cap member 13 on an opening 29 which is adapted to the circumference of the cap part 1 3, that has the shape of a Reuleaux triangle.
- the opening 29 On the inside, the opening 29 is provided with a coding in the form of projections 31, which, at matching coding, are complementary to the recesses 21 of the key part on the cap part 13.
- the protrusions 31 do not extend to the edge of the annular body 25 situated at the top in FIG.
- the projections 31 form upwards paragraphs, which can be brought into abutment with the corresponding paragraphs on the recessed ends of the recesses 21 of the cap part 1 3, so that in an axial advancing movement of the container or vial 5 on the infusion container 1 to the cap part 1 3 the ring body 25 inevitably entrains.
- the removal device 27 has a the inner diameter of the sleeve-shaped receptacle 9 adapted disc 35 as a carrier for a centrally located piercing spike 37 which is formed in a conventional manner as a multi-channel cannula and on both sides of the disc 35th protrudes to perforate both the opening portion 50 of the infusion bottle 1 and the opening portion 48 of the vial 5 for the opening operation.
- a centrally located piercing spike 37 which is formed in a conventional manner as a multi-channel cannula and on both sides of the disc 35th protrudes to perforate both the opening portion 50 of the infusion bottle 1 and the opening portion 48 of the vial 5 for the opening operation.
- the periphery of the disc 35 are superscript Functional elements. Of these, three guide plates are designated 39, with which the disc 35 is guided during driving movements on the inner wall of the sleeve-shaped receptacle 9.
- each two tabs each with three interconnected Zungentei len 41, 43 and 45.
- the annular element 25 forming the blocking element of the locking device is located at the upper edge of the sleeve of the receptacle 9. In this case, the annular body 35 is in the locked, ie, axially non-movable state.
- the removal device 27 located under the annular body 25 in turn is locked against axial displacement movement, because the disc 35 is engaged with the locking lugs 49 'ien to easily splaying outwardly Zungentei 41 in a locking groove 51 of the sleeve.
- the annular body 25 serving as a blocking element is also in the locked position because the tongue parts 45 of the raised lugs of the disc 35 prevent the movement of the annular body 25. This condition is shown in FIG. If the codings of the cap part 13 of the vial 5 and the annular body 25 are suitable, the cap part 13, as shown in FIGS. 10 and 11, can be introduced into the annular body 25.
- FIGS. 1 to 25 illustrate in the manner of functional sketches the encryption system provided in the exemplary embodiment shown.
- FIG. 1 shows that on the circumference of the cap part 1 3, which has the shape of a Reuleaux triangle with rounded corners, a coding region is provided on each side of the triangle, each coding region having two groups 61 and 63 with coding positions and the groups 61 , 63 are spatially offset from each other by a code-free intermediate region 65.
- the key element can be inserted in three positions (orientations) into a lock coded in the same way.
- the coding of co- depositing one of the groups 61, 63, the filling volume of the respective vial 5, while the other group 61 or 63 represents the type of an ingredient of a container.
- the coding on the cap part 13 is formed in each case by recesses 21 provided within the groups 61, 63. In the sketch-like representation of Fig. 1 7, the raw state, without coding by recesses 21 is shown.
- the coding in the respective group 61 designates the nature of a container substance, for example the type of solvent present in the infusion bottle 1
- the coding of the group 63 designates a volume, for example the volume of a solvent, of a substance contained in the vial 5 should be added or may be added.
- the annular body 25 forming the lock correspondingly identifies the projections 31 for the respective coding groups 61, 63 the volume of the infusion bottle 1 or the type of container contents, for example of the special solvent present in the infusion bottle 1.
- FIGS. 18 shows an example in which the cap part 13 signals, through a depression 21 in a first coding position of the group 61, that the vial 5 is intended for delivery to an ingredient A of the bottle 1, while the group 63 does not contain a recess 21 , which in turn signals that the bottle 1 contains a certain volume of solvent.
- a recess 21 is formed in the groups 63 over several coding positions, which signals a different solvent volume, while a depression in the groups 61 signals a different solvent, for example a solvent B, at a coding position differing from FIG , for example 50 ml, corresponding to the well in group 63.
- FIG. 21 shows that the bottle 5 is provided with a bottle 1 can be combined containing the solvent A with 250 ml.
- FIG. 22 shows, however, the combination is not possible with a bottle 1 which contains the solvent B of a different volume, for example 50 ml.
- Fig. 26 shows the selected in the embodiment described so far triangle shape
- Fig. 27 shows a different, non-circular outline shape in the form of a kind of ellipse 69.
- shape irregularities such as a pattern of protrusions and depressions, of which in FIG Fig. 28 only a projection 71 is shown, may be provided, which in turn may be provided in mutually remote groups.
- the key-lock connection is possible only in a unique, relative insertion (orientation), while in the ellipse 69 shown in Fig. 27 on both long sheet sides coding groups may be provided, so that the key-lock connection at two relative rotational positions is possible.
- recesses of a component it is also possible for recesses of a component to occur instead of the projections which then fit into projections of the respective other component.
- FIG. 29 shows a highly schematically simplified representation of an embodiment in which the body 73 of the removal device that carries the piercing mandrel 37 itself forms a kind of pot which forms the lock element with its inner wall 75 into which the cap part 13 of FIG
- Vial 5 can be used with appropriate coding so that the cap part 1 3 when applied to the body 73 moves this for the perforation. Since the body 73 is guided during the movement with its circumferential rib 75 in a threaded track 77 of the sleeve of the receptacle 9, the perforation process is advantageously carried out under a rotational movement of the piercing spigot 37th
- Fig. 30 illustrates in a highly schematically simplified representation of another embodiment of the key-lock design.
- the sleeve body forming the receptacle 9 of the connecting device and the body 73 of the removal device carrying the piercing spike 37 are already preassembled on the vial 5, although its opening region 48 has not yet been pierced.
- the coding of the key-lock system provides a pin 79 or more pins on the body, which are retractable into corresponding holes 61 which are formed as a lock on the neck portion 8 of the bottle 1 in a coded arrangement.
- Figures 31 and 32 provides as a key on the cap portion 1 3 of the vial 5, a pattern of axial bores 83 and a corresponding pattern of pins 85 on the carrier 73 of the piercing mandrel 37 before.
- a pattern of axial bores 83 and a corresponding pattern of pins 85 on the carrier 73 of the piercing mandrel 37 before.
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- Fluid Mechanics (AREA)
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Warehouses Or Storage Devices (AREA)
- Branching, Merging, And Special Transfer Between Conveyors (AREA)
- Apparatus For Making Beverages (AREA)
- Filling Of Jars Or Cans And Processes For Cleaning And Sealing Jars (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL15721575T PL3291786T3 (pl) | 2015-05-06 | 2015-05-06 | System pobierania z pojemników |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/EP2015/000921 WO2016177383A1 (fr) | 2015-05-06 | 2015-05-06 | Système de prélèvement de contenu de récipient |
Publications (2)
Publication Number | Publication Date |
---|---|
EP3291786A1 true EP3291786A1 (fr) | 2018-03-14 |
EP3291786B1 EP3291786B1 (fr) | 2019-07-10 |
Family
ID=53174971
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP15721575.7A Active EP3291786B1 (fr) | 2015-05-06 | 2015-05-06 | Système de prélèvement de contenu de récipient |
Country Status (14)
Country | Link |
---|---|
US (1) | US10932990B2 (fr) |
EP (1) | EP3291786B1 (fr) |
JP (1) | JP6595620B2 (fr) |
KR (1) | KR102444990B1 (fr) |
CN (1) | CN107567325B (fr) |
AU (1) | AU2015393961B2 (fr) |
BR (1) | BR112017022694B1 (fr) |
CA (1) | CA2984968A1 (fr) |
ES (1) | ES2749427T3 (fr) |
MX (1) | MX2017013994A (fr) |
PL (1) | PL3291786T3 (fr) |
RU (1) | RU2696486C2 (fr) |
SG (1) | SG11201708573UA (fr) |
WO (1) | WO2016177383A1 (fr) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2702333C2 (ru) * | 2015-05-06 | 2019-10-08 | Кохер-Пластик Машиненбау Гмбх | Система перемещения содержимого контейнеров |
CN109297893B (zh) * | 2018-10-26 | 2021-03-12 | 竹田(无锡)汽配制造有限公司 | 一种用于汽车零部件检验的加速热老化试验装置 |
EP3747421A1 (fr) * | 2019-06-06 | 2020-12-09 | Fresenius Kabi Deutschland GmbH | Emballage médical conçu sous forme de poche à perfusion ainsi que procédé de transfert du liquide d'une flacon dans une poche à perfusion |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5114411A (en) * | 1990-11-19 | 1992-05-19 | Habley Medical Technology Corporation | Multi-chamber vial |
JPH04329956A (ja) * | 1991-04-30 | 1992-11-18 | Takeda Chem Ind Ltd | 個別密封容器に収容した薬剤の無菌保持混合装置 |
JP2605345Y2 (ja) * | 1992-05-01 | 2000-07-10 | 株式会社大塚製薬工場 | 薬剤容器 |
CN2149899Y (zh) * | 1993-06-19 | 1993-12-22 | 张振桥 | 一次性多种药液快速汲送混合器 |
WO1995000101A1 (fr) * | 1993-06-28 | 1995-01-05 | Roussel Morishita Co., Ltd. | Recipient a usage medical |
JPH08126683A (ja) * | 1994-10-31 | 1996-05-21 | Fujisawa Pharmaceut Co Ltd | 輸液用容器 |
GB9611562D0 (en) * | 1996-06-03 | 1996-08-07 | Applied Research Systems | Device |
FR2753624B1 (fr) * | 1996-09-25 | 1999-04-16 | Biodome | Dispositif de connexion, en particulier entre un recipient avec bouchon perforable et une seringue |
DE10142450C1 (de) * | 2001-08-31 | 2003-06-18 | Aventis Behring Gmbh | Vorrichtung zum Zusammenführen von Komponenten unter sterilen Bedingungen |
CN2745587Y (zh) * | 2004-06-24 | 2005-12-14 | 霍平安 | 内压式粉针剂自动预混加药注射器 |
US20060235364A1 (en) * | 2005-04-13 | 2006-10-19 | Wizard Med, Llc | Needle-less fluid delivery assembly and error prevention system |
AU2010310457B2 (en) * | 2009-10-23 | 2015-07-02 | Amgen Inc. | Vial adapter and system |
WO2012085017A2 (fr) * | 2010-12-22 | 2012-06-28 | Sanofi-Aventis Deutschland Gmbh | Cartouche spécialisée |
WO2012128115A1 (fr) * | 2011-03-18 | 2012-09-27 | テルモ株式会社 | Adaptateur d'aiguille de piqûre intégré |
CN102283774B (zh) * | 2011-09-14 | 2013-05-08 | 重庆莱美药业股份有限公司 | 带双针加药器的软瓶 |
US20140005629A1 (en) * | 2012-06-29 | 2014-01-02 | Hospira, Inc. | Medicament admixing system |
FR3001953B1 (fr) * | 2013-02-14 | 2016-01-01 | Transformation Des Elastomeres A Usages Medicaux Et Ind Soc D | Dispositif de fixation pour obturer un reservoir de produit fluide. |
WO2015075221A1 (fr) * | 2013-11-25 | 2015-05-28 | Xellia Pharmaceuticals Aps | Système de récipient pour thérapie intraveineuse |
RU2702333C2 (ru) * | 2015-05-06 | 2019-10-08 | Кохер-Пластик Машиненбау Гмбх | Система перемещения содержимого контейнеров |
-
2015
- 2015-05-06 US US15/570,417 patent/US10932990B2/en active Active
- 2015-05-06 JP JP2017557383A patent/JP6595620B2/ja active Active
- 2015-05-06 EP EP15721575.7A patent/EP3291786B1/fr active Active
- 2015-05-06 SG SG11201708573UA patent/SG11201708573UA/en unknown
- 2015-05-06 CA CA2984968A patent/CA2984968A1/fr not_active Abandoned
- 2015-05-06 KR KR1020177035067A patent/KR102444990B1/ko active IP Right Grant
- 2015-05-06 AU AU2015393961A patent/AU2015393961B2/en not_active Ceased
- 2015-05-06 WO PCT/EP2015/000921 patent/WO2016177383A1/fr active Application Filing
- 2015-05-06 ES ES15721575T patent/ES2749427T3/es active Active
- 2015-05-06 MX MX2017013994A patent/MX2017013994A/es unknown
- 2015-05-06 RU RU2017139786A patent/RU2696486C2/ru active
- 2015-05-06 PL PL15721575T patent/PL3291786T3/pl unknown
- 2015-05-06 BR BR112017022694-4A patent/BR112017022694B1/pt not_active IP Right Cessation
- 2015-05-06 CN CN201580079666.3A patent/CN107567325B/zh not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AU2015393961A1 (en) | 2017-12-07 |
CN107567325B (zh) | 2020-09-22 |
RU2017139786A (ru) | 2019-06-06 |
AU2015393961B2 (en) | 2020-04-09 |
BR112017022694B1 (pt) | 2021-12-14 |
SG11201708573UA (en) | 2017-11-29 |
JP2018521709A (ja) | 2018-08-09 |
CA2984968A1 (fr) | 2016-11-10 |
KR20180030779A (ko) | 2018-03-26 |
BR112017022694A2 (pt) | 2018-07-17 |
US10932990B2 (en) | 2021-03-02 |
MX2017013994A (es) | 2018-03-14 |
WO2016177383A1 (fr) | 2016-11-10 |
EP3291786B1 (fr) | 2019-07-10 |
RU2696486C2 (ru) | 2019-08-02 |
PL3291786T3 (pl) | 2019-12-31 |
ES2749427T3 (es) | 2020-03-20 |
US20180153772A1 (en) | 2018-06-07 |
JP6595620B2 (ja) | 2019-10-23 |
RU2017139786A3 (fr) | 2019-06-06 |
CN107567325A (zh) | 2018-01-09 |
KR102444990B1 (ko) | 2022-09-20 |
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