WO1997006842A1 - Spray applicator - Google Patents
Spray applicator Download PDFInfo
- Publication number
- WO1997006842A1 WO1997006842A1 PCT/GB1996/002011 GB9602011W WO9706842A1 WO 1997006842 A1 WO1997006842 A1 WO 1997006842A1 GB 9602011 W GB9602011 W GB 9602011W WO 9706842 A1 WO9706842 A1 WO 9706842A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- container
- pump
- apphcator
- needle
- membrane
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
- B05B11/0005—Components or details
- B05B11/0037—Containers
- B05B11/0054—Cartridges, i.e. containers specially designed for easy attachment to or easy removal from the rest of the sprayer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0065—Inhalators with dosage or measuring devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
- B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
- B05B11/10—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle
- B05B11/1042—Components or details
- B05B11/1043—Sealing or attachment arrangements between pump and container
- B05B11/1046—Sealing or attachment arrangements between pump and container the pump chamber being arranged substantially coaxially to the neck of the container
- B05B11/1047—Sealing or attachment arrangements between pump and container the pump chamber being arranged substantially coaxially to the neck of the container the pump being preassembled as an independent unit before being mounted on the container
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/08—Inhaling devices inserted into the nose
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
- B05B11/0005—Components or details
- B05B11/0037—Containers
- B05B11/0038—Inner container disposed in an outer shell or outer casing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
- B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
- B05B11/02—Membranes or pistons acting on the contents inside the container, e.g. follower pistons
- B05B11/028—Pistons separating the content remaining in the container from the atmospheric air to compensate underpressure inside the container
Definitions
- This invention relates to spray applicators, particularly for dispensing pharmaceutical substances.
- One established method of dispensing pharmaceuticals is by spray e.g. as a nasal or oral spray. This method has the advantage as compared with sub-cutaneous or intravenal injection that it is easier for a patient with poor co-ordination or muscular weakness to administer the pharmaceutical himself.
- containers fitted with a pump or aerosol packaged products have been employed. However, these methods have proved to be unsatisfactory for packaging pharmaceuticals which are sensitive to substances in the atmosphere, such as compounds which degrade by contact with water or oxygen.
- one object of the present invention to provide an applicator for dispensing pharmaceuticals in the form of a spray, which minimises contact with atmospheric components until the product is dispensed.
- a spray applicator for dispensing a pharmaceutical from a sealed container, said applicator comprising means for holding said sealed container, a manually operable pump for delivering said pharmaceutical as a nasal spray and a hollow needle associated with said pump for penetrating a membrane sealing the container and dispensing the pharmaceutical through the pump.
- the applicator of the present invention is particularly designed for dispensing pharmaceuticals which are sensitive to oxygen or water.
- a compound is apomorphine hydrochloride (or other pharmaceutically acceptable salt) which is widely used in the treatment of Parkinson's disease.
- apomorphine is conveniently applied as a nasal spray and is rapidly absorbed through the nasal membrane.
- the spray applicator may, however, be adapted for other purposes, e.g. for applying a spray to the mouth and for dispensing other pharmaceuticals via the mouth or nose, particularly for treating the mouth, nose and lungs.
- the pump component of the applicator may be constructed as a metering pump so that on actuation of the pump, a metered dose of the pharmaceutical is sprayed into the patient's nose or mouth.
- the applicator includes means for moving the needle towards the membrane automatically on actuation or just prior to actuation ofthe pump.
- the needle may move towards and penetrate a membrane sealing the container in which the pharmaceutical is packaged.
- the applicator may include a removable device such as a clip, ring or tag which prevents the needle penetrating the membrane or prevents, respectively, means carrying the needle and sealed container from coming together until the applicator is intended to be used.
- a removable device such as a clip, ring or tag which prevents the needle penetrating the membrane or prevents, respectively, means carrying the needle and sealed container from coming together until the applicator is intended to be used.
- the pharmaceutical container preferably has a wall or plug which is movable to displace Uquid as it is pumped out of the container by the pump device.
- a wall or plug which is movable to displace Uquid as it is pumped out of the container by the pump device.
- Such moveable wall or plug may be urged inwardly by a spring or other mechanical device so as to assist priming the pump, although the spring is not essential.
- the container may be constructed as a collapsible container, such as a tube, by making the walls from a flexible material such as a plastics sheet material.
- One pharmaceutical apphcation of the spray apphcator is for dispensing compounds for controlling Parkinson's Disease. Patients suffering from Parkinson's Disease often have difficulty in manipulating devices for administering their medication.
- a further feature of the apphcator of the invention is to provide a dispensing cap in which the outlet from the pump is angled obhquely, thus providing a platform on the cap of the apphcator which enables the patient to operate the pump conveniently with his thumb.
- Figure 1 is a longitudinal section through the apphcator in assembled condition.
- Figure 2 is a perspective view of a clip for preventing the needle penetrating the sealed container.
- Figure 3 shows the components of the apphcator in a disassembled state.
- Figure 4 is a schematic view showing an alternative method of actuating the pump.
- Figure 5 is a longitudinal view in section of a second embodiment ofthe apphcator in its "use" position
- Figure 6 is a similar se ⁇ ion through the apphcator shown in Figure 5, but in its "rest” position:
- Figures 7 shows the disassembled components of the apphcator shown in Figures 5 and 6:
- Figures 8A and 8B are two perspective views of a modified dispenser.
- the nasal apphcator comprises a container (1) shaped to receive a sealed vial (2) into which the pharmaceutical is packaged.
- Vial (2) is of a type which is currently used in the pharmaceutical industry for packaging injectable materials.
- the vial comprises a glass or plastics tube (3) having a lower end which is closed with a rubber or plastic bung or plug (4).
- the upper end of the vial has membrane (5) which is designed to be penetrated by a hypodermic needle for removing the contents. After penetration of the membrane the membrane is sufficiently elastic to close around the needle and seal self against inadvertent escape of hquid or escape under the pressure arising during pumping of doses of hquid from the container.
- Vial (2) is designed to be a multi-dose container so that as Uquid is removed from the vial (2), plug (4) moves upwardly to displace the Uquid so removed.
- a spring (6) may be employed to assist this action and/or priming of the pump but is not essential.
- container (1) is threaded to receive a cap (7) and a pump holder (8) is mounted for axial sUding movement on the neck (9) of the contamer (1).
- Crimped onto the neck (10) of the pump holder (8) is a pump (11) and mounted on the upper end of the pump is a nasal actuator and overcap (12) and (13) respectively.
- Pump (11) is of the kind conventionally used for pumping pharmaceuticals from closed containers.
- the pump may be an airless mechanical pump with or without a dosing device such as those manufactured by Perfect- Valois or their parent company Valois Step under model No. 'VT 7'.
- An example of a metering pump of this kind is also described in WO 95/09054.
- the lower end of the pump (11) has a tubular portion (14) to which a hollow needle (15) is attached either internally or externally, e.g. by means of a luer-type conne ⁇ ion.
- Cap (13) which is a press fit of actuator (12) is removed and the actuator pressed down by placing the fingers on ledges (16). This causes pump holder (8) to move downwardly until needle (15) penetrates the membrane (5) and enters the hquid contained in vial (2). Continuing downward pressure causes the pump to take in a dose of the pharmaceutical and to spray the dose through the nasal actuator (12). On release of such finger pressure, needle (15) remains in the vial with the membrane sealing around the needle to prevent escape of hquid between the outer surface ofthe needle and the membrane. This is because the underside 26 ofthe cap engages with the recess 25 ofthe cap 8 or the annular proje ⁇ ion 27 engages in the groove 21.
- the piston (not shown) within pump 11 is returned to its initial position by a return spring within the pump housing 11. This aspirates Uquid into the pump ready for dispensing the next dose from the vial. Further doses of Uquid can be pumped from the vial by the patient as required by pressing on the ledges 16.
- a removable cUp (20) may be fitted into a groove (21) in the neck (9) of container (1).
- the cUp (20) may be manufa ⁇ ured from a springy plastics material so that it is readily removed by pulling the tag or ring which is attached to it.
- the chp (20) When the chp (20) is in place, however, its thickness or an abutment protruding from it, prevents the pump holder moving down the neck (9) sufficiently far to aUow the hollow needle to penetrate the membrane (5).
- Figure 4 shows an altemative way of depressing the actuator (12) for patients who have very poor co-ordination or muscular power.
- the container (1) may be gripped by a holder (30) having a lever (31) mounted thereon.
- Lever (31) has an arm (32) which is shaped to press onto shoulders (16) of the nasal actuator (12).
- lever arm (33) By operating lever arm (33). the patient is able to actuate the apphcator with mmim ⁇ m mechanical force.
- the holder may be formed with a threaded, removable base for introducing the vial and the neck (7) may be formed integraUy with the body (1).
- the pump unit may be crimped downwardly onto the neck of the holder and be arranged to be movable downwardly to permit the needle to enter the membrane (5).
- the holder (1) may, for example, be made from a clear plastics material so that the patient can see whether the vial is empty.
- the pharmaceutical turns green after exposure to atmospheric oxygen. Once the contents of the vial are observed to have changed to a green colour which is sufficiently deep (as indicated by a shade chart on the apphcator or packaging), to indicate that the pharmaceutical is no longer effe ⁇ ive.
- An important aspe ⁇ ofthe apphcation of this invention is that the pharmaceutical in the vial remains sealed from the atmosphere until the patient uses the apphcator for the first time.
- Figures 5, 6, 7, 8 A & 8B show modified apphcators which include a number of modifications but work in a similar fashion to the apphcator shown in Figures 1 to 4.
- the modified dispenser comprises an outer hoUow component (101) forming one part of a container, preferably moulded from plastics material.
- the pump (105) is the same kind of metering pump as already described in connection with Figures 1 to 4.
- the vial (111) is essentially as described in relation to the embodiments of Figures 1 to 4. The differences concern the container for the vial and the nozzle through which the product is dispensed.
- Component (101) is open at one end (102) and at its other end (103) is formed with a mouth and throat (104) for receiving a dosing pump (105).
- Pump (105) is preferably crimped into the mouth (104) of component (101). e.g. with an aluminium closure ferrule.
- a hollow needle ( 106) is fitted to the pump (105).
- a second component (107) of the container is shdably received in the tubular hoUow part of component (101). Again, the second component is conveniently moulded from plastics material.
- Component (107) is formed with two longitudinaUy spaced grooves (108) and (109) and the inside of the component (101) is formed with a corresponding annular ring or proje ⁇ ion (110).
- Component (107) is formed with a tubular cavity for receiving a vial (111) and has a closed base (112) and a neck (113).
- Vial (111) is r ⁇ ained within the component (107) by a threaded cap (114) which engages with corresponding threads on the inside of the neck of the component (107).
- the cap (114) may be a fri ⁇ ion fit in the neck of component (107) or one of the components may have lug(s) which engage with groove(s) or recesses.
- the shoulder of the vial (111) will abut against the cap (114) or the neck will abut against a ledge (115).
- a sUght gap is shown in the drawing.
- Vial (111) is a tube open at its lower end but includes a sealing plug (1 16) (preferably of elastomeric material).
- Plug (116) is preferably in contact with a spring (117) tending to urge the plug towards the neck ofthe vial.
- the cap (114) is formed with a slot (118) into which a guard strip (119) slides.
- Guard strip (119) passes through slots (118A & 1 18B) in components (101 & 107) which are ahgned with slots (118) in cap (114).
- the width and toughness of strip (119) is such that it would be difficult for needle (106) to penetrate it and reach the membrane across the neck of vial (111).
- Tube (120) is received within a nasal spray head (121) which has a dispensing nozzle (122) conne ⁇ ed to the tube (120).
- Nozzle (122) extends obhquely to the centre Une of the dispenser so as to provide a convenient ledge (123) for the patient to apply finger pressure to operate the device.
- the dispenser shown in Figures 5, 6 and 7 works in the following manner.
- the projection (110) engages in groove (108) and releasably retains the inner component in relation to the outer component (101) in the position shown in Figure 6.
- the guard strip (119) is pulled out by pulling on the ring (120).
- the dispenser can then be operated by pressing the base (112) on a flat surface and pressing, e.g. with the thumb on the ledge (123). This causes the inner component to be pressed into the outer component (101) and the needle to penetrate the membrane (124) across the neck ofthe vial.
- the annular proje ⁇ ion (110) engages in the groove (109) thus retaining the component (107) within the component (101).
- proje ⁇ ion (110) can be made to be a better fit in groove (109) than in groove (108) so that it is easier to dislodge projection (110) from groove (108) than groove (109).
- the walls ofthe components (101,107) may be transparent or include a window. This arrangement enables the contents ofthe vial to be checked, e.g. to see if the vial contains sufficient Uquid for one more treatment or, in the case of some medicaments, to check the appearance of the contents since this can undergo a colour change which may indicate it is no longer effe ⁇ ive.
- Figures 8A and 8B show external perspe ⁇ ive views of a modified dispenser.
- the vial (not visible) is contained within a body 400 which may be formed from inner and outer components similar to components ( 101 , 107) in Figures 5 and 6.
- a guard strip (401 ) is received in a slot (402) and prevents the dispenser being actuated inadvertently.
- a spray head (403) is fitted to the discharge tube of the pump and provides a platform
- a closure cap (405) may be fitted over the nozzle to prote ⁇ the nozzle for storage and transport.
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Pulmonology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/011,586 US6145703A (en) | 1995-08-18 | 1996-08-16 | Spray applicator |
JP9509066A JPH11514254A (en) | 1995-08-18 | 1996-08-16 | Spray applicator |
EP96927806A EP0846011A1 (en) | 1995-08-18 | 1996-08-16 | Spray applicator |
GB9803168A GB2319485B (en) | 1995-08-18 | 1996-08-16 | Spray applicator |
AU67503/96A AU707525B2 (en) | 1995-08-18 | 1996-08-16 | Spray applicator |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9516984.3A GB9516984D0 (en) | 1995-08-18 | 1995-08-18 | Spray applicator |
GB9516984.3 | 1995-08-18 | ||
GBGB9604759.2A GB9604759D0 (en) | 1995-08-18 | 1996-03-06 | Spray applicator |
GB9604759.2 | 1996-03-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1997006842A1 true WO1997006842A1 (en) | 1997-02-27 |
Family
ID=26307596
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB1996/002011 WO1997006842A1 (en) | 1995-08-18 | 1996-08-16 | Spray applicator |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0846011A1 (en) |
JP (1) | JPH11514254A (en) |
CN (1) | CN1193283A (en) |
AU (1) | AU707525B2 (en) |
CA (1) | CA2229666A1 (en) |
WO (1) | WO1997006842A1 (en) |
Cited By (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999032185A1 (en) * | 1997-12-19 | 1999-07-01 | Astrazeneca Ab | Device for delivering liquid containing medicament |
WO2000046109A1 (en) * | 1999-02-02 | 2000-08-10 | Smithkline Beecham P.L.C. | Container with spaced apart label |
US6186141B1 (en) | 1996-05-10 | 2001-02-13 | Glaxo Wellcome Inc. | Unit dose dispensing device |
WO2001012338A1 (en) * | 1999-08-16 | 2001-02-22 | Ing. Erich Pfeiffer Gmbh | Dispenser for liquids or for viscous or sprayable products |
DE19944211A1 (en) * | 1999-09-15 | 2001-03-22 | Pfeiffer Erich Gmbh & Co Kg | Device for the optionally atomized application of an in particular liquid medium |
WO2000049988A3 (en) * | 1999-02-23 | 2001-09-07 | Boehringer Ingelheim Int | Cartridge for a liquid |
WO2002056950A3 (en) * | 2001-01-12 | 2002-10-24 | Becton Dickinson Co | Medicament respiratory delivery device |
WO2002060517A3 (en) * | 2001-01-12 | 2002-11-07 | Becton Dickinson Co | Medicament respiratory delivery device and method |
WO2002055133A3 (en) * | 2001-01-12 | 2002-11-14 | Becton Dickinson Co | Medicament respiratory delivery device, cartridge and method of making same |
US6685691B1 (en) | 1998-02-27 | 2004-02-03 | Boehringer Ingelheim Gmbh | Container for a medicinal liquid |
FR2843001A1 (en) * | 2002-07-30 | 2004-02-06 | Thiphaine Bichot | PERFUME CARTRIDGE PERFUME DISPENSER |
WO2004064906A1 (en) * | 2003-01-17 | 2004-08-05 | Langford Stanley C | Actuation inhibitor for metered dose inhalers |
WO2005087299A1 (en) * | 2004-03-10 | 2005-09-22 | Glaxo Group Limited | A dispensing device |
US7090093B2 (en) | 1998-11-07 | 2006-08-15 | Boehringer Ingelheim International Gmbh | Pressure compensation device for a two-part container |
WO2011160932A1 (en) * | 2010-06-24 | 2011-12-29 | Boehringer Ingelheim International Gmbh | Nebulizer |
US9545487B2 (en) | 2012-04-13 | 2017-01-17 | Boehringer Ingelheim International Gmbh | Dispenser with encoding means |
US9682202B2 (en) | 2009-05-18 | 2017-06-20 | Boehringer Ingelheim International Gmbh | Adapter, inhalation device, and atomizer |
US9724482B2 (en) | 2009-11-25 | 2017-08-08 | Boehringer Ingelheim International Gmbh | Nebulizer |
US9744313B2 (en) | 2013-08-09 | 2017-08-29 | Boehringer Ingelheim International Gmbh | Nebulizer |
US9757750B2 (en) | 2011-04-01 | 2017-09-12 | Boehringer Ingelheim International Gmbh | Medicinal device with container |
US9827384B2 (en) | 2011-05-23 | 2017-11-28 | Boehringer Ingelheim International Gmbh | Nebulizer |
US10004857B2 (en) | 2013-08-09 | 2018-06-26 | Boehringer Ingelheim International Gmbh | Nebulizer |
US10011906B2 (en) | 2009-03-31 | 2018-07-03 | Beohringer Ingelheim International Gmbh | Method for coating a surface of a component |
US10016568B2 (en) | 2009-11-25 | 2018-07-10 | Boehringer Ingelheim International Gmbh | Nebulizer |
US10099022B2 (en) | 2014-05-07 | 2018-10-16 | Boehringer Ingelheim International Gmbh | Nebulizer |
US10124129B2 (en) | 2008-01-02 | 2018-11-13 | Boehringer Ingelheim International Gmbh | Dispensing device, storage device and method for dispensing a formulation |
US10124125B2 (en) | 2009-11-25 | 2018-11-13 | Boehringer Ingelheim International Gmbh | Nebulizer |
US10195374B2 (en) | 2014-05-07 | 2019-02-05 | Boehringer Ingelheim International Gmbh | Container, nebulizer and use |
US10722666B2 (en) | 2014-05-07 | 2020-07-28 | Boehringer Ingelheim International Gmbh | Nebulizer with axially movable and lockable container and indicator |
JP2021104837A (en) * | 2019-12-26 | 2021-07-26 | 株式会社吉野工業所 | Discharge container |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
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FR2813593B1 (en) * | 2000-09-07 | 2002-12-06 | Valois Sa | MULTIDOSE TYPE FLUID PRODUCT DISPENSING DEVICE |
DE102005052898A1 (en) * | 2005-11-03 | 2007-05-10 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Method and device for dosing medicaments |
JP2009072563A (en) * | 2007-08-30 | 2009-04-09 | Univ Nihon | Inhalator attachment |
JP5191215B2 (en) * | 2007-11-19 | 2013-05-08 | 伸晃化学株式会社 | Nasal drops container |
JP6356795B2 (en) * | 2013-07-17 | 2018-07-11 | ダウ グローバル テクノロジーズ エルエルシー | Mucosal composition containing methylcellulose |
DE102013220492A1 (en) * | 2013-10-10 | 2015-04-16 | Aptar Radolfzell Gmbh | Child-resistant discharge device |
CN103706006B (en) * | 2013-12-13 | 2015-12-23 | 中山市美捷时包装制品有限公司 | A kind of medical spray gun |
FR3023188B1 (en) * | 2014-07-04 | 2016-08-19 | Aptar France Sas | DEVICE FOR DISPENSING FLUID PRODUCT. |
US10300228B2 (en) * | 2014-08-26 | 2019-05-28 | Innovosciences, Llc | Thermal modulation of an inhalable medicament |
JP7313096B2 (en) * | 2021-04-19 | 2023-07-24 | マニュファクチャリング、コスト、カルキュレーション、(エムセーセーアーベー)、アクチボラグ | personal security device |
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EP0569611A1 (en) * | 1992-05-13 | 1993-11-18 | Siemens Aktiengesellschaft | Spray device, particularly pocket spray device |
WO1995000195A1 (en) * | 1993-06-18 | 1995-01-05 | Habley Medical Technology Corporation | Medication sprayer |
EP0679443A1 (en) * | 1994-04-26 | 1995-11-02 | Bespak plc | Dispensing pump |
-
1996
- 1996-08-16 JP JP9509066A patent/JPH11514254A/en active Pending
- 1996-08-16 EP EP96927806A patent/EP0846011A1/en not_active Withdrawn
- 1996-08-16 CN CN96196362A patent/CN1193283A/en active Pending
- 1996-08-16 AU AU67503/96A patent/AU707525B2/en not_active Ceased
- 1996-08-16 WO PCT/GB1996/002011 patent/WO1997006842A1/en not_active Application Discontinuation
- 1996-08-16 CA CA002229666A patent/CA2229666A1/en not_active Abandoned
Patent Citations (6)
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US4770323A (en) * | 1986-01-17 | 1988-09-13 | Aerosol Inventions And Development S.A. A.I.D. S.A. | Sterile packaging of liquid and semi-liquid fluids |
EP0531257A1 (en) * | 1991-09-05 | 1993-03-10 | Ciba-Geigy Ag | Method and device for storing and administering peptid containing dispersions |
EP0546607A1 (en) * | 1991-12-03 | 1993-06-16 | Glaxo Group Limited | Dispenser |
EP0569611A1 (en) * | 1992-05-13 | 1993-11-18 | Siemens Aktiengesellschaft | Spray device, particularly pocket spray device |
WO1995000195A1 (en) * | 1993-06-18 | 1995-01-05 | Habley Medical Technology Corporation | Medication sprayer |
EP0679443A1 (en) * | 1994-04-26 | 1995-11-02 | Bespak plc | Dispensing pump |
Cited By (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
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Also Published As
Publication number | Publication date |
---|---|
EP0846011A1 (en) | 1998-06-10 |
AU6750396A (en) | 1997-03-12 |
AU707525B2 (en) | 1999-07-15 |
JPH11514254A (en) | 1999-12-07 |
CN1193283A (en) | 1998-09-16 |
CA2229666A1 (en) | 1997-02-27 |
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