EP3747421A1 - Emballage médical conçu sous forme de poche à perfusion ainsi que procédé de transfert du liquide d'une flacon dans une poche à perfusion - Google Patents

Emballage médical conçu sous forme de poche à perfusion ainsi que procédé de transfert du liquide d'une flacon dans une poche à perfusion Download PDF

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Publication number
EP3747421A1
EP3747421A1 EP19178711.8A EP19178711A EP3747421A1 EP 3747421 A1 EP3747421 A1 EP 3747421A1 EP 19178711 A EP19178711 A EP 19178711A EP 3747421 A1 EP3747421 A1 EP 3747421A1
Authority
EP
European Patent Office
Prior art keywords
spike
connector
vial
infusion bag
medical packaging
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP19178711.8A
Other languages
German (de)
English (en)
Inventor
Torsten Brandenburger
Ismael Rahimy
Beatrix Heuel-Hömmen
Alexander Degen
Janine BERG
Junda Liu
Christian NITSCHE
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fresenius Kabi Deutschland GmbH
Original Assignee
Fresenius Kabi Deutschland GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fresenius Kabi Deutschland GmbH filed Critical Fresenius Kabi Deutschland GmbH
Priority to EP19178711.8A priority Critical patent/EP3747421A1/fr
Priority to CN202080041841.0A priority patent/CN113966211A/zh
Priority to PCT/EP2020/065816 priority patent/WO2020245455A1/fr
Priority to MX2021014800A priority patent/MX2021014800A/es
Priority to BR112021022052A priority patent/BR112021022052A2/pt
Priority to KR1020217043166A priority patent/KR20220017434A/ko
Priority to US17/615,636 priority patent/US20220370290A1/en
Priority to CA3141515A priority patent/CA3141515A1/fr
Priority to EP20730428.8A priority patent/EP3979973A1/fr
Priority to AU2020286973A priority patent/AU2020286973A1/en
Publication of EP3747421A1 publication Critical patent/EP3747421A1/fr
Priority to CL2021003181A priority patent/CL2021003181A1/es
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2055—Connecting means having gripping means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/06—Ampoules or carpules
    • A61J1/065—Rigid ampoules, e.g. glass ampoules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/10—Bag-type containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1406—Septums, pierceable membranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1468—Containers characterised by specific material properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1475—Inlet or outlet ports
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/18—Arrangements for indicating condition of container contents, e.g. sterile condition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2051—Connecting means having tap means, e.g. tap means activated by sliding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2089—Containers or vials which are to be joined to each other in order to mix their contents

Definitions

  • the invention relates to a medical packaging designed as an infusion bag which can be filled with a medical liquid for infusion, for parenteral nutrition or for enteral nutrition and which comprises a connector for connecting a vial.
  • the invention further relates to a connector for connecting a vial to an infusion bag and a method for providing a fluid connection between a vial and an infusion bag.
  • a port of the infusion bag As a so-called connector for a vial (also referred to as a “vial”).
  • Vials are designed as small bottles with a beaded or flared cap which comprises a septum which can be pierced by a hollow needle, in particular a so-called spike. Liquid can be added or removed via the hollow needle or the spike.
  • the substances present in the vial can be, for example, toxic drugs, such as cytostatics, for example.
  • a connector for connecting a vial can, for example, be attached directly to the infusion bag and the spike so that the liquid can flow directly from the vial into the infusion bag and / or from the infusion bag into the vial to dissolve the powder via the connector. This not only simplifies the transfer of the medical substance, but also increases safety, since there is a closed system.
  • Such a connector for an infusion bag is, for example, in the laid-open specification WO 2012/101178 A1 (Fresenius Kabi Kunststoff GmbH) shown.
  • the connector comprises a spike, with both an opening and a closing of a fluid connection between the vial and the infusion bag being possible through an axial movement of the spike. After the vial has been attached, the spike is clamped in the septum and can thus be moved by axially displacing the vial both to open and to close the fluid connection.
  • the invention is based on the object of providing a connector via which a fluid connection between a vial and a medical packaging designed as an infusion bag is made possible in a simple manner.
  • the object of the invention is already achieved by a medical packaging designed as an infusion bag, by a connector and by a method for providing a fluid connection according to one of the independent claims.
  • the invention relates generally to medical packaging designed as an infusion bag which comprises a connector for connecting a vial.
  • the connector comprises a spike for piercing the septum of the vial to provide an initially closed fluid connection to the inner volume of the infusion bag. By rotating the spike, the fluid connection is opened and can be closed again if necessary.
  • the spike can be easily rotated by turning the vial pushed onto the spike in order to open or close the connector.
  • the invention enables the insertion of the vial into the connector and the opening of the fluid connection to be carried out in a simple and secure manner with one movement.
  • the vial is locked in a vial receptacle of the connector and can preferably not be removed again without being destroyed.
  • the invention can be divided into two different embodiments. Features common to both embodiments can also be combined with one another.
  • the spike is preferably arranged on a spike carrier and a fluid connection is established on the end face.
  • the fluid connection can be established by opening an opening with the Spike connected channel is brought into intersection with a channel of a seal by a rotary movement.
  • the invention provides in particular that a seal is used with a, preferably essentially axial, channel which is sealed at the end when the connector is in the closed state.
  • This embodiment of the invention is thus based on an end seal.
  • This can for example be realized by a rotatable plate which comprises an opening which can be brought into intersection with an opening in the seal.
  • the rotatable plate can in particular be part of a spike carrier.
  • the opening of a channel connected to the spike is arranged radially offset to an axis of rotation of the spike.
  • the spike is rotated about its central axis relative to the connector housing.
  • the spike can be brought into fluid connection with the channel of the seal via a channel, which preferably runs obliquely radially outward.
  • the channel of the seal is preferably also arranged radially offset from the central axis of the spike.
  • the spike is arranged on a spike carrier comprising a disk.
  • the disc is rotatable in front of the seal arranged, wherein the seal comprises a, preferably axial, channel extending through the seal.
  • The, preferably axial, channel of the seal can be brought into intersection with an opening on or in the disk by rotating the disk.
  • the opening on or in the disc is located on the opposite side of the spike and is connected to the spike by means of a channel, in particular an inclined channel.
  • the disk can be rotatably arranged between an upper part and a central part of the connector.
  • the upper part and the middle part can in particular be locked to one another. Simple production can thus be ensured.
  • the upper part is simultaneously designed as a vial receptacle and holds the collar of the vial firmly in the inserted state.
  • the seal is preferably arranged between a lower part and the central part of the connector.
  • the lower part and the middle part are in particular locked together.
  • the lower part comprises the connecting section of the connector, in particular the or a welding section.
  • the connector has three essential housing components, namely the lower part, the middle part and the upper part.
  • the housing components are preferably latched to one another so that an adhesive or welded connection can be dispensed with.
  • the seal is preferably fixed in a form-fitting manner between the lower part and the central part, whereas the spike is arranged with a rotatable spike carrier between the central part and the upper part.
  • the spike and the disc are designed in particular as a one-piece plastic component.
  • the spike is designed as an injection-molded component together with the disk.
  • a component can be provided in a simple manner which can be arranged in the housing of the connector and, together with the seal, results in a valve in that the disk with an opening which is connected to the spike via a channel is connected to a channel of the seal is brought into overlap.
  • the spike is preferably only rotated about its central axis.
  • the opening on the spike carrier is located radially offset to the central axis and thus to the axis of rotation.
  • the opening on the spike carrier moves around the axis of rotation and can thus be brought into overlap with the channel of the seal, which is also radially offset from the axis of rotation.
  • the spike When the connector is opened, the spike is therefore only rotated and essentially does not move axially. This facilitates the formation of a form fit between the septum of the vial and the spike.
  • the connector comprises a tamper-evident closure which comprises a removable cap covering the spike.
  • the tamper-evident closure is preferably designed such that the cap comprises a breakable insert.
  • the cap can be designed as a break-off part and separated from the insert.
  • the insert is preferably secured in the upper part of the connector.
  • the spike is preferably designed in such a way that it is arranged in the piercing septum of the vial, secured against rotation.
  • the spike has, at least in sections, a non-round cross-section, particularly preferably comprising an edge, and / or comprises lateral form-locking elements, e.g. Ribs that can press or cut into the septum.
  • a non-round cross-section particularly preferably comprising an edge
  • lateral form-locking elements e.g. Ribs that can press or cut into the septum.
  • the spike can in particular have a polygonal, for example trapezoidal, cross section in its cross section.
  • the spike can have a rib extending radially along the spike, at least in sections. This can in particular be designed in such a way that it cuts into the septum and thus forms an anti-twist device.
  • the at least one rib can, in particular, be designed as a fin which, starting from a side wall of the spike, enlarges towards the rear.
  • the rib, in particular the fin, can press or cut into the septum of the vial and thus form a form fit.
  • the connector is preferably designed in such a way that the spike can be moved from a closed to an open position by more than an eighth of a turn and / or less than a full turn, in particular by about a quarter of a turn.
  • the connector can thus be easily opened and, depending on the embodiment, also easily closed again.
  • the fluid connection can preferably also be closed again by a rotary movement in the direction opposite to the opening direction.
  • liquid can flow both from the vial into the infusion bag and from the infusion bag into the vial, for example in order to dissolve an active ingredient present as a powder and / or to initially dilute a liquid active ingredient.
  • the fluid connection can be closed in order to prevent a remainder of the infusion liquid from flowing back into the vial or remaining there during the infusion.
  • the infusion bag is preferably formed from foils welded together, in particular polypropylene foils.
  • the connector comprises a vial receptacle in which the vial or the head of the vial can be locked.
  • the vial When connected, the vial is not only held by the spike, but also mechanically locked to the connector with its head, which forms a collar.
  • the vial receptacle is preferably designed in such a way that the connection between the vial and the connector cannot be released again when used as intended.
  • the lower part of the connector can be connected directly to the foil of the infusion bag, e.g. by comprising a weld-in boat which is welded into a weld seam of the infusion bag.
  • the connector is designed as an adapter in which a housing part of the connector can be coupled or connected to the port of an infusion bag, for example via a Luer or a Luer lock connection.
  • the connector preferably the lower part of the connector, has a connection piece for connection to a port instead of the connection section for welding.
  • the connector comprises a lower part and a middle part, the sealing element being arranged at least in the middle part, the lower part and the middle part being locked to one another.
  • the middle part and the lower part are thus simply latched to one another during the assembly of the connector, the sealing element being inserted between them and being held in a clamping manner.
  • the sealing element is preferably compressed when it is locked.
  • the lower part and the middle part are preferably secured against rotation relative to one another, in particular by means of interlocking positive locking elements.
  • the sealing element can be provided with a circumferential annular section which is positively secured in a groove provided by the housing of the connector.
  • the groove of the housing can in particular comprise a lower section in the lower part and an upper section in the central part.
  • the sealing element consists at least of an elastic material, in particular of polyisoprene, bromobutyl or chlorobutyl.
  • the spike is preferably made of plastic.
  • the spike consists of a hard material as the housing components of the connector, in particular as the lower part of the connector. This makes it easy for the spike to pierce the septum.
  • the material of the spike comprises a polycarbonate.
  • This material is hard and at the same time autoclavable.
  • the housing components of the connector, in particular the lower part, the middle part and / or the upper part with its vial receptacle, preferably comprise polypropylene.
  • the connector comprises an indicator which shows whether the connector is open or closed.
  • the connector can in particular comprise at least one lateral window through which the indicator can be seen in the open or closed position of the connector.
  • the housing of the connector preferably comprises two windows, the user each after which window the indicator can be seen through, it is easy to see whether the connector is open or closed.
  • the connector in which the spike or a component connected to the spike is latched in the open state in such a way that the spike can no longer be turned back, can also only comprise a window which indicates that the connector is in its open position.
  • the indicator is arranged on a spring which allows the indicator to snap into one of the windows when the connector is in the open and / or closed state.
  • the optical readability of the indicator can be improved, since it looks into the window, which is formed by an opening in the housing wall, or looks out of the opening.
  • An acoustic signal for example in the form of a click, can also be generated by snapping the indicator into the window, so that the user is acoustically signaled that the connector is in an open position, for example.
  • the indicator arranged on a spring can also provide a noticeable resistance which has to be overcome when rotating the vial in order to move the spike out of an open and / or a closed position.
  • the indicator can also provide latching, for example in that it is designed as a hook which latches with the window and thus prevents the spike or a component connected to the spike from turning back.
  • a second embodiment of the invention comprises an axially displaceable spike.
  • the fluid connection can preferably also be closed again by a rotary movement in the opposite direction.
  • liquid can flow both from the vial into the infusion bag and from the infusion bag into the vial, for example around a powder dissolve existing active ingredient and / or to first dilute a liquid active ingredient.
  • the fluid connection can be closed in order to prevent a residue of the infusion liquid from flowing back into the vial and remaining in the vial during the infusion, transport and / or further handling.
  • the infusion bag is preferably formed from foils welded together, in particular polypropylene foils.
  • the spike which can also be referred to as a hollow needle, comprises an axial channel through which liquid can flow to the lateral opening.
  • the lateral opening is preferably sealed by an annular sealing element.
  • the side opening can be provided with a large opening cross section, in particular of over 2 mm 2 .
  • the actuation of the valve formed by the connector is comfortable and safe. It is also possible in a simple manner to design the spike so as to be secured against rotation with respect to the septum of the vial, via which the spike is rotated, since the rotary movement is directed perpendicular to the piercing direction. A rotation lock between the spike and the septum does not make it difficult to puncture the septum.
  • the rotation of the vial causes the spike to rotate in the connector.
  • the rotation of the vial is a relative rotation of the vial with respect to the housing of the connector and / or with respect to the medical packaging, which is preferably designed as an infusion bag.
  • the spike can thus also be rotated by rotating the medical packaging and / or the connector with respect to the vial.
  • the connector comprises a vial receptacle in which the vial or the head of the vial can be locked.
  • the vial is not only held by the spike in the connected state, but is also mechanically locked to the head of the vial, which forms a collar, with the connector.
  • the vial receptacle is preferably designed in such a way that the connection between the vial and the connector cannot be released again when used as intended.
  • the spike preferably comprises a thread, in particular an external thread, which is guided in a thread, in particular in an internal thread, of a housing part of the connector, in particular a lower part.
  • the thread with which an axial displacement is generated via a rotary movement, is preferably located behind the lateral opening, as seen from the vial.
  • the spike comprises a thread and a piercing section with a tip, the lateral opening preferably being located between the piercing section and the thread.
  • the lower part of the connector can be connected directly to the film of the infusion bag, for example by comprising a welding boat which is welded into a weld seam of the infusion bag.
  • the connector is designed as an adapter in which a housing part of the connector can be coupled or connected to the port of an infusion bag, for example via a Luer or a Luer lock connection.
  • the connector preferably the lower part of the connector, has a connection piece for connection to a port instead of the connection section for welding.
  • the thread is preferably designed to be at least two-part, particularly preferably precisely two-part. In this way, a relatively large axial displacement can be achieved in a simple manner during the rotary movement, in particular of more than 2 mm for half a rotation.
  • the thread of the spike and / or the thread of a housing part of the connector comprises recesses for the passage of liquid. This allows the liquid to flow past the thread over a large free cross-section.
  • the thread of the housing part can be segmented.
  • recesses are provided in the thread or in the threads. These are such that axial channels are formed in the thread which extend along the inside of the housing part, preferably along the channel in the lower part of the connector.
  • the thread of the spike preferably also comprises at least one, preferably several, axially extending recesses.
  • the recesses can in particular be designed as a flattening of the thread teeth.
  • the recesses of the thread on the spike at least partially overlap with the recesses of the Thread in the housing part of the connector.
  • An axially extending channel is thus formed in the thread. This enables an axial fluid connection from the side opening to the infusion bag.
  • the spike is preferably designed in such a way that it sits in the septum of the vial in a manner secured against rotation. This is possible in particular through a cross-section deviating from a round shape.
  • the spike can have an at least sectionally polygonal, in particular trapezoidal, cross section.
  • the spike extends through a lower part of the connector and through another adjacent housing part of the connector, in particular through a central part which is connected to the lower part, the lower part being sealed off from the adjacent housing part via the sealing element.
  • the sealing element thus not only seals the lateral opening of the spike in the closed state of the fluid connection, but also simultaneously forms a seal between the inner volume of the infusion bag and the outside.
  • the sealing element sits in particular between the lower housing part and the middle housing part of the connector.
  • the connector is preferably designed such that the spike is moved from a closed to an open position by a quarter turn or more and / or less than a full turn, in particular by approximately half a turn.
  • the connector comprises a lower part with a thread for the spike and a Middle part, the sealing element being arranged at least in the middle part, the lower part and middle part being locked together.
  • the middle part and the lower part are thus simply latched to one another during the assembly of the connector, the sealing element being inserted between them and being held in a clamping manner.
  • the sealing element is preferably compressed when it is locked.
  • the lower part and the middle part are preferably secured against rotation relative to one another, in particular by means of interlocking teeth.
  • a sealing element with a circumferential annular section can be used, which is secured in a form-fitting manner in a groove provided by the housing of the connector.
  • the groove of the housing can in particular comprise a lower section in the lower part and an upper section in the central part.
  • the sealing element consists at least of an elastic material, in particular of TPE (Thermpolastic Elastomer), polyisoprene, EPDM (ethylene-propylene-diene rubber), bromobutyl or chlorobutyl.
  • TPE Thermpolastic Elastomer
  • EPDM ethylene-propylene-diene rubber
  • bromobutyl or chlorobutyl an elastic material, in particular of TPE (Thermpolastic Elastomer), polyisoprene, EPDM (ethylene-propylene-diene rubber), bromobutyl or chlorobutyl.
  • the spike is preferably made of plastic.
  • the spike consists of a hard material as the housing components of the connector, in particular as the lower part of the connector. This makes it easy for the spike to pierce the septum.
  • the material of the spike comprises a polycarbonate.
  • This material is hard and at the same time autoclavable.
  • the housing components of the connector, in particular the lower part, the central part and / or the vial receptacle, preferably comprise polypropylene.
  • the invention also relates to medical packaging designed as an infusion bag, in particular having one or more of the features described above.
  • the infusion bag comprises a connector, wherein the connector comprises a spike for piercing the septum of the vial to provide a fluid connection to the interior volume of the infusion bag.
  • the connector comprises a vial receptacle with a plurality of clamping fingers inclined inwardly in the direction of insertion of the vial.
  • a number of clamping fingers distributed over the circumference of the connector enable the vial to be locked securely in the connector, which preferably cannot be released without being destroyed.
  • the connector preferably comprises 4 to 10, particularly preferably 6 to 10 clamping fingers distributed over the circumference.
  • the clamping fingers are preferably at an angle of more than 10 °, preferably more than 30 °, particularly preferably more than 40 ° and / or less than 80 °, preferably less than, in the insertion direction of the vial with respect to a plane perpendicular to a central axis of the connector 70 °, particularly preferably less than 60 °, inclined.
  • the individual clamping fingers are preferably designed to taper to a point.
  • the clamping fingers are pointed both in plan view (in width) and that the thickness of the clamping fingers is reduced towards the tip.
  • the thickness of the clamping fingers is reduced, in particular, towards the tip, in that they are flattened both on an upper side and on an underside towards the tip.
  • the vial receptacle comprises a funnel-shaped, in particular cup-shaped, section for inserting the vial or for inserting the head of the vial.
  • the head of the vial is centered on the spike when it is inserted.
  • the invention also relates to a connector for medical packaging, in particular for the medical packaging described above.
  • the connector can have all of the above features relating to the connector.
  • the invention is also described in detail by a connector for a medical packaging for providing a fluid connection between the medical packaging and a vial, the connector comprising a spike for piercing a septum of the vial and a sealing element surrounding the spike, characterized in that the spike is designed to be rotatable in the connector and comprises a channel with a lateral opening which adjoins the sealing element in a closed fluid connection or rests against it in a sealing manner, the spike being axially displaceable by a rotary movement of the vial such that the lateral opening of the channel is moved axially out of the sealing element and the fluid connection between the vial and the medical packaging is opened.
  • the invention is also described in detail by a connector for a medical packaging for providing a fluid connection between of the medical packaging and a vial, wherein the connector comprises a spike for piercing a septum of the vial, characterized in that the spike is arranged on a spike carrier comprising a disk, the disk being rotatably arranged in front of a seal, the seal being an axial one Channel comprises, wherein the axial channel of the seal can be brought into intersection with an opening on the disk by a rotary movement of the disk and thus the fluid connection between the vial and the medical packaging is opened.
  • the connector is a component of the port of the medical packaging.
  • the connector is permanently connected to the medical packaging.
  • the medical packaging can be designed as an infusion bag or an infusion bottle, for example.
  • the connector is designed as an initially separate adapter that can be connected to the port of a medical packaging.
  • the connector comprises a connection piece, which e.g. can be connected to the port of a medical packaging.
  • the port can e.g. on an infusion bag or on the cap of an infusion bottle.
  • the connection piece of the connector can e.g. be designed as a male Luer lock connector, which can be connected to a female Luer lock connector of a medical packaging.
  • the invention further relates to a method for providing a fluid connection between a first medical packaging, preferably designed as a vial, and a connector comprising a spike of a second medical packaging, preferably designed as an infusion bag.
  • the second medical packaging preferably corresponds to the medical packaging described above Packaging.
  • the connector, the first medical packaging and / or the second medical packaging can have all of the above-referenced features.
  • the invention is described in detail by a method for providing a fluid connection between a first medical packaging, preferably designed as a vial, and a connector comprising a spike of a second medical packaging, preferably designed as an infusion bag, wherein the first medical packaging is pushed onto the connector of the second medical packaging, so that the spike pierces a septum of the first medical packaging to provide a, preferably initially closed, fluid connection to the internal volume of the second medical packaging, characterized in that the spike is rotated by a rotational movement of the first medical packaging and / or the connector and the fluid connection from the first medical packaging to the second medical packaging is thereby opened.
  • the spike can be turned back again by a rotational movement of the first medical packaging and / or the connector, so that the fluid connection is closed again.
  • the spike is rotated by a rotary movement of the vial, thereby opening a fluid connection to the infusion bag.
  • the rotary actuation of the spike via the septum of the vial enables the fluid connection to be opened comfortably.
  • an anti-rotation device between the spike and the septum can be provided in a simple manner without making it difficult to puncture the septum.
  • the spike is arranged on a spike carrier comprising a disk.
  • the disc is rotatably arranged in front of a seal.
  • the seal includes an axial channel.
  • the disk comprises an opening through which a channel leads to the spike.
  • the spike when opening, as described above, the spike is displaced axially, a lateral opening being moved out of a sealing element.
  • FIGS. 1 to 19 show a first embodiment of the invention in which the vial 90 is arranged on a rotatable disk 404.
  • Fig. 1 is a representation of a medical packaging designed as an infusion bag 70 to which a vial 90 is to be connected.
  • the infusion bag 70 consists of foils welded to one another via the transverse weld seams 71 and longitudinal weld seams 72.
  • the infusion bag 70 has a Hanger 73 for attaching the infusion bag 70 to a stand.
  • the infusion bag 70 further comprises at least one removal port 80.
  • the removal port 80 consists of a lower part 81 welded into the transverse weld seam 71 of the infusion bag 70 and an upper part 82 which has a break-off part 83.
  • the removal port 80 also comprises a septum (not shown in the figures) that is fixed between the lower part 81 and the upper part 82, preferably in a clamping manner.
  • the septum of the removal port 80 can be pierced, for example, with a spike of a transfer set, in order to remove the infusion liquid and deliver it to a patient.
  • the infusion bag 70 comprises a further port which is designed as a connector 60 with which a fluid connection to a vial 90 can be established.
  • the connector 60 comprises a lower part 100, which in this embodiment is welded in in the area 74 of the weld seam 71. Further details on the connector 60 are explained using the following figures.
  • the connector 60 provides a further access or port via which liquid can be transferred from the vial 90 into the infusion bag 70. Furthermore, it is also possible to first transfer liquid from the infusion bag 70 into the vial 90, for example in order to dissolve a solid, for example powdery, active ingredient present there and then transfer the solution produced back into the infusion bag 70.
  • the vial 90 comprises a cap 91, which is designed in particular as a flanged metal cap or as a bounce closure, and which comprises a septum which can be pierced by the spike of the connector 60.
  • the cap 500 is first removed from the connector 60 in this exemplary embodiment.
  • the vial 90 with the cap 91 first is then pushed into the connector 60, the funnel-shaped or, in particular, cup-shaped configuration of the connector 60 simplifying the centered insertion.
  • the septum of the vial 90 is pierced by the spike 401 of the connector 60 and the cap 91 of the vial 90 or the head of the vial 90, which is designed in the form of a collar, latches in the connector 60.
  • a fluid connection between the vial 90 and the infusion bag 70 can then be opened by rotating the vial 90, which also rotates the spike 401.
  • the connector 60 comprises a valve which can be both opened and closed, preferably via a rotary movement.
  • FIG. 14 is a perspective view of the connector 60 without the infusion bag 70.
  • the lower part 100 of the connector 60 comprises a connecting section for the infusion bag 70, which is designed in particular as a welded section 101.
  • the weld-in section 101 is in this exemplary embodiment formed like a boat.
  • a channel 102 leads through the lower part 100 of the connector 60 into the infusion bag 70.
  • the lower part 100 is connected to the middle part 200, the middle part 200 in turn being connected to the vial receptacle 301 of the upper part 300.
  • the lower part 100 of the connector 60 can also comprise a connector for connecting to a port.
  • the connector 60 is designed as a separate adapter for a port.
  • the connection piece of the connector 60 can be designed, for example, as a, preferably male, Luer connector or Luer lock connector.
  • FIG. 3 is an exploded perspective view of the FIG Fig. 2 illustrated connector 60.
  • the housing of the connector 60 comprises a lower part 100, a middle part 200 and an upper part 300.
  • the lower part 100 and the middle part 200 as well as the middle part 200 and the upper part 300 are preferably each locked to one another.
  • the connector 60 can thus be mounted without a welded or glued connection.
  • the seal 600 is inserted between the lower part 100 and the central part 200.
  • the spike carrier 400 with the spike 401 is inserted between the middle part 200 and the upper part 300.
  • the cap 500 is inserted from below into the upper part 300, which is designed as a break-off part and thus serves as a tamper-evident closure.
  • the upper part 300 comprises the funnel-shaped vial receptacle 301, which facilitates the insertion of the vial 90. Once inserted, vial 90 is locked in vial receptacle 301 and cannot be removed again.
  • the middle part comprises windows 201, 202, by means of which the user recognizes whether the connector 60 is open or closed.
  • the spike carrier 400 is rotated by means of the spike 401 connected to the vial 90, in this embodiment e.g. by about a quarter of a turn.
  • a stop 207 for the spike carrier 400 can be seen on an inner wall of the middle part 200, by means of which the rotational movement of the spike carrier 400 is limited.
  • FIG. 14 is a perspective view of the spike carrier 400 with the spike 401.
  • the spike carrier 400 comprises a disk 404 and, in cooperation with the seal 600, forms a valve in order to at least open the connector 60.
  • the spike carrier 400 shown here is provided for an embodiment of a connector 60 in which the connector 60 can be opened and closed again.
  • This embodiment of the invention has the advantage that medical fluid can be prevented from flowing back into the vial 90 during the administration of the medical fluid.
  • the disk 404 and the spike 401 are preferably designed as a one-piece plastic component, in particular a plastic injection-molded component.
  • the spike 401 tapers to the tip 402.
  • the tip 402 is preferably pointed to allow the septum in the vial 90 to be easily pierced.
  • the spike 401 Opposite the tip 402, the spike 401 comprises an incision 403, which preferably ends in a central area of the spike 401.
  • the lateral incision 403 makes it easier for liquid to pass through and also enables the vial 90 to be almost completely emptied.
  • Stiffening webs 405 are located at the foot of the spike 401, which reinforce the spike 401 at the boundary between the upper side of the disk 404 and the spike 401.
  • the stiffening webs 405 can also serve as a stop for the cap 91 of the vial 90 in the inserted state.
  • the stiffening webs, starting from a base of the spike 401, run as webs which extend in a star shape along the top of the disk 404.
  • the spike 401 further comprises radially extending ribs 414.
  • the radially extending ribs 414 are designed in particular as fins starting from a front or central region of the spike 401, which taper towards the front and enlarge radially in the direction of the disk 404.
  • the ribs 414 can cut into the septum of the vial 90 and thus form an anti-twist device.
  • the anti-rotation lock formed in this way benefits from the fact that when the spike 401 is rotated with the spike carrier 400, the latter does not move axially.
  • the ribs 414 therefore remain at one level when the connector 60 is opened.
  • the septum of the vial 90 can be pushed as far as possible onto the spike 401 when it is inserted into the connector 60. When the spike 401 is rotated, this maximally deferred position generally does not change.
  • the disk 404 further comprises at least one stop 406, in particular two stops 406, which, in cooperation with a stop 207 of the central part 200, limit the rotational movement of the spike carrier 400 with the spike 401.
  • the at least one stop 406 of the disk 404 is designed as a radial step in the outer circumference of the disk 404.
  • the disk 404 further comprises an indicator 407 which extends radially outward and which can be seen through a window 201 in the closed state and through another window 202 of the central part 200 of the connector 60 in the open state.
  • the indicator 407 preferably has a different color than the central part adjoining the window or windows 201, 202.
  • the indicator 407 is designed in such a way that it projects into the windows 201, 202 designed as openings in the housing wall and springs back with the spike 401 when the spike carrier 400 is rotated.
  • the indicator 407 can provide a noticeable resistance which must be overcome in order to move the spike carrier 400 out of one of the end positions (open or closed).
  • the indicator 407 can also be designed in such a way that when it snaps into one of the windows 201, 202 there is an audible noise, in particular in the form of a click. The user is thus signaled both optically and acoustically that the connector 60 is, for example, in an open end position. Furthermore, an indentation 407a is arranged in the outer circumference of the disk 404. The indentation 407a is for the indicator point 202 (open). In the closed state, the indentation 407a is offset to the rear at the point 202 in order to better distinguish the difference in position.
  • FIG. 11 is a plan view of the underside of the spike carrier 400, that is to say of the side opposite the spike 401.
  • the two stops 406 restrict the rotatability of the spike carrier 400 with the spike 401 in both directions of rotation, e.g. to about a quarter turn.
  • the opening 408 migrates about the axis of rotation 415 and, when the connector 60 is in an open state, it intersects with a channel 601 of the seal.
  • the indicator 407 is connected to springs 409 on both sides via arcuate sections 410, the springs 409 being connected to the disk 404.
  • the indicator 407 which is resilient in this way radially inward is designed such that behind the springs 409, the indicator 407 and the arcuate portion 410 there is a recessed area 416 in which the plate formed by the disc 404 is recessed.
  • the indicator 407 and the springs 409 are thus formed by a remaining side wall of the disk 404.
  • the springs 409 are designed, in particular, as leaf springs which are formed by a remaining side wall of the disk 404 due to the recessed area 416.
  • the indicator 407 protrudes from the side of the ring formed from the disk 404 and can spring into the window 201, 202 of the middle part 200 in the end positions.
  • the indicator 407 is formed in one piece with the rest of the spike carrier 400 here.
  • the arcuate sections 410 reduce the stresses in the material during compression, since the deformations can be distributed over a longer material section.
  • the opening 408 merges into the spike 401 via the channel 411 running transversely to the channel 412 of the spike 401.
  • the channel 411 can in particular open into the channel 412 of the spike 401 at an angle of 30 ° to 60 °.
  • the opening 408 on the disk 404 is arranged radially offset to the axis of rotation 415.
  • the channel 412 of the spike 401 preferably runs coaxially to the axis of rotation of the spike carrier 400.
  • the vial 90 connected to the spike 201 is defeated when the connector 90 is opened therefore essentially just a rotary movement around its own central axis.
  • the disk 404 further comprises a rotary disk 413.
  • the rotary disk 413 within which the opening 408 is located, protrudes as a circular plate and, in the assembled state, sits in the receptacle 211 of the central part 200 (see FIG Fig. 8 ).
  • the surface of the turntable 413 lies against the seal 600 and thus closes the channel 601 in the seal 600.
  • the opening 408 is brought into intersection with the channel 601 of the seal. This allows liquid to flow via the channel 412 of the spike 401 through the opening 408 into the infusion bag 70 (or vice versa).
  • FIG. 3 is a perspective view of the middle part 200.
  • the middle part 200 consists of a coupling section 203 for the upper part 300 and a coupling section 204 for the lower part 100.
  • the coupling section 204 for the lower part 100 has a smaller diameter than the coupling section 203 for the upper part 300.
  • the coupling section 204 comprises a seal receptacle 205 for the seal 600.
  • the seal receptacle 205 is provided with a structured wall, in particular with a corrugation or toothing, which brings about a positive fit with the lower part 100 and / or the seal 600 and thus a Provides anti-twist protection.
  • the seal receptacle 205 is arranged radially offset to the axis of rotation 415 of the spike 401 or of the spike carrier 400.
  • a recess 206 which can in particular have a sickle-like shape, is located adjacent to the seal receptacle 205 in the coupling section 204.
  • the recess 206 primarily serves to save material. It goes without saying that the recess 206 can therefore also be dispensed with.
  • the groove 209 designed as an annular groove, in which the lower part 100 with a corresponding web 105 (see Fig. 10 ) is locked.
  • the seal receptacle 205 comprises an axially extending annular groove 210 which serves as a form-fit element for the seal 600.
  • the coupling section 203 for the upper part 300 with the vial receptacle 301 also includes at least one groove 208, in particular two spaced apart grooves 208, in order to be able to latch with the coupling piece 303 of the upper part 300 via the at least one collar 304.
  • the disk 404 of the spike carrier 400 is located between the upper part 300 and the middle part 200.
  • the rotary disk 413 sits in the receptacle 211 of the middle part 200.
  • the stop 207 limits the rotation of the spike 401 in both directions of rotation in cooperation with the stops 406 of the spike carrier 404.
  • FIG. 6 is an axial sectional view of seal 600.
  • the seal 600 comprises an axial channel 601 for the passage of liquid.
  • the seal 600 comprises a contact surface 602 for the disk 404 or, more precisely, for the rotary disk 413, which in the closed state sits in a sealing manner on the seal 600.
  • the opening 408 of the rotary disks 413 overlaps with the channel 601 of the seal 600.
  • the seal 600 Adjacent to the contact surface 602, the seal 600 comprises an axially extending annular groove 603, so that an annular ridge 604 extending axially forwards is formed adjacent to this annular groove.
  • the edge-side web 604 serves as a form-fit element and, in the assembled state, sits in an annular groove 210 of the central part 200.
  • the web 604 is set back with respect to the contact surface 602 for the spike carrier 400 or the rotary disk 413 of the spike carrier 400.
  • annular ridge 605 On the side opposite the contact surface 602 there is also an annular ridge 605 on the edge which adjoins a receiving area 606 for the lower part 100.
  • the lower annular edge-side web 604 and the upper annular edge-side web 604 together form an im Substantial T-shaped flange for secure fastening of the seal in the connector 60.
  • transition area 607 in which a horizontally running bottom of the receiving area 606 merges in a stepped manner into the axially extending side wall of the channel 601.
  • Fig. 10 3 is a perspective view of the base 100.
  • the lower part 100 is locked with the annular web 105 in the annular groove 209 of the central part 200.
  • the lower part 100 comprises a web 104 and a ring 106 adjacent to the web 105 for engaging the receiving area 606 of the seal 600.
  • the end face of the web 104 comes to rest on the top of the annular edge web 605 of the seal 600
  • the web 104 is provided with a structure, in particular a corrugation or toothing, in order, together with the corrugation or toothing in the seal receptacle 205, to prevent rotation for the lower part 100 and the middle part 200 and / or the seal 600 effect.
  • a ring 106 extending axially forward is arranged adjacent to the web 104 in the receiving region 606 of the seal 600 and thus presses the seal 600 into the seal receiving 205.
  • the weld-in section 101 preferably has a central axis which coincides with the axis of rotation 415 of the spike 401.
  • the seal 600 and thus the coupling section formed by the web 105 for latching, on the other hand, is arranged radially offset to the axis of rotation 415.
  • One end of a channel 107 extending through the lower part 100 is located here, radially offset from the axis of rotation 415 of the spike 401 or the spike carrier 400.
  • Fig. 11 is a perspective view of the upper part 300 with the vial receptacle 301.
  • the vial receptacle 301 comprises a cup-shaped or funnel-shaped section 302, to which the coupling piece 303 adjoins the at least one, in particular the two, collar 304 for snapping into the middle part 200.
  • the at least one collar 304 latches in the in Fig. 8
  • the vial receptacle 301 further comprises a multiplicity of clamping fingers 305 inclined in the insertion direction of the vial 90.
  • the upper part 300 is preferably secured against rotation with respect to the central part 200.
  • the upper part 300 can e.g. comprise at least one web 306 which runs axially along the coupling piece 303 and which engages in a corresponding axial groove 208 of the central part 200.
  • the clamping fingers 305 taper in their width from the outer base inward. In the embodiment shown, they end on the inside in a tip 307.
  • the outer bases of the clamping fingers 305 each merge a substantially round section into each other. Between the tips 307, the clamping fingers 305 are round, in particular essentially circular.
  • the clamping fingers 305 are inclined in the insertion direction by the angle ⁇ .
  • the degrees given in the general part of the description relate to the underside of the clamping fingers 305.
  • the angle ⁇ by which the clamping fingers 305 are inclined in the insertion direction of the vial 90 is in particular between 40 ° and 60 °.
  • the thickness of the clamping fingers 305 in that they are flattened both on their upper side and on their underside towards the tip 307.
  • the clamping fingers 305 thus claw on the underside of the cap 91 or the head of the vial 90. It is no longer possible to pull the vial 90, once connected to the connector 60, out of the connector 60 without being destroyed.
  • FIG. 6 is a perspective view of the cap 500, which serves as a tamper-evident seal for the connector 60.
  • the cap 500 includes an axially extending spike sheath 501.
  • the spike cover 501 is connected to an annular insert 503 via webs 502.
  • the ring-shaped insert 503 is in the assembled state behind a step 308 (see Fig. 18 ) of the upper part 300 is locked.
  • the spike cover 501 can thus be removed from the insert 503 by breaking off at the webs 502.
  • FIGS. 15 to 17 an alternative embodiment variant of the first embodiment of the invention is explained, in which the spike 401 is secured against rotation in such a way that the connector 60 can be opened by the user, but not closed again.
  • this embodiment variant essentially corresponds to that with reference to FIG FIGS. 1 to 14 illustrated embodiment.
  • FIG. 3 is a perspective view of the center portion 200.
  • this middle part 200 has only a single window 202 through which the user recognizes that the connector 60 is open.
  • FIG. 3 is a plan view of the underside of the middle part 200.
  • a plurality of latching hooks 212 are arranged on the side wall of the central part 200.
  • the middle part 200 further comprises the stop 213, on which the stop 406a of the in FIG Fig. 17 illustrated spike carrier 400 rests with the spike 401.
  • the first latching hook 212a acts as a stop of the middle part 200 for the second stop 406b.
  • the spike carrier 400 also includes the resilient hook 417, which when the spike 401 is rotated glides past the locking teeth 212 via a sliding surface 418, springs in behind a locking tooth 212 and thus, in cooperation with the locking teeth 212, forms an anti-twist device that prevents the spike carrier from turning back 400 prevented with the spike 401.
  • the resilient hook 417 engages in one of the locking teeth 212, the spike carrier 400 is rotated further in such a way that it cannot be rotated back again.
  • the open end position can in turn be signaled by the hook 417 protruding into the window 202 and / or by an audible click when the hook 417 engages in the window 202.
  • the resilient hook 417 forms a security against rotation in the window 202 in the open state. Due to the stop 406a of the spike carrier 400 resting on the first latching hook 212a and the anti-rotation lock by the hook 417 engaged in the window 202, the spike carrier 400 cannot be rotated in the open position of the connector 60 in any direction.
  • the connector 60 is now open and can no longer be closed.
  • FIG. 3 is an axial sectional view of the FIG FIGS. 1 to 14 illustrated connector 60 in its closed state.
  • the housing of the connector 60 consists of the lower part 100, the middle part 200 and the upper part 300.
  • the seal 600 is clamped between the lower part 100 and the central part 200, the lower part 100 and the central part 200 being locked to one another.
  • the spike carrier 400 with the disk 404 is located between the upper part 300 comprising the vial receptacle 301 and the middle part 200.
  • the channel 601 of the seal 600 which leads to the channel 102 of the lower part 100, is through the disk 404 , more precisely through the in Fig. 6
  • the illustrated rotary disk 413 of the disk 404 is closed.
  • the user can now break off the cap 500, more precisely the spike casing 501 of the cap 500.
  • the cap 500 is locked with the insert 503 behind a step 308 of the upper part 300.
  • Fig. 19 shows the connector 60 in an axial sectional view after the cap 500 has been broken off and the spike 401 has been rotated.
  • the rotation of the spike 401 was brought about in particular by rotating the connected vial 90 (not shown here).
  • the spike 401 was rotated as well, since the spike 401 is inserted into the septum of the vial 90 so that it cannot rotate.
  • the disk 404 of the spike carrier 400 was rotated by rotating the spike 401 in such a way that the channel 411 with the opening 408 (see FIG Fig. 6 ) intersects with the channel 601 of the seal 600.
  • Fluid can now flow through the channel 412 of the spike 401 through the channel of the seal 601 and the channel 102 of the lower part 100 into the infusion bag 70 or vice versa.
  • the fluid connection now extending through the connector 60 is symbolized by a dashed arrow.
  • the channel 601 of the seal 600 is arranged radially offset from the axis of rotation 415 of the spike 401.
  • the weld-in section 101 is preferably located centrally on the axis of rotation 415 of the spike. It goes without saying that the channel 102, which runs through the weld-in section 101, can run laterally offset to the axis of rotation 415.
  • an overall symmetrical structure By aligning the axis of rotation 415 according to a central axis, preferably both the lower part 100, the central part 200 and the upper part 300, an overall symmetrical structure, seen from the outside, is provided in which the torques occurring when the spike 401 is rotated evenly from both halves of the Welding section 101 are intercepted.
  • FIG. 3 is a flow chart of an exemplary embodiment of a method according to the invention which is used with all embodiments of medical packaging, in particular also with the one in FIGS Figures 1 to 19 shown infusion bag 70 and / or in Figures 1 'to 19' shown infusion bag 1, is feasible.
  • the vial is inserted into the vial holder of the connector. Due to the clamping fingers of the vial receptacle, the vial is now inseparably connected to the connector. When it was inserted, the spike pierced the vial septum. The inseparable connection prevents unintentional loosening of the vial. In particular, this prevents ingredients from getting out of the vial and / or the infusion bag when the vial is loosened.
  • the septum of the vial rotates the spike with it and thus opens a fluid connection between the medical packaging, in particular the vial and the infusion bag.
  • the open end position is preferably signaled to the user by an audible and / or perceptible latch.
  • the liquid from the vial can now be transferred to the medical packaging, e.g. the infusion bag, flow, or if the vial contains a solid, liquid can initially flow from the medical packaging into the vial, so that the solid can dissolve in the liquid.
  • the medical packaging e.g. the infusion bag
  • the vial contains a solid
  • liquid can initially flow from the medical packaging into the vial, so that the solid can dissolve in the liquid.
  • the user can then turn the vial back in the opposite direction so that the connector closes again. This prevents liquid from flowing back into the emptied vial.
  • the connector is locked in the open end position in such a way that it can no longer be closed.
  • the user removes the cap of the removal port and connects the medical packaging, for example the infusion bag, to a transfer system in order to administer the medical liquid.
  • the medical packaging for example the infusion bag
  • the use of the connector according to the invention enables simple and safe metering of the substances contained in the vial.
  • Fig. 1 'to Fig. 19' show a second embodiment of the invention, in which the spike 10 has a lateral opening 33 and is axially displaced by a rotary movement.
  • Fig. 1 ' is a representation of a medical packaging designed as an infusion bag 1, to which a vial 5 is to be connected.
  • the infusion bag 1 consists of foils welded to one another via the weld seams 7 and 8.
  • the infusion bag 1 has a hanger 9 for attaching the infusion bag 1 to a stand.
  • the infusion bag 1 further comprises at least one removal port 4.
  • the removal port 4 consists of a lower part 4a welded into the weld seam 7 of the bag 1 and an upper part 4b which has a break-off part 4c.
  • the removal port 4 also comprises a septum (not shown in the figures) that is fixed between the lower part 4a and the upper part 4b, preferably in a clamping manner.
  • the septum of the removal port 4 can be pierced, for example with a spike of a transfer set, in order to remove the infusion fluid and deliver it to a patient.
  • the infusion bag 1 further comprises the port 2, which is designed as a connector 3 with which a fluid connection to a vial 5 can be established.
  • the connector 3 comprises the lower part 3 a, which in this embodiment is welded in in the area 6 of the weld seam 7. Further details on the connector 3 are explained using the following figures.
  • the connector 3 provides a further access or port 2, via which liquid can be transferred from the vial 5 into the infusion bag 1. It is also possible to transfer liquid from the infusion bag 1 into the vial 5, for example in order to dissolve a solid, for example powdery, active ingredient present there and then to transfer the solution produced back into the infusion bag 1.
  • the vial 5 comprises a cap 12, which is designed in particular as a flanged metal cap or as a bounce closure, and which has a septum 52 (see FIG Fig. 19 ' ) which can be pierced by the spike 10 of the connector 3.
  • the sealing film 11 is first pulled off the connector 3 in this exemplary embodiment. It goes without saying that instead of the sealing film 11, a cap or a combination of sealing film and cap can also be provided (not shown).
  • the vial 5 is then pushed into the connector 3 with the cap 12 first, the funnel-shaped or, in particular, cup-shaped configuration of the connector 3 simplifying the centered insertion.
  • the septum 52 of the vial 5 is pierced by the spike 10 and the cap 12 of the vial 5 or the head of the vial 5, which is designed in the form of a collar, latches in the connector 3 (see FIG Fig 18a ' and 18b ' ).
  • a fluid connection between the vial 5 and the infusion bag 1 can then be opened by rotating the vial 5, by which the spike 10 is also rotated.
  • the connector 3 comprises a valve, which can be opened and closed, preferably via a rotary movement.
  • FIG. 3 is a perspective view of only the connector 3 (without infusion bag 1) with the vial 5 connected to the connector 3.
  • the vial 5 is locked in the cup-shaped or funnel-shaped vial receptacle 14.
  • the lower part 3 a of the connector 3 comprises a connection section for the infusion bag 1, which is designed in particular as a welded section 18.
  • the weld-in section 18 is formed in the shape of a boat in this exemplary embodiment.
  • a channel 17 leads through the lower part 3a of the connector 3 into the infusion bag 1.
  • the lower part 3 a is connected to the middle part 13, the middle part 13 in turn being connected to the vial receptacle 14.
  • the middle part 13 and the vial receptacle 14 can also be designed in one piece in another embodiment, not shown.
  • the lower part 3 a of the connector 3 can also comprise a connection piece for connection to a port according to another exemplary embodiment.
  • the Connector 3 designed as a separate adapter for a port.
  • the connection piece of the connector 3 can for example be designed as a Luer connector or a Luer lock connector.
  • Fig. 3 ' is a side view of the connector 3, the housing of which consists of the lower part 3, the middle part 13 and the vial receptacle 14.
  • the housing of the connector 3 is thus designed in three parts in this exemplary embodiment.
  • the coupling section 19 is located between the lower part 3a of the connector 3 and the middle part 13.
  • the coupling section 15 is located between the middle part 13 and the vial receptacle 14.
  • the three housing components can in particular, as will be explained in detail below, be locked together.
  • the coupling section 15 between the central part 13 and the vial receptacle 14 here has a larger diameter than the coupling section 19 between the lower part 3a and the central part 13, since the coupling section 15 is adapted to the larger vial receptacle 14.
  • the spike 10 is arranged inside the housing. It is designed as a hollow needle, preferably made of plastic, and protrudes into the vial receptacle 14, which is designed in the form of a funnel or cup in sections.
  • the vial receptacle 14 comprises an edge-side recess 16.
  • the recess 16 enables the user to see the entire interior volume of the (transparent) vial 5. He can use this to For example, check whether the vial 5 is completely emptied or the active ingredient is completely dissolved.
  • Fig. 4 ' 13 is a perspective exploded view of the components of the connector 3.
  • the components of the connector 3 include the lower part 3 a, the spike 10, the sealing element 21, the middle part 13 and the vial receptacle 14.
  • the lower part 3a of the connector 3 with the channel 17 comprises the weld-in section 18 and, on the opposite side, the coupling section 19 of the lower part 3a to the middle part 13.
  • the sealing element 21, which has the passage 25 for the spike 10, is inserted between the lower part 3 a and the middle part 13.
  • the sealing element 21 serves both to seal the infusion bag 1 and, in cooperation with the spike 10, as a valve component.
  • the spike 10 comprises the thread 23 which, in the assembled state, is seated in a thread 28 of the lower part 3a (see also FIG Fig. 6 ' ).
  • the thread 23 of the spike 10 is preferably designed as an external thread and the thread 28 of the lower part 3a is designed as an internal thread.
  • the coupling section 15 of the middle part 13 is in turn locked onto the connecting section 24 of the vial receptacle 14.
  • the center piece 13 and the vial receptacle 14 can also be formed in one piece.
  • FIG. 5 is a perspective view of the lower part 3 a, which has the coupling section 19 to the middle part 13 and the weld-in section 18.
  • Fig. 6 ' Fig. 3 is an axial sectional view of the base 3a and 3b
  • Fig. 7 ' Fig. 3 is a plan view of the base 3a (seen from the infusion bag 1).
  • the connecting section 19 comprises the collar 26, which is locked in a corresponding groove 39 of the middle part 13 (see Fig. 14 ' ).
  • the coupling section 19 further comprises a toothing 27 which, in the assembled state, is a toothing 36 of the central part 13 (see also FIG Fig. 14 ' ) engages and forms an anti-twist device.
  • the face end 40 of the lower part 3a engages in the sealing element 21 in its assembled state.
  • the face end 40 of the lower part 3c comes to rest on the top of the sealing element 21 next to the ring 34 of the sealing element 21.
  • the thread 28 of the lower part 3a is, as in particular in FIG Fig. 7 ' shown, formed segmented.
  • the thread 28 comprises five segments.
  • axially extending recesses 50 are provided between the segments of the thread 28, which, in the open state of the connector 3, in cooperation with the spike 10, form at least one axially extending channel for the passage of liquid.
  • Fig. 8 ' shows a first side view on the left, a second side view rotated by 90 ° in the middle, and another on the right perspective view of the spike 10.
  • the spike 10 is formed from plastic, for example from a polycarbonate.
  • the spike 10 comprises the puncture section 29. This has a tip 30.
  • a lateral incision 22 also extends from the tip 30 into the side wall of the spike 10 and ends within the puncture section 29. On the one hand, this makes it easier to pierce the septum of the vial 5. On the other hand, this provides a large cross section for liquid to pass through.
  • the spike 10 comprises a lateral opening 33 for the passage of liquid.
  • the side opening 33 is sealed in the assembled and closed state of the connector 3 by the sealing element 21 (see FIG Fig. 18a ' and 18b).
  • the spike 10 here comprises a two-course thread 23, which in this exemplary embodiment has recesses 49 designed as a flattening of the thread teeth. These recesses 49 are arranged axially one behind the other.
  • the recesses 49 overlap at least in sections with the recesses 50 of the thread 28 of the lower part 3a so that at least one axially extending channel is formed for the passage of liquid.
  • Fig. 9 ' is an axial sectional view of the spike 10.
  • the spike 10 is at least partially designed as a hollow needle.
  • the piercing section 29 of the spike 10 comprises an axially extending channel 31, which in the central region of the Spikes 10 merges into a side, preferably radially, extending channel 32 through which the lateral opening 33 is formed.
  • the axially extending channel 31 and the radially extending channel 32 together form the channel or passage for transferring the liquid from the vial 5 into the infusion bag 1 or from the infusion bag 1 into the vial 5.
  • the piercing section 29 of the spike 10 is not round, at least in sections.
  • the piercing section 29 of the spike 10 is preferably polygonal, in particular trapezoidal, shaped at least in sections.
  • Fig. 11 ' Fig. 13 is a perspective view of the sealing member 21 made of an elastic material.
  • the sealing element 21 comprises a central passage 25, the side wall 48 of which surrounds the spike 10 in a sealing manner in the assembled state.
  • the side wall 48 also seals the side opening 33 of the spike 10 in the closed state.
  • the sealing element 21 comprises radial webs 47 on its upper side and / or its lower side (not shown in the figures), which in particular can also serve as an anti-twist device.
  • the sealing element 21 is firmly clamped between the lower part 3 a and the central part 13, the webs 47 can optionally be dispensed with.
  • the sealing element 21 comprises an edge-side ring 34 which forms a circumferential T-shaped section of the sealing element 21 rotated by 90 °.
  • This ring is in the assembled state 34 on one side positively secured in an end-face annular groove 37 of the central part 13 (see FIG Fig. 14 ' ).
  • the ring 34 is secured between the front end 40 of the lower part 3a, which engages in the sealing element 21, and the head piece 20 of the middle part 13, so that a form fit is present on both sides of the sealing element.
  • An inner flange 35 of the sealing element 21 which extends in the direction of the central part 13 engages in the annular section 38 of the central part 13 (see also FIG Fig. 14 ' as well as 18 and 19).
  • the sealing element 21 is securely fixed between the lower part 3a and the central part 13 without the risk of being pushed out.
  • Fig. 13 ' is a perspective view of the middle part 13, which comprises the coupling section 15 for the vial receptacle 14 and the head piece 20 for inserting the lower part 3a.
  • Fig. 14 ' is a corresponding sectional view of the middle part 13.
  • the head piece 20 is designed as a coupling section 41 for inserting the coupling section 19 of the lower part 3a.
  • the head piece 20 comprises the groove 39, in which the collar 26 of the lower part 3a is latched in the assembled state (see also FIG Fig. 6 ' as Fig. 18a ' / b 'and 19').
  • the head piece 20 is provided with a toothing 36 on the inside below the radial groove 39 in which the collar 26 of the lower part 3 a latches.
  • the sealing element 21 is seated in the area of the toothing.
  • the toothing 36 acts on the one hand as an anti-twist device for the sealing element 21, which is pressed together and thus presses into the toothing 36.
  • the frontal annular groove 37 serves, as described above, as a form-locking element for the circumferential ring 34 of the sealing element 21.
  • the flange 35 of the sealing element 21 engages in the inner annular section 38 of the central part 13.
  • the coupling section 15 comprises two circumferential grooves 42, in each of which a collar 43 of the vial receptacle 14 is locked (see FIG Fig. 15 ' ).
  • FIG. 3 is a perspective view of the vial receptacle 14.
  • the vial receptacle 14 comprises a cup-shaped or funnel-shaped section 44, to which the coupling piece 51 with the here two collars 43 for the central part 13 adjoins.
  • the vial receptacle 14 further comprises a multiplicity of clamping fingers 45 inclined in the insertion direction of the vial 5.
  • the clamping fingers 45 taper in width from the outer base inward. On the inside, they end in a point 46 in the embodiment shown.
  • the outer bases of the clamping fingers 45 each merge into one another via an essentially round section. Between the tips 46, the clamping fingers 45 are rounded, in particular essentially circular.
  • the clamping fingers 45 are inclined in the insertion direction by the angle ⁇ .
  • the degrees given in the general part of the description relate to the underside of the clamping fingers 45.
  • the angle ⁇ by which the clamping fingers 45 are inclined in the insertion direction of the vial 5 is in particular between 40 ° and 60 °.
  • the thickness of the clamping fingers 45 in that they are flattened both on their upper side and on their underside towards the tip 46.
  • the clamping fingers 45 thus claw on the underside of the cap 12 or the head of the vial. Pulling the vial 5, once connected to the connector 3, out of the connector 3 is not possible without destruction.
  • Fig. 18a ' and 18b ' show an axial sectional view of the entire connector 3 in a closed state of the fluid connection.
  • Fig. 18a ' shows the connector 3 as such without the vial 5.
  • Fig. 18b ' shows the connector 3 with the connected vial 5.
  • the vial 5 is connected to the connector 3 in a latching manner. In the connected state, the spike 10 of the connector 3 penetrates the septum 52 in the vial 5.
  • the spike 10 can be transferred into an open and a closed end position by rotating the vial 5. This provides a valve for opening and closing the fluid connection between the vial 5 and the infusion bag 1.
  • the vial 5 is rotated relative to the connector 3.
  • the opening and The fluid connection can also be closed by rotating the connector 3 with respect to the vial 5.
  • Fig. 18a ' and 18b ' the closed end position of the spike 10.
  • the lateral opening 33 which is formed by the radial channel 32 extending from the axial channel 31 of the spike 10 is closed by the sealing element 21.
  • the sealing element 21 inserted between the lower part 3a and the middle part 13 seals the infusion bag 1 from the outside.
  • Fig. 19 ' shows in a sectional view the vial 5 inserted into the connector 3, the connector 3 now being in its open state.
  • the spike 10 penetrates the septum 52 of the vial 5.
  • the spike 10 is in an open end position of the connector 3.
  • the spike 10 locked in a rotationally secure manner in the septum 52 of the vial 5 is also rotated.
  • the spike 10 is thereby rotated into the open end position. Because the thread 23 of the spike 10 23 is rotated in the thread 28 of the lower part 4a by the co-rotation of the spike 10. As a result, the spike 10 is displaced in the axial direction in such a way that the radial channel 32 and thus the lateral opening 33 are moved out of the sealing element 21.
  • a fluid can now flow via the lateral opening 33 past the thread 23 of the spike 10 via the channel 17 in the lower part 3a into the infusion bag 1 or in the opposite direction.
  • the spike 10 In the open state, the spike 10 preferably comes to rest in an end position.
  • the fluid connection can preferably also be closed again in that the vial 5 is turned back so far that the spike 10 is in the position shown in FIG Fig. 18b ' end position shown comes to rest.
  • the invention made it possible to provide a connector 3 for a vial 5, for example for connecting a vial 5 to an infusion bag 1, which can be operated comfortably and safely.

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Hematology (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
EP19178711.8A 2019-06-06 2019-06-06 Emballage médical conçu sous forme de poche à perfusion ainsi que procédé de transfert du liquide d'une flacon dans une poche à perfusion Pending EP3747421A1 (fr)

Priority Applications (11)

Application Number Priority Date Filing Date Title
EP19178711.8A EP3747421A1 (fr) 2019-06-06 2019-06-06 Emballage médical conçu sous forme de poche à perfusion ainsi que procédé de transfert du liquide d'une flacon dans une poche à perfusion
KR1020217043166A KR20220017434A (ko) 2019-06-06 2020-06-08 인퓨젼 백의 형태의 의료용 패키징 및 바이알로부터 인퓨젼 백으로 액체를 전달하기 위한 방법
PCT/EP2020/065816 WO2020245455A1 (fr) 2019-06-06 2020-06-08 Emballage médical conçu comme une poche de perfusion et procédé pour transférer le liquide d'un flacon dans une poche de perfusion
MX2021014800A MX2021014800A (es) 2019-06-06 2020-06-08 Envase medico en forma de bolsa de infusion y metodo para transferir liquido de una ampolla a una bolsa de infusion.
BR112021022052A BR112021022052A2 (pt) 2019-06-06 2020-06-08 Embalagem de produto medicinal na forma de um saco de infusão e método para transferir líquido a partir de um frasco para um saco de infusão
CN202080041841.0A CN113966211A (zh) 2019-06-06 2020-06-08 设计为输液袋的医疗包装以及将液体从小瓶转移到输液袋的方法
US17/615,636 US20220370290A1 (en) 2019-06-06 2020-06-08 Medical packaging in the form of an infusion bag and method for transferring liquid from a vial to an infusion bag
CA3141515A CA3141515A1 (fr) 2019-06-06 2020-06-08 Emballage medical concu comme une poche de perfusion et procede pour transferer le liquide d'un flacon dans une poche de perfusion
EP20730428.8A EP3979973A1 (fr) 2019-06-06 2020-06-08 Emballage médical conçu comme une poche de perfusion et procédé pour transférer le liquide d'un flacon dans une poche de perfusion
AU2020286973A AU2020286973A1 (en) 2019-06-06 2020-06-08 Medical packaging in the form of an infusion bag and method for transferring liquid from a vial to an infusion bag
CL2021003181A CL2021003181A1 (es) 2019-06-06 2021-11-30 Envase médico en forma de bolsa de infusión y método para transferir líquido de una ampolla a una bolsa de infusión

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP19178711.8A EP3747421A1 (fr) 2019-06-06 2019-06-06 Emballage médical conçu sous forme de poche à perfusion ainsi que procédé de transfert du liquide d'une flacon dans une poche à perfusion

Publications (1)

Publication Number Publication Date
EP3747421A1 true EP3747421A1 (fr) 2020-12-09

Family

ID=66776196

Family Applications (2)

Application Number Title Priority Date Filing Date
EP19178711.8A Pending EP3747421A1 (fr) 2019-06-06 2019-06-06 Emballage médical conçu sous forme de poche à perfusion ainsi que procédé de transfert du liquide d'une flacon dans une poche à perfusion
EP20730428.8A Pending EP3979973A1 (fr) 2019-06-06 2020-06-08 Emballage médical conçu comme une poche de perfusion et procédé pour transférer le liquide d'un flacon dans une poche de perfusion

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP20730428.8A Pending EP3979973A1 (fr) 2019-06-06 2020-06-08 Emballage médical conçu comme une poche de perfusion et procédé pour transférer le liquide d'un flacon dans une poche de perfusion

Country Status (10)

Country Link
US (1) US20220370290A1 (fr)
EP (2) EP3747421A1 (fr)
KR (1) KR20220017434A (fr)
CN (1) CN113966211A (fr)
AU (1) AU2020286973A1 (fr)
BR (1) BR112021022052A2 (fr)
CA (1) CA3141515A1 (fr)
CL (1) CL2021003181A1 (fr)
MX (1) MX2021014800A (fr)
WO (1) WO2020245455A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2974449T3 (es) * 2018-05-17 2024-06-27 Becton Dickinson France Conector para conectar un dispositivo médico de inyección a un recipiente

Citations (8)

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Publication number Priority date Publication date Assignee Title
WO1984004673A1 (fr) * 1983-05-20 1984-12-06 Bengt Gustavsson Dispositif pour le transfert d'une substance
DE3503460A1 (de) * 1984-02-24 1985-09-05 Farmitalia Carlo Erba S.p.A., Mailand/Milano Sicherheitseinrichtung zum verbinden einer injektionsspritze mit dem mund oder der oeffnung einer ein pharmazeutisches praeparat enthaltenden flasche oder einem kleinen rohr zur abgabe eines pharmazeutischen praeparats von der injektionsspritze
WO1986001712A1 (fr) * 1984-09-14 1986-03-27 Baxter Travenol Laboratories, Inc. Dispositif de reconstitution
US4735608A (en) * 1986-05-14 1988-04-05 Del F. Kahan Apparatus for storing and reconstituting antibiotics with intravenous fluids
WO2007149960A2 (fr) * 2006-06-22 2007-12-27 Baxter International Inc. récipient de reconstitution de médicament et système
WO2012101178A1 (fr) 2011-01-25 2012-08-02 Fresenius Kabi Deutschland Gmbh Dispositif de liaison destiné à relier un premier réservoir à un deuxième réservoir
WO2014033710A1 (fr) * 2012-08-26 2014-03-06 Medimop Medical Projects Ltd Dispositifs de transfert de médicament liquide utilisant la rotation manuelle pour des actionnements d'étape de communication d'écoulement double
WO2016177383A1 (fr) * 2015-05-06 2016-11-10 Kocher-Plastik Maschinenbau Gmbh Système de prélèvement de contenu de récipient

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Publication number Priority date Publication date Assignee Title
US6071270A (en) * 1997-12-04 2000-06-06 Baxter International Inc. Sliding reconstitution device with seal
FR2878737B1 (fr) * 2004-12-07 2007-03-16 Maptech Soc Par Actions Simpli Dispositif de securite pour flacon a usage medical

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1984004673A1 (fr) * 1983-05-20 1984-12-06 Bengt Gustavsson Dispositif pour le transfert d'une substance
DE3503460A1 (de) * 1984-02-24 1985-09-05 Farmitalia Carlo Erba S.p.A., Mailand/Milano Sicherheitseinrichtung zum verbinden einer injektionsspritze mit dem mund oder der oeffnung einer ein pharmazeutisches praeparat enthaltenden flasche oder einem kleinen rohr zur abgabe eines pharmazeutischen praeparats von der injektionsspritze
WO1986001712A1 (fr) * 1984-09-14 1986-03-27 Baxter Travenol Laboratories, Inc. Dispositif de reconstitution
US4735608A (en) * 1986-05-14 1988-04-05 Del F. Kahan Apparatus for storing and reconstituting antibiotics with intravenous fluids
WO2007149960A2 (fr) * 2006-06-22 2007-12-27 Baxter International Inc. récipient de reconstitution de médicament et système
WO2012101178A1 (fr) 2011-01-25 2012-08-02 Fresenius Kabi Deutschland Gmbh Dispositif de liaison destiné à relier un premier réservoir à un deuxième réservoir
WO2014033710A1 (fr) * 2012-08-26 2014-03-06 Medimop Medical Projects Ltd Dispositifs de transfert de médicament liquide utilisant la rotation manuelle pour des actionnements d'étape de communication d'écoulement double
WO2016177383A1 (fr) * 2015-05-06 2016-11-10 Kocher-Plastik Maschinenbau Gmbh Système de prélèvement de contenu de récipient

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US20220370290A1 (en) 2022-11-24
MX2021014800A (es) 2022-01-18
WO2020245455A1 (fr) 2020-12-10
AU2020286973A1 (en) 2021-11-25
CL2021003181A1 (es) 2022-07-15
BR112021022052A2 (pt) 2022-04-26
CA3141515A1 (fr) 2020-12-10
KR20220017434A (ko) 2022-02-11
EP3979973A1 (fr) 2022-04-13
CN113966211A (zh) 2022-01-21

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