DE784487T1 - Ein präparat und ein verfahren zur gewebevermehrung - Google Patents
Ein präparat und ein verfahren zur gewebevermehrungInfo
- Publication number
- DE784487T1 DE784487T1 DE0784487T DE94909365T DE784487T1 DE 784487 T1 DE784487 T1 DE 784487T1 DE 0784487 T DE0784487 T DE 0784487T DE 94909365 T DE94909365 T DE 94909365T DE 784487 T1 DE784487 T1 DE 784487T1
- Authority
- DE
- Germany
- Prior art keywords
- tissue
- agent
- pseudoplastic
- copolymers
- injecting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 title claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 6
- 239000004480 active ingredient Substances 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 229920000642 polymer Polymers 0.000 claims 3
- 230000002787 reinforcement Effects 0.000 claims 3
- 239000000126 substance Substances 0.000 claims 3
- 229920001577 copolymer Polymers 0.000 claims 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 1
- LCTORNIWLGOBPB-GASJEMHNSA-N (3r,4s,5s,6r)-2-amino-6-(hydroxymethyl)oxane-2,3,4,5-tetrol Chemical group NC1(O)O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O LCTORNIWLGOBPB-GASJEMHNSA-N 0.000 claims 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims 1
- 102000008186 Collagen Human genes 0.000 claims 1
- 108010035532 Collagen Proteins 0.000 claims 1
- 229920001605 Dextranomer Polymers 0.000 claims 1
- 229920001503 Glucan Polymers 0.000 claims 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims 1
- 229920001397 Poly-beta-hydroxybutyrate Polymers 0.000 claims 1
- 229920000331 Polyhydroxybutyrate Polymers 0.000 claims 1
- 229920002472 Starch Polymers 0.000 claims 1
- 229920000615 alginic acid Polymers 0.000 claims 1
- 235000010443 alginic acid Nutrition 0.000 claims 1
- 239000001768 carboxy methyl cellulose Substances 0.000 claims 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims 1
- 229940105329 carboxymethylcellulose Drugs 0.000 claims 1
- 229920001436 collagen Polymers 0.000 claims 1
- 229960002864 dextranomer Drugs 0.000 claims 1
- 239000000835 fiber Substances 0.000 claims 1
- 229920002674 hyaluronan Polymers 0.000 claims 1
- 229960003160 hyaluronic acid Drugs 0.000 claims 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims 1
- 229940071826 hydroxyethyl cellulose Drugs 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 229920000747 poly(lactic acid) Polymers 0.000 claims 1
- 239000012779 reinforcing material Substances 0.000 claims 1
- 239000008107 starch Substances 0.000 claims 1
- 235000019698 starch Nutrition 0.000 claims 1
- 238000005728 strengthening Methods 0.000 claims 1
- 238000013268 sustained release Methods 0.000 claims 1
- 239000012730 sustained-release form Substances 0.000 claims 1
- 229920001285 xanthan gum Polymers 0.000 claims 1
- 239000000230 xanthan gum Substances 0.000 claims 1
- 235000010493 xanthan gum Nutrition 0.000 claims 1
- 229940082509 xanthan gum Drugs 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/26—Mixtures of macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/52—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/041—Mixtures of macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/145—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/0059—Cosmetic or alloplastic implants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Vascular Medicine (AREA)
- Dermatology (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Surgery (AREA)
- Transplantation (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Claims (9)
1. Biokompatibles Mittel zur Gewebeverstärkung, umfassend einen pseudoplastischen Polymerträger in einer Menge von 0,05 bis 50% (w/w) des
gesamten Mittels; und eine oder mehrere Gewebe verstärkende Substanz(en), die wasserunlöslich, biokompatibel und bioabbaubar ist/sind.
2. Mittel nach Anspruch 1, wobei der pseudoplastische Polymerträger aus
Glucoseaminglucanen wie Hyaluronsäure, Hydroxyethylcellulose, Carboxymethylcellulose, Xanthangummi und Alginaten ausgewählt ist.
3. Mittel nach Anspruch 1, wobei die Gewebe verstärkende Substanz ein Polymer
und aus Collagen, Stärke, Dextranomer, Polylactid und Copolymeren davon, und
Poly-ß-hydroxybutyrat und Copolymeren davon ausgewählt ist.
4. Mittel nach einem der Ansprüche 1 bis 3, wobei die Gewebe verstärkenden
Substanzen oberflächenmodifiziert sind, um das Wachstum von spezifischen Zelltypen anzuregen oder zu hemmen.
5. Zusammensetzung nach einem der Ansprüche 1 bis 4, ebenfalls umfassend einen
oder mehrere therapeutisch wirksame(n) Bestandteil(e).
6. Mittel nach Anspruch 5, wobei der/die wirksame(n) Bestandteil(e) in einer Form,
die verzögerte Freisetzung gewährleistet, vorliegt/vorliegen.
7. Verfahren zur Gewebeverstärkung, umfassend:
DE/EP O 784487 T1
Injizieren eines Mittels aus einem pseudoplastischen Träger, umfassend ein
Gewebe verstärkendes Material und gegebenenfalls einen wirksamen Bestandteil, in die erforderliche Stelle des menschlichen oder tierischen Körpers zur
Verstärkung des Gewebes an und rund um die Stelle.
8. Verfahren nach Anspruch 7, umfassend Injizieren des Mittels unter faseroptischer
Anleitung.
9. Verfahren nach Anspruch 7 oder 8, umfassend Wiederholen der Injektion nach
einer bestimmten Zeitspanne.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3442293A | 1993-03-19 | 1993-03-19 | |
PCT/SE1994/000060 WO1994021299A1 (en) | 1993-03-19 | 1994-01-27 | A composition and a method for tissue augmentation |
Publications (1)
Publication Number | Publication Date |
---|---|
DE784487T1 true DE784487T1 (de) | 1999-11-04 |
Family
ID=21876306
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE0784487T Pending DE784487T1 (de) | 1993-03-19 | 1994-01-27 | Ein präparat und ein verfahren zur gewebevermehrung |
Country Status (6)
Country | Link |
---|---|
US (1) | US5633001A (de) |
EP (1) | EP0784487A1 (de) |
JP (1) | JP2995090B2 (de) |
CA (1) | CA2158638C (de) |
DE (1) | DE784487T1 (de) |
WO (1) | WO1994021299A1 (de) |
Families Citing this family (126)
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US6174999B1 (en) | 1987-09-18 | 2001-01-16 | Genzyme Corporation | Water insoluble derivatives of polyanionic polysaccharides |
EP0784487A1 (de) * | 1993-03-19 | 1997-07-23 | Medinvent | Ein präparat und ein verfahren zur gewebevermehrung |
EP2025353A2 (de) * | 1993-04-30 | 2009-02-18 | Massachusetts Institute of Technology | Injizierbare Polysaccharid-Zell-Zusammensetzungen |
US5709854A (en) * | 1993-04-30 | 1998-01-20 | Massachusetts Institute Of Technology | Tissue formation by injecting a cell-polymeric solution that gels in vivo |
US5516532A (en) * | 1994-08-05 | 1996-05-14 | Children's Medical Center Corporation | Injectable non-immunogenic cartilage and bone preparation |
US6294202B1 (en) * | 1994-10-06 | 2001-09-25 | Genzyme Corporation | Compositions containing polyanionic polysaccharides and hydrophobic bioabsorbable polymers |
US5591724A (en) * | 1995-02-14 | 1997-01-07 | Bioniche Inc. | Method for treating the urinary bladder and associated structures using hyaluronic acid |
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US5741685A (en) * | 1995-06-07 | 1998-04-21 | Children's Medical Center Corporation | Parenchymal cells packaged in immunoprotective tissue for implantation |
US5827937A (en) * | 1995-07-17 | 1998-10-27 | Q Med Ab | Polysaccharide gel composition |
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FR2764514B1 (fr) * | 1997-06-13 | 1999-09-03 | Biopharmex Holding Sa | Implant injectable en sous-cutane ou intradermique a bioresorbabilite controlee pour la chirurgie reparatrice ou plastique et la dermatologie esthetique |
WO1999043270A1 (en) * | 1998-02-24 | 1999-09-02 | Gerigene Medical Corporation | Augmentation and repair of dermal, subcutaneous, and vocal cord tissue defects |
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US5143724A (en) * | 1990-07-09 | 1992-09-01 | Biomatrix, Inc. | Biocompatible viscoelastic gel slurries, their preparation and use |
SE509991C2 (sv) * | 1992-07-20 | 1999-03-29 | Bengt Hjalmar Aagerup Med Firm | Biologiskt nedbrytbar vävnadsförstärkning |
EP0784487A1 (de) * | 1993-03-19 | 1997-07-23 | Medinvent | Ein präparat und ein verfahren zur gewebevermehrung |
-
1994
- 1994-01-27 EP EP94909365A patent/EP0784487A1/de not_active Ceased
- 1994-01-27 JP JP6520914A patent/JP2995090B2/ja not_active Expired - Lifetime
- 1994-01-27 CA CA002158638A patent/CA2158638C/en not_active Expired - Lifetime
- 1994-01-27 WO PCT/SE1994/000060 patent/WO1994021299A1/en not_active Application Discontinuation
- 1994-01-27 US US08/525,558 patent/US5633001A/en not_active Expired - Lifetime
- 1994-01-27 DE DE0784487T patent/DE784487T1/de active Pending
Also Published As
Publication number | Publication date |
---|---|
EP0784487A1 (de) | 1997-07-23 |
US5633001A (en) | 1997-05-27 |
JP2995090B2 (ja) | 1999-12-27 |
CA2158638A1 (en) | 1994-09-29 |
JPH08507713A (ja) | 1996-08-20 |
WO1994021299A1 (en) | 1994-09-29 |
CA2158638C (en) | 1999-11-30 |
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