Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
  • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
  • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
  • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
  • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
  • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
  • A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
• • D—TEXTILES; PAPER
  • D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
  • D04C—BRAIDING OR MANUFACTURE OF LACE, INCLUDING BOBBIN-NET OR CARBONISED LACE; BRAIDING MACHINES; BRAID; LACE
  • D04C1/00—Braid or lace, e.g. pillow-lace; Processes for the manufacture thereof
  • D04C1/06—Braid or lace serving particular purposes
• • D—TEXTILES; PAPER
  • D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
  • D04C—BRAIDING OR MANUFACTURE OF LACE, INCLUDING BOBBIN-NET OR CARBONISED LACE; BRAIDING MACHINES; BRAID; LACE
  • D04C3/00—Braiding or lacing machines
  • D04C3/48—Auxiliary devices
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
  • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
  • A61B2017/00526—Methods of manufacturing
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
  • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
  • A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
  • A61B2017/00646—Type of implements
  • A61B2017/00659—Type of implements located only on one side of the opening
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
  • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
  • A61B2017/00831—Material properties
  • A61B2017/00867—Material properties shape memory effect
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
  • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
  • A61F2/0063—Implantable repair or support meshes, e.g. hernia meshes
  • A61F2002/0068—Implantable repair or support meshes, e.g. hernia meshes having a special mesh pattern
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
  • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
  • A61F2/02—Prostheses implantable into the body
  • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
  • A61F2/06—Blood vessels
  • A61F2/07—Stent-grafts
  • A61F2002/075—Stent-grafts the stent being loosely attached to the graft material, e.g. by stitching
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
  • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
  • A61F2230/0063—Three-dimensional shapes
  • A61F2230/0073—Quadric-shaped
  • A61F2230/0078—Quadric-shaped hyperboloidal
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
  • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
  • A61F2230/0063—Three-dimensional shapes
  • A61F2230/0073—Quadric-shaped
  • A61F2230/008—Quadric-shaped paraboloidal
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
  • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
  • A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
  • A61F2250/0039—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in diameter
• • D—TEXTILES; PAPER
  • D10—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
  • D10B—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
  • D10B2509/00—Medical; Hygiene
  • D10B2509/08—Hernia repair mesh
• • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
  • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
  • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
  • Y10T29/00—Metal working
  • Y10T29/49—Method of mechanical manufacture
  • Y10T29/49826—Assembling or joining
  • Y10T29/49838—Assembling or joining by stringing

Definitions

• the present invention relates to a method for manufacturing a medical implant openwork structure, including a body conduit stent commonly known as “stent” or an implant for closing a hole in a body wall, commonly referred to as “plug” .
• the invention also relates to an implant obtained by this method.
• a tubular stent It is well known to restore the lumen section of a body lumen by means of a tubular stent.
• This stent commonly called “stent”
• stent is deformable between a state of contraction, allowing its introduction and its sliding in body ducts to the level of the site to be treated, and a state of extension, in which it is supported against the duct wall to be treated and ensures the recovery of said duct section.
• Such a stent may also be used to implant a prosthetic system into a body lumen, for example a heart valve, or to isolate an arterial hernia.
• stents or plugs including stents formed by laser cutting a thin sheet of suitable metal material, or formed by braiding several metal son, including shape memory alloy.
• stents and plugs have the disadvantage of being relatively difficult to manufacture.
• the stents also have the disadvantage of being somewhat adaptable to the diameter variations they can adopt, so that stents of different diameter must be manufactured to treat different body conduits of different diameters.
• Braided stents also have the disadvantage of being relatively aggressive at their ends, which can have significant damaging consequences.
• EP 0 857 471 describes several stent structures, two of which, with a "mesh grid" are difficult to manufacture and have no adaptability of diameter or shape.
• This document also describes a stent formed by a single wire each strand of which travels helically from one end to the other of the stent and is braided to the other strands. At the ends of the stent, each strand is connected to the next strand by a bend.
• This stent structure is considered to remedy only partially the aforementioned drawbacks, particularly with regard to the adaptability of the diameter or shape of the stent and the relatively aggressive nature of its ends.
• the free ends of the first and the last strand are able to protrude beyond the ends of the stent when the diameter or shape of this stent is changed, and thus be particularly aggressive for a body conduit.
• the present invention aims to remedy all of the aforementioned drawbacks of stent manufacturing processes according to the prior art.
• Its main objective is therefore to provide a method of manufacturing a medical implant openwork structure, including a "stent” or a “plug”, relatively easy to implement and to obtain perfectly functional implants.
• Yet another object of the invention is to provide a method for obtaining a stent whose ends are not aggressive for the walls of the treated body duct.
• the method comprises, in a manner known per se, the step of forming the structure from a single wire, by running each wire strand helically from one end to the other of the structure and intersecting this strand. to other previously arranged strands.
• the method further comprises the steps of:
• the method according to the invention thus consists in: a) using a single wire to form a tubular perforated structure; b) forming a first strand whose free end is located substantially set back from a first location corresponding to a first end of the structure to make and run the first strand along a helical path to a second location corresponding to a second end of the structure to achieve, the first strand forming a loop at the second location, thus identifying a second strand; c) running the second strand along a helical path to said first location, intersecting this second strand with the first strand if it meets the latter, said second strand forming a loop at this first location, thus individualizing a strand following ; d) running this next strand along a helical path to the opposite location, intersecting this next strand with the anterior strand or strands it encounters, this next strand forming a loop at
• the absence of welds between the strands and the deformability of the loops also has the essential advantage of allowing a considerable variation of the angles formed by the strands between them.
• the multiple slips of these strands allow an enlarged variability of the different diameters that can be acquired by said structure, and thus the obtaining of a stent having widened possibilities of diameter variations, which allow it to be used to treat a wider range of diameters of body ducts.
• the loops formed by the wire at the ends of said structure participate in these expanded possibilities of deformation and are furthermore not aggressive for the wall of the treated body duct.
• the arrangement of the free ends of the first and the last strand largely set back from the ends of the stent allow wide adaptations of the diameter and / or the shape of the stent without risking that these ends protrude beyond the ends of the stent and that they are not likely to constitute injurious injections for the body duct to be treated.
• the resulting structure can be used as such as a tubular stent. It then has the advantage of having a diameter that can easily vary or have a shape easily adaptable to the conformation of the body site to be treated.
• This structure can also be used as a sketch for obtaining a stent or "plug" of specific shapes.
• the process then comprises:
• the crossing of a strand with the other strands that this strand encounters is done according to a braiding, that is to say that this strand passes alternately on a strand it meets then under the next strand, and and so on.
• This braiding gives the structure a holding allowing it to be used as such as a stent or to serve as a blank for the manufacture of other implants, including plugs. This braiding also allows a reliable stop of the first and the last strand formed by the wire.
• the wire used may in particular be a shape memory alloy wire, in particular the nickel-titanium alloy known under the name "NITINOL".
• the diameter of the wire used can range from 0.15 to 0.5 mm.
• the diameter of the structures that can be manufactured by the process according to the invention is very wide, and ranges from 5 to 100 mm.
• the method may comprise the step of placing on said structure a longitudinal shortening means of this structure, capable of passing from an elongation state to a state of shortening.
• This means of longitudinal shortening allows the deployment of the structure, or to facilitate this deployment.
• This means of longitudinal shortening may be an elastic means, for example a strap of elastic material, in particular silicone; this means can also be shape memory and go from its state of elongation to its state of shortening by reheating at body temperature following the implantation of the structure. Said longitudinal shortening means may in particular be engaged through two loops formed at the ends of said structure.
• the method may further comprise the step of coating said structure with a sealed flexible wall, especially a teflon sheet sewn to this structure.
• the latter is thus waterproof and can isolate an arterial hernia when it is in place.
• Figures 1 to 4 are perspective views of a device used for the implementation of this method, respectively showing four successive steps that includes this method;
• Figure 5 is a perspective view of the perforated tubular structure obtained; for the clarity of the drawing, this structure is fictitiously represented as opaque, the foreground parts hiding the parts in the background;
• Figure 6 is a view of said structure similar to Figure 5, at another angle, the structure being equipped with an elastic strap forming a means of longitudinal shortening;
• Figure 7 is a perspective view of another device used for the implementation of this method;
• Figure 8 is a perspective view of this device with placement on it of a perforated tubular structure;
• Figure 9 is a view of this perforated tubular structure, after withdrawal from the device; here also, this structure is fictitiously represented as opaque;
• FIGS. 10 to 12 are respectively front, side and sectional views, after placement on a body wall, of an implant obtained from the perforated tubular structure shown in FIG. 9, this implant being intended to close off an existing hole in a body wall;
• FIGS. 13 and 14 are respectively side and sectional views, after placement on a body wall, of another implant obtained from the perforated tubular structure shown in FIG. 9, this implant also being intended to seal a existing hole in a body wall;
• Figures 15 and 16 are side views of two examples of perforated tubular structures obtainable by the method according to the invention. For simplicity, the parts or elements found on these different devices and structures will be designated by the same numerical references and will not be described again.
• FIG. 1 represents a tubular mandrel 1 pierced with holes 2 regularly distributed on its wall, these holes 2 being aligned longitudinally and transversely.
• the mandrel 1 comprises series of holes regularly distributed over its circumference, receiving with friction, but with removability, cylindrical pins 3.
• the mandrel 1 further comprises a hole 4 arranged slightly recessed from one of its ends 1b.
• the mandrel 1 is intended to be used to manufacture a perforated tubular structure 10 as shown in FIGS. 5 and 6 by means of a single wire 11.
• This wire 11 is in particular made of a shape memory alloy known by the name "Nitinol".
• a suitable length of wire 11 is cut, for example four meters, and a wire end 11a is fixed to the mandrel 1 by engagement in the hole 4 and around the end edge of the mandrel 1 and then twist of this end 11a on itself.
• the wire 11 is then passed around a pin 3 of the end 1b slightly angularly offset, and then along the wall of the mandrel 1, in a helical path passing over holes 2 aligned on this path.
• the first strand 11b of wire thus formed runs along the wall of the mandrel 1 and is then engaged around the corresponding pin 3 of the end 1a, forming a loop around this pin 3, thus individualizing a second strand 11c.
• this second strand 11c is passed along the wall of the mandrel 1 along a helical path until it returns to a corresponding pin 3 of the end 1b and forms a loop 12 around the latter, individualizing thus a strand 11d following.
• the number of holes 2 and pins 3 is determined so that the second strand 11c returns to the pin 3 adjacent to the pin 3 which is engaged in the previous strand 11b.
• Each strand is braided with the other strands that it crosses, that is to say, passes alternately on a strand it meets then under the next strand, and so after. This braiding is facilitated by the holes 2 and the conformation of the free end 11e of the wire 11 hook.
• the last strand is braided with the strands it encounters, then the end of this strand is cut to the desired length, so that it is set back from the corresponding end of the mandrel 1, namely the end 1a in the example shown.
• the first strand 11b is then cut to the desired length, so that its end is set back from the end 1b, then the pins 3 are extracted from the holes which receive them so as to release the structure 10 and to make it possible to remove the of the mandrel 1 by sliding.
• the structure 10 thus formed therefore does not comprise welds between the strands of wire 11, or twists at its ends but loops 12.
• the absence of welds between the strands and the existence of these loops 12 allow a sliding strands against each other when transverse stresses are exerted transversely on the structure 10, and this sliding allows a significant variation in the angles that form the strands between them and therefore the diameter that can acquire said structure 10.
• the latter can be used as it is and constitute a body conduit stent commonly called "stent".
• stent After manufacture in the aforementioned manner, it undergoes in this case one or more heat treatments to stabilize its shape and give it superelastic properties.
• the structure 10 may also be deformed to form a stent of smaller or larger diameter, or a stent of particular shape, for example with a median constriction.
• a suitable restraining device maintaining the structure 10 in the form to be obtained before heat treatment, is used in each case, namely a compression tube for the production of a stent of smaller diameter, a mandrel of larger diameter than the mandrel 1 for the manufacture of a larger diameter stent, or a shape suitable in other cases.
• 15 and 16 show in this regard two examples of perforated structures 10A, 10B obtained by braiding on a mandrel of suitable shape or by deformation of the structure 10 and then heat treatment thereof in the deformed state, namely a structure 10A whose one end is flared and a structure 10B whose middle zone is bulged.
• the structure 10A can notably serve as a stent for treating a tetralogy of Fallot
• the structure 10B can be used as an aortic stent for the placement of an aortic valve, the swelling area adapting to the valsalva sinus.
• FIG. 6 shows a structure 10 obtained in the manner previously described, on which a silicone bracelet 13 has been put in place, engaged through two loops 12 substantially aligned longitudinally.
• This bracelet 13 is elastic and is stretched when the structure 10 is in a state of radial contraction, given the closure of the angles that form the strands between them during this contraction, and therefore the increase in the length of the structure 10.
• This contraction is released, at the time of placing the implant that forms this structure, the bracelet 13 tends to resume its undrawn form, as shown by the arrows 15.
• This bracelet 13 is therefore, in a simple manner, a longitudinal shortening means of said structure 10, which allows, or promotes, the deployment of this structure 10.
• FIGS. 7 to 9 show a mandrel 1 designed to allow the manufacture of a stent structure 10 shown in FIG. 9, comprising a central narrowing 17.
• the mandrel 1 in this case comprises two longitudinal end portions 20 of larger diameter and a middle portion 21 of smaller diameter.
• the parts 20 comprise the holes 18 for receiving the pins 3.
• One of the parts 20 is removable with respect to the portion 21, to allow the removal of the structure 10 obtained from the mandrel 1.
• a structure 10 as shown in Figure 5 is implemented on the mandrel 1, the length of the latter being such that the strands extend loosely between the pins 3 to allow to develop said narrowing 17.
• the loops 12 allow a perfect maintenance of the structure 10 on the mandrel 1 by means of the pins 3.
• One or more compression yarns 22 is then used to form the retracted medial portion 17 of the structure 10, as shown in FIG. 8, to suitably shape the stent and maintain it in that shape during the subsequent heat treatment (s). .
• the stent thus obtained is particularly intended to allow the establishment of a prosthetic valve in a body duct. It is covered with a waterproof sheet, especially Teflon.
• the shrinkage structure 17 shown in FIG. 9 may also serve as a blank for the fabrication of implants 23, 24 as shown in FIGS. 10 to 14.
• Implants 23 is of the kind commonly called “plug", which is capable of closing a hole in a body wall 100, in particular an interventricular hole in a heart. It comprises for this purpose a median portion 25 intended to be engaged in said hole, one or two flanges 26 adjacent to this central portion 25, able to bear against said wall 100, on either side thereof, and a sheet of material closing the opening that forms the middle portion 25, including a teflon sheet.
• FIG. 12 shows that the implant 23 can receive one or more elastic clips 27 ensuring the maintenance of the two flanges 26 on either side of the wall 100.
• the implant 24 shown in Figures 13 and 14 is intended for receiving a prosthetic valve and to allow its mounting on a wall or similar body area.
• a portion 10a corresponding to slightly less than the longitudinal half of the structure 10 is folded over the other part 10b of this structure 10 and is folded radially outwardly at its free end portion 10c, thus to form one of the two flanges 26.
• the end portion 10d of the other portion 10b of the structure 10 opposite the portion 10a is bent radially outward, and makes it possible to form the other flange 26.
• the structure 10 thus deformed is placed in a restraining device which maintains it in this form then undergoes the appropriate heat treatment or treatments stabilizing its shape and conferring on it superelastic properties.
• the implant 24 also receives a waterproof sheet which covers it, in particular Teflon.
• the invention provides a method of manufacturing a medical implant with openwork structure, in particular a "stent” or a “plug", relatively easy to implement and allowing the obtaining implants 10, 23, 24 remaining perfectly functional.

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• Health & Medical Sciences (AREA)
• Engineering & Computer Science (AREA)
• Life Sciences & Earth Sciences (AREA)
• Biomedical Technology (AREA)
• Animal Behavior & Ethology (AREA)
• General Health & Medical Sciences (AREA)
• Veterinary Medicine (AREA)
• Heart & Thoracic Surgery (AREA)
• Public Health (AREA)
• Surgery (AREA)
• Cardiology (AREA)
• Molecular Biology (AREA)
• Medical Informatics (AREA)
• Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
• Textile Engineering (AREA)
• Oral & Maxillofacial Surgery (AREA)
• Transplantation (AREA)
• Vascular Medicine (AREA)
• Manufacturing & Machinery (AREA)
• Prostheses (AREA)
• Media Introduction/Drainage Providing Device (AREA)

Applications Claiming Priority (3)

Publications (1)

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Family Applications (1)

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Cited By (60)

Families Citing this family (171)

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• 2002
  • 2002-11-20 FR FR0214522A patent/FR2847155B1/fr not_active Expired - Fee Related
• 2003
  • 2003-11-05 EP EP03767908A patent/EP1562515A1/fr not_active Withdrawn
  • 2003-11-05 US US10/514,329 patent/US20050283962A1/en not_active Abandoned
  • 2003-11-05 AU AU2003292341A patent/AU2003292341A1/en not_active Abandoned
  • 2003-11-05 CA CA002506305A patent/CA2506305A1/fr not_active Abandoned
  • 2003-11-05 JP JP2004554589A patent/JP2006506201A/ja active Pending
  • 2003-11-05 WO PCT/FR2003/003296 patent/WO2004047681A1/fr active Application Filing

Non-Patent Citations (1)

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