EP1735020A1 - Injizierbare vernetzte und unvernetzte alginate und ihre verwendung in der medizin und in der ästhetischen chirurgie - Google Patents
Injizierbare vernetzte und unvernetzte alginate und ihre verwendung in der medizin und in der ästhetischen chirurgieInfo
- Publication number
- EP1735020A1 EP1735020A1 EP05707688A EP05707688A EP1735020A1 EP 1735020 A1 EP1735020 A1 EP 1735020A1 EP 05707688 A EP05707688 A EP 05707688A EP 05707688 A EP05707688 A EP 05707688A EP 1735020 A1 EP1735020 A1 EP 1735020A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- alginate
- use according
- crosslinked
- solution
- microcapsules
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/042—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
Definitions
- the chemical denervation eg by Botulmumtoxm A
- the surface leveling and on the third the treatment with "fillers” - the dermis is relined with endogenous or foreign substances.
- the present invention describes the novel use of alginates for the application as "F ⁇ ller M substance.
- foreign fillers which mainly consist of biological substances such as collagen or hyaluronic acid (eg: collagen: Zyderm ® , Zyplast ® , Atelocollagen ® , Resoplast ® ® .
- Hyaluronic acid is a mucopolysaccharide that is found in almost every part of a living organism and especially in the skin. Chemically, hyaluronic acid is made from straight polymer chains. ten with a molecular weight in the range of several hundred thousand to million daltons, which contain repeating disaccharide units from N-acetylglucosamine and glucuronic acid, which are linked together by glycosidic bonds.
- GSD gastroesophageal reflux disease
- Gastroosophageal reflux disease describes the backflow of acidic, enzymatic fluid from the stomach to the esophagus. It causes heartburn , Regurgitation and vomiting of gastric acid in the mouth or even in the lungs.
- the consequences of "GERD” are burns of the esophagus and the formation of ulcers, whereby the normal epithelial tissue is replaced by pathological tissue.
- the lower oesophageal sphincter muscle closes after eating. This does not happen in patients suffering from “GERD”, instead the muscle relaxes and the gastric acid can flow through the esophagus if the stomach contracts. This is the main cause of "GERD”, other causes are possible.
- the material should be injectable through a narrow cannula without the geometric shapes, e.g. Microcapsules are destroyed. 2. The material must be so variable for the different applications that short to long-term stability can be achieved in vivo. 3. The material should remain at the injection site and not migrate. 4. The material should be soluble in an emergency or after the end of the indication. 5. The material must be biocompatible.
- the alkali salts of the alginates are water-soluble, while the salts of the alginates with most divalent or polyvalent cations form insoluble gels (so-called hydrogels) in aqueous solution.
- the large physical range of variation of the alginates is given by a number of factors: viscosity (or molecular weight distribution), concentration, ratio of the monomers and the affinity of the cation used for the crosslinking. For example, it is known that alginates cross-linked with calcium form less stable hydrogels than alginates cross-linked with barium.
- substances can also be added to the algmat or covalently bound to the alginate which create a histological connection after the injection between the algmat capsules or the algae gel and the surrounding tissue.
- adhesion proteins eg RGD tripeptides.
- the microcapsules for the treatment of urinary incontinence and the vesico-ureteral reflux disease are injected into the ureteral sphincter, the bladder sphincter or the urethral muscles.
- the sphincter volume increases in proportion to the volume of the microcapsules injected. This reduces the inner lumen of the sphincter muscle and allows a better contraction of the muscle, which reduces the likelihood of urinary incontinence.
- other forms of use described above can also be used, e.g. B. Injection of calcium crosslinked microcapsules from alginate or injection of uncrosslinked algae gel with and without methods for in situ crosslinking.
- the implantation should preferably be carried out using standard techniques which correspond to the state of the art, e.g. endoscopic or laparoscopic techniques.
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Dermatology (AREA)
- Surgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Manufacturing Of Micro-Capsules (AREA)
Abstract
Description
Claims
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102004019241A DE102004019241A1 (de) | 2004-04-16 | 2004-04-16 | Injizierbare vernetzte und unvernetzte Alginate und ihre Verwendung in der Medizin und in der ästhetischen Chirurgie |
PCT/EP2005/002201 WO2005105167A1 (de) | 2004-04-16 | 2005-03-02 | Injizierbare vernetzte und unvernetzte alginate und ihre verwendung in der medizin und in der ästhetischen chirurgie |
Publications (1)
Publication Number | Publication Date |
---|---|
EP1735020A1 true EP1735020A1 (de) | 2006-12-27 |
Family
ID=34961026
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP05707688A Withdrawn EP1735020A1 (de) | 2004-04-16 | 2005-03-02 | Injizierbare vernetzte und unvernetzte alginate und ihre verwendung in der medizin und in der ästhetischen chirurgie |
Country Status (5)
Country | Link |
---|---|
US (2) | US8163714B2 (de) |
EP (1) | EP1735020A1 (de) |
BR (1) | BRPI0509924A (de) |
DE (1) | DE102004019241A1 (de) |
WO (1) | WO2005105167A1 (de) |
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2004
- 2004-04-16 DE DE102004019241A patent/DE102004019241A1/de not_active Withdrawn
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- 2005-03-02 BR BRPI0509924-2A patent/BRPI0509924A/pt active Search and Examination
- 2005-03-02 US US10/599,980 patent/US8163714B2/en not_active Expired - Fee Related
- 2005-03-02 WO PCT/EP2005/002201 patent/WO2005105167A1/de active Application Filing
-
2007
- 2007-02-27 US US11/679,665 patent/US20070189114A1/en not_active Abandoned
Non-Patent Citations (1)
Title |
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See references of WO2005105167A1 * |
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BRPI0509924A (pt) | 2007-09-18 |
DE102004019241A1 (de) | 2005-11-03 |
US20070179117A1 (en) | 2007-08-02 |
US20070189114A1 (en) | 2007-08-16 |
US8163714B2 (en) | 2012-04-24 |
WO2005105167A1 (de) | 2005-11-10 |
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