EP1368605B1 - Verfahren zur schonenden gewinnung von trockenextrakten - Google Patents
Verfahren zur schonenden gewinnung von trockenextrakten Download PDFInfo
- Publication number
- EP1368605B1 EP1368605B1 EP02732476A EP02732476A EP1368605B1 EP 1368605 B1 EP1368605 B1 EP 1368605B1 EP 02732476 A EP02732476 A EP 02732476A EP 02732476 A EP02732476 A EP 02732476A EP 1368605 B1 EP1368605 B1 EP 1368605B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- liquid
- extract
- drying chamber
- plant extract
- nozzle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B5/00—Drying solid materials or objects by processes not involving the application of heat
- F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
Definitions
- the present invention relates to a process for the gentle recovery of dry extracts, especially dry plant extracts, especially foaming Dry plant extracts.
- Dry plant extracts are usually prepared by adding one Extracts plant material with the aid of a solvent or solvent mixture, for example, by maceration or percolation and after separation of the Extraction residue, the obtained fluid extract or the tincture obtained to Dry clothes.
- Conventional drying methods include fluidized bed drying or Narrowing to a thick or spissum extract followed by vacuum belt drying or tray drying of this spissum extract.
- the batch to be dried fluid extract from above pumped into the mixing and drying chamber and then applied a vacuum. If continuous operation is desired, the fluid extract to be dried becomes pumped below the filling level in the mixing and drying chamber.
- Object of the present invention is therefore to provide a method which the gentle extraction of dry plant extracts with foaming Ingredients allowed and / or which further accelerate the out of the EP-B-0 753 306 known drying method allowed.
- the method according to the invention accordingly differs from the previously known one Procedure that the liquid plant extract in a specific way in the Mixing and drying chamber is introduced. More specifically, according to the invention, a finely distributed introduction by at least one nozzle above the level of the Mixing and drying chamber.
- nozzles for uniform introduction over the volume of the mixing and drying chamber, the use of multiple nozzles (2 to 10, preferably 2 to 4 nozzles) may be provided. These can be arranged in series or in clusters be preferred, with arrangements that a uniform moistening allow the chamber.
- Each nozzle generates a droplet spray cone in at least one spatial direction ⁇ 30 °, preferably ⁇ 60 °, and most preferably ⁇ 90 °. More preferred rotationally symmetric spray cones such as circular hollow cones or full cones. The Choice of the appropriate cone shape depends on the shape of the mixing and drying chamber, the number of nozzles and the evaporator capacity of the drying plant from.
- a linear arrangement of the nozzles and a formation of a spray cone be preferred in a plane normal to the row of nozzles.
- the nozzles in the same arrangement can also with high evaporator performance Generation of full cones, but at lower evaporator power generation be preferred by Hohlkegeln.
- the nozzles used according to the invention produce a Drop spray cone of ⁇ 30 ° for fine distribution or distribution of the pumped liquid plant extract.
- the mean drop size of the sprayed liquid Plant extract is in drops of ⁇ 300 microns, preferably ⁇ 150 microns and still more preferably ⁇ 100 ⁇ m. The smaller the drops, the larger the surface the evaporation takes place, and therefore the faster the drying. Vice versa the smaller drop size requires a higher pressure difference, so the Drop size down in this regard are limited.
- the delivery rate seen as the sum of all nozzles, is less than or equal to the evaporator capacity the drying plant to accumulate liquid material in to avoid the mixing and drying chamber.
- the Delivery rate for a volume of mixed and Drying chamber of 2000 I and an evaporator capacity of> 300 l / h is the Delivery rate as the sum of all nozzles, for example, ⁇ 250 l / h, preferably ⁇ 150 l / h and most preferably ⁇ 120 l / h.
- the optimization of the delivery rate of the nozzle is within the skill of the artisan and is based on the given parameters by means of usual routine measures on the respectively used vacuum drying plant align.
- the extract becomes at a pressure difference of> 100 mbar between drying chamber and reservoir in the mixing and drying chamber initiated.
- This pressure difference can be achieved by applying a pressure of outside and / or applying a vacuum to the mixing and drying chamber generated become.
- the pressure difference is exclusively by applying a vacuum generated to the mixing and drying chamber while the reservoir or the Feed line of the liquid extract is under atmospheric pressure.
- the pressure difference is at ⁇ 500 mbar, even more preferably at ⁇ 900 mbar.
- the drying itself is usually carried out at a jacket temperature of 20 ° C to 50 ° C and a product temperature between 20 ° C and 40 ° C and a pressure between 0.5 and 1000 mbar.
- the jacket temperature of 20 ° C to 45 ° C, and most preferably from 20 ° C to 40 ° C.
- the product temperature is preferably between 20 and 30 ° C, most preferably at 25 ° C.
- Of the Pressure is preferably 5 to 100 mbar, more preferably 30 to 70 mbar.
- the liquid plant extract can basically be sprayed at any temperature provided it is liquid at this temperature. Upwards is the spraying temperature of the plant extract by the decomposition temperature of the desired Plant ingredients limited. Because the pressure of the drying chamber is smaller as the pressure of the liquid plant extract is before it passes through the nozzle, relaxes the liquid plant extract after spraying in the mixed and Drying chamber. This cools the liquid plant extract. Is preferred therefore, the spraying temperature of the liquid plant extract immediately before Spray greater than or equal to the product temperature. The temperature of the liquid Plant extract may also be greater than or equal to the jacket temperature prior to spraying provided this temperature exceeds the decomposition temperature the corresponding ingredients. The injection temperature of the liquid plant extract between 20 and 120 ° C, more preferably between 30 and 100 ° C, and most preferably between 30 and 80 ° C. The extract is preferred heated to the desired temperature just before spraying.
- the nozzles to be used may be single nozzles or multiple nozzles with at least 2 channels, preferably 2 to 4 and most preferably 2 channels is.
- About the multiple nozzles can be at least two different liquid Plant extracts and maximally according to the number of channels different Plant extracts simultaneously and / or successively in the mixing and drying chamber be introduced. This allows mixed dry extracts of different Origin are produced. Needless to say, only one extract can be used by all Channels of a multi-nozzle are sprayed.
- any liquid plant extract be dried.
- liquid plant extracts containing active ingredients such as essential oils (terpenes), phenols, lignins, polysaccharides, proteins, carotenes, Lipids, acids, betaines, etc. are preferred over the inventive Process but dried plant extracts containing foam-forming ingredients.
- foaming ingredients may include saponins, soaps, Polysaccharides, lignins, phenols, waxes and / or proteins.
- the foam-forming ingredients are saponins, soaps and / or Proteins
- the liquid plant extract may be from the whole plant or parts like flowers, Leaves, stems, roots and fruits or mixtures thereof are obtained.
- the liquid plant extract is, for example, an extract Echinacea (sun hat), Salvia officinalis (sage), Agnus castus (chaste tree), Allium cepa (onion), Rosmarinus officinalis (rosemary), Thymus vulgaris (Thyme), Origanum maiorana (marjoram), Camomilla recutica and Anthemis nobilis (Camomile), camphora (camphor), mentha piperita (peppermint), mentha (mint), piperis (Pepper), Pinus (pine, mountain pine), citrus fruits such as orange, lime and Lemon, Melissa officinalis (Melissa), Hedera Helix, Hippocastanus (Horse Chestnut), Curcuma (Turmeric), Galphimia Glauca, Cinnamomum (Cinnamon), Cimicifuga (
- the liquid plant extract is an extract of Cimicifuga (Black cohosh), Primula (primrose), Valeriana officinalis (valerian), Gentiana (gentian), Plantaginis (plantain), Phytolacca americana, Belamcanda or mixtures the same. Most preferably, they are extracts of Cimicifuga, Plantaginus or Phytolacca americana.
- a dry material in the mixing and drying chamber Prior to spraying the liquid plant extract a dry material in the mixing and drying chamber are presented.
- the dry material is preferably selected from the group consisting of customary auxiliaries and carriers, Plant dry extract (s) and mixtures thereof.
- auxiliary and Carrier may be selected from the group consisting of acrylic and methacrylic derivatives, Alginic acid, sorbic acid derivatives such as alpha-octadecyl-omega-hydroxypoly (oxyethylene) -5-sorbic acid, Amino acids and their derivatives, in particular amine compounds such as choline, lecithin and Phosphatidylcholine, gum arabic, flavorings, ascorbic acid, carbonates such as for example, sodium, potassium, magnesium and calcium carbonate and hydrogen carbonate, hydrogen phosphates and phosphates of sodium, potassium, Calcium and magnesium, carmellose sodium, dimethicone, dyes, flavorings, Preservatives, thickeners, softeners, gelatin, glucose syrups, Silica, preferably fumed silica, hydromellose, Benzoates, especially sodium and potassium benzoate, macrogol, magnesia, Fatty acids and their derivatives and salts such as stearic acid and stearates
- the dry matter is a plant extract or mixtures of such dry plant extracts, for example from a pre-produced one Charge to the again liquid plant extract under dry conditions is sprayed on.
- the examples were equipped on a plant IUT 2000 from Glatt Inox with stirrer and chopper, and with different nozzles of the company Schlick (full cone nozzles with various nozzle openings and spray valves).
- Schlick full cone nozzles with various nozzle openings and spray valves.
- a flapper valve to vent the reactor below the vapor filtration the nozzles listed below and with connected to the reservoir of liquid plant extract.
- a vacuum was applied to the reactor.
- the delivery rate of Nozzle was adapted to the product-specific evaporation capacity of the plant IUT 2000 customized.
- a root extract of Cimicifuga with an ethanol content of 50% prepared in water by conventional methods was as described above, at a temperature of 25 ° C and a vacuum of about 70 mbar is drawn into the IUT 2000 system via a 0.8 mm bore nozzle, the nozzle produced a full cone of 60 °.
- the droplet size was about ⁇ 100 ⁇ m.
- the evaporator performance and the flow rate were about 150-200 l / h.
- In the mixing and drying chamber was an excipient content of about 80% lactose monohydrate submitted.
- the jacket temperature was set to 40 ° C and the Vacuum applied to about 70 mbar. Thereafter, with the spraying of the solution began.
- Example 2 Under similar vacuum and temperature conditions as in Example 1 was a 50% (v./v.) Ethanolic leaf extract of Plantaginis (2500 L) Plantago lanceolata using a nozzle with 0.6 mm bore, which has a full cone of 120 ° produced, with an evaporation capacity and a capacity of about 180 l / h dried. The drop size was about 250 microns. The result was 1000 kg Spissum Extract received within one day.
- Cimicifuga and Plantaginis Drying of Cimicifuga and Plantaginis was previously due to the high Foaming in the plant IUT 2000 after the known from EP-B-0 753 306 Procedure not possible. In Phytolacca the previous drying time was four Days, because of the foaming the vacuum always repealed and the foam had to be broken while drying according to the invention Procedure needed only one day. For Cimicifuga and Plantaginis drying times were according to the method of the invention of two days or one day to dryness or to Spissum (Plantaginis) needed.
Landscapes
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Mechanical Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Medicines Containing Plant Substances (AREA)
- Preparation Of Fruits And Vegetables (AREA)
- Saccharide Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Vaporization, Distillation, Condensation, Sublimation, And Cold Traps (AREA)
- Extraction Or Liquid Replacement (AREA)
Description
Claims (14)
- Verfahren zur schonenden Gewinnung von Trockenextrakten, bei dem man einen flüssigen Extrakt in eine Vakuumtrocknungsanlage einbringt, die ein sich durch eine zylindrische Misch- und Trockenkammer erstreckendes mehrschenkliges Rührwerk mit eigenem Antrieb sowie einen durch einen Stator rotierenden Zerhacker aufweist, und den flüssigen Extrakt bei einer Manteltemperatur von 20°C bis 50°C, einer Produkttemperatur zwischen 20°C und 40°C, einem Druck zwischen 0,5 und 1.000 mbar, einer Rührerumdrehungsgeschwindigkeit von größer 0 bis 10 Upm und einer Zerhackerumdrehungsgeschwindigkeit von 200 bis 800 Upm trocknet,
dadurch gekennzeichnet, dass
der flüssige Extrakt bei einer Druckdifferenz von > 100 mbar zwischen Trockenkammer und Reservoir durch mindestens eine Düse oberhalb des Füllstandes der Misch- und Trockenkammer in diese eingesprüht wird, wobei die Düse(n) je mindestens in einer Raumrichtung einen Tropfen-Sprühkegel von ≥ 30° erzeugt bzw. erzeugen, die mittlere Tropfengröße des eingesprühten flüssigen Extrakts ≤ 300 µm ist und die Förderleistung der Düse(n) (litre/h) kleiner oder gleich der Verdampferleistung (litre/h) der Trocknungsanlage ist. - Verfahren gemäß Anspruch 1, zur Gewinnung eines Pflanzentrockenextrakts aus einem flüssigen Pflanzenextrakt.
- Verfahren nach Anspruch 2, worin die Temperatur des flüssigen Pflanzenextrakts vor dem Einsprühen größer oder gleich der Produkttemperatur ist.
- Verfahren nach Anspruch 2, worin die Temperatur des flüssigen Pflanzenextrakts vor dem Einsprühen größer oder gleich der Manteltemperatur ist.
- Verfahren nach Anspruch 1 oder 2, worin die Düse(n) einen rotationssymmetrischen Tropfen-Streukegel erzeugt bzw. erzeugen.
- Verfahren nach Anspruch 1 oder 2, wobei die Druckdifferenz durch Anlegen eines Vakuums an die Misch- und Trockenkammer erzeugt wird.
- Verfahren nach Anspruch 1 oder 2, wobei über Mehrfachdüsen mit mindestens 2 Kanälen mindestens zwei verschiedene flüssige Extrakte gleichzeitig und/oder nacheinander in die Misch- und Trockenkammer eingebracht werden.
- Verfahren nach Anspruch 2, worin der flüssige Pflanzenextrakt schaumbildende Inhaltsstoffe enthält.
- Verfahren nach Anspruch 8, in dem die schaumbildenden Inhaltsstoffe Saponine, Seifen und/oder Proteine darstellen.
- Verfahren nach einem der Ansprüche 2 bis 8, bei dem der flüssige Pflanzenextrakt ein Extrakt von Cimicifuga (Traubensilberkerze), Primula (Primel), Valeriana offcinalis (Baldrian), Gentiana (Enzian), Plantaginis (Wegerich), Phytolacca americana, Belane Canda oder Gemischen derselben darstellt.
- Verfahren nach Anspruch 2, bei dem vor dem Einsprühen des flüssigen Pflanzenextrakts ein Trockenmaterial in der Trockenkammer vorgelegt wird, ausgewählt aus der Gruppe bestehend aus üblichen Hilfs- und Trägerstoffen, Pflanzentrockenextrakt(en) und Mischungen davon.
- Verfahren nach Anspruch 11, wobei die Hilfs- und Trägerstoffe ausgewählt sind unter Mono-, Di- und Polysacchariden, Silikaten, PVP, Stearaten und deren Mischungen.
- Verfahren nach Anspruch 1 oder 2, wobei die Druckdifferenz durch Anlegen eines Vakuums auf 10 bis 100 mbar an die Trockenkammer erzeugt wird, die Düse(n) einen rotationssymmetrischen Tropfen-Sprühkegel von ≥ 60° erzeugt bzw. erzeugen, die mittlere Tropfengröße ≤ 150 µm ist, die Förderleistung der Düse(n) ≥ 120 l/h beträgt und mit der Verdampferleistung der Vakuumtrocknungsanlage im Wesentlichen identisch ist und die Temperatur des flüssigen Extrakts vor dem Einsprühen höher als die Produkttemperatur ist und in einem Bereich von 30°C bis 80°C liegt.
- Verfahren nach Anspruch 13, wobei in der Trockenkammer ein Trockenmaterial gemäß Anspruch 10 vorgelegt wird.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SI200230226T SI1368605T1 (sl) | 2001-03-12 | 2002-03-12 | Postopek za neagresivno pridobivanje suhih ekstraktov |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10112167A DE10112167C2 (de) | 2001-03-12 | 2001-03-12 | Verfahren zur schonenden Gewinnung von Trockenextrakten |
DE10112167 | 2001-03-12 | ||
PCT/EP2002/002714 WO2002073108A1 (de) | 2001-03-12 | 2002-03-12 | Verfahren zur schonenden gewinnung von trockenextrakten |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1368605A1 EP1368605A1 (de) | 2003-12-10 |
EP1368605B1 true EP1368605B1 (de) | 2005-11-09 |
Family
ID=7677371
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP02732476A Expired - Lifetime EP1368605B1 (de) | 2001-03-12 | 2002-03-12 | Verfahren zur schonenden gewinnung von trockenextrakten |
Country Status (7)
Country | Link |
---|---|
US (1) | US6996919B2 (de) |
EP (1) | EP1368605B1 (de) |
AT (1) | ATE309513T1 (de) |
DE (2) | DE10112167C2 (de) |
DK (1) | DK1368605T3 (de) |
ES (1) | ES2251592T3 (de) |
WO (1) | WO2002073108A1 (de) |
Cited By (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102007044916A1 (de) | 2007-09-19 | 2009-04-23 | Bionorica Ag | Kosmetische oder dermatologische Zusammensetzung zur topischen Verwendung |
DE102008054127A1 (de) | 2008-10-31 | 2010-05-06 | Bionorica Ag | Hydrolysate aus Pflanzenextrakten sowie diese enthaltendes antibakterielles Mittel |
DE102009011152A1 (de) | 2009-03-05 | 2010-09-09 | Bionorica Ag | Hydrolysate aus Pflanzenextrakten sowie diese enthaltendes antibakterielles Mittel |
DE102009019104A1 (de) | 2009-04-29 | 2010-11-04 | Bionorica Se | Kosmetische oder dermatologische Zusammensetzung enthaltend Hydrolysate aus Pflanzenextrakten |
DE102009041753A1 (de) | 2009-09-16 | 2011-03-24 | Bionorica Se | Wasch-, Reinigungs- oder Desinfektionsmittel enthaltend Hydrolysate aus Pflanzenextrakten |
WO2011048221A1 (de) | 2009-10-22 | 2011-04-28 | Bionorica Se | Entzündungshemmendes mittel enthaltend hydrolysate aus pflanzenextrakten |
WO2011134667A2 (de) | 2010-04-29 | 2011-11-03 | Bionorica Se | Ausgewählte hydrolysate aus pflanzenextrakten sowie diese enthaltendes antibakterielles mittel |
WO2011134679A2 (de) | 2010-04-30 | 2011-11-03 | Bionorica Se | Ausgewählte pflanzenextrakte zur behandlung von entzündungserkrankungen |
DE102010021842A1 (de) | 2010-05-28 | 2011-12-01 | Bionorica Se | Thymian/Primel oder Efeu zur Behandlung von chronischobstruktiven Lungenerkrankungen (COPD) |
DE102010040705A1 (de) | 2010-09-14 | 2012-03-15 | Bionorica Se | Blütenextrakt von Primula flos zur Behandlung und Prophylaxe von Entzündungen oder viralen Infektionen |
EP2545932A1 (de) | 2011-07-12 | 2013-01-16 | Bionorica Se | Ausgewählte Cimicifuga-Fraktionen zur Behandlung von Osteoporose |
WO2013007807A1 (de) | 2011-07-12 | 2013-01-17 | Bionorica Se | Ausgewählte cimicifuga-fraktionen zur behandlung von osteoporose |
EP2620155A1 (de) | 2012-01-30 | 2013-07-31 | Bionorica SE | Arzneimittel enthaltend Cimicifuga zur Anwendung bei der Behandlung von Sarkopenie und Herzmuskelschwäche |
EP2810650A1 (de) | 2013-06-06 | 2014-12-10 | Bionorica Se | Arzneimittel enthaltend Thymian und Primel oder Thymian und Efeu als PDE-4-Hemmer |
EP3498306A1 (de) | 2017-12-16 | 2019-06-19 | Bionorica SE | Extrakte aus vitex agnus castus zur behandlung und diagnose von brustkrebs |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7833777B2 (en) * | 2005-08-22 | 2010-11-16 | Nature Technologies International Llc | Stabilized actively aerated compost tea |
WO2009111685A1 (en) * | 2008-03-06 | 2009-09-11 | Sensient Flavors Llc | Herbal extracts and flavor systems for oral products and methods of making the same |
EP2559438A1 (de) | 2011-08-19 | 2013-02-20 | Bionorica Se | Verfahren zur Herstellung von Trockenextrakten |
SI2744504T1 (sl) | 2011-08-19 | 2015-09-30 | Bionorica Se | Postopek za pripravo suhih ekstraktov |
CN103134272A (zh) * | 2011-11-23 | 2013-06-05 | 天津天士力现代中药资源有限公司 | 一种板蓝根提取物的干燥方法 |
CN103900354A (zh) * | 2014-04-14 | 2014-07-02 | 天津中新药业集团股份有限公司达仁堂制药厂 | 一种改进清肺消炎丸干燥的生产方法 |
CN107772196A (zh) * | 2016-08-30 | 2018-03-09 | 东钜能源科技实业有限公司 | 真空干燥萃取系统及其操作方法 |
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CH408781A (de) * | 1964-04-24 | 1966-02-28 | Anderwert Fritz | Verfahren zur Trocknung von zerstäubbarem Gut durch Sublimation und Trockeneinrichtung zur Ausführung des Verfahrens |
DE2849862A1 (de) | 1978-11-17 | 1980-05-29 | Constantin Dipl Ing Sandu | Kombinierte konvektions- und strahlungs-anlage fuer mehrstufige vakuum-verdampfung |
ES2088523T3 (es) | 1991-09-05 | 1996-08-16 | Tsumura & Co | Procedimiento de preparacion de capsulas de gelatina dura que contienen extractos de hierbas chinas. |
IL105658A (en) * | 1993-05-11 | 1995-10-31 | Ultrasonic Dryer Ltd | Spray drying system |
DE19525026A1 (de) * | 1995-07-10 | 1997-01-16 | Plantamed Arzneimittel Gmbh | Verfahren zur Herstellung von pharmazeutischen Zubereitungen mit höherem Gehalt an etherischen Ölen und Phenolen |
DE19547973C2 (de) | 1995-12-21 | 1999-08-12 | Plantamed Arzneimittel Gmbh | Verfahren zur schonenden Keimreduzierung von pharmazeutischen Zubereitungen |
ATE219963T1 (de) | 1998-12-15 | 2002-07-15 | Bionorica Ag | Verfahren zur herstellung von arzneimittelvorprodukte für tabletten, pellets und dragees |
CA2361807A1 (en) * | 1999-02-03 | 2000-08-10 | Julia Eva Diederichs | Compressed air inhaler for pulmonary application of liposomal powder aerosols and powder aerosols suitable therefor |
-
2001
- 2001-03-12 DE DE10112167A patent/DE10112167C2/de not_active Expired - Lifetime
-
2002
- 2002-03-12 DK DK02732476T patent/DK1368605T3/da active
- 2002-03-12 DE DE50204865T patent/DE50204865D1/de not_active Expired - Lifetime
- 2002-03-12 US US10/471,308 patent/US6996919B2/en not_active Expired - Lifetime
- 2002-03-12 ES ES02732476T patent/ES2251592T3/es not_active Expired - Lifetime
- 2002-03-12 EP EP02732476A patent/EP1368605B1/de not_active Expired - Lifetime
- 2002-03-12 WO PCT/EP2002/002714 patent/WO2002073108A1/de not_active Application Discontinuation
- 2002-03-12 AT AT02732476T patent/ATE309513T1/de active
Cited By (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102007044916A1 (de) | 2007-09-19 | 2009-04-23 | Bionorica Ag | Kosmetische oder dermatologische Zusammensetzung zur topischen Verwendung |
DE102008054127A1 (de) | 2008-10-31 | 2010-05-06 | Bionorica Ag | Hydrolysate aus Pflanzenextrakten sowie diese enthaltendes antibakterielles Mittel |
DE102009011152A1 (de) | 2009-03-05 | 2010-09-09 | Bionorica Ag | Hydrolysate aus Pflanzenextrakten sowie diese enthaltendes antibakterielles Mittel |
DE102009019104A1 (de) | 2009-04-29 | 2010-11-04 | Bionorica Se | Kosmetische oder dermatologische Zusammensetzung enthaltend Hydrolysate aus Pflanzenextrakten |
DE102009041753A1 (de) | 2009-09-16 | 2011-03-24 | Bionorica Se | Wasch-, Reinigungs- oder Desinfektionsmittel enthaltend Hydrolysate aus Pflanzenextrakten |
WO2011032707A1 (de) | 2009-09-16 | 2011-03-24 | Bionorica Se | Wasch-, reinigungs- oder desinfektionsmittel enthaltend hydrolysate aus pflanzenextrakten |
WO2011048221A1 (de) | 2009-10-22 | 2011-04-28 | Bionorica Se | Entzündungshemmendes mittel enthaltend hydrolysate aus pflanzenextrakten |
DE102009050407A1 (de) | 2009-10-22 | 2011-06-22 | Bionorica SE, 92318 | Entzündungshemmendes Mittel enthaltend Hydrolysate aus Pflanzenextrakten |
WO2011134667A2 (de) | 2010-04-29 | 2011-11-03 | Bionorica Se | Ausgewählte hydrolysate aus pflanzenextrakten sowie diese enthaltendes antibakterielles mittel |
WO2011134679A2 (de) | 2010-04-30 | 2011-11-03 | Bionorica Se | Ausgewählte pflanzenextrakte zur behandlung von entzündungserkrankungen |
DE102010019099A1 (de) | 2010-04-30 | 2011-11-03 | Bionorica Se | Ausgewählte Pflanzenextrakte zur Behandlung von Entzündungserkrankungen |
DE102010021842A1 (de) | 2010-05-28 | 2011-12-01 | Bionorica Se | Thymian/Primel oder Efeu zur Behandlung von chronischobstruktiven Lungenerkrankungen (COPD) |
WO2011147992A1 (de) | 2010-05-28 | 2011-12-01 | Bionorica Se | Thymian / primel oder efeu zur behandlung von chronischobstruktiven lungenerkrankungen („copd") |
DE102010040705A1 (de) | 2010-09-14 | 2012-03-15 | Bionorica Se | Blütenextrakt von Primula flos zur Behandlung und Prophylaxe von Entzündungen oder viralen Infektionen |
WO2012035082A1 (de) | 2010-09-14 | 2012-03-22 | Bionorica Se | Blütenextrakt von primula flos zur behandlung und prophylaxe von entzündungen oder viralen infektionen |
EP2545932A1 (de) | 2011-07-12 | 2013-01-16 | Bionorica Se | Ausgewählte Cimicifuga-Fraktionen zur Behandlung von Osteoporose |
WO2013007807A1 (de) | 2011-07-12 | 2013-01-17 | Bionorica Se | Ausgewählte cimicifuga-fraktionen zur behandlung von osteoporose |
EP2620155A1 (de) | 2012-01-30 | 2013-07-31 | Bionorica SE | Arzneimittel enthaltend Cimicifuga zur Anwendung bei der Behandlung von Sarkopenie und Herzmuskelschwäche |
WO2013113772A1 (de) | 2012-01-30 | 2013-08-08 | Bionorica Se | Arzneimittel enthaltend cimicifuga zur anwendung bei der behandlung von sarkopenie und herzmuskelschwäche |
EP2810650A1 (de) | 2013-06-06 | 2014-12-10 | Bionorica Se | Arzneimittel enthaltend Thymian und Primel oder Thymian und Efeu als PDE-4-Hemmer |
EP3498306A1 (de) | 2017-12-16 | 2019-06-19 | Bionorica SE | Extrakte aus vitex agnus castus zur behandlung und diagnose von brustkrebs |
WO2019115822A1 (de) | 2017-12-16 | 2019-06-20 | Bionorica Se | Extrakte aus vitex agnus castus zur behandlung und diagnose von brustkrebs |
Also Published As
Publication number | Publication date |
---|---|
DE10112167C2 (de) | 2003-02-13 |
DK1368605T3 (da) | 2006-03-27 |
WO2002073108A1 (de) | 2002-09-19 |
US6996919B2 (en) | 2006-02-14 |
US20040128852A1 (en) | 2004-07-08 |
ATE309513T1 (de) | 2005-11-15 |
ES2251592T3 (es) | 2006-05-01 |
DE10112167A1 (de) | 2002-10-02 |
EP1368605A1 (de) | 2003-12-10 |
DE50204865D1 (de) | 2005-12-15 |
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