EP1353857B1 - Primärverpackungseinheit für mehrere vereinzelte filmplättchen als darreichungsformen - Google Patents

Primärverpackungseinheit für mehrere vereinzelte filmplättchen als darreichungsformen Download PDF

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Publication number
EP1353857B1
EP1353857B1 EP02702263A EP02702263A EP1353857B1 EP 1353857 B1 EP1353857 B1 EP 1353857B1 EP 02702263 A EP02702263 A EP 02702263A EP 02702263 A EP02702263 A EP 02702263A EP 1353857 B1 EP1353857 B1 EP 1353857B1
Authority
EP
European Patent Office
Prior art keywords
compartments
package unit
administration forms
primary package
sealed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP02702263A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP1353857A1 (de
Inventor
Christian Von Falkenhausen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LTS Lohmann Therapie Systeme AG
Original Assignee
LTS Lohmann Therapie Systeme AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LTS Lohmann Therapie Systeme AG filed Critical LTS Lohmann Therapie Systeme AG
Publication of EP1353857A1 publication Critical patent/EP1353857A1/de
Application granted granted Critical
Publication of EP1353857B1 publication Critical patent/EP1353857B1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
    • B65D75/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
    • B65D75/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
    • B65D75/34—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents and having several recesses to accommodate a series of articles or quantities of material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/52—Details
    • B65D75/58—Opening or contents-removing devices added or incorporated during package manufacture
    • B65D75/5855—Peelable seals
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
    • B65D75/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
    • B65D75/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
    • B65D75/325—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil
    • B65D75/327—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil and forming several compartments
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/52—Details
    • B65D75/527—Tear-lines for separating a package into individual packages

Definitions

  • the invention relates to a primary packaging unit for several separated film platelets as dosage forms, the in this in trained in several rows subjects are arranged, in particular for circular dosage forms.
  • Medicaments in solid form are usually singulated into dosage units (dosage forms) and packaged individually in primary packaging in a predetermined number and dispensed as a so-called card to the patient or consumer containing the dosage forms between at least two layers sealed together.
  • dosage forms for drugs, such as tablets or dragees
  • the dosage form of the "wafer” is a film plate of, for example, a polymeric component and an active ingredient having a predetermined amount of active ingredient, which is tuned in its thickness and its dimensions to the amount of active ingredient to be dispensed.
  • DE 198 00 682 a primary packaging for such film platelets is described.
  • This has an underlayer and a top layer, between which wafer-shaped film platelets are enclosed as dosage forms in compartments (compartments).
  • Upper layer and lower layer are connected to each other by sealing seams or areas in which perforations are introduced as predetermined breaking lines in the areas between the compartments, which allow as required separation of the individual compartments of the primary packaging unit.
  • an unsealed edge may be disposed adjacent each compartment on at least one side outside the sealing area, or the top and bottom layers may be mutually offset and interconnected so that a protruding edge of one of the two layers is formed.
  • the post-published WO-A-01/62621 relates to a primary packaging unit with a lower layer and an upper layer. In this, the two layers are not connected to each other in predetermined areas and thereby form a tear-open.
  • the invention is that in a Primärverpakkungsech for several isolated dosage forms in Form of film platelets consisting of a lower layer and a formed with this sealed upper class, between those surrounded by seal areas individual subjects are designed for the dosage forms in their area the upper and lower layers are unsealed, at least two rows of subjects are formed, and the Subjects and dosage forms of the adjacent rows to each other staggered or, alternatively, that the compartments are arranged annularly.
  • the multi-row Positioning with an offset of the compartments or even the annular positioning of the dosage forms leads to a denser packing per unit area and thus too smaller primary packaging units.
  • the primary packaging unit for round wafer-shaped Film plate provided as a dosage form, in which the compartments are arranged so that the offset of the in these enclosed dosage forms half Distance between the centers of two adjacent administration forms corresponds to one row, and that all neighboring ones Dosage forms have the same distance from each other.
  • the connecting lines form the midpoints of the dosage forms isosceles triangles.
  • the offset may be be chosen differently.
  • the distance between the edges of two adjacent ones Dosage forms between 3 mm and 50 mm, preferably between 6 mm and 20 mm.
  • the dosage forms are it preferably with circular dosage forms with a diameter between 0.5 and 3 cm and with a thickness between 50 and 700 ⁇ m.
  • the primary packing points the subjects associated tear tabs formed thereby are that in their area the upper class not with the lower class is connected and the upper class in the the subjects facing away from the area with the lower layer sealed upper layer is separated.
  • the tear tabs borders on predetermined tear lines, which are in the sealed Upper layer of the compartments surrounding areas arranged are. With the help of a pull tab, the upper class becomes along the a trainees surrounding tear line of the lower layer separated, and the respective compartment is opened. The dosage form is accessible.
  • the pull tabs are Advantageously arranged so that they are in between the compartments protrude intermediate spaces given a neighboring row.
  • annularly arranged compartments In annularly arranged compartments, they are in trained in the area enclosed by the subjects and aligned to the center of the round primary packaging unit and can be easily grabbed there. The neighboring ones Trays remain unaffected when a tray is torn open and closed.
  • the two layers are particularly suitable Polyethylene (PE), polyethylene terephthalate (PET), Polypropylene (PP) and ethylene-vinyl acetate copolymer (EVA), but also paper, aluminum or composites of these materials.
  • PE Polyethylene
  • PET polyethylene terephthalate
  • PP Polypropylene
  • EVA ethylene-vinyl acetate copolymer
  • the upper layer and the lower layer consist of different materials. It can be advantageous too, for one of the two layers or just for the Upper layer to use a transparent material.
  • the primary packaging unit is made by a Striped drug form withdrawn from a supply roll and one also pulled from such a train is supplied from the material of the underlayer and out the drug delivery forms, in particular circular dosage forms, according to the predetermined Arrangement in primary packing, punched out or be cut out and the residual material is separated, by passing the residual material web over a separating edge the dosage forms dissolved from the dressing remain on the web of the material of the lower layer and be advanced with this. Following the separation is positioned on the lower course and on this Dosage forms a web of the material of Upper layer fed and with the material of the lower layer sealed in predetermined areas. After that, the Upper web for the formation of tear tabs and tear lines through and punched. Finally, the sealed Composite with the dosage forms positioned according to the sample separated from the following lanes.
  • Fig. 1 shows in conjunction with Fig. 1a a Primärverpakkungsech arranged with five in two rows I and II circular film platelets as dosage forms 1 with a Diameter of 1.9 cm and a thickness of 200 microns.
  • each one is three adjacent dosage forms 1 positioned so that these form an isosceles triangle, so that the adjacent dosage forms 1 of both rows I and II have a distance S from each other. The distance its edges is 1.7 cm.
  • the primary packaging unit is made of a sub-layer 2 of a composite of Paper, aluminum and polyethylene with a thickness of 500 microns and a sealed with this upper layer 3 of a Composite of polyethylene terephthalate, polypropylene and Polyethylene formed with a thickness of 70 microns, between which subjects 4 are formed for the dosage forms 1 are in their area the two layers 2 and 3 are not are sealed together.
  • the diameter of the compartments 4 is 2.2 cm and is thus larger than that of the dosage forms 1, so that around this annular Airspace 5 is given.
  • the subjects 4 are tongue-shaped Areas 6 of the upper class 3 assigned, not with the Underlayer 2 are sealed and those in the area respective tray 4 facing away from the rest of the upper class 3 are separated and as gripping and tear tabs serve.
  • Fig. 2 shows a primary packaging unit with only four compartments 8 and dosage forms 1, in which they have a greater distance from each other than in the above-described embodiment.
  • Fig. 3 is a primary packaging of a lower layer 11 of a composite of paper, aluminum and polyethylene having a thickness of 500 microns and sealed with this top layer 12 of a composite of polyethylene terephthalate, polypropylene and polyethylene having a thickness of 70 microns and shown seven between these annularly arranged compartments 13 and seven housed in these dosage forms 1.
  • This primary packaging represents a weekly package from which a dosage form 1 is to be taken every day.
  • the arrangement of the compartments 13 is made so that they lie with their centers on a circle of a diameter of 9.5 cm and a regular distance S 3 of 3.5 cm from each other.
  • the upper layer 12 is recessed in the region of a gap 14 given by the predetermined number of dosage forms and the dimensioning and sealed in the hatched areas 15 with the lower layer 11.
  • This primary packaging is also provided with tongue-shaped tear-open tabs (16) formed by unsealed areas 16 of the upper layer 12, which are separated from one another and point all toward the center. Between the compartments 13, tear lines 17 are formed in the sealed area.
  • Fig. 4 the procedure for producing a Primary packaging unit shown.
  • the drug web 20 is a punching station 21 in a predetermined cycle intermittently fed and before this with the web-shaped material the lower layer 2, in which (21) circular dosage forms 1, according to the predetermined Packaging pattern of the primary packaging unit according to Fig. 1, Fig. 2 or Fig. 3, on the web of the Under layer 2 are punched out.
  • the material web of the lower layer 2 is a not further shown Transport mechanism 22 moved forward in time. Carry out the residual material web 23 about a separation edge 24 with a small diameter, the dosage forms 1 are separated and are in the predetermined packaging position on the web of the lower class 2.
  • the material web of the upper class. 3 supplied as a cover layer and with the material web of the lower layer 2 in a sealing station 25 after a predetermined Sealed pattern, with both the areas to Training of subjects 4 (13) as well as the areas in which the tear tabs 6 (16) are formed, unsealed stay.
  • the upper-layer web is in one Punching station 26 according to a predetermined pattern for training punctured by predetermined tear lines 7 (10, 17) and for separation the tear tabs (16) punched.
  • a subsequent Cutting station 27 will be the so designed Primary packaging unit P separated from the following.

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Chemical & Material Sciences (AREA)
  • Composite Materials (AREA)
  • Packages (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Containers And Plastic Fillers For Packaging (AREA)
  • Buffer Packaging (AREA)
  • Packaging Of Machine Parts And Wound Products (AREA)
  • Bending Of Plates, Rods, And Pipes (AREA)
EP02702263A 2001-01-23 2002-01-14 Primärverpackungseinheit für mehrere vereinzelte filmplättchen als darreichungsformen Expired - Lifetime EP1353857B1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10102818 2001-01-23
DE10102818A DE10102818A1 (de) 2001-01-23 2001-01-23 Primärverpackungseinheit für mehrere vereinzelte Filmplättchen als Darreichungsformen
PCT/EP2002/000287 WO2002059012A1 (de) 2001-01-23 2002-01-14 Primärverpackungseinheit für mehrere vereinzelte filmplättchen als darreichungsformen

Publications (2)

Publication Number Publication Date
EP1353857A1 EP1353857A1 (de) 2003-10-22
EP1353857B1 true EP1353857B1 (de) 2004-08-18

Family

ID=7671412

Family Applications (1)

Application Number Title Priority Date Filing Date
EP02702263A Expired - Lifetime EP1353857B1 (de) 2001-01-23 2002-01-14 Primärverpackungseinheit für mehrere vereinzelte filmplättchen als darreichungsformen

Country Status (10)

Country Link
US (1) US7293653B2 (es)
EP (1) EP1353857B1 (es)
JP (1) JP2004517011A (es)
KR (1) KR100808612B1 (es)
AT (1) ATE273869T1 (es)
DE (2) DE10102818A1 (es)
DK (1) DK1353857T3 (es)
ES (1) ES2227425T3 (es)
PT (1) PT1353857E (es)
WO (1) WO2002059012A1 (es)

Families Citing this family (15)

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JP2005504437A (ja) * 2001-09-20 2005-02-10 ユニバーシティ・オブ・アラバマ・アット・バーミンガム・リサーチ・ファウンデーション 中間赤外マイクロチップレーザ：飽和可能吸収体材料を有するＺｎＳ：Ｃｒ２＋レーザ
US7770732B2 (en) 2002-10-04 2010-08-10 Alpex Pharma Sa Blister packaging
US20060169601A1 (en) * 2003-12-23 2006-08-03 Lyon Stephen C Medicinal container
DE102004017030A1 (de) * 2004-04-02 2005-10-20 Schering Ag Flachkapseln
US20060207911A1 (en) * 2005-03-15 2006-09-21 Bullock John D Emergency medical treatment system
US20060254949A1 (en) * 2005-05-12 2006-11-16 Staggs William B Jr Credit card-shaped drug delivery system
US7758484B2 (en) * 2005-12-30 2010-07-20 3M Innovative Properties Company Packaging and method for making the same
DE102006041921A1 (de) 2006-09-07 2008-03-27 Lts Lohmann Therapie-Systeme Ag Verpackung für wirkstoffhaltige Filme und Verfahren für deren Herstellung
ES2652592T3 (es) 2006-10-02 2018-02-05 Apr Applied Pharma Research S.A. Formas de dosificación de película no mucoadhesiva
JP5184925B2 (ja) * 2007-03-15 2013-04-17 株式会社シード コンタクトレンズ用出荷容器及びその連結構造
US20110198261A1 (en) * 2008-08-11 2011-08-18 Boehringer Ingelheim International Gmbh Blister pack
DE102010028351A1 (de) 2010-04-29 2011-11-03 Bayer Schering Pharma Aktiengesellschaft Wafertasche
US20120305584A1 (en) * 2011-06-06 2012-12-06 Omnicare Inc. Administration methods and packagings for oral medications
JP6209971B2 (ja) * 2014-01-16 2017-10-11 大日本印刷株式会社 ブリスター容器
US11229579B2 (en) * 2014-11-11 2022-01-25 Brian Dufour Layered multiple single-dose medication systems and assemblies

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US4398634A (en) * 1981-11-12 1983-08-16 Wrapade Machine Company, Inc. Child-proof package system
CH655913A5 (en) * 1982-04-16 1986-05-30 Ernst Ramseier Packaging unit
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Also Published As

Publication number Publication date
ATE273869T1 (de) 2004-09-15
DK1353857T3 (da) 2004-12-27
PT1353857E (pt) 2004-12-31
US20040050749A1 (en) 2004-03-18
ES2227425T3 (es) 2005-04-01
US7293653B2 (en) 2007-11-13
JP2004517011A (ja) 2004-06-10
WO2002059012A1 (de) 2002-08-01
DE10102818A1 (de) 2002-08-08
KR20030093201A (ko) 2003-12-06
KR100808612B1 (ko) 2008-02-28
EP1353857A1 (de) 2003-10-22
DE50200857D1 (de) 2004-09-23

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