Classifications

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  • C07—ORGANIC CHEMISTRY
  • C07D—HETEROCYCLIC COMPOUNDS
  • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
  • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
  • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
  • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07D—HETEROCYCLIC COMPOUNDS
  • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
  • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
  • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
  • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
  • C07D263/18—Oxygen atoms
  • C07D263/20—Oxygen atoms attached in position 2
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P25/00—Drugs for disorders of the nervous system
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
  • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P9/00—Drugs for disorders of the cardiovascular system
  • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
  • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
  • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
  • C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
  • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
  • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
  • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
  • C07C311/03—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms
  • C07C311/05—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms to acyclic carbon atoms of hydrocarbon radicals substituted by nitrogen atoms, not being part of nitro or nitroso groups
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
  • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
  • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
  • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
  • C07C311/18—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms, not being part of nitro or nitroso groups
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07D—HETEROCYCLIC COMPOUNDS
  • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
  • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
  • C07D295/26—Sulfur atoms
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07D—HETEROCYCLIC COMPOUNDS
  • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
  • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
  • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07D—HETEROCYCLIC COMPOUNDS
  • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
  • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Definitions

• the invention relates to compounds of the formula
• NHSO 2 A NHSO 2 Ar, COOR 5 , CON (R 5 ) 2 , CONHAr, COR 5 , COAr, S (O) n A or S (O) n Ar,
• R 4 A cycloalkyl, - [C (R 5 ) 2 ] m Ar, - [C (R 5 ) 2 ] m Het or
• R - 5 b H, A or benzyl, XO, NR 5 or CH 2.
• W is a bond, -SO 2 -, -CO-, -COO- or -CONR 5 -,
• a alkyl with 1-20 C atoms, in which one or two CH 2 groups can be replaced by O or S atoms or by -CR 5 CR 5 groups and / or 1-7 H atoms by F,
• the invention also relates to the optically active forms, the racemates, the diastereomers and the hydrates and solvates of these compounds.
• the object of the invention was to find new compounds with valuable properties, in particular those which can be used for the production of medicaments.
• the compounds of the formula I and their salts have very valuable pharmacological properties with good tolerability.
• they show factor Xa inhibitory properties and can therefore be used to combat and prevent thromboembolic disorders such as thrombosis, myocardial infarction, arteriosclerosis, inflammation, apoplexy, angina pectoris, restenosis after angioplasty and claudication intermittently.
• Aromatic amidine derivatives with antithrombotic activity are known, for example, from EP 0 540 051 B1. Cyclic guanidines for the treatment of thromboembolic disorders are described, for example, in WO 97/08165. Aromatic heterocycles with factor Xa inhibitory activity are known, for example, from WO 96/10022.
• the antithrombotic and anticoagulant effect of the compounds according to the invention is attributed to the inhibitory effect against the activated coagulation protease, known under the name factor Xa, or to the inhibition of other activated serine proteases such as factor VIII, factor IXa or thrombin.
• Factor Xa is one of the proteases involved in the complex process of blood clotting. Factor Xa catalyzes the conversion of prothrombin to thrombin. Thrombin cleaves fibrinogen into fibrin monomers, which after cross-linking make an elementary contribution to thrombus formation. Activation of thrombin can lead to the occurrence of thromboembolic disorders. However, inhibition of thrombin can inhibit fibrin formation involved in thrombus formation. The measurement of the inhibition of thrombin can e.g. using the method of G.F. Cousins et al. in Circulation 1996, 94, 1705-1712.
• Inhibition of factor Xa can thus prevent thrombin from being formed.
• the compounds of formula I according to the invention and their salts interfere with the blood coagulation process by inhibiting factor Xa and thus inhibit the formation of thrombi.
• the compounds of the formula I according to the invention can furthermore be inhibitors of the coagulation factors factor VIIa, factor IXa and thrombin of the blood coagulation cascade.
• the inhibition of factor Xa by the compounds according to the invention and the measurement of the anticoagulant and antithrombotic activity can be determined by customary in vitro or in vivo methods.
• a suitable method is e.g. by J. Hauptmann et al. in Thrombosis and Haemostasis 63, 220-223 (1990).
• the inhibition of factor Xa can also be measured, for example, by the method of T. Hara et al. in thromb. Haemostas. 71, 314-319 (1994).
• the coagulation factor VIa initiates the extrinsic part of the coagulation cascade after binding to the tissue factor and contributes to the activation of factor X to factor Xa.
• Inhibition of factor VIIa thus prevents the formation of factor Xa and thus the subsequent formation of thrombin.
• the inhibition of the factor VIIa by the compounds according to the invention and the measurement of the anticoagulant and antithrombotic activity can be determined by customary in vitro or in vivo methods.
• a common method for measuring the inhibition of factor VIIa is e.g. by H. F. Ronning et al. in Thrombosis Research 1996, 84, 73-81.
• the compounds of the formula I can be used as active pharmaceutical ingredients in human and veterinary medicine, in particular for combating and preventing thromboembolic disorders such as thrombosis, myocardial infarction, arteriosclerosis, inflammation, apoplexy, angina pectoris, restenosis after angioplasty and claudication .
• thromboembolic disorders such as thrombosis, myocardial infarction, arteriosclerosis, inflammation, apoplexy, angina pectoris, restenosis after angioplasty and claudication .
• the invention relates to the compounds of formula I and their
• W denotes -SO 2 - or -CO-
• W means -SO 2 - or -CO-
• R 4 has the meaning given in claim 1,
• L denotes Cl, Br, I or a free or reactively functionally modified OH group
• R 2 has the meaning given in claim 1,
• L denotes Cl, Br, I or a free or reactively functionally modified OH group
• R 2 has the meaning given in claim 1,
• R 3 and X together are -CO-N- to form a 5-ring
• X means NH and R 3 H
• R 1 , R 2 , R 4 , Y and W have the meanings given in claim 1,
• Solvate means addition compounds with e.g. organic inert solvents such as e.g. with alcohols such as methanol, ethanol or propanol.
• A means alkyl, is linear or branched, and has 1 to 20, preferably 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 or 12 carbon atoms.
• A is preferably methyl, furthermore ethyl, propyl, isopropyl, butyl, isobutyl, sec-butyl or tert-butyl, further also pentyl, 1-, 2- or 3-methylbutyl, 1, 1-, 1, 2 - or 2,2-dimethylpropyl, 1-ethylpropyl, hexyl, 1-, 2-, 3- or 4-methylpentyl, 1, 1-, 1, 2-, 1, 3-, 2,2-, 2 , 3- or 3,3-dimethylbutyl, 1- or 2-ethylbutyl, 1-ethyl-1-methylpropyl, 1-ethyl-2-methylpropyl, 1, 1, 2- or 1, 2,2-trimethylpropyl, heptyl, Octyl, nonyl or decyl.
• A also means e.
• OR 5 means OH, OA or benzyloxy, where OA preferably means methoxy, ethoxy, propoxy, butyloxy or hexyloxy.
• Cycloalkyl preferably means cyclopropyl, cyclobutyl, cyclopentyl, cyciohexyl or cycloheptyl. Cycloalkyl also means, for example, the residue of a bicyclic terpene, such as 3-menthyl, and the camphor-10-yl residue is particularly preferred.
• COR 5 is acyl and preferably means formyl, acetyl, propionyl, but also butyryl, pentanoyl or hexanoyl.
• R 2 preferably denotes H, fluorine, chlorine, bromine, iodine, hydroxy, methoxy,
• R 2 means H.
• R 3 preferably denotes A, benzyl, CH 2 COOH or CH 2 COOA, but in particular H.
• R 4 preferably denotes, for example, A, cycloalkyl, Ar, CH 2 Ar, CH 2 CH 2 Ar,
• R 5 denotes H, A or benzyl, but in particular H.
• X denotes O, NH, NA or N-benzyl, and also CH 2 .
• R 3 and X together also mean -CO-N-, with the -CH 2 -CH-O-
• Y preferably denotes, for example, O, NH, N-methyl, N-ethyl, N-Ar, N-CH 2 -Ar, N-Het, N-CH 2 -Het, N-COOA, N-CH 2 -COOA, N -CH 2 -COOH, N-CH 2 -
• W preferably means, for example, a bond, -SO 2 - or -CO-, further also -COO- or -CONH-.
• Ar preferably denotes unsubstituted phenyl or naphthyl, further preferably e.g. by A, fluorine, chlorine, bromine, iodine, hydroxy, methoxy, ethoxy, propoxy, butoxy, pentyloxy, hexyloxy, benzyloxy, phenethyloxy, methylthio, ethylthio, methylsulfinyl, ethylsulfinyl, methylsulfonyl, ethylsulfonyl, phenylsulfinyl, phenylsulfonyl, nitro, amino, methylamino Ethyl
• Ar therefore preferably means e.g. o-, m- or p-tolyl, o-, m- or p-ethyl
• Het preferably means e.g. 2- or 3-furyl, 2- or 3-thienyl, 1-, 2- or 3-pyrrolyl, 1-, 2, 4- or 5-imidazolyl, 1-, 3-, 4- or 5-pyrazolyl, 2 -, 4- or 5-oxazolyl, 3-, 4- or 5-isoxazolyl, 2-, 4- or 5-thiazolyl, 3-, 4- or 5-isothiazolyl, 2-, 3- or 4-pyhdyl, 2 -, 4-, 5- or 6-pyhmidinyl, further preferably 1, 2,3-triazol-1-, -4- or -5-yl, 1, 2,4-thazol-1-, -3- or 5 -yl, 1- or 5-tetrazolyl, 1, 2,3-oxadiazol-4- or -5-yl, 1, 2,4-oxadiazol-3- or - 5-yl, 1, 3,4-thiadiazol- 2- or -5-yl, 1, 2,4-thiadiazol-3- or -5-yl,
• heterocyclic radicals can also be partially or completely hydrogenated.
• Het can, for. B. also mean 2,3-dihydro-2-, -3-, -4- or -5-furyl,
• Het is unsubstituted or substituted one or more times by shark, A, Ar ', COOR 5 , CN, N (R 5 ) 2 , NO 2 , Ar-CONH-CH 2 .
• Multiple means two, three, four or five times. Het very particularly preferably means unsubstituted or mono- or polysubstituted by shark, A, phenyl, OR 5 , COOR 5 , CN, N (R 5 ) 2 , NO 2 , NHCOA, NHCOPhenyl and / or carbonyl oxygen - or -5-yl, thiophene-2-or -5-yl, chroman-6-yl, pyridin-2-, 3- or -4-yl, Pyrimidin-2- or -5-yl, benzothiophen-2-yl, 1, 3-benzodioxol-4- or 5-yl, 1, 4-benzodioxan-5- or -6-yl, 2,1,3-benzothiadiazole -4- or -5-yl.
• the compounds of the formula I can have one or more chiral centers and therefore exist in various stereoisomeric forms.
• the invention relates in particular to those compounds of the formula I in which at least one of the radicals mentioned has one of the preferred meanings indicated above.
• R 2 denotes H
• R 3 represents R 5 or - (CH 2 ) m -COOR 5
• Ic R 4 A cycloalkyl, - (CH 2 ) ⁇ Ar
• R 4 A cycloalkyl, - (CH 2 ) m Ar, - (CH 2 ) m Het or
• R 5 is H, A or benzyl
• W is a bond, -SO 2 -, -CO-, -COO- or -CONH-,
• Atoms can be replaced by F
• A phenyl, OR 5 , COOR 5 , CN, N (R 5 ) 2 , NO 2 , NHCOA, NHCOPhenyl and / or carbonyl oxygen substituted thiazol-2-, 4- or -5-yl, thiophene-2-or -5 -yl, chroman-6-yl, pyridin-2-, 3- or -4-yl, pyrimidin-2- or -5-yl, benzothiophene-2-yl, 1, 3-benzodioxol-4- or 5-yl , 1,4-benzodioxan-5- or -6-yl, 2,1,3-benzothiadiazol-4- or -5-yl. means.
• the starting materials can also be formed in situ, so that they are not isolated from the reaction mixture, but instead are immediately reacted further to give the compounds of the formula I.
• Compounds of the formula I can preferably be obtained by liberating compounds of the formula I from one of their functional derivatives by treatment with a solvolysing or hydrogenolysing agent.
• Preferred starting materials for solvolysis or hydrogenolysis are those which otherwise correspond to the formula I, but instead of one or more free amino and / or hydroxyl groups contain corresponding protected amino and / or hydroxyl groups, preferably those which instead of an H atom, which is connected to an N atom. carry an amino protecting group, especially those which, instead of an HN group, carry an R'-N group, in which R 'represents an amino protecting group, and / or those which carry a hydroxy protecting group instead of the H atom of a hydroxy group, e.g. those which correspond to the formula I, but instead of a group -COOH carry a group -COOR "in which R" denotes a hydroxyl protective group.
• Preferred starting materials are also the oxadiazole derivatives, which can be converted into the corresponding amidino compounds.
• the introduction of the oxadiazole group succeeds e.g. by reaction of the cyan compounds with hydroxylamine and reaction with phosgene, dialkyl carbonate, chloroformate, N, N'-carbonyldiimidazole or acetic anhydride.
• amino protecting group is generally known and refers to groups which are suitable for protecting (blocking) an amino group from chemical reactions, but which are easily removable after the desired chemical reaction has been carried out at other locations in the molecule. Unsubstituted or substituted acyl, aryl, aralkoxymethyl or aralkyl groups are particularly typical of such groups. Since the amino protective groups are removed after the desired reaction (or reaction sequence), their type and size is otherwise not critical; however, preference is given to those having 1-20, in particular 1-8, carbon atoms.
• acyl group is to be understood in the broadest sense in connection with the present process.
• acyl groups derived from aliphatic, araliphatic, aromatic or heterocyclic carboxylic acids or sulfonic acids, and in particular alkoxycarbonyl, aryloxycarbonyl and especially aralkoxycarbonyl groups.
• acyl groups are alkanoyl such as acetyl, propionyl, butyryl; Aralkanoyl such as phenylacetyl; Aroyl such as benzoyl or toluyl; Aryloxyalkanoyl such as POA; Alkoxycarbonyl such as methoxycarbonyl, ethoxycarbonyl, 2,2,2-trichloroethoxycarbonyl, BOC (tert-butyloxycarbonyl), 2-iodoethoxycarbonyl; Aralkyloxycarbonyl such as CBZ ("carbobenzoxy"), 4-methoxybenzyloxycarbonyl, FMOC; Arylsulfonyl such as Mtr.
• Preferred amino protective groups are BOC and Mtr, furthermore CBZ, Fmoc, benzyl and acetyl.
• hydroxyl protecting group is also generally known and refers to groups which are suitable for protecting a hydroxyl group against chemical reactions, but which are easily removable after the desired chemical reaction has been carried out elsewhere in the molecule. Typical of such groups are the unsubstituted or substituted aryl, aralkyl or acyl groups mentioned above, and also alkyl groups.
• the nature and size of the hydroxyl protective groups is not critical since they are removed again after the desired chemical reaction or reaction sequence; are preferred
• hydroxy Protecting groups include benzyl, p-nitrobenzoyl, p-toluenesulfonyl, tert-butyl and acetyl, with benzyl and tert-butyl being particularly preferred.
• Suitable inert solvents are preferably organic, for example carboxylic acids such as acetic acid, ethers such as tetrahydrofuran or dioxane, amides such as DMF, halogenated hydrocarbons such as dichloromethane, and also alcohols such as methanol, ethanol or isopropanol, and water. Mixtures of the abovementioned solvents are also suitable. TFA is preferably used in excess without the addition of another solvent, perchloric acid in the form of a mixture of acetic acid and 70% perchloric acid in a ratio of 9: 1.
• the reaction temperatures for the cleavage are advantageously between about 0 and. about 50 °, preferably between 15 and 30 ° (room temperature).
• the groups BOC, OBut and Mtr can e.g. B. preferably with TFA in dichloromethane or with about 3 to 5N HCl in dioxane at 15-30 °, the FMOC group with an about 5 to 50% solution of dimethylamine, diethylamine or piperidine in DMF at 15-30 °.
• Hydrogenolytically removable protective groups can, for. B. by treatment with hydrogen in the presence of a catalyst (z. B. a noble metal catalyst such as palladium, advantageously on a support such as coal).
• a catalyst z. B. a noble metal catalyst such as palladium, advantageously on a support such as coal.
• Suitable solvents are the above, especially z. B. alcohols such as methanol or ethanol or amides such as DMF.
• the hydrogenolysis is generally carried out at temperatures between about 0 and 100 ° and pressures between about 1 and 200 bar, preferably at 20-30 ° and 1-10 bar.
• Hydrogenolysis of the CBZ group succeeds e.g. B. good at 5 to 10% Pd / C in methanol or with ammonium formate (instead of hydrogen) on Pd / C in methanol / DMF at 20-30 °.
• W denotes -S0 2 - or -CO-
• R 2 and R have the meanings given in Claim 1, can preferably be obtained by reacting compounds of the formula II with compounds of the formula III.
• L preferably denotes Cl, Br, I or a reactively modified OH group such as e.g. an activated ester, an imidazolide or alkylsulfonyloxy with 1-6 C atoms (preferred
• Methylsulfonyloxy or arylsulfonyloxy with 6-10 C atoms (preferably phenyl or p-tolylsulfonyloxy).
• the reaction is generally carried out in an inert solvent, in the presence of an acid-binding agent, preferably an alkali metal or alkaline earth metal hydroxide, carbonate or bicarbonate or another salt of a weak acid of the alkali metal or alkaline earth metal, preferably potassium , Sodium, calcium or cesium.
• an acid-binding agent preferably an alkali metal or alkaline earth metal hydroxide, carbonate or bicarbonate or another salt of a weak acid of the alkali metal or alkaline earth metal, preferably potassium , Sodium, calcium or cesium.
• an organic base such as triethylamine, dimethylaniline, pyridine or quinoline or an excess of the amine component of the formula II or the alkylation derivative of the formula III can also be favorable.
• the Reak tion time is between a few minutes and 14 days, depending on the conditions used, the reaction temperature is between about 0 ° and 150 °, normally between 20 ° and 130 °.
• Suitable inert solvents are e.g. Hydrocarbons like hexane,
• the starting compounds of the formulas II and III are generally known. If they are new, they can be manufactured according to methods known per se.
• W is a bond
• R 2 and R 4 have the meanings given in claim 1
• R 3 and X together -CO-N- to form a 5-ring.
• R 4 - [C (R 5 ) 2 ] m Ar or - [C (R 5 ) 2 ] m Het, n 0, and R 2 has the meaning given in Claim 1, can preferably be obtained by using compounds of Formula V is reacted with compounds of the formula VI.
• L is preferably Cl, Br, I or a reactively modified OH group such as e.g. an activated
• Esters an imidazolide or alkylsulfonyloxy with 1-6 C atoms (preferably methylsulfonyloxy) or arylsulfonyloxy with 6-10 C atoms (preferably phenyl- or p-tolylsulfonyloxy).
• Formula VI is preferably carried out in an inert solvent and at temperatures as indicated above.
• W is -CONH-, and R and R .4 have the meanings given in Claim 1, can preferably be obtained by using compounds of the formula II
• W is -CONH-, and R 2 and R 5 have the meanings given in claim 1, are reacted with compounds of the formula VII.
• reaction of these compounds of the formula II, in which W is -CONH-, with compounds of the formula VII is preferably carried out in an inert solvent and at temperatures as indicated above.
• the starting compounds of the formula II, in which W is -CONH-, and of the formula VII are generally known. If they are new, they can be manufactured according to methods known per se.
• W is SO 2 , and R 2 and R 4 have the meanings given in Claim 1, can preferably be obtained by using compounds of the formula II in which
• L is preferably Cl, Br, I or a reactively modified OH group such as e.g. an activated ester, an imidazolide or alkylsulfonyloxy with 1-6 C atoms (preferably methylsulfonyloxy) or arylsulfonyloxy with 6-10 C atoms (preferably phenyl- or p-tolylsulfonyloxy).
• a reactively modified OH group such as e.g. an activated ester, an imidazolide or alkylsulfonyloxy with 1-6 C atoms (preferably methylsulfonyloxy) or arylsulfonyloxy with 6-10 C atoms (preferably phenyl- or p-tolylsulfonyloxy).
• reaction of the compounds of formula II, wherein Y N [C (R 5 ) 2 ] m —COOR 5 means that compounds of the formula VIII are preferably carried out in an inert solvent and at temperatures as indicated above.
• R 3 denotes H
• R 1 , R 2 , R 4 , Y and W have the meanings given in claim 1, can be liberated from their oxazolidinone derivatives by treatment with a solvolysing or hydrogenolysing agent.
• the addition is preferably carried out in several stages by, in a manner known per se, a) converting the nitrile with H 2 S into a thioamide, which is converted into the corresponding S-alkylimidothioester using an alkylating agent, for example CH 3 I in turn, reacts with NH 3 to form the amidine, b) converting the nitrile with an alcohol, for example ethanol in the presence of HCl, into the corresponding imidoester and treating it with ammonia, or c) reacting the nitrile with lithium bis (trimethylsilyl) amide and the product then hydrolyzed.
• a compound of the formula I into another compound of the formula I by one or more radicals Y, R 1 , R 2 , R 3 and / or R 4 into one or more radicals (e ) Y, R 1 , R 2 , R 3 and / or R 4 , for example by acylating an amino group or nitro groups (for example by hydrogenation on Raney nickel or Pd carbon in an inert solvent such as methanol or ethanol) reduced to amino groups.
• Esters can e.g. are saponified with acetic acid or with NaOH or KOH in water, water-THF or water-dioxane at temperatures between 0 and 100 °.
• free amino groups can be acylated in the usual way with an acid chloride or anhydride or alkylated with an unsubstituted or substituted alkyl halide, advantageously in an inert solvent such as dichloromethane or THF and / or in the presence of a base such as triethylamine or pyridine at temperatures between -60 and + 30 °.
• a base of the formula I can be converted into the associated acid addition salt using an acid, for example by reacting equivalent amounts of the base and the acid in an inert solvent such as ethanol and subsequent evaporation.
• acids that provide physiologically acceptable salts are suitable for this implementation. So inorganic acids can be used, e.g.
• Toluenesulfonic acid naphthalene mono- and disulfonic acids, lauryl sulfuric acid. Salts with physiologically unacceptable acids, for example picrates, can be used for the isolation and / or purification of the compounds of the formula I.
• compounds of the formula I with bases for example sodium or potassium hydroxide or carbonate
• bases can be converted into the corresponding metal, in particular alkali metal or alkaline earth metal, or into the corresponding ammonium salts.
• Physiologically harmless organic bases such as ethanol amine, can also be used.
• the pharmaceutical activity of the racemates or the stereoisomers of the compounds according to the invention can differ, it may be desirable to use the enantiomers.
• the end product or even the intermediates can be separated into enantiomeric compounds by chemical or physical measures known to the person skilled in the art or can already be used as such in the synthesis.
• diastereomers are formed from the mixture by reaction with an optically active release agent.
• Suitable release agents are e.g. optically active acids, such as the R and S forms of tartaric acid, diacetyltartaric acid, dibenzoyltartaric acid, mandelic acid, malic acid, lactic acid, suitable N-protected amino acids (e.g. N-benzoylproline or N-benzenesulfonylproline) or the various optically active camphorsulfonic acids.
• Aqueous or alcoholic solvent mixtures such as e.g. Hexane / isopropanol / acetonitrile e.g. in the ratio 82: 15: 3.
• the invention further relates to the use of the compounds of the formula I and / or their physiologically acceptable salts for the production of pharmaceutical preparations, in particular on non-chemical ischemic way. They can be brought into a suitable dosage form together with at least one solid, liquid and / or semi-liquid carrier or auxiliary and, if appropriate, in combination with one or more further active ingredients.
• the invention further relates to pharmaceutical preparations containing at least one compound of the formula I and / or one of its physiologically acceptable salts.
• Suitable carriers are organic or inorganic substances which are suitable for enteral (for example oral), parenteral or topical application and do not react with the new compounds, for example water, vegetable oils, benzyl alcohols, alkylene glycols, polyethylene glycols, glyceryl triacetate, gelatin , Carbohydrates such as lactose or starch, magnesium stearate, talc, petroleum jelly.
• Tablets, pills, dragees, capsules, powders, granules, syrups, juices or drops are used in particular for oral use, supplements for rectal use, solutions, preferably oily or aqueous solutions, furthermore suspensions, emulsions or implants for which topical application ointments, creams or powder.
• the new compounds can also be lyophilized and the lyophilizates obtained e.g. can be used for the production of injectables.
• the specified preparations can be sterilized and / or auxiliary substances such as lubricants, preservatives, stabilizers and / or wetting agents, emulsifiers, salts for influencing the osmotic pressure, buffer substances, coloring, flavoring and / or several other active substances included, e.g. one or more vitamins.
• auxiliary substances such as lubricants, preservatives, stabilizers and / or wetting agents, emulsifiers, salts for influencing the osmotic pressure, buffer substances, coloring, flavoring and / or several other active substances included, e.g. one or more vitamins.
• the compounds of formula I and their physiologically acceptable salts can be used in the control and prevention of thromboembolic disorders such as thrombosis, myocardial infarction, arteriosclerosis, inflammation, apoplexy, angina pectoris, restenosis after angioplasty and intermittent claudication.
• thromboembolic disorders such as thrombosis, myocardial infarction, arteriosclerosis, inflammation, apoplexy, angina pectoris, restenosis after angioplasty and intermittent claudication.
• the substances according to the invention are generally preferably administered in doses between about 1 and 500 mg, in particular between 5 and 100 mg, per dosage unit.
• the daily dosage is preferably between about 0.02 and 10 mg / kg body weight.
• the specific dose for each patient depends on a wide variety of factors, for example on the effectiveness of the particular compound used, on the age, body weight, general health, sex, on the diet, on the time and route of administration, on the rate of elimination and combination of drugs and severity of the disease to which the therapy applies. Oral application is preferred.
• customary work-up means: if necessary, water is added, if necessary, depending on the constitution of the end product, the pH is adjusted to between 2 and 10, extracted with ethyl acetate or dichloromethane, separated off, dries the organic phase over sodium sulfate, evaporates and purifies by chromatography on silica gel and / or by crystallization.
• a solution of 100 mg of 3- [4- (5-methyl- [1, 2,4] -oxadiazol-3-yl) phenyl] -5-piperazin-1-y! Methyl-oxazolidin-2-one (“ A ") [obtainable by reacting methanesulfonic acid 3- [4- (5-methyl- [1,2,4] oxadiazol-3-yl) phenyl] -2-oxo-oxazolidin-5-ylmethyl ester with 1-tert .-Butoxycarbonylpiperazine and sodium hydrogen carbonate in acetonitrile; Cleavage of the BOC group with HCI / dioxane and subsequent treatment with sodium hydroxide solution] and 110 mg of 2,4,6-trichlorobenzenesulfonyl chloride in 10 ml of dichloromethane is mixed with 400 mg of 4-dimethylaminopyhdine on polystyrene and stirred for 18 hours at room temperature.
• the compound is obtained analogously from 4- ⁇ 2-oxo-5- [4- (6-methoxy-2-naphthylsulfonyl) piperazin-1-ylmethyl] oxazolidin-3-yl ⁇ benzamidine
• the BOC group is split off with TFA in dichloromethane and 5- (4-aminopiperidin-1-ylmethyl) -3- [4- (5-methyl- [1, 2,4] - oxadiazol-3- yl) phenyl] oxazolidin-2-one ("B").
• Example 15 A solution of 4-oxiranylmethoxy-benzonitrile and BOC-piperazine in methanol is stirred under reflux for 4 hours. After the usual work-up, 4- [2-hydroxy-3- (4-BOC-piperazin-1-yl) propoxy] benzonitrile is obtained. The subsequent reaction with hydroxylamine hydrochloride gives N-hydroxy-4- [2-hydroxy-3- (4-BOC-piperazin-1-yl) propoxy] benzamidine. Subsequent acylation with acetic anhydride gives 2-acetoxy-1 - (4-BOC-piperazin-1-yl) -3- [4- (5-methyl- [1, 2,4] -oxadiazol-3-yl) - phenoxy] propane. After splitting off the BOC group with HCl in dioxane, the reaction with 4-propylphenylsulfonyl chloride gives the compound

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