EP1126922B1 - Pressure-compensating device for a dual container - Google Patents

Pressure-compensating device for a dual container Download PDF

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Publication number
EP1126922B1
EP1126922B1 EP99957289A EP99957289A EP1126922B1 EP 1126922 B1 EP1126922 B1 EP 1126922B1 EP 99957289 A EP99957289 A EP 99957289A EP 99957289 A EP99957289 A EP 99957289A EP 1126922 B1 EP1126922 B1 EP 1126922B1
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EP
European Patent Office
Prior art keywords
channel
container
characterized
outer container
use according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP99957289A
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German (de)
French (fr)
Other versions
EP1126922A1 (en
Inventor
Dieter Hochrainer
Heinrich Kladders
Bernd Zierenberg
Joachim Eicher
Martin Essing
Matthias Hausmann
Gilbert Wuttke
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Boehringer Ingelheim International GmbH
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Boehringer Ingelheim International GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DE19851404 priority Critical
Priority to DE19851404A priority patent/DE19851404A1/en
Application filed by Boehringer Ingelheim International GmbH filed Critical Boehringer Ingelheim International GmbH
Priority to PCT/EP1999/008542 priority patent/WO2000027543A1/en
Publication of EP1126922A1 publication Critical patent/EP1126922A1/en
Application granted granted Critical
Publication of EP1126922B1 publication Critical patent/EP1126922B1/en
Anticipated expiration legal-status Critical
Application status is Expired - Lifetime legal-status Critical

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Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65DCONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D83/00Containers or packages with special means for dispensing contents
    • B65D83/0055Containers or packages provided with a flexible bag or a deformable membrane or diaphragm for expelling the contents
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B05SPRAYING OR ATOMISING IN GENERAL; APPLYING LIQUIDS OR OTHER FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05BSPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00Single-unit, i.e. unitary, hand-held apparatus comprising a container and a discharge nozzle attached thereto, in which flow of liquid or other fluent material is produced by the muscular energy of the operator at the moment of use or by an equivalent manipulator independent from the apparatus
    • B05B11/0005Components or details
    • B05B11/0037Containers
    • B05B11/0039Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means
    • B05B11/0041Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means compensating underpressure without contact of the fluid remaining in the container with the atmospheric air
    • B05B11/00412Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means compensating underpressure without contact of the fluid remaining in the container with the atmospheric air the means being a collapsible or foldable bag or membrane
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B05SPRAYING OR ATOMISING IN GENERAL; APPLYING LIQUIDS OR OTHER FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05BSPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00Single-unit, i.e. unitary, hand-held apparatus comprising a container and a discharge nozzle attached thereto, in which flow of liquid or other fluent material is produced by the muscular energy of the operator at the moment of use or by an equivalent manipulator independent from the apparatus
    • B05B11/0005Components or details
    • B05B11/0037Containers
    • B05B11/0039Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means
    • B05B11/0044Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means compensating underpressure by ingress of atmospheric air into the container, i.e. with venting means
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B05SPRAYING OR ATOMISING IN GENERAL; APPLYING LIQUIDS OR OTHER FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05BSPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00Single-unit, i.e. unitary, hand-held apparatus comprising a container and a discharge nozzle attached thereto, in which flow of liquid or other fluent material is produced by the muscular energy of the operator at the moment of use or by an equivalent manipulator independent from the apparatus
    • B05B11/0005Components or details
    • B05B11/0037Containers
    • B05B11/0039Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means
    • B05B11/0044Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means compensating underpressure by ingress of atmospheric air into the container, i.e. with venting means
    • B05B11/00444Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means compensating underpressure by ingress of atmospheric air into the container, i.e. with venting means with provision for filtering or cleaning the air flow drawn into the container
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B05SPRAYING OR ATOMISING IN GENERAL; APPLYING LIQUIDS OR OTHER FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05BSPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00Single-unit, i.e. unitary, hand-held apparatus comprising a container and a discharge nozzle attached thereto, in which flow of liquid or other fluent material is produced by the muscular energy of the operator at the moment of use or by an equivalent manipulator independent from the apparatus
    • B05B11/0005Components or details
    • B05B11/0037Containers
    • B05B11/0039Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means
    • B05B11/0044Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means compensating underpressure by ingress of atmospheric air into the container, i.e. with venting means
    • B05B11/00446Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means compensating underpressure by ingress of atmospheric air into the container, i.e. with venting means the means being located at the bottom of the container or of an enclosure surrounding the container

Abstract

Dual containers, consisting of an inner container (2) and a diffusion-tight outer container (1) are used for medical fluids. The inner container collapses when the fluid is removed. A pressure-compensating device is required to compensate the pressure between the gas chamber (15) that is located between the inner and outer container and the surrounding area of the dual container, whereby the loss of fluid is kept to a minimum by diffusion from the collapsible inner container. At least one duct (7) that links the gas-filled space to the surrounding area of the dual container is used for this purpose. The time constant for compensation of a pressure differential of several millibars is several hours. This is achieved by selecting the length of the duct and cross section thereof. The at least one duct can be produced individually or a plurality of ducts can be provided in the form of pores in an open-pored sintered material or a permeable membrane. The pressure-compensating device enables the dual container to be stored for years and, if the fluid is removed in portions in a correct manner, it can be used for several weeks. During these periods, the amount of liquid in the inner container or the concentration thereof varies substantially less than if a dual container known per se is used.

Description

  • The invention relates to a pressure equalization device for a double container, which consists of a rigid outer container and a collapsible inner container. The inner container contains a liquid.
  • The invention aims to provide a device which is suitable for the pressure equalization between the ambient air and the gas space between the inner container and the outer container, which is economical to produce and which is protected against clogging.
  • It is known to store liquids containing, for example, a medicament in a flexible inner container located in a rigid outer container until use. When removing liquid from the inner container by means of a metering pump, the inner container collapses. If the outer container contains no opening, creates a vacuum in the closed space between the two containers. When using a metering pump, which can only produce a low suction pressure, the removal of liquid is made more difficult as soon as the negative pressure between the two containers has become about as large as the suction pressure. Then it is necessary to bring about a pressure equalization in the space between the two containers.
  • In DE - 41 39 555 a container is described which consists of a rigid outer container and an easily deformable inner bag. This container is made by coextrusion blow molding of two thermoplastic materials, which do not connect with each other. The outer container has a closed bottom and contains at least one opening for pressure equalization between the environment and the space between outer container and inner bag. The outer container has in its shoulder portion at least one unwelded seam between two opposite non-welded together wall sections of the outer container. Preferably, two unwelded seams are provided in the shoulder region of the outer container. The inner bag is sealed in this area by welds. Due to the unwelded seam sections in the shoulder region of the outer container, air can enter into the intermediate space between outer container and inner bag. The non-welded edge edges at the open seam in the shoulder region of the outer container tend to lie against each other under reduced pressure. Therefore, it is further proposed to preferably provide a plurality of holes in the upper region of the wall of the outer container as ventilation openings, which are produced for example by ultrasound or mechanically by perforating the outer container. All openings in the wall of the outer container in the shoulder area and upper wall area are covered by means of the housing of the patch on the container pump.
  • The double containers of the prior art contain open seams or holes in the outer container. The outer container is invariably made of a thermoplastic material.
  • If the flexible inner container is not completely diffusion-tight and the liquid in the inner container is volatile or contains volatile constituents, liquid will be lost in the inner container due to diffusion or the composition of the liquid will change in an unacceptable manner. This effect is favored if after completion of the pressure equalization in the space between the outer container and the inner container for a long time no air flows in and the pressure equalization openings in the outer container have a cross section as in the known double containers.
  • Thus, the object is to provide a device for a double container, which is suitable for the pressure equalization between the ambient air and the gas space between the inner container and the outer container, even if the inner container contains a liquid which is volatile or contains a volatile component, against which the inner container is limited diffusion-tight. Even with years of storage of the filled double container and months of proper service life of the double container, the amount of liquid in the inner container or the concentration of liquid components only in one Change extent that is much smaller than when using one of the known double container.
  • This object is achieved by a pressure equalization device for a double container, which consists of an outer container and an inner container. The inner container contains an at least partially volatile liquid. The double container is located in a gas-filled environment. The pressure compensation device is characterized by the following features:
    • The inner container is limited diffusion-tight and collapsible against the at least partially volatile liquid. The outer container is diffusion-tight and stiff.
    • The outer container is tightly connected to the inner container.
    • Between both containers, a gas-filled gap before present.
    • At least one channel connects the gas-filled space between the outer container and the inner container with the environment of the double container.
    • The at least one channel has a cross-sectional area with an equivalent diameter of 10 .mu.m to 500 .mu.m.
    • The at least one channel has a length that is five thousand times to one-half times the equivalent diameter of the at least one channel.
  • The equivalent diameter of the at least one channel is the diameter of a circle whose area is equal to the cross-sectional area of the at least one channel. The at least one channel may preferably be one hundred times to one-tenth, more preferably ten to one times as long as the equivalent diameter of the at least one channel.
  • The channel preferably has a cross section which is about as wide as it is high, that is to say preferably a round or approximately square cross section or a triangular cross section. Furthermore, the channel cross-section can be rectangular, trapezoidal, semicircular, slot-shaped or irregularly shaped. The ratio of the side lengths of a slot-shaped channel can be up to 50 to 1. Several channels may be arranged regularly, for example at the crossing points of a grid, or irregularly, for example statistically distributed. The cross-sectional area of the channel is less than 1 mm 2 and can be up to the range of some a thousand square microns.
  • The channel may be straight or curved or shaped as a meander, a spiral or a screw. The channel may, preferably as a bore, be mounted in the wall of the outer container. Further, the channel can be mounted in a - preferably made of plastic - insert attached to the wall of the outer container, preferably in an inverted recess in the bottom of the outer container, tightly mounted. In this case, the space facing the end of the channel is in communication with an opening in the wall of the outer container. This opening has a larger cross section than the channel.
  • At the one end of the channel, preferably at the end facing the environment, may be attached as dust protection, a gas-permeable filter, for. B. a non-woven fabric or a body made of open-pored sintered material.
  • The environment facing the end of the channel may be closed during the storage period of the filled with a liquid double container with a sealing foil which is completely or partially demolished or pierced prior to the first removal of liquid from the inner container.
  • The wall of the at least one channel may be smooth or rough.
  • The at least one channel can be produced as a microbore, for example by means of a laser beam, in a plate. A meandering or spiral channel may be generated, for example, by selective etching of a silicon surface; Such a channel may have a triangular or trapezoidal cross-section. Further, a channel having a triangular cross section and almost any shape can be obtained by embossing a (metal) surface. A helical channel may be mounted on the surface of a cylinder inserted in a pipe. Further, such a channel may be mounted on the mantle surface of a hollow cylinder in which a cylindrical body is inserted. Almost arbitrarily shaped channels can be produced by lithography and impression in plastic or metal.
  • The half-lives and tenths of the pressure equalization at a pressure difference below 20 hPa (20 mbar) between The 3 milliliter ambient and gas space are exemplified for channels of circular cross section, length and diameter in the table. Channel- Half-life hours Tenth value hours length mm diameter μm 0.2 80 1.8 5.8 0.2 70 3.3 10.6 0.2 60 6.4 21.0 0.2 50 13.5 0.2 50 13.5 1 75 13.5 10 133 13.5 100 236 13.5
  • Instead of the one channel, a plurality of such channels may be provided, or a plate of porous material with open pores, for example of an open-pored sintered material, may be provided. The pores have an average pore diameter of 0.1 .mu.m to 150 .mu.m. The pore volume is from 1% to 40% of the volume of the sintered body. The sintered body may be made of plastic such as polyethylene, polypropylene, polyvinylidene fluoride, or of glass, quartz, ceramic or metal. The plate thickness can be from 1 mm to 5 mm. The preferably round plate may preferably be tightly inserted into a recess in the bottom of the outer container, for example pressed or glued.
  • Further, a permeable membrane containing a plurality of such channels can be used in the form of a film, a woven or a nonwoven, which may consist of a thermoplastic material such as polytetrafluoroethylene or polyetheretherketone or of an elastomeric plastic such as silicone or latex. Permeable membranes in the form of a woven or nonwoven fabric may consist of natural fibers, mineral fibers, glass fibers, carbon fibers, metal fibers or plastic fibers. Further, a permeable membrane in the form of a sheet of metal - such as Gold, silicon, nickel, stainless steel - or made of glass or ceramic.
  • The channels in such permeable membranes may be irregular in shape and made, for example, by ion bombardment or by plasma etching. Further, the channels may be regularly arranged and made, for example, by lithography and impression or by laser drilling; In this case, the many channels within the permeable membrane may be within close tolerances on the shape and size of the channel cross-section and channel length.
  • The diffusion-tight outer container is preferably made of a rigid material, for example of metal. Such an outer container facilitates the storage and handling of the double container and protects the inner container against mechanical effects from the outside.
  • The pressure compensation device according to the invention is used for example in a double container, which serves to receive a medical fluid containing, for example, dissolved in a solvent drug. As solvents, for example, water, ethanol or mixtures thereof are suitable. As medicaments, for example, Berotec (fenoterol hydrobromide; 1- (3,5-dihydroxyphenyl) -2 - [[1- (4-hydroxybenzyl) ethyl] amino] ethanol hydrobromide), Atrovent (ipratropium bromide ), Berodual (combination of fenoterol hydrobromide and ipratropium bromide), salbutamol (or albuterol), Combivent, Oxivent (oxitropium bromide), Ba 679 (tiotropium bromide), BEA 2108 (di (2-thienyl) glycolic acid tropol ester), flunisolide, budesonide and others used.
  • The pressure compensation device according to the invention has the following advantages:
    • It contains no moving parts and is a static device.
    • The gas permeability is adjustable, even when using a permeable membrane or a sintered plate.
    • With every pressure difference, it enables pressure equalization to begin immediately.
    • A pressure difference is gradually compensated. The time constant and thus the duration of the pressure equalization can be adapted to the timing of the metered removal of liquid from the inner container when used as intended.
    • It is suitable for diffusion-proof outer containers made of any material. The outer container may be made of a rigid material - such as metal or plastic - or of a resilient material.
    • It does not allow any accidental intervention in the gas space between the outer and inner container and protects the collapsible inner container.
    • After the equalization time, the pressure difference is practically zero.
    • It establishes a defined connection between the gas space and the ambient air.
    • It is permeable to gas when the sealing foil is removed and allows gas to pass in both directions.
    • It requires no external intervention and no external force and is continuously effective.
    • A volatile substance diffused from the liquid present in the inner container through the wall of the inner container into the intermediate space between the inner and outer containers escapes predominantly from the intermediate space by diffusion through the at least one channel. Thus, even with a very long service life of the liquid in the inner container, only an extremely small proportion of a volatile substance is lost from the liquid in the inner container. This loss is much smaller than in known double containers.
    • The containing a liquid in the inner container double container is storable for many months without appreciable loss of substance and usable for several months, even with limited diffusion tightness of the inner container.
    • It can be economically produced in large quantities.
  • The pressure compensation device according to the invention is used, for example, in a double container which contains, for example, in the atomizer described in WO 97/12687 the liquid to be atomized.
  • The device according to the invention will be explained in more detail by way of example with reference to the figures.
  • FIG. 1a shows a section through the double container before the first removal of liquid. The outer container (1) contains the collapsible inner container (2), which is filled with a liquid (3). The sampling nozzle (4) protrudes into the liquid. The inner container is with its (not shown end) tightly connected to the outer container. Between the two containers is the gas space (5). In the bottom (6) of the outer container of the straight channel (7) is attached, which connects the gas space (5) with the environment outside of the double container. This channel is covered with the sealing film (8).
  • Figure 1b shows a section through the double container after a part of the liquid has been removed from the inner container. The sealing film (8) is shown partially demolished, the inner container is shown partially collapsed.
  • Figure 2 shows a section through a further embodiment of the double container before the first removal of liquid from the inner container. The straight channel (7) is sealed at its end facing the environment with a pressed-in plug (9). This plug is removed by hand using the loop (10) before liquid is removed from the inner container for the first time.
  • FIG. 3 a shows a spiral-shaped channel (11) with a little more than three turns in the outside of the bottom (6) of the outer container (1). FIG. 3b shows a section through this embodiment. One end of the channel opens into the recess (12), the other end in the opening (13). The spiral channel is closed with the sealing foil (8), which is punctured by the needle (14) before the first withdrawal of liquid.
  • FIG. 4 shows a further embodiment in section through the double container. The bottom (6) of the outer container contains a recess in which the insert (15) is located, which is sealed with the annular seal (17) against the wall of the recess. The insert (15) contains the straight channel (7), one end of which opens into the opening (18) in the bottom of the recess. At the other end of the channel (7) is the filter (16).
  • FIG. 5 shows a further embodiment in section, in which the insert (19) is located in an inwardly projecting recess in the bottom (6) of the outer container. The insert (19) is secured with the snap connection (20) in the recess and sealed by means of the sealing ring (21) against the recess. The straight channel (23) is mounted outside the center of the insert (19). Its one end opens into the opening (25) in the bottom of the recess, its other end opens into a recess in the insert (19), in which a filter (24) is mounted. The insert (19) contains a further recess (26). The channel (22) connects the recess (26) with the recess for the filter (24). The insert (19) is covered with the sealing film (8), which is pierced before the first removal of liquid (3) from the inner container (2) by means of the needle (14). When the insert (19) is pressed into the recess in the container bottom (6), the correct position of the insert must be ensured so that the opening (25) lies in front of the channel (23).
  • Figure 6 shows an embodiment in section, in which the insert (27) is also mounted in an inwardly projecting recess in the container bottom (6). The insert (27) is fastened by means of the snap connection (20) in the recess and sealed by means of the sealing ring (21) against the recess. The straight channel (23) opens into the circumferential groove (28a, 28b) in the insert (27). The circumferential groove can be different deep. In FIG. 6, it is flatter at the point (28a) in the region of the channel (23) than in its remaining part (28b). The opening (25) in the bottom of the recess opens at each azimuthal position of the insert (27) in the circumferential groove (28).
  • In Figure 7, another embodiment is shown in section. In a recessed inward recess in the bottom (6) of the outer container, a plate (29) made of sintered material is pressed. The depression in the bottom contains the opening (25). During the storage period, the bottom of the outer container is covered with the sealing film (8), which is pierced or torn off before the first removal of liquid from the inner container.

Claims (21)

  1. Use of a double container situated in a gas-filled environment, consisting of a diffusion-tight and rigid outer container (1) and a collapsible inner container (2) in an atomizer, wherein
    - a pressure equalization device is present on the double container for the gradual equalization of a pressure difference between the inside and the outside of the container, said device being formed such that
    - the inner container (2) is to a limited extent diffusion-tight vis-à-vis an at least partially volatile liquid (3) situated inside it, and is collapsible and
    - the inner container (2) is tightly connected to the outer container and
    - a gas-filled intermediate space (5) is present between the two containers and
    - at least one channel (7; 11; 23) connects the gas-filled intermediate space (5) between the outer container (1) and the inner container (2) to the environment of the double container and
    - the at least one channel has a cross-sectional area with an equivalent diameter of 10 micrometres to 500 micrometers and
    - the at least one channel has a length which is five thousand times to one-tenth the size of the equivalent diameter of the at least one channel.
  2. Use according to claim 1, characterized in that the length of the at least one channel (7; 11; 23) is preferably one hundred times to one-tenth, particularly preferably ten times to one time the size of the equivalent diameter of the at least one channel.
  3. Use according to claims 1 and 2, characterized in that
    - the at least one channel (7; 11; 23) has a round, an approximately square, a triangular or a trapezoidal cross section.
  4. Use according to claims 1 to 3, characterized in that
    - the at least one channel (7; 23) is straight,
    - or is formed as a meander or as a spiral (11) or as a helix.
  5. Use according to claims 1 to 4, characterized in that
    - the at least one channel (7; 11) is fitted in the wall of the outer container,
    - or the channel is fitted in an insert (15; 19; 27) preferably made of plastic, which is fitted in the wall of the outer container (1), preferably in a recess (12) projecting into the outer container and which is connected to an opening (18; 25) in the wall of the outer container (1).
  6. Use according to claims 1 to 5, characterized in that
    - the at least one channel (7; 11; 23) has a cross-sectional area of less than 1 square millimetre.
  7. Use according to claims 1 to 6, characterized in that
    - at one end of the at least one channel (7; 23), preferably at the end facing the environment, a gas-permeable filter (16; 24) is fitted.
  8. Use according to claims 1 to 7, characterized in that
    - the end of the at least one channel (7; 11; 23) facing the environment is sealed with a sealing foil (8).
  9. Use according to claim 1, characterized in that
    - the at least one channel has a plurality of pores which connect the gas space between the outer container and the inner container with the environment of the double container, the pores being present in a plate (29) made of open-pored sintered material,
    - and which have an average pore diameter of 0.1 micrometre to 150 micrometres with a pore volume of 1% to 40% of the volume of the sintered body.
  10. Use according to claim 1, characterized in that
    - the at least one channel is a plurality of channels which are present in a permeable membrane in the form of a foil, a woven fabric or a non-woven fabric.
  11. Use according to claim 10, characterized in that
    - the at least one channel is a plurality of channels which are present in a permeable membrane made of a thermoplastic plastic such as polytetrafluoroethylene or polyetheretherketone,
    - or which are situated in a permeable membrane made of an elastomer such as silicone or latex.
  12. Use according to claim 10, characterized in that
    - the at least one channel is a plurality of channels which are present in a permeable membrane in the form of a foil made of metal such as gold, silicon, nickel, high-grade steel or of glass or ceramic, and which are arranged in an irregular manner.
  13. Use according to claim 9, characterized in that
    - the at least one channel is a plurality of channels which are present as pores in a plate made of open-pored sintered plastic, preferably of polyethylene, polypropylene, polyvinylidene fluoride or of glass, quartz, ceramic or metal.
  14. Use according to claim 1, characterized in that
    - the outer container (1) is made of a rigid material, preferably of a metal.
  15. Use according to claim 1, characterized in that
    - the double container contains a medicinal liquid.
  16. Use according to claim 15, characterized in that
    - the medicinal liquid contains an active ingredient which is chosen from the group fenoterol hydrobromide; 1-(3,5-dihydroxy-phenyl)-2-[[1-(-4-hydroxybenzyl)-ethyl]-amino]-ethanol hydrobromide, ipratropium bromide, a combination of fenoterol hydrobromide and ipratropium bromide, salbutamol, a combination of salbutamol and ipratropium bromide, oxitropium bromide, tiotropium bromide, di-(2-thienyl) glycolic acid tropenol ester, flunisolide, budesonide, the active ingredient being dissolved in water, ethanol or a mixture thereof.
  17. Atomizer which contains a double container situated in a gas-filled environment, consisting of a diffusion-tight and rigid outer container (1) and a collapsible inner container (2), characterized in that
    - a pressure equalization device is present on the double container for the gradual equalization of a pressure difference between the inside and the outside of the container, said device being formed such that
    - the inner container (2) is to a limited extent diffusion-tight vis-à-vis an at least partially volatile liquid (3) present inside it, and is collapsible and
    - the inner container (2) is tightly connected to the outer container and
    - a gas-filled intermediate space (5) is present between the two containers and
    - at least one channel (7; 11; 23) connects the gas-filled intermediate space (5) between the outer container (1) and the inner container (2) to the environment of the double container and
    - the at least one channel has a cross-sectional area with an equivalent diameter of 10 micrometres to 500 micrometers and
    - the at least one channel has a length which is five thousand times to one-tenth the size of the equivalent diameter of the at least one channel.
  18. Atomizer according to claim 17, characterized in that the at least one channel additionally has the features of the at least one channel, which are defined in claims 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 or 13.
  19. Atomizer according to claim 17 or 18, characterized in that
    - the outer container (1) is made of a rigid material, preferably a metal.
  20. Atomizer according to one of claims 17 to 19, characterized in that
    - the double container contains a medicinal liquid.
  21. Atomizer according to claim 20, characterized in that
    - the medicinal liquid contains an active ingredient which is chosen from the group fenoterol hydrobromide; 1-(3,5-dihydroxy-phenyl)-2-[[1-(-4-hydroxybenzyl)-ethyl]-amino]-ethanol hydrobromide, ipratropium bromide, a combination of fenoterol hydrobromide and ipratropium bromide, salbutamol, a combination of salbutamol and ipratropium bromide, oxitropium bromide, tiotropium bromide, di-(2-thienyl) glycolic acid tropenol ester, flunisolide, budesonide, the active ingredient being dissolved in water, ethanol or a mixture thereof.
EP99957289A 1998-11-07 1999-11-08 Pressure-compensating device for a dual container Expired - Lifetime EP1126922B1 (en)

Priority Applications (3)

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DE19851404 1998-11-07
DE19851404A DE19851404A1 (en) 1998-11-07 1998-11-07 Pressure relief device for a double container
PCT/EP1999/008542 WO2000027543A1 (en) 1998-11-07 1999-11-08 Pressure-compensating device for a dual container

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SI9930909T SI1126922T1 (en) 1998-11-07 1999-11-08 Pressure-compensating device for a dual container

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JP2002529323A (en) 2002-09-10
EA002433B1 (en) 2002-04-25
IL142903D0 (en) 2002-04-21
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TW438706B (en) 2001-06-07
DE59913371D1 (en) 2006-06-01
CO5070693A1 (en) 2001-08-28
CN1323247A (en) 2001-11-21
DK1126922T3 (en) 2006-07-17
JP3474538B2 (en) 2003-12-08
AR021230A1 (en) 2002-07-03
AU1504800A (en) 2000-05-29
US6223933B1 (en) 2001-05-01
CZ20011607A3 (en) 2002-03-13
ZA200103481B (en) 2002-04-30
EA200100525A1 (en) 2001-12-24
HU0104415A2 (en) 2002-03-28
AU758174B2 (en) 2003-03-20
CA2348403A1 (en) 2000-05-18
EP1126922A1 (en) 2001-08-29
UA67813C2 (en) 2001-09-17
MY122356A (en) 2006-04-29
PE20000835A1 (en) 2000-10-03
BG105447A (en) 2001-11-30
BR9915726A (en) 2001-10-23
CN1105606C (en) 2003-04-16
EG22134A (en) 2002-08-30
PT1126922E (en) 2006-06-30
EE200100247A (en) 2002-12-16
NZ511655A (en) 2003-01-31
HK1039915A1 (en) 2003-08-22
US20040182867A1 (en) 2004-09-23
PL347587A1 (en) 2002-04-08
TR200101271T2 (en) 2002-03-21
SI1126922T1 (en) 2006-10-31
DE19851404A1 (en) 2000-05-11
YU31301A (en) 2003-02-28
SK286476B6 (en) 2008-11-06
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HRP20010313B1 (en) 2009-03-31
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BG64897B1 (en) 2006-08-31
NO20012216L (en) 2001-07-04
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