EP2376341B1 - Fermeture pour récipient à médicament - Google Patents

Fermeture pour récipient à médicament Download PDF

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Publication number
EP2376341B1
EP2376341B1 EP09771718.5A EP09771718A EP2376341B1 EP 2376341 B1 EP2376341 B1 EP 2376341B1 EP 09771718 A EP09771718 A EP 09771718A EP 2376341 B1 EP2376341 B1 EP 2376341B1
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EP
European Patent Office
Prior art keywords
closure
seal element
wall
sealing element
retaining element
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP09771718.5A
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German (de)
English (en)
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EP2376341A1 (fr
Inventor
Dirk ZÖLCHER
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West Pharmaceutical Services Deutschland GmbH and Co KG
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West Pharmaceutical Services Deutschland GmbH and Co KG
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Application filed by West Pharmaceutical Services Deutschland GmbH and Co KG filed Critical West Pharmaceutical Services Deutschland GmbH and Co KG
Publication of EP2376341A1 publication Critical patent/EP2376341A1/fr
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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D41/00—Caps, e.g. crown caps or crown seals, i.e. members having parts arranged for engagement with the external periphery of a neck or wall defining a pouring opening or discharge aperture; Protective cap-like covers for closure members, e.g. decorative covers of metal foil or paper
    • B65D41/02—Caps or cap-like covers without lines of weakness, tearing strips, tags, or like opening or removal devices
    • B65D41/023—Caps or cap-like covers without lines of weakness, tearing strips, tags, or like opening or removal devices with integral internal sealing means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D51/00—Closures not otherwise provided for
    • B65D51/002—Closures to be pierced by an extracting-device for the contents and fixed on the container by separate retaining means

Definitions

  • the invention relates to a closure for a preferably sterile medicament container, which closure for connection to the medicament container is thermally deformable by heating, has a prefabricated closure body which is cup-shaped with a bottom and a wall, and which has at least one puncture opening in the bottom of its cup shape , wherein at this closure body in the region of the bottom of its cup shape, an elastic-soft sealing element is arranged such that the at least one puncture opening is closed by the sealing element and a part of the sealing element in the use position of the closure is accessible from outside, wherein the closure body of the Wall independent holding element has, which protrudes in the position of use of the closure inwardly from the bottom of the cup-shaped closure body, and wherein a receptacle for the sealing element is formed by the holding element and the Dichtele ment is arranged in the recording.
  • closures are previously known according to the preamble of claim 1, which made it be that first a closure body is produced in the form of a cap and in a further manufacturing step in the same tool or a part thereof, the elastic-soft sealing element is injected into the cap.
  • the sealing element is injected into the closure body, whereby a large area connection area between sealing element and closure body is formed, and that the closed by the closure medicine bottle has at its mouth a bottle cap integrally connected to the medicine bottle, to which the sealing element in the unused state sealingly the bottle cap rests and is supported by this at least partially.
  • the production of such an arrangement requires complex tool.
  • a closure of the type mentioned is known, which is thermally deformable for connection to a medicament container by heating and a has prefabricated closure body which is cup-shaped with a bottom and a wall.
  • an elastic-soft sealing element is arranged such that the at least one puncture opening is closed by the sealing element.
  • the sealing element is arranged in a retaining element serving as a receptacle, which protrudes inward in the position of use of the closure from the bottom of the pot-shaped closure body.
  • the cavity formed by the cylindrical holding member may be filled with a preferably rubber-made sealing material.
  • the cylindrical holding element of the WO 2009/0954881 A1 Prior art closure also has the end facing the container interior an outer or bottom wall, which must be pierced by means of a spray cannula, such that after removal of the cannula a puncture hole remains in the outer wall.
  • the present invention has for its object to provide a closure for a particularly sterile medication container, in which the maintenance of the sealing element is improved on the cap.
  • the sealing element is prefabricated, inserted into the receptacle and held therein under prestress, and that the sealing element is materially connected to the closure body.
  • the sealing element is prefabricated, inserted into the receptacle and held therein under prestress.
  • the advantage here is that an inserted in use with a cannula or needle in the sealing element puncture hole can be automatically closed by the bias of the sealing element after use.
  • the sealing element with the closure body is materially connected, for example by injection, gluing or welding.
  • the closure body may consist of non-elastic material, for example a hard plastic.
  • the puncture openings may be closed from outside by removable covers before use.
  • the bottom is flat or flat. But it can also be used a curved outward or inward floor.
  • the medicament container may, for example, be a bottle or a pouch or a general container for preferably liquid medicaments.
  • the medication container is often placed down or suspended, so that the bottom of the cup shape of the closure body is disposed under the wall.
  • a particularly good decoupling of the retaining element from the deformation forces, which are introduced under thermal stress of the closure body in the closure body, is achieved when the holding element is spaced from the wall of the cup shape of the closure body and with this at least in sections, preferably over the entire extension of the holding element on the bottom of the pot shape, forming a gap.
  • the holding element may consist of several individual parts which cooperate for receiving the sealing element, or the holding element may be formed integrally. It is particularly advantageous if the holding element describes a contour which rotates along the bottom of the at least one piercing opening. The holding element can thus introduce a bias on the arranged in the receptacle sealing element, which is directed to the respective puncture opening.
  • a decoupling of the retaining element from the wall can be provided that extends from the retaining element and the wall of the cup shape of the closure body formed space over the entire length of the contour.
  • the holding element passes through the sealing element and / or that the holding element engages along the contour on a circumference of the sealing element at least in sections.
  • the sealing element from several sides, preferably on all sides with respect to the bottom of the closure body, be held by the holding member to the closure body.
  • the holding element has ribs which engage the inserted sealing element and which are each oriented transversely to the extension direction of the circumference of the sealing element.
  • the holding element is formed as a wall.
  • An embodiment of the retaining element as a web can also be provided.
  • the retaining element has segments, which are each adapted to a portion of the circumference of the sealing element. These segments thus follow the circumference of the sealing element and engage in these sections of the sealing element.
  • the holding element may be formed, for example, as a continuous wall or as a continuous web.
  • the holding element is integrally formed with the closure body.
  • the sealing element is made of rubber material or TPE material.
  • the closure body can be made, for example, from a thermoplastic material, ie a fusible plastic.
  • a puncture opening may be used to introduce a drug into a dilution solution while the other puncture opening may be provided to remove the now diluted drug.
  • These puncture openings can be arranged in a common plane.
  • the holding element describes a contour which rotates the at least two puncture openings together.
  • the holding element forms a receptacle in which a sealing element can be arranged for both puncture openings.
  • the holding element forms a constriction in the receptacle for the sealing element in a region between the at least two puncture openings.
  • the advantage here is that by this constriction and a bias voltage can be introduced to the sealing element whose force component is substantially parallel to the connecting line of the puncture openings. This results in a substantially all-sided bias in the sealing element in the areas of the puncture openings.
  • Another advantage is that can be saved by the constriction material of the sealing element.
  • the holding element can thus be a spectacle-shaped or eight-shaped Describe contour, which is predetermined by the twin arrangement of the circular puncture openings.
  • a separate receptacle for a sealing element is formed by the holding element at each puncture opening of the closure body.
  • These sealing elements may be integrally connected to one another outside the respective receptacle.
  • the bottom of the cup shape of the closure in particular in the region of the edge of the puncture opening or puncture openings, covering part of the sealing element in the position of use of the closure to the outside.
  • the holding element maintains a minimum distance from the puncture opening, in particular from the circumference or edge of the puncture opening.
  • the sealing element is limited in one of the at least one puncture opening adjacent region of the bottom end face.
  • the advantage here is that bulging of the sealing element is avoided when expanding the cap. It is particularly advantageous if the area surrounds the pierceable opening or it borders.
  • the sealing element is arranged axially spaced from the wall. The advantage here is that the sealing element is mechanically decoupled from the wall, so that expanding or relieving deformation forces that are applied by the wall, for example in a thermal treatment, not or only reduced transferred to the sealing element.
  • the invention is advantageously applicable to an infusion container in which the closure of the infusion container is designed according to the invention.
  • FIG. 1 shows a generally designated 1 closure for a sterile medicament container according to the prior art in a sectional view, wherein the sectional plane is selected so that it is perpendicular to the plane defined by the opening of the medicament container level.
  • the closure 1 has a closure body 2, which is made of a hard, so non-elastic, material.
  • This closure body 2 forms a pot shape with a flat or flat bottom 3 and a wall 5 adjoining the bottom 3.
  • the wall 5 On the wall 5, another wall 4 connects.
  • the wall 5 has a diameter receded from the wall 4, whereby a shoulder 13 is formed between the wall 4 and the wall 5.
  • the bottom 3 and the wall 5 form a receptacle 6 for a Seal element 7 made of TPE material.
  • the sealing element 7 closes from the inside in the FIG. 1 no further evident, as in the embodiment of Figure 7 trained puncture openings 8.
  • the part of the sealing element 7 located behind the puncture openings 8 in the use position of the closure 1 is accessible from the outside.
  • liquids can be added to or taken out of the medicament container by passing a cannula or needle or the like through the puncture opening 8 and the sealing element 7 arranged behind it.
  • the hole remaining in the sealing element 7 after removal of the cannula or needle or the like is automatically closed again. This is achieved in that the sealing element 7 is arranged under prestress in the receptacle 6.
  • FIG. 2 shows an exemplary sectional view through such a deformed closure.
  • FIG. 3 shows another known from the prior art closure 1, which essentially like the closure 1 according to FIG. 1 is constructed, but to improve the retention of the sealing element 7 in the closure body 2, the sealing element 7 is connected at its periphery 9 cohesively with the wall 5.
  • FIG. 5 shows an inventive embodiment of a closure 1 in a sectional view, wherein the sectional plane as in the FIGS. 1 to 4 is selected.
  • the closure 1 according to FIG. 5 has a prefabricated, hard closure body 2.
  • This closure body 2 made of a thermoplastic, non-elastic material has - as by comparison with FIG. 7 becomes clear - an oval pot shape with a flat or flat bottom 3 and a subsequent to this floor 3 wall 5.
  • the closure 1 has the same appearance as the closures according to Figure 1 to 4 ,
  • the closure body 2 On its inside in the position of use facing the interior of the medication container inside, however, the closure body 2 additionally has a holding element 11, through which a receptacle 12 for the sealing element 7 is formed.
  • the holding element 11 is inwardly from the bottom 3 of the cup-shaped closure body 2 from.
  • the sealing element 7 is made of an elastic-soft material and closes two in FIG. 7 closer apparent piercing openings 8, which are formed in the bottom 3 of the closure body 2.
  • the sealing element 7 is made of TPE material, for example. It is also a sealing element 7 made of rubber or other elastic material used.
  • FIG. 6 shows an exemplary sectional view through the closure 1 according to FIG. 5 after deformation due to thermal Stress.
  • FIG. 7 shows a three-dimensional side view of the outside of the closure body. 2
  • the closure body 2 has a cup shape, which is formed by the bottom 3 and the walls 4 and 5.
  • the closure body 2 is withdrawn in its diameter in the region of the wall 5 relative to the wall 4, whereby a shoulder 13 is formed.
  • the bottom 3 and the shoulder 13 thus form end faces and are axially oriented, while the walls 4 and 5 form radially aligned surfaces.
  • the wall 5 with the bottom 3 are thus pot-shaped out of the shoulder 13.
  • puncture openings 8 are introduced, through which for filling or for the removal of liquids cannulas or the like are performed.
  • the puncture openings 8 are arranged in a twin arrangement.
  • FIG. 8 shows a three-dimensional view of the in use position of the closure 1 inner part of the cap. 2
  • the wall 4 forms a further pot shape with the shoulder 13, wherein the shoulder 13 represents the bottom of this further pot shape.
  • the shoulder 13 represents the bottom of this further pot shape.
  • first pot shape is embedded.
  • the holding element 11 projects from the bottom 3 and thus forms with the bottom 3 a receptacle 12 for the sealing element 7, which in FIG. 8 is not apparent.
  • the holding element 11 is formed as a wall and describes a contour which surrounds the puncture openings 8 together.
  • the bottom 3 extends on both sides of the holding element 11, whereby in the region of the edge of the puncture openings 8 a part of the sealing element 7 arranged in the receptacle 12 is covered outwards.
  • the holding element 11 holds a minimum distance 17 from the puncture openings 8. Since the holding element 11 extends around the two puncture openings 8 like a spectacle, the distance of the holding element 11 from the puncture openings 8 in the area between the puncture openings 8 is greater than the minimum distance 17. This minimum distance 17 for each puncture opening 8 surrounds the puncture opening 8 and covers it Area formed by the bottom 3, which is the Sealing element 7 in the position of use in the receptacle 12 frontally limited to the outside, so that it does not fall out or can bulge outward.
  • the contour which describes the holding element 11 is chosen to match the dimensions of the sealing element 7.
  • the inserted or injected sealing element 7 thus comes along its entire circumference 9 with the holding element 11 in touching contact.
  • the holding element 11 thus acts on these contact points on the sealing element 7 and holds this.
  • the holding member 11 is integrally formed as protruding from the bottom wall 3 with the closure body 2.
  • the holding element 11 is spaced from the wall 5 along the contour described by the holding element 11 and thus forms a gap 16 with the wall 5. Holding element 11 and wall 5 thus close the intermediate space 16.
  • This gap 16 serves to compensate for the deformation forces in the closure body 2, whereby the resulting deformation does not act on the shape of the holding element 11.
  • the gap 16 extends over the entire length of the contour described by the holding member 11.
  • a constriction 14 is formed in the region of the receptacle 12 which is arranged between the puncture openings 8.
  • This constriction 14 has the effect that a force component, which runs essentially parallel to the connecting line of the centers of the puncture openings 8 or with this line at an acute angle, preferably of less than 45, can be introduced to the sealing element 7 in the region of the puncture openings 8 via a pretension °, includes.
  • the sealing element 7 is frictionally connected in the receptacle 12 with the closure body 2, since due to the bias of the sealing element 7, the static friction between the periphery 9 of the sealing element and the holding member 11 is increased.
  • FIG. 9 shows a further inventive embodiment of a closure cap 2.
  • the closure body 2 according to Figure 9 differs from the closure body 2 according to FIG. 8 in that the holding element 11 is formed from a plurality of separate segments 15, which jointly describe a contour which surrounds the two puncture openings 8.
  • the individual segments 15 of the retaining element 11 engage in each case against a section of the circumference 9 of the sealing element 7.
  • the segments 15 are adapted in their shape in each case to a portion of the circumference 9 of the sealing element 7.
  • the contour described by the holding element 11, which surrounds the puncture openings 8 together, is identical to the contour of the holding element 11 according to FIG. 8 ,
  • the holding member 11 also forms a constriction 14 in the region of the receptacle 12 between the puncture openings 8 for the purpose described above.
  • the contour and thus the segments 15 maintain a minimum distance 17 to the puncture openings 8, which is greater than zero.
  • a puncture opening 8 enclosing and bounding area of the bottom 3 is formed for each puncture opening 8, which limits the sealing element 7 in the position of use in the receptacle 12 frontally to the outside, so that it can not fall out or bulge outward.
  • the holding element 11 is spaced from the wall 5 of the cup-shaped closure body 2, whereby between the segments 15 and the wall 5 each intermediate spaces 16 are formed.
  • the segments 15 are decoupled from movements of the wall 5, for example thermal deformations, and deformation forces in the closure body 2 are essentially not transmitted to the holding element 11 and therefore do not substantially change the shape of the receptacle 12 Sealing element 7 even in this embodiment, even then held securely on the closure body 2 and receives even then its bias when the rest of the closure body 2 deforms.
  • the holding element 11 is formed independently of the wall 5.
  • sealing element 7 If the sealing element 7 is injected into the receptacle 12, material of the sealing element 7 also passes through the gaps between the segments 15 into the area between the holding element 11 and the wall 5. In this case, the segments 15 of the holding element 11 penetrate the sealing element 7 ,
  • a closure body 2 which is prefabricated from a non-elastic material, a pot shape with a bottom 3 and a wall 4, 5 on.
  • a puncture opening 8 is introduced, which is provided for the addition or removal of liquid drugs.
  • This puncture opening 8 is sealed by a sealing element 7.
  • the sealing element 7 is held in a receptacle 12, which is formed by the bottom 3 and one of this bottom 3 in the position of use of the closure 1 inwardly projecting retaining element 11.

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  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Closures For Containers (AREA)

Claims (19)

  1. Fermeture conçue pour un récipient à médicaments, de préférence stérile, laquelle fermeture (1) est apte à la déformation thermique par chauffage, en vue de la liaison avec ledit récipient à médicaments, est munie d'un corps obturateur (2) préfabriqué qui est réalisé en forme de pot comprenant un fond (3) et une paroi (5), et est percée d'au moins un orifice de perforation (8) dans le fond (3) de sa configuration en pot, sachant qu'un élément d'étanchement (7) doué de souplesse élastique est mis en place sur ce corps obturateur (2), dans la région du fond (3) de sa configuration en pot, de façon telle que l'orifice de perforation (8) à présence minimale soit obturé par l'élément d'étanchement (7), et qu'une partie dudit élément d'étanchement (7) soit accessible de l'extérieur en position d'utilisation de ladite fermeture (1), caractérisée par le fait que le corps obturateur (2) est pourvu d'un élément de retenue (11) indépendant de la paroi (5) et faisant saillie, en position d'utilisation de la fermeture (1), vers l'intérieur au-delà du fond (3) dudit corps obturateur (2) en forme de pot, ledit élément de retenue (11) donnant naissance à un logement (12) dédié à l'élément d'étanchement (7), et ledit élément d'étanchement (7) étant disposé dans ledit logement (12) ; par le fait que l'élément d'étanchement (7) est préfabriqué, est inséré dans le logement (12) et est retenu dans ce dernier sous l'effet d'une précontrainte ; et par le fait que ledit élément d'étanchement (7) est relié audit corps obturateur (2) par une solidarisation matérielle.
  2. Fermeture selon la revendication 1, caractérisée par le fait que l'élément de retenue (11) est situé à distance de la paroi (5) de la configuration en pot du corps obturateur (2) et forme un espace interstitiel (16) avec cette dernière, au moins par zones.
  3. Fermeture selon la revendication 1 ou 2, caractérisée par le fait que l'élément de retenue (11) définit un profil ceinturant l'orifice de perforation (8) à présence minimale, le long du fond (3).
  4. Fermeture selon l'une des revendications 1 à 3, caractérisée par le fait que l'espace interstitiel (16), formé par l'élément de retenue (11) et par la paroi (5) de la configuration en pot du corps obturateur (2), s'étend sur toute la longueur du profil.
  5. Fermeture selon l'une des revendications 1 à 4, caractérisée par le fait que l'élément de retenue (11) vient coopérer au moins par zones, le long du profil, avec un pourtour (9) de l'élément d'étanchement (7).
  6. Fermeture selon l'une des revendications 1 à 5, caractérisée par le fait que l'élément de retenue (11) est pourvu de nervures qui viennent coopérer avec l'élément d'étanchement (7) inséré et sont orientées, à chaque fois, transversalement par rapport à la direction de l'étendue du pourtour (9) dudit élément d'étanchement (7).
  7. Fermeture selon l'une des revendications 1 à 6, caractérisée par le fait que l'élément de retenue (11) est réalisé sous la forme d'un cloisonnement.
  8. Fermeture selon l'une des revendications 1 à 7, caractérisée par le fait que l'élément de retenue (11) est pourvu de segments (15) respectivement adaptés à une zone du pourtour (9) de l'élément d'étanchement (7).
  9. Fermeture selon l'une des revendications 1 à 8, caractérisée par le fait que l'élément de retenue (11) vient coopérer avec l'élément d'étanchement (7) le long de l'intégralité du pourtour (9) dudit élément d'étanchement (7).
  10. Fermeture selon l'une des revendications 1 à 9, caractérisée par le fait que l'élément de retenue (11) est réalisé d'une seule pièce avec le corps obturateur (2).
  11. Fermeture selon l'une des revendications 1 à 10, caractérisée par le fait que l'élément d'étanchement (7) est fabriqué en un matériau du type caoutchouc ou TPE.
  12. Fermeture selon l'une des revendications 1 à 11, caractérisée par le fait que le corps obturateur (2) présente, dans le fond (3) de sa configuration en pot, au moins deux orifices de perforation (8) obturés par l'élément d'étanchement (7), ou par un élément d'étanchement (7) respectif, une partie d'un élément d'étanchement, ou de l'élément d'étanchement (7), étant respectivement accessible à travers chaque orifice de perforation (8) en position d'utilisation de ladite fermeture (1).
  13. Fermeture selon la revendication 12, caractérisée par le fait que l'élément de retenue (11) définit un profil qui ceinture, conjointement, les deux orifices de perforation (8) à présence minimale.
  14. Fermeture selon l'une des revendications 12 ou 13, caractérisée par le fait que l'élément de retenue (11) forme, dans une région située entre les deux orifices de perforation (8) à présence minimale, un rétrécissement (14) ménagé dans le logement (12) dédié à l'élément d'étanchement (7).
  15. Fermeture selon l'une des revendications 12 à 14, caractérisée par le fait que l'élément de retenue (11) donne naissance, au niveau de chaque orifice de perforation (8) du corps obturateur (2), à un logement distinct (12) dédié à un élément d'étanchement (7).
  16. Fermeture selon l'une des revendications 1 à 15, caractérisée par le fait que le fond (3) de la configuration en pot de ladite fermeture (1) recouvre une partie de l'élément d'étanchement (7), vers l'extérieur, en position d'utilisation de ladite fermeture (1).
  17. Fermeture selon l'une des revendications 1 à 16, caractérisée par le fait que l'élément d'étanchement (7) est délimité frontalement par le fond (3) dans une région (17) voisine de l'orifice de perforation (8) à présence minimale et marquant, de préférence, le tracé périphérique ou marginal dudit orifice de perforation (8).
  18. Fermeture selon l'une des revendications 1 à 17, caractérisée par le fait que l'élément d'étanchement (7) est placé à distance de la paroi (5) dans le sens axial.
  19. Récipient de perfusion, caractérisé par le fait que la fermeture dudit récipient de perfusion est réalisée conformément à l'une des revendications 1 à 18.
EP09771718.5A 2008-12-09 2009-12-04 Fermeture pour récipient à médicament Active EP2376341B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102008060995A DE102008060995A1 (de) 2008-12-09 2008-12-09 Verschluss für ein Medikamentenbehältnis
PCT/EP2009/008677 WO2010066382A1 (fr) 2008-12-09 2009-12-04 Fermeture pour récipient à médicament

Publications (2)

Publication Number Publication Date
EP2376341A1 EP2376341A1 (fr) 2011-10-19
EP2376341B1 true EP2376341B1 (fr) 2013-07-31

Family

ID=41716590

Family Applications (1)

Application Number Title Priority Date Filing Date
EP09771718.5A Active EP2376341B1 (fr) 2008-12-09 2009-12-04 Fermeture pour récipient à médicament

Country Status (7)

Country Link
US (1) US8616401B2 (fr)
EP (1) EP2376341B1 (fr)
CN (2) CN104015995B (fr)
BR (1) BRPI0923234B1 (fr)
DE (1) DE102008060995A1 (fr)
ES (1) ES2433219T3 (fr)
WO (1) WO2010066382A1 (fr)

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DE102014003501B3 (de) * 2014-03-14 2015-04-30 Klaus-Dieter Beller Verschlusskappe für Behältnisse, Herstellverfahren und Spritzgusswerkzeug
DE102015006489A1 (de) 2015-05-22 2016-11-24 Kocher-Plastik Maschinenbau Gmbh Kunststoff-Behältererzeugnis
DE102016009594A1 (de) 2016-08-06 2018-02-08 Kocher-Plastik Maschinenbau Gmbh Verfahren zum Herstellen eines Verschlusses bei einem aus Kunststoff hergestellten Behälter
DE102017000048A1 (de) * 2017-01-05 2018-07-05 Kocher-Plastik Maschinenbau Gmbh Behälter
DE102018124115A1 (de) * 2018-09-28 2020-04-02 Schott Schweiz Ag Primärpackmittel für pharmazeutische Substanzen
FR3098200B1 (fr) * 2019-07-03 2021-05-28 A Raymond Et Cie Double emballage pour objet destiné à demeurer stérile
US20240124201A1 (en) 2021-02-19 2024-04-18 Braunform Gmbh Cap for closing a container for administering a medication, and method for producing same
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BRPI0923234B1 (pt) 2019-05-14
WO2010066382A1 (fr) 2010-06-17
CN104015995A (zh) 2014-09-03
CN102256881A (zh) 2011-11-23
DE102008060995A1 (de) 2010-06-10
BRPI0923234A2 (pt) 2016-01-26
EP2376341A1 (fr) 2011-10-19
ES2433219T3 (es) 2013-12-10
CN102256881B (zh) 2014-04-02
US20110240642A1 (en) 2011-10-06
US8616401B2 (en) 2013-12-31
CN104015995B (zh) 2017-07-07

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