EP1200984B1 - Verfahren und vorrichtung zur clusterfragmentation - Google Patents

Verfahren und vorrichtung zur clusterfragmentation Download PDF

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Publication number
EP1200984B1
EP1200984B1 EP00956226A EP00956226A EP1200984B1 EP 1200984 B1 EP1200984 B1 EP 1200984B1 EP 00956226 A EP00956226 A EP 00956226A EP 00956226 A EP00956226 A EP 00956226A EP 1200984 B1 EP1200984 B1 EP 1200984B1
Authority
EP
European Patent Office
Prior art keywords
cluster
fragmentation
fragments
clusters
interface
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP00956226A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP1200984A2 (de
Inventor
Christoph Gebhardt
Hartmut Schröder
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Original Assignee
Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max Planck Gesellschaft zur Foerderung der Wissenschaften eV filed Critical Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Publication of EP1200984A2 publication Critical patent/EP1200984A2/de
Application granted granted Critical
Publication of EP1200984B1 publication Critical patent/EP1200984B1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F03—MACHINES OR ENGINES FOR LIQUIDS; WIND, SPRING, OR WEIGHT MOTORS; PRODUCING MECHANICAL POWER OR A REACTIVE PROPULSIVE THRUST, NOT OTHERWISE PROVIDED FOR
    • F03H—PRODUCING A REACTIVE PROPULSIVE THRUST, NOT OTHERWISE PROVIDED FOR
    • F03H1/00—Using plasma to produce a reactive propulsive thrust
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J27/00—Ion beam tubes
    • H01J27/02—Ion sources; Ion guns
    • H01J27/026—Cluster ion sources
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0459—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for solid samples
    • H01J49/0463—Desorption by laser or particle beam, followed by ionisation as a separate step
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
    • H05H3/00—Production or acceleration of neutral particle beams, e.g. molecular or atomic beams
    • H05H3/02—Molecular or atomic beam generation

Definitions

  • a well-known method for the transfer of large molecules into the Gas phase represents the MALDI method (matrix assisted laser distortion ionizaton) (e.g., U.S. Patent No. 5,828,063).
  • MALDI method matrix assisted laser distortion ionizaton
  • U.S. Patent No. 5,828,063 matrix assisted laser distortion ionizaton
  • the invention will now be described by way of example with reference to FIG the collision of clusters with solid, flat substrate surfaces explained.
  • the invention is correspondingly at Collisions at gas phase / liquid interfaces and / or otherwise shaped interfaces or with radiation-induced Fragmentation applicable.
  • the figures show only schematic, enlarged illustrations of clusters and cluster fragments, while dimensions and compositions according to the principles explained below depending on the application to get voted.
  • Fig. 2 illustrates at the same time the application of the invention Cluster fragmentation for quantification and analysis of clusters and aerosol particles, in particular of natural origin.
  • the incident particle 10 a cluster or aerosol particle with possibly unknown Composition, which by suitable devices transferred from a sample space in the cluster fragmentation space has been.
  • the cluster or aerosol particle 10 is before the Fragmentation fed to a reactant, which is responsible for formation of charge carrier pairs in the cluster or aerosol particles 10 leads.
  • the feeder can, as shown, in the push with a Reactionpartnerbedeckten surface done.

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  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Combustion & Propulsion (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Plasma & Fusion (AREA)
  • General Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Analytical Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)
  • Treating Waste Gases (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Electrotherapy Devices (AREA)
  • Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
EP00956226A 1999-07-21 2000-07-20 Verfahren und vorrichtung zur clusterfragmentation Expired - Lifetime EP1200984B1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19934173A DE19934173A1 (de) 1999-07-21 1999-07-21 Verfahren und Vorrichtung zur Clusterfragmentation
DE19934173 1999-07-21
PCT/EP2000/006956 WO2001008196A2 (de) 1999-07-21 2000-07-20 Verfahren und vorrichtung zur clusterfragmentation

Publications (2)

Publication Number Publication Date
EP1200984A2 EP1200984A2 (de) 2002-05-02
EP1200984B1 true EP1200984B1 (de) 2005-10-26

Family

ID=7915529

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00956226A Expired - Lifetime EP1200984B1 (de) 1999-07-21 2000-07-20 Verfahren und vorrichtung zur clusterfragmentation

Country Status (6)

Country Link
US (1) US7247845B1 (ja)
EP (1) EP1200984B1 (ja)
JP (1) JP2003505704A (ja)
AT (1) ATE308114T1 (ja)
DE (2) DE19934173A1 (ja)
WO (1) WO2001008196A2 (ja)

Cited By (3)

* Cited by examiner, † Cited by third party
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DE102012008259A1 (de) 2012-04-25 2013-10-31 Bruker Daltonik Gmbh Ionenerzeugung in Massenspektrometern durch Clusterbeschuss
DE102012011647A1 (de) 2012-06-08 2013-12-12 Bruker Daltonik Gmbh Analyse von Mikroben aus Mikrokolonien mittels MALDI-Massenspektrometrie
DE102012011648A1 (de) 2012-06-08 2013-12-12 Bruker Daltonik Gmbh Analyse von Mikroben aus Mikrokolonien mittels MALDI-Massenspektrometrie

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WO2005001869A2 (en) * 2003-06-06 2005-01-06 Ionwerks Gold implantation/deposition of biological samples for laser desorption three dimensional depth profiling of tissues
DE102004051785B4 (de) 2004-10-25 2008-04-24 Bruker Daltonik Gmbh Proteinprofile mit Luft-MALDI
US7723678B2 (en) * 2006-04-04 2010-05-25 Agilent Technologies, Inc. Method and apparatus for surface desorption ionization by charged particles
US8835880B2 (en) * 2006-10-31 2014-09-16 Fei Company Charged particle-beam processing using a cluster source
JP5023886B2 (ja) * 2007-08-28 2012-09-12 株式会社島津製作所 大気圧ｍａｌｄｉ質量分析装置
US9144627B2 (en) 2007-09-14 2015-09-29 Exogenesis Corporation Methods for improving the bioactivity characteristics of a surface and objects with surfaces improved thereby
WO2012027330A1 (en) * 2010-08-23 2012-03-01 Exogenesis Corporation Method and apparatus for neutral beam processing based on gas cluster ion beam technology
US10670960B2 (en) 2010-08-23 2020-06-02 Exogenesis Corporation Enhanced high aspect ratio etch performance using accelerated neutral beams derived from gas-cluster ion beams
US20170303383A1 (en) * 2010-08-23 2017-10-19 Exogenesis Corporation Method for neutral beam processing based on gas cluster ion beam technology and articles produced thereby
US10202684B2 (en) 2010-08-23 2019-02-12 Exogenesis Corporation Method for neutral beam processing based on gas cluster ion beam technology and articles produced thereby
US9799488B2 (en) * 2010-08-23 2017-10-24 Exogenesis Corporation Method and apparatus for neutral beam processing based on gas cluster ion beam technology
US10825685B2 (en) 2010-08-23 2020-11-03 Exogenesis Corporation Method for neutral beam processing based on gas cluster ion beam technology and articles produced thereby
US10181402B2 (en) 2010-08-23 2019-01-15 Exogenesis Corporation Method and apparatus for neutral beam processing based on gas cluster ion beam technology and articles produced thereby
US11199769B2 (en) 2010-08-23 2021-12-14 Exogenesis Corporation Method and apparatus for neutral beam processing based on gas cluster ion beam technology
US10556042B2 (en) 2011-08-19 2020-02-11 Exogenesis Corporation Drug delivery system and method of manufacturing thereof
WO2013028761A1 (en) 2011-08-22 2013-02-28 Exogenesis Corporation Drug delivery system and method of manufacturing thereof
US9315798B2 (en) 2011-08-22 2016-04-19 Exogenesis Corporation Methods for improving the bioactivity characteristics of a surface and objects with surfaces improved thereby
JP6320933B2 (ja) * 2011-12-28 2018-05-09 マイクロマス・ユーケー・リミテッド 衝突イオン発生器および分離器
JP5984424B2 (ja) * 2012-02-27 2016-09-06 国立大学法人京都大学 基板洗浄方法、基板洗浄装置及び真空処理装置
GB201307792D0 (en) * 2013-04-30 2013-06-12 Ionoptika Ltd Use of a water cluster ion beam for sample analysis
EP3800657A1 (en) 2015-03-06 2021-04-07 Micromass UK Limited Desorption electrospray ionisation mass spectrometry ("desi-ms") and desorption electroflow focusing ionisation ("deffi-ms") analysis of biological samples on swabs
EP4257967A3 (en) 2015-03-06 2024-03-27 Micromass UK Limited Collision surface for improved ionisation
WO2016142679A1 (en) 2015-03-06 2016-09-15 Micromass Uk Limited Chemically guided ambient ionisation mass spectrometry
US10978284B2 (en) 2015-03-06 2021-04-13 Micromass Uk Limited Imaging guided ambient ionisation mass spectrometry
GB2555921B (en) * 2015-03-06 2021-09-15 Micromass Ltd Endoscopic tissue identification tool
GB2551669B (en) 2015-03-06 2021-04-14 Micromass Ltd Physically guided rapid evaporative ionisation mass spectrometry ("Reims")
WO2016142683A1 (en) 2015-03-06 2016-09-15 Micromass Uk Limited Improved ionisation of gaseous samples
US10777397B2 (en) 2015-03-06 2020-09-15 Micromass Uk Limited Inlet instrumentation for ion analyser coupled to rapid evaporative ionisation mass spectrometry (“REIMS”) device
CN108700590B (zh) 2015-03-06 2021-03-02 英国质谱公司 细胞群体分析
CA2978048A1 (en) 2015-03-06 2016-09-15 Micromass Uk Limited Liquid trap or separator for electrosurgical applications
EP3265823B1 (en) 2015-03-06 2020-05-06 Micromass UK Limited Ambient ionization mass spectrometry imaging platform for direct mapping from bulk tissue
US11282688B2 (en) 2015-03-06 2022-03-22 Micromass Uk Limited Spectrometric analysis of microbes
CN107646089B (zh) 2015-03-06 2020-12-08 英国质谱公司 光谱分析
CA2978042A1 (en) 2015-03-06 2016-09-15 Micromass Uk Limited Tissue analysis by mass spectrometry or ion mobility spectrometry
GB201517195D0 (en) 2015-09-29 2015-11-11 Micromass Ltd Capacitively coupled reims technique and optically transparent counter electrode
US11454611B2 (en) 2016-04-14 2022-09-27 Micromass Uk Limited Spectrometric analysis of plants

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US4755344A (en) * 1980-04-11 1988-07-05 The United States Of America As Represented By The United States Department Of Energy Method and apparatus for the production of cluster ions
US4378499A (en) * 1981-03-31 1983-03-29 The Bendix Corporation Chemical conversion for ion mobility detectors using surface interactions
US5053343A (en) * 1985-02-15 1991-10-01 Environmental Technologies Group, Inc. Selective ionization of gas constituents using electrolytic reactions
IL81375A (en) * 1987-01-23 1990-11-05 Univ Ramot Method and apparatus for producing ions by surface ionization of energy-rich molecules and atoms
US4851669A (en) * 1988-06-02 1989-07-25 The Regents Of The University Of California Surface-induced dissociation for mass spectrometry
US4935623A (en) * 1989-06-08 1990-06-19 Hughes Aircraft Company Production of energetic atom beams
US5051582A (en) 1989-09-06 1991-09-24 The United States Of America As Represented By The Secretary Of The Air Force Method for the production of size, structure and composition of specific-cluster ions
US5239820A (en) 1991-11-18 1993-08-31 California Institute Of Technology Electric propulsion using C60 molecules
US5338931A (en) * 1992-04-23 1994-08-16 Environmental Technologies Group, Inc. Photoionization ion mobility spectrometer
US5780862A (en) * 1994-01-11 1998-07-14 Siess; Harold E. Method and apparatus for generating ions
US5577092A (en) * 1995-01-25 1996-11-19 Kublak; Glenn D. Cluster beam targets for laser plasma extreme ultraviolet and soft x-ray sources
DE19617011C2 (de) * 1996-04-27 2000-11-02 Bruker Daltonik Gmbh Matrixkomponentengemisch für die matrixunterstützte Laserdesorption und Ionisierung sowie Verfahren zur Zubereitung eines Matrixkomponentengemisches
US5767511A (en) * 1996-07-25 1998-06-16 Raytheon Company Mean cluster size determination using water capture

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102012008259A1 (de) 2012-04-25 2013-10-31 Bruker Daltonik Gmbh Ionenerzeugung in Massenspektrometern durch Clusterbeschuss
DE102012008259B4 (de) * 2012-04-25 2014-06-26 Bruker Daltonik Gmbh Ionenerzeugung in Massenspektrometern durch Clusterbeschuss
DE102012011647A1 (de) 2012-06-08 2013-12-12 Bruker Daltonik Gmbh Analyse von Mikroben aus Mikrokolonien mittels MALDI-Massenspektrometrie
DE102012011648A1 (de) 2012-06-08 2013-12-12 Bruker Daltonik Gmbh Analyse von Mikroben aus Mikrokolonien mittels MALDI-Massenspektrometrie
DE102012011648B4 (de) 2012-06-08 2018-06-14 Bruker Daltonik Gmbh Analyse von Mikroben aus Mikrokolonien mittels MALDI-Massenspektrometrie
DE102012011647B4 (de) 2012-06-08 2020-07-02 Bruker Daltonik Gmbh Analyse von Mikroben aus Mikrokolonien mittels MALDI-Massenspektrometrie

Also Published As

Publication number Publication date
US7247845B1 (en) 2007-07-24
JP2003505704A (ja) 2003-02-12
DE50011459D1 (de) 2005-12-01
ATE308114T1 (de) 2005-11-15
WO2001008196A2 (de) 2001-02-01
WO2001008196A3 (de) 2001-12-06
EP1200984A2 (de) 2002-05-02
DE19934173A1 (de) 2001-01-25

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