EP2067772A3 - Dérivés de dibenzo[b,f]azepine et leur préparation - Google Patents

Dérivés de dibenzo[b,f]azepine et leur préparation Download PDF

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Publication number
EP2067772A3
EP2067772A3 EP09153375A EP09153375A EP2067772A3 EP 2067772 A3 EP2067772 A3 EP 2067772A3 EP 09153375 A EP09153375 A EP 09153375A EP 09153375 A EP09153375 A EP 09153375A EP 2067772 A3 EP2067772 A3 EP 2067772A3
Authority
EP
European Patent Office
Prior art keywords
dibenzo
intermediates
azepine
azepine intermediates
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP09153375A
Other languages
German (de)
English (en)
Other versions
EP2067772B1 (fr
EP2067772A2 (fr
Inventor
Peter Fünfschilling
Daniel Kaufmann
Oliver Lohse
Ulrich Beutler
Werner Zaugg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Pharma GmbH
Novartis AG
Original Assignee
Novartis Pharma GmbH
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9885081&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP2067772(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Pharma GmbH, Novartis AG filed Critical Novartis Pharma GmbH
Priority to SI200130996T priority Critical patent/SI2067772T1/sl
Publication of EP2067772A2 publication Critical patent/EP2067772A2/fr
Publication of EP2067772A3 publication Critical patent/EP2067772A3/fr
Application granted granted Critical
Publication of EP2067772B1 publication Critical patent/EP2067772B1/fr
Priority to CY20111100572T priority patent/CY1111567T1/el
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
    • C07D223/26—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a double bond between positions 10 and 11
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
    • C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
    • C07D223/28—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a single bond between positions 10 and 11

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Epoxy Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
EP09153375A 2000-02-07 2001-02-07 Dérivés de dibenzo[b,f]azepine et leur préparation Expired - Lifetime EP2067772B1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
SI200130996T SI2067772T1 (sl) 2000-02-07 2001-02-07 Dibenzo(b,f)azepinski intermediati
CY20111100572T CY1111567T1 (el) 2000-02-07 2011-06-16 Ενδιαμεσα διβενζο (b,f) αζεπινης

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0002740.9A GB0002740D0 (en) 2000-02-07 2000-02-07 Organic compounds
EP01915203A EP1265868B1 (fr) 2000-02-07 2001-02-07 Préparartion de Dérivés de DIBENZO[B,F]AZEPINE

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
EP01915203A Division EP1265868B1 (fr) 2000-02-07 2001-02-07 Préparartion de Dérivés de DIBENZO[B,F]AZEPINE
EP01915203.2 Division 2001-02-07

Publications (3)

Publication Number Publication Date
EP2067772A2 EP2067772A2 (fr) 2009-06-10
EP2067772A3 true EP2067772A3 (fr) 2009-08-19
EP2067772B1 EP2067772B1 (fr) 2011-04-13

Family

ID=9885081

Family Applications (2)

Application Number Title Priority Date Filing Date
EP09153375A Expired - Lifetime EP2067772B1 (fr) 2000-02-07 2001-02-07 Dérivés de dibenzo[b,f]azepine et leur préparation
EP01915203A Expired - Lifetime EP1265868B1 (fr) 2000-02-07 2001-02-07 Préparartion de Dérivés de DIBENZO[B,F]AZEPINE

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP01915203A Expired - Lifetime EP1265868B1 (fr) 2000-02-07 2001-02-07 Préparartion de Dérivés de DIBENZO[B,F]AZEPINE

Country Status (34)

Country Link
US (1) US7112673B2 (fr)
EP (2) EP2067772B1 (fr)
JP (1) JP4859322B2 (fr)
KR (5) KR100931753B1 (fr)
CN (2) CN100455572C (fr)
AR (2) AR029442A1 (fr)
AT (2) ATE427938T1 (fr)
AU (1) AU767724B2 (fr)
BR (1) BR0107922A (fr)
CA (3) CA2639210C (fr)
CO (1) CO5271705A1 (fr)
CY (1) CY1111567T1 (fr)
CZ (1) CZ301572B6 (fr)
DE (2) DE60138271D1 (fr)
DK (1) DK2067772T3 (fr)
ES (2) ES2324900T3 (fr)
GB (1) GB0002740D0 (fr)
HK (1) HK1052501A1 (fr)
HU (1) HU229420B1 (fr)
IL (3) IL150613A0 (fr)
MX (1) MXPA02007629A (fr)
MY (1) MY136474A (fr)
NO (1) NO324949B1 (fr)
NZ (1) NZ520329A (fr)
PE (1) PE20011078A1 (fr)
PL (2) PL217225B1 (fr)
PT (2) PT1265868E (fr)
RU (1) RU2303591C2 (fr)
SI (1) SI2067772T1 (fr)
SK (1) SK287217B6 (fr)
TR (1) TR200201655T2 (fr)
TW (1) TWI284638B (fr)
WO (1) WO2001056992A2 (fr)
ZA (1) ZA200206219B (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1302464A1 (fr) * 2001-10-09 2003-04-16 Max India Limited Procédé pour la préparation de 10-méthoxycarbamazépine
US6670472B2 (en) 2001-10-09 2003-12-30 Max India Limited Process for the preparation of 10-methoxycarbamazepine
US7091339B2 (en) 2002-06-14 2006-08-15 Taro Pharmaceuticals Usa, Inc. Method of preparing a 5H-dibenz(b,f)azepine-5-carboxamide
ITMI20040452A1 (it) 2004-03-09 2004-06-09 Clariant Lsm Italia Spa Processo per la preparazione di oxcarbazepina
MX2007014114A (es) 2005-05-10 2008-03-14 Intermune Inc Derivados de piridona para modular el sistema de proteina cinasa activada por estres.
ATE496623T1 (de) * 2006-04-26 2011-02-15 Supernus Pharmaceuticals Inc Oxcarbazepin-zubereitungen für kontrollierte freisetzung mit sigmoidalem freisetzungsprofil
US20090082335A1 (en) * 2007-09-26 2009-03-26 Protia, Llc Deuterium-enriched oxcarbazepine
CA3034994A1 (fr) 2008-06-03 2009-12-10 Intermune, Inc. Composes et procedes de traitement des troubles inflammatoires et fibrotiques
US20150232426A1 (en) 2012-09-26 2015-08-20 Ranbaxy Laboratories Limited Process for the preparation of oxcarbazepine and its use as intermediate in the preparation of eslicarbazepine acetate
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
JP6863742B2 (ja) * 2013-09-11 2021-04-21 ジ・アドミニストレーターズ・オブ・ザ・チューレーン・エデュケーショナル・ファンド 新規アントラニルアミドとその使用
CN106459042B (zh) 2014-04-02 2019-06-28 英特穆恩公司 抗纤维化吡啶酮类

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996021649A1 (fr) * 1995-01-13 1996-07-18 Trifarma, S.R.L. PROCEDE DE PREPARATION DU 10-OXO-10,11-DIHYDRO-5H-DIBENZ(b,f)AZEPIN-5-CARBOXAMIDE

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4847374A (en) * 1987-01-27 1989-07-11 Ciba-Geigy Corporation Process for the manufacture of N,N-(Dibenzohexatrienylene)ureas
US6355680B1 (en) * 1996-02-20 2002-03-12 Exocell, Inc. Albumin-binding compounds that prevent nonenzymatic glycation and that may be used for treatment of glycation-related pathologies
IT1283594B1 (it) * 1996-04-12 1998-04-22 Trifarma Srl Derivati della 5h-dibenz- (b,f)-azepin-5-carbossiammide, loro preparazione e uso come sostanze ad azione medicinale
ATE344791T1 (de) * 1997-07-01 2006-11-15 Warner Lambert Co 2-(4-brom or 4-iod phenylamino)benzoesäurederivate und ihre anwendung als mek-inhibitoren
US6048856A (en) * 1997-12-17 2000-04-11 Novo Nordisk A/S Heterocyclic compounds

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996021649A1 (fr) * 1995-01-13 1996-07-18 Trifarma, S.R.L. PROCEDE DE PREPARATION DU 10-OXO-10,11-DIHYDRO-5H-DIBENZ(b,f)AZEPIN-5-CARBOXAMIDE

Also Published As

Publication number Publication date
PL356404A1 (en) 2004-06-28
EP2067772B1 (fr) 2011-04-13
IL188183A (en) 2011-02-28
PL217225B1 (pl) 2014-06-30
KR100966209B1 (ko) 2010-06-25
CA2395601C (fr) 2010-01-05
TR200201655T2 (tr) 2002-11-21
HU229420B1 (en) 2013-12-30
AU4237301A (en) 2001-08-14
CN1394204A (zh) 2003-01-29
AR079237A2 (es) 2012-01-04
PT1265868E (pt) 2009-07-15
ES2324900T3 (es) 2009-08-19
DE60138271D1 (de) 2009-05-20
IL150613A0 (en) 2003-02-12
DK2067772T3 (da) 2011-07-18
CA2724295A1 (fr) 2001-08-09
CN1721409A (zh) 2006-01-18
RU2002123334A (ru) 2004-01-10
ATE505459T1 (de) 2011-04-15
PT2067772E (pt) 2011-07-13
BR0107922A (pt) 2002-10-22
PE20011078A1 (es) 2001-11-16
ZA200206219B (en) 2003-04-04
NO20023575L (no) 2002-07-26
CZ301572B6 (cs) 2010-04-21
SK11262002A3 (sk) 2003-02-04
KR20100018069A (ko) 2010-02-16
RU2303591C2 (ru) 2007-07-27
CO5271705A1 (es) 2003-04-30
HUP0300243A2 (hu) 2003-06-28
EP2067772A2 (fr) 2009-06-10
CN1244563C (zh) 2006-03-08
IL150613A (en) 2010-05-17
MY136474A (en) 2008-10-31
NZ520329A (en) 2003-11-28
CA2724295C (fr) 2011-07-26
CZ20022676A3 (cs) 2002-11-13
DE60144456D1 (de) 2011-05-26
CA2395601A1 (fr) 2001-08-09
WO2001056992A2 (fr) 2001-08-09
KR20090102882A (ko) 2009-09-30
CA2639210A1 (fr) 2001-08-09
NO324949B1 (no) 2008-01-14
WO2001056992A3 (fr) 2002-01-24
SK287217B6 (sk) 2010-03-08
CA2639210C (fr) 2011-05-03
AU767724B2 (en) 2003-11-20
TWI284638B (en) 2007-08-01
US7112673B2 (en) 2006-09-26
KR101216285B1 (ko) 2012-12-28
AR029442A1 (es) 2003-06-25
US20030032800A1 (en) 2003-02-13
MXPA02007629A (es) 2002-12-13
HUP0300243A3 (en) 2005-07-28
JP4859322B2 (ja) 2012-01-25
ATE427938T1 (de) 2009-04-15
CN100455572C (zh) 2009-01-28
KR20080103608A (ko) 2008-11-27
PL214039B1 (pl) 2013-06-28
SI2067772T1 (sl) 2011-08-31
CY1111567T1 (el) 2015-10-07
KR100931753B1 (ko) 2009-12-14
NO20023575D0 (no) 2002-07-26
GB0002740D0 (en) 2000-03-29
HK1052501A1 (en) 2003-09-19
JP2003521536A (ja) 2003-07-15
KR20020071033A (ko) 2002-09-11
EP1265868B1 (fr) 2009-04-08
KR20080003016A (ko) 2008-01-04
EP1265868A2 (fr) 2002-12-18
PL392476A1 (pl) 2010-11-22
ES2363490T3 (es) 2011-08-05

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