WO1995000195A1

WO1995000195A1 - Medication sprayer

Info

Publication number: WO1995000195A1
Application number: PCT/US1993/005892
Authority: WO
Inventors: Terry M. Haber; William H. Smedley; Clark B. Foster
Original assignee: Habley Medical Technology Corporation
Priority date: 1993-06-18
Filing date: 1993-06-18
Publication date: 1995-01-05
Also published as: AU4642393A

Abstract

A medication sprayer (2) is used to spray a liquid medication (110) directly from a vial (4) having a needle pierceable septum (6). The sprayer includes a body (10) reciprocally housing the vial. A spike assembly (60) includes an air inlet spike (66), connected to the ambient environment (108), and a liquid exit spike (68), both piercing the septum. The liquid exit spike is fluidly coupled to a piston/cylinder arrangement (88, 26, 36) having a combination piston/flapper valve (88, 102) at one end of the cylinder (26) and a supplemental check valve (36) at the other end. The vial, spike assembly and piston/flapper valve move in unison to pump liquid through the piston/flapper valve into the cylinder, to pull air into the vial and to pump liquid in the cylinder through the supplemental check valve, past a spray nozzle (44) and into the ambient environment.

Description

MEDICATION SPRAYER

BACKGROUND OF THE INVENTION Many topical medications, including antiseptics, analgesics and anesthetics, are applied to reduce tactile sensation, cause numbing or aid in the healing process. Often, antifungal medications are also applied topically. Various types of hand held sprayers have been developed. However, many of them require specialized medication storage containers or require the transfer of the liquid medication from its storage container into the sprayer. The requirement of using specialized containers to store the liquid medication not only can increase cost but also may reduce the availability of certain medications in a topical spray form. The need to transfer a liquid medication from its initial, sterile container into the sprayer increases the possibility of contamination, exposes the liquid medication to oxygen, thus potentially reducing its shelf life, and also increases the risk of spilling the medication.

SUMMARY OF THE INVENTION The present invention is directed to a medication sprayer which is simple in construction, easy to operate and permits liquid medication to be sprayed directly from a conventional vial of the type having a septum at one end.

The medication sprayer includes a hollow body which houses the vial for reciprocal axial movement within the body. Two hollow spikes, an air inlet spike and a liquid exit spike, are driven through the septum of the vial and into the interior of the vial. The air inlet spike is typically connected to the ambient environment while the liquid exit spike is fluidly coupled to a piston/cylinder arrangement.

The piston/cylinder arrangement preferably has a flapper valve at one end of a piston and a supplemental check valve at the other end. Moving the piston/flapper valve within the cylinder away from the supplemental check valve during a return stroke, which, in the preferred embodiment, occurs by moving the vial axially along the interior of the body, causes a partial vacuum to be created within the cylinder. This pulls liquid from the vial into the cylinder while simultaneously causing air to enter into the vial, replacing the removed liquid, through the air inlet spike. The delivery stroke moves the combination piston/flapper valve towards the supplemental check valve to force the liquid medication in the cylinder through the supplemental check valve, past a spray nozzle and into the ambient environment.

Other features and advantages of the invention will appear from the following description in which the preferred embodiment has been set forth in detail in conjunction with the accompanying drawings.

BRIEF DESCRIPTION OF THE DRAWINGS Fig. 1 is an exploded isometric view showing a medication sprayer made according to the invention in conjunction with a conventional vial;

Fig. 2 shows the sprayer and vial of Fig. 1 in an assembled condition with the vial at the proximal position prior to a delivery stroke;

Fig. 3 is an enlarged view of a portion of the sprayer of Fig. 2 showing the flapper valve element in an open position;

Fig. 4 is an enlarged view of a portion of the sprayer of Fig. 2 illustrating the duckbill-type supplemental check valve; and Fig. 5 is an enlarged view of a portion of the sprayer of Fig. 2 showing the nozzle.

DESCRIPTION OF THE PREFERRED EMBODIMENT Figs. 1 and 2 illustrate a medication sprayer 2 used with a conventional vial 4. Vial 4 is a type having a pierceable septum 6 at one end 8. Sprayer 2 includes a body 10 having a hollow interior 12 and a pair of outwardly extending finger ledges 14. Vial 4 and interior 12 are sized so that vial 4 sits within interior 12 and adjacent the proximal end 16 of body 10.

Body 10 has internal threads 18 at the distal end 20 of the body. A pump cylinder assembly 22 has a threaded flange 24 sized to engage internal threads 18 of body 10.

Pump cylinder assembly 22 includes a pump cylinder 26 which defines a variable volume pump cylinder bore 28 formed therein. Pump cylinder assembly 22 also includes a threaded tip 30 which extends past distal end 20. A check valve housing 32, having internal threads 34, is threadably mounted to threaded tip 30 to secure housing 32 to assembly 22 and body 10. Before doing so, a duckbill-type supplemental check valve 36, see Fig. 4, is secured between threaded tip 30 and check valve housing 32 within an open region 38 defined within housing 32.

A nozzle assembly 40, including a nozzle housing 42 and a nozzle 44, is mounted to a threaded tip 46 of housing 32 through the engagement of internal threads 48 formed in nozzle housing 42. Nozzle 44 is a conventional element such as nozzle insert no. 300029.001 made by Pfeiffer of Germany.

A pump assembly 60 is mounted within interior 12 of body 10 for movement parallel to an axis 62. Pump assembly 60 includes a disc-like spike support 64 to which an air inlet spike 66 and a liquid exit spike 68, both hollow, extend from the proximal end 70 of spike support 64. Pump assembly 60 also includes a shank 72 extending from the distal end 74 of spike support 64. Shank 72 is hollow so that a fluid pathway 76 is defined from the tip 78 of liquid exit spike 68 to the distal end 80 of shank 72. Air inlet spike 66 is also hollow and has its interior coupled to an air filter cavity 82 within which an air filter 84 is housed. Air filter 84 is used to filter the air which is drawn into vial 4 as discussed below. Filter 84 can be made of a variety of material such as cotton or foam. Free flow of air into cavity 82 is ensured by the provision of cutouts 86 adjacent cavity 82. A piston 88 is mounted to distal end 80 of shank 72 and is positioned for reciprocal movement within variable volume pump cylinder bore 28. Reciprocal movement of the piston 88 varies the volume of the variable volume pump cylinder bore 28.

Interior 12 of body 10 includes an enlarged region 90 within which piston assembly 60 can move parallel to axis 62. Enlarged region 90 is bounded at one end by a radially inwardly extending ledge 92 against which proximal end 70 of pump assembly 60 presses when biased in the proximal direction 94 by a coil compression spring 96. Spring 96 is captured within an annular recess 98 created between pump cylinder 26 and threaded flange 24 so to normally bias spike assembly 60 against ledge 92.

To use medication sprayer 2, one inserts vial 4 through proximal end 16 of body 10 so that spikes 66, 68 pierce septum 6. Pressing vial 4 in the distal direction 100 causes vial 4 and piston assembly 60 to move in distal direction 100 to compress spring 96. This also causes piston 88 to move along pump cylinder 26 towards supplemental check valve 36 and decreases the volume of the variable volume bore 28. Movement in this direction causes a flapper valve element 102 attached to a distal end of the piston 88 to drag against the cylinder wall 104, thus sealing the distal end of fluid pathway 76. This creates a higher pressure region within variable volume cylinder bore 28 and forces any fluid within the variable volume cylinder bore 28 through check valve 36, along a conduit 106 formed in check valve housing 32, past nozzle 44 and into an ambient environment 108. At the end of this delivery stroke, return spring 96 forces piston 88, piston assembly 60, and vial 4 in proximal direction 94 from a distal position to the proximal position of Fig. 2 during a return stroke. Doing so creates a partial vacuum within variable volume cylinder bore 28 which causes liquid medication 110 within vial 4 to pass through liquid exit spike 68, along fluid pathway 76, and into variable volume bore 28. Simultaneously, air is drawn into vial 4 through filter 84 and air inlet spike 66 to replace the liquid medication 110 drawn into variable volume bore 28. In this way, the pressure within vial 4 remains substantially at atmospheric pressure. If desired, air inlet spike 66 could be connected to a source of inert gas, such as nitrogen, in the event that liquid medication 110 is sensitive to oxygen degradation. Repeating the reciprocal movement of vial 4 causes liquid medication 110 to be sprayed from medication sprayer 2 into ambient environment 108.

Vial 4 is preferably a conventional glass vial. Most of the parts of sprayer 2 can be made of a medical grade plastic, such as polycarbonate. Spikes 66, 68 are medical grade stainless steel needles while return spring 96 is medical grade stainless steel as well. Piston 88 and supplemental check valve 36 are both silistac rubber. Other materials may be used as well.

Modification and variation can be made to the disclosed embodiment without departing from the subject of the invention as defined in the following claims.

Claims

WHAT IS CLAIMED IS:

1. A medication sprayer comprising: a body adapted to receive a container having a septum and an interior containing a liquid medication, the body including a variable volume bore and a nozzle fluidly coupled to the variable volume bore; a pump assembly reciprocally mounted to the body for reciprocal movement in proximal and distal directions and including a piston, the piston being at least partially positioned within the variable volume bore and having a distal end, whereby movement of the pump assembly in the distal direction moves the piston within the variable volume bore and decreases the volume of the variable volume bore so that liquid in the variable volume bore is forced through the nozzle; and means for drawing liquid medication from the interior of the container and into the variable volume bore through a fluid path when the pump assembly is reciprocated in the proximal direction, the fluid path being at least partially housed within the piston.

2. The medication sprayer of claim 1 wherein: the liquid medication drawing means comprises a check valve positioned along the fluid path.

3. The medication sprayer of claim 2 wherein: the check valve comprises a flapper hingedly mounted to the distal end of the piston.

4. The medication sprayer of claim 1 wherein: the liquid medication drawing means comprises a hollow spike, the hollow spike being positioned to pierce the septum of the container when the container is mounted to the body, the fluid path being defined at least partially by the hollow spike.

5. The medication sprayer of claim 4 wherein: the hollow spike is mounted to the pump assembly.

6. The medication sprayer of claim 1 further comprising: an air intake spike coupled to the body, the air intake spike being positioned to pierce the septum of the container when the container is mounted to the body.

7. The medication sprayer of claim 1 further comprising: a supplemental check valve positioned between the variable volume bore and the nozzle, the supplemental check valve preventing a fluid flow in a direction from the nozzle to the variable volume bore.

8. A medication sprayer comprising: a body having a nozzle; means for reciprocally mounting a container to the body for reciprocal movement in proximal and distal directions, the container having an interior containing a liquid medication; means for extracting the liquid medicant from the container when the container is reciprocally mounted to the body, the extracting means being operatively coupled to the reciprocally mounting means when the container reciprocates in the proximal direction; and means for forcing the liquid through the nozzle when the container is reciprocally mounted to the body, the extracting means being operatively coupled to the reciprocally mounting means when the container reciprocates in the distal direction.

9. The medication sprayer of claim 8 further comprising: a hollow bore housed within the body; the liquid extracting means extracting liquid from the container and into the hollow bore; and the liquid forcing means forcing the liquid from the hollow bore through the nozzle.

10. The medication sprayer of claim 8 wherein: the liquid medicant forcing means comprises a piston at least partially housed within the hollow bore and having a distal end.

11. The medication sprayer of claim 9 wherein: the liquid medication extracting means comprises a flapper hingedly mounted to the distal end of the piston, and a fluid path fluidly coupling the distal end of the piston and the interior of the container when the container is reciprocally mounted to the body.

12. A medication sprayer, for use with a container containing a liquid medication, the sprayer comprising: a body adapted to receive the container; dual port means for providing gas and liquid ports into the interior of the container; a nozzle carried by the body; delivery means for (a) pumping the liquid medication from the container through the liquid port, (b) replacing the pumped liquid medication with a gas which passes into the container through the gas port, and (c) forcing liquid medication pumped from the container through the nozzle and into the ambient environment, the delivery means including a piston and cylinder assembly and being actuated by reciprocal movement of the container when the container is mounted to the body, the piston and cylinder assembly including a cylinder and a piston, coupled to the container, for reciprocal movement with the container between a distal position and a proximal position, the cylinder having a cylinder wall, the delivery means also including a check valve fluidly coupling the container and the cylinder; the check valve including a flapper element which frictionally engages the cylinder wall as the piston moves between the distal position and the proximal position, the friction between the cylinder wall and the flapper element being sufficient and the flapper element constructed to cause the flapper element to seal the cylinder from the container when the piston moves towards the distal position and to fluidly couple the cylinder to the container when the piston moves towards the proximal position.