EP1126922B1 - Druckausgleichsvorrichtung für einen doppelbehälter - Google Patents

Druckausgleichsvorrichtung für einen doppelbehälter Download PDF

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Publication number
EP1126922B1
EP1126922B1 EP99957289A EP99957289A EP1126922B1 EP 1126922 B1 EP1126922 B1 EP 1126922B1 EP 99957289 A EP99957289 A EP 99957289A EP 99957289 A EP99957289 A EP 99957289A EP 1126922 B1 EP1126922 B1 EP 1126922B1
Authority
EP
European Patent Office
Prior art keywords
channel
container
outer container
use according
inner container
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP99957289A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP1126922A1 (de
Inventor
Dieter Hochrainer
Heinrich Kladders
Bernd Zierenberg
Joachim Eicher
Martin Essing
Matthias Hausmann
Gilbert Wuttke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim International GmbH
Original Assignee
Boehringer Ingelheim International GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim International GmbH filed Critical Boehringer Ingelheim International GmbH
Priority to SI9930909T priority Critical patent/SI1126922T1/sl
Publication of EP1126922A1 publication Critical patent/EP1126922A1/de
Application granted granted Critical
Publication of EP1126922B1 publication Critical patent/EP1126922B1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C13/00—Details of vessels or of the filling or discharging of vessels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D83/00—Containers or packages with special means for dispensing contents
    • B65D83/0055—Containers or packages provided with a flexible bag or a deformable membrane or diaphragm for expelling the contents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/0005—Components or details
    • B05B11/0037—Containers
    • B05B11/0039—Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means
    • B05B11/0044—Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means compensating underpressure by ingress of atmospheric air into the container, i.e. with venting means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/0005—Components or details
    • B05B11/0037—Containers
    • B05B11/0039—Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means
    • B05B11/0044—Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means compensating underpressure by ingress of atmospheric air into the container, i.e. with venting means
    • B05B11/00444—Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means compensating underpressure by ingress of atmospheric air into the container, i.e. with venting means with provision for filtering or cleaning the air flow drawn into the container
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/0005—Components or details
    • B05B11/0037—Containers
    • B05B11/0039—Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means
    • B05B11/0044—Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means compensating underpressure by ingress of atmospheric air into the container, i.e. with venting means
    • B05B11/00446—Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means compensating underpressure by ingress of atmospheric air into the container, i.e. with venting means the means being located at the bottom of the container or of an enclosure surrounding the container
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/02—Membranes or pistons acting on the contents inside the container, e.g. follower pistons
    • B05B11/026—Membranes separating the content remaining in the container from the atmospheric air to compensate underpressure inside the container

Definitions

  • the invention relates to a pressure equalization device for a double container, which consists of a rigid outer container and a collapsible inner container.
  • the inner container contains a liquid.
  • the invention aims to provide a device which is suitable for the pressure equalization between the ambient air and the gas space between the inner container and the outer container, which is economical to produce and which is protected against clogging.
  • a container which consists of a rigid outer container and an easily deformable inner bag.
  • This container is made by coextrusion blow molding of two thermoplastic materials, which do not connect with each other.
  • the outer container has a closed bottom and contains at least one opening for pressure equalization between the environment and the space between outer container and inner bag.
  • the outer container has in its shoulder portion at least one unwelded seam between two opposite non-welded together wall sections of the outer container. Preferably, two unwelded seams are provided in the shoulder region of the outer container.
  • the inner bag is sealed in this area by welds. Due to the unwelded seam sections in the shoulder region of the outer container, air can enter into the intermediate space between outer container and inner bag.
  • the non-welded edge edges at the open seam in the shoulder region of the outer container tend to lie against each other under reduced pressure. Therefore, it is further proposed to preferably provide a plurality of holes in the upper region of the wall of the outer container as ventilation openings, which are produced for example by ultrasound or mechanically by perforating the outer container. All openings in the wall of the outer container in the shoulder area and upper wall area are covered by means of the housing of the patch on the container pump.
  • the double containers of the prior art contain open seams or holes in the outer container.
  • the outer container is invariably made of a thermoplastic material.
  • the object is to provide a device for a double container, which is suitable for the pressure equalization between the ambient air and the gas space between the inner container and the outer container, even if the inner container contains a liquid which is volatile or contains a volatile component, against which the inner container is limited diffusion-tight. Even with years of storage of the filled double container and months of proper service life of the double container, the amount of liquid in the inner container or the concentration of liquid components only in one Change extent that is much smaller than when using one of the known double container.
  • the equivalent diameter of the at least one channel is the diameter of a circle whose area is equal to the cross-sectional area of the at least one channel.
  • the at least one channel may preferably be one hundred times to one-tenth, more preferably ten to one times as long as the equivalent diameter of the at least one channel.
  • the channel preferably has a cross section which is about as wide as it is high, that is to say preferably a round or approximately square cross section or a triangular cross section.
  • the channel cross-section can be rectangular, trapezoidal, semicircular, slot-shaped or irregularly shaped.
  • the ratio of the side lengths of a slot-shaped channel can be up to 50 to 1.
  • Several channels may be arranged regularly, for example at the crossing points of a grid, or irregularly, for example statistically distributed.
  • the cross-sectional area of the channel is less than 1 mm 2 and can be up to the range of some a thousand square microns.
  • the channel may be straight or curved or shaped as a meander, a spiral or a screw.
  • the channel may, preferably as a bore, be mounted in the wall of the outer container. Further, the channel can be mounted in a - preferably made of plastic - insert attached to the wall of the outer container, preferably in an inverted recess in the bottom of the outer container, tightly mounted. In this case, the space facing the end of the channel is in communication with an opening in the wall of the outer container. This opening has a larger cross section than the channel.
  • At the one end of the channel preferably at the end facing the environment, may be attached as dust protection, a gas-permeable filter, for. B. a non-woven fabric or a body made of open-pored sintered material.
  • the environment facing the end of the channel may be closed during the storage period of the filled with a liquid double container with a sealing foil which is completely or partially demolished or pierced prior to the first removal of liquid from the inner container.
  • the wall of the at least one channel may be smooth or rough.
  • the at least one channel can be produced as a microbore, for example by means of a laser beam, in a plate.
  • a meandering or spiral channel may be generated, for example, by selective etching of a silicon surface;
  • Such a channel may have a triangular or trapezoidal cross-section.
  • a channel having a triangular cross section and almost any shape can be obtained by embossing a (metal) surface.
  • a helical channel may be mounted on the surface of a cylinder inserted in a pipe. Further, such a channel may be mounted on the mantle surface of a hollow cylinder in which a cylindrical body is inserted. Almost arbitrarily shaped channels can be produced by lithography and impression in plastic or metal.
  • a plurality of such channels may be provided, or a plate of porous material with open pores, for example of an open-pored sintered material, may be provided.
  • the pores have an average pore diameter of 0.1 .mu.m to 150 .mu.m.
  • the pore volume is from 1% to 40% of the volume of the sintered body.
  • the sintered body may be made of plastic such as polyethylene, polypropylene, polyvinylidene fluoride, or of glass, quartz, ceramic or metal.
  • the plate thickness can be from 1 mm to 5 mm.
  • the preferably round plate may preferably be tightly inserted into a recess in the bottom of the outer container, for example pressed or glued.
  • a permeable membrane containing a plurality of such channels can be used in the form of a film, a woven or a nonwoven, which may consist of a thermoplastic material such as polytetrafluoroethylene or polyetheretherketone or of an elastomeric plastic such as silicone or latex.
  • Permeable membranes in the form of a woven or nonwoven fabric may consist of natural fibers, mineral fibers, glass fibers, carbon fibers, metal fibers or plastic fibers.
  • a permeable membrane in the form of a sheet of metal - such as Gold, silicon, nickel, stainless steel - or made of glass or ceramic.
  • the channels in such permeable membranes may be irregular in shape and made, for example, by ion bombardment or by plasma etching. Further, the channels may be regularly arranged and made, for example, by lithography and impression or by laser drilling; In this case, the many channels within the permeable membrane may be within close tolerances on the shape and size of the channel cross-section and channel length.
  • the diffusion-tight outer container is preferably made of a rigid material, for example of metal. Such an outer container facilitates the storage and handling of the double container and protects the inner container against mechanical effects from the outside.
  • the pressure compensation device is used for example in a double container, which serves to receive a medical fluid containing, for example, dissolved in a solvent drug.
  • solvents for example, water, ethanol or mixtures thereof are suitable.
  • medicaments for example, Berotec (fenoterol hydrobromide; 1- (3,5-dihydroxyphenyl) -2 - [[1- (4-hydroxybenzyl) ethyl] amino] ethanol hydrobromide), Atrovent (ipratropium bromide ), Berodual (combination of fenoterol hydrobromide and ipratropium bromide), salbutamol (or albuterol), Combivent, Oxivent (oxitropium bromide), Ba 679 (tiotropium bromide), BEA 2108 (di (2-thienyl) glycolic acid tropol ester), flunisolide, budesonide and others used.
  • the pressure compensation device according to the invention is used, for example, in a double container which contains, for example, in the atomizer described in WO 97/12687 the liquid to be atomized.
  • FIG. 1a shows a section through the double container before the first removal of liquid.
  • the outer container (1) contains the collapsible inner container (2), which is filled with a liquid (3).
  • the sampling nozzle (4) protrudes into the liquid.
  • the inner container is with its (not shown end) tightly connected to the outer container. Between the two containers is the gas space (5).
  • In the bottom (6) of the outer container of the straight channel (7) is attached, which connects the gas space (5) with the environment outside of the double container. This channel is covered with the sealing film (8).
  • Figure 1b shows a section through the double container after a part of the liquid has been removed from the inner container.
  • the sealing film (8) is shown partially demolished, the inner container is shown partially collapsed.
  • Figure 2 shows a section through a further embodiment of the double container before the first removal of liquid from the inner container.
  • the straight channel (7) is sealed at its end facing the environment with a pressed-in plug (9). This plug is removed by hand using the loop (10) before liquid is removed from the inner container for the first time.
  • FIG. 3 a shows a spiral-shaped channel (11) with a little more than three turns in the outside of the bottom (6) of the outer container (1).
  • FIG. 3b shows a section through this embodiment. One end of the channel opens into the recess (12), the other end in the opening (13). The spiral channel is closed with the sealing foil (8), which is punctured by the needle (14) before the first withdrawal of liquid.
  • FIG. 4 shows a further embodiment in section through the double container.
  • the bottom (6) of the outer container contains a recess in which the insert (15) is located, which is sealed with the annular seal (17) against the wall of the recess.
  • the insert (15) contains the straight channel (7), one end of which opens into the opening (18) in the bottom of the recess. At the other end of the channel (7) is the filter (16).
  • FIG. 5 shows a further embodiment in section, in which the insert (19) is located in an inwardly projecting recess in the bottom (6) of the outer container.
  • the insert (19) is secured with the snap connection (20) in the recess and sealed by means of the sealing ring (21) against the recess.
  • the straight channel (23) is mounted outside the center of the insert (19). Its one end opens into the opening (25) in the bottom of the recess, its other end opens into a recess in the insert (19), in which a filter (24) is mounted.
  • the insert (19) contains a further recess (26).
  • the channel (22) connects the recess (26) with the recess for the filter (24).
  • the insert (19) is covered with the sealing film (8), which is pierced before the first removal of liquid (3) from the inner container (2) by means of the needle (14).
  • the insert (19) is pressed into the recess in the container bottom (6), the correct position of the insert must be ensured so that the opening (25) lies in front of the channel (23).
  • Figure 6 shows an embodiment in section, in which the insert (27) is also mounted in an inwardly projecting recess in the container bottom (6).
  • the insert (27) is fastened by means of the snap connection (20) in the recess and sealed by means of the sealing ring (21) against the recess.
  • the straight channel (23) opens into the circumferential groove (28a, 28b) in the insert (27).
  • the circumferential groove can be different deep. In FIG. 6, it is flatter at the point (28a) in the region of the channel (23) than in its remaining part (28b).
  • the opening (25) in the bottom of the recess opens at each azimuthal position of the insert (27) in the circumferential groove (28).
  • FIG 7 another embodiment is shown in section.
  • a plate (29) made of sintered material is pressed.
  • the depression in the bottom contains the opening (25).
  • the bottom of the outer container is covered with the sealing film (8), which is pierced or torn off before the first removal of liquid from the inner container.

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Packages (AREA)
  • Filling Or Discharging Of Gas Storage Vessels (AREA)
  • External Artificial Organs (AREA)
  • Supplying Of Containers To The Packaging Station (AREA)
  • Accommodation For Nursing Or Treatment Tables (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Nozzles (AREA)
  • Table Devices Or Equipment (AREA)
  • Closures For Containers (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
EP99957289A 1998-11-07 1999-11-08 Druckausgleichsvorrichtung für einen doppelbehälter Expired - Lifetime EP1126922B1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
SI9930909T SI1126922T1 (sl) 1998-11-07 1999-11-08 Naprava za izenacevanje tlaka za dvojni vsebnik

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19851404A DE19851404A1 (de) 1998-11-07 1998-11-07 Druckausgleichsvorrichtung für einen Doppelbehälter
DE19851404 1998-11-07
PCT/EP1999/008542 WO2000027543A1 (de) 1998-11-07 1999-11-08 Druckausgleichsvorrichtung für einen doppelbehälter

Publications (2)

Publication Number Publication Date
EP1126922A1 EP1126922A1 (de) 2001-08-29
EP1126922B1 true EP1126922B1 (de) 2006-04-26

Family

ID=7887035

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99957289A Expired - Lifetime EP1126922B1 (de) 1998-11-07 1999-11-08 Druckausgleichsvorrichtung für einen doppelbehälter

Country Status (40)

Country Link
US (2) US6223933B1 (no)
EP (1) EP1126922B1 (no)
JP (1) JP3474538B2 (no)
KR (1) KR100618934B1 (no)
CN (1) CN1105606C (no)
AR (1) AR021230A1 (no)
AT (1) ATE324183T1 (no)
AU (1) AU758174B2 (no)
BG (1) BG64897B1 (no)
BR (1) BR9915726A (no)
CA (1) CA2348403A1 (no)
CO (1) CO5070693A1 (no)
CY (1) CY1106118T1 (no)
CZ (1) CZ20011607A3 (no)
DE (2) DE19851404A1 (no)
DK (1) DK1126922T3 (no)
EA (1) EA002433B1 (no)
EE (1) EE04517B1 (no)
EG (1) EG22134A (no)
ES (1) ES2262348T3 (no)
HK (1) HK1039915B (no)
HR (1) HRP20010313B1 (no)
HU (1) HUP0104415A3 (no)
ID (1) ID29230A (no)
IL (1) IL142903A0 (no)
MY (1) MY122356A (no)
NO (1) NO20012216L (no)
NZ (1) NZ511655A (no)
PE (1) PE20000835A1 (no)
PL (1) PL194219B1 (no)
PT (1) PT1126922E (no)
SA (1) SA99200737B1 (no)
SI (1) SI1126922T1 (no)
SK (1) SK286476B6 (no)
TR (1) TR200101271T2 (no)
TW (1) TW438706B (no)
UA (1) UA67813C2 (no)
WO (1) WO2000027543A1 (no)
YU (1) YU49457B (no)
ZA (1) ZA200103481B (no)

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HRP20010313A2 (en) 2002-06-30
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PT1126922E (pt) 2006-06-30
UA67813C2 (uk) 2004-07-15
DE19851404A1 (de) 2000-05-11
HK1039915B (zh) 2003-08-22
NO20012216D0 (no) 2001-05-04
YU49457B (sh) 2006-03-03
WO2000027543A1 (de) 2000-05-18
CN1323247A (zh) 2001-11-21
CZ20011607A3 (cs) 2002-03-13
EE200100247A (et) 2002-12-16
DE59913371D1 (de) 2006-06-01
ZA200103481B (en) 2002-04-30
HRP20010313B1 (en) 2009-03-31
KR20010080953A (ko) 2001-08-25
HK1039915A1 (en) 2002-05-17
AU1504800A (en) 2000-05-29
ID29230A (id) 2001-08-16
HUP0104415A3 (en) 2004-04-28
BG64897B1 (bg) 2006-08-31
NO20012216L (no) 2001-07-04
US20040182867A1 (en) 2004-09-23
KR100618934B1 (ko) 2006-09-01
CA2348403A1 (en) 2000-05-18
SI1126922T1 (sl) 2006-10-31
CY1106118T1 (el) 2011-06-08
YU31301A (sh) 2003-02-28
MY122356A (en) 2006-04-29
BG105447A (en) 2001-11-30
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PL347587A1 (en) 2002-04-08
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EP1126922A1 (de) 2001-08-29
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DK1126922T3 (da) 2006-07-17
PL194219B1 (pl) 2007-05-31
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US7090093B2 (en) 2006-08-15
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