EP0904847B1 - Behälter mit versiegeltem Einsatz und Pumpe zum Öffnen der Versiegelung - Google Patents

Behälter mit versiegeltem Einsatz und Pumpe zum Öffnen der Versiegelung Download PDF

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Publication number
EP0904847B1
EP0904847B1 EP98104631A EP98104631A EP0904847B1 EP 0904847 B1 EP0904847 B1 EP 0904847B1 EP 98104631 A EP98104631 A EP 98104631A EP 98104631 A EP98104631 A EP 98104631A EP 0904847 B1 EP0904847 B1 EP 0904847B1
Authority
EP
European Patent Office
Prior art keywords
container
pump device
insert
base
wall
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP98104631A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP0904847A1 (de
Inventor
Roland Kneer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gaplast GmbH
Original Assignee
Gaplast GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DE19742559A priority Critical patent/DE19742559C2/de
Priority to ES98104631T priority patent/ES2206776T3/es
Application filed by Gaplast GmbH filed Critical Gaplast GmbH
Priority to DK98104631T priority patent/DK0904847T3/da
Priority to EP98104631A priority patent/EP0904847B1/de
Priority to DE59809472T priority patent/DE59809472D1/de
Priority to AT98104631T priority patent/ATE248660T1/de
Priority to PT98104631T priority patent/PT904847E/pt
Priority to CN98809483A priority patent/CN1112262C/zh
Priority to SK411-2000A priority patent/SK286670B6/sk
Priority to CZ20000956A priority patent/CZ297286B6/cs
Priority to UA2000042377A priority patent/UA53752C2/uk
Priority to HU0003839A priority patent/HU223435B1/hu
Priority to TR2000/00857T priority patent/TR200000857T2/xx
Priority to BR9812367-0A priority patent/BR9812367A/pt
Priority to PCT/DE1998/002444 priority patent/WO1999016552A1/de
Priority to AU96204/98A priority patent/AU731460B2/en
Priority to JP2000513677A priority patent/JP4231623B2/ja
Priority to RU2000110627/12A priority patent/RU2201296C2/ru
Priority to CA2303880A priority patent/CA2303880C/en
Priority to US09/508,893 priority patent/US6412659B1/en
Publication of EP0904847A1 publication Critical patent/EP0904847A1/de
Priority to NO20001467A priority patent/NO319538B1/no
Application granted granted Critical
Publication of EP0904847B1 publication Critical patent/EP0904847B1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/0005—Components or details
    • B05B11/0037—Containers
    • B05B11/0038—Inner container disposed in an outer shell or outer casing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/10—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle
    • B05B11/1042—Components or details
    • B05B11/1043—Sealing or attachment arrangements between pump and container
    • B05B11/1046—Sealing or attachment arrangements between pump and container the pump chamber being arranged substantially coaxially to the neck of the container
    • B05B11/1047—Sealing or attachment arrangements between pump and container the pump chamber being arranged substantially coaxially to the neck of the container the pump being preassembled as an independent unit before being mounted on the container
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/10—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle
    • B05B11/1081—Arrangements for pumping several liquids or other fluent materials from several containers, e.g. for mixing them at the moment of pumping

Definitions

  • the invention relates to a container with a pump device for dispensing a liquid container content, such as a liquid drug.
  • the container preferably has the shape of a vial with a bottle neck on which a spray pump or vacuum pump sits by depressing it of the upper pump part in the direction of the bottle neck predetermined amount of the liquid container contents in a chamber of the pump and then - with the next pump stroke - off fine channels of the upper pump part ejects, the liquid is atomized finely at an outlet nozzle.
  • the liquid can also be dispensed drop by drop.
  • Pumps are used, for example, to spray a liquid drug widespread in the nose.
  • the invention preferably relates to those containers which are produced by the coextrusion blow molding process are made and from a rigid Outer container and consist of a soft inner bag, the Materials do not weld together.
  • the preferred container is by squeezing the tubular preform sealed in the blow mold Bottom seam of the inner bag in an outwardly protruding Bottom web of the outer container is clamped, the outer web is also closed by means of a weld seam, which itself has formed in that the weld seam of the inner bag due to a jamming effect in the bottom seam of the outer container forming section withdrawn from the separation point Has.
  • the wall of the outer container contains pressure equalization openings, for example through unwelded shoulder seams of the outer container or can be formed in that a Chip of the outer container cut flat on a convex section is, when the knife hits the Inner bag of the latter not damaged, but inside is pushed away. With the gradual release of the liquid The inner bag is increasingly contracting inside the container, whereby for pressure equalization according to ambient air through the Pressure equalization openings in the space between the outer container and the inner bag enters.
  • the invention is not based on the use of such Container limited, and the container does not have to necessarily have a bottle shape with a bottle neck.
  • the container according to the invention is also preferred for receiving of a liquid drug is provided and will follow described using such an example, although emphasized is that he will also take up and dispense another liquid is suitable if it consists of two substances, namely one solvent in the container and one in a second chamber of the container, initially kept separately, preferably in the solid state active ingredient is miscible.
  • Some active pharmaceutical ingredients such as hormones are not long-term stable if they are dissolved in a liquid, which is especially the case when there are no preservatives can be added. To remedy this create, it is known to freeze such active ingredients in Store form and in a solvent before use enter with the active ingredient in the dissolved state a liquid Drugs forms, for example, by means of a Pipette can be administered.
  • the present invention has for its object a container with a Specify the pump device that is used to receive and dispense a liquid an active ingredient that is not stable in the long term.
  • the opening of the container preferably in the neck of the container, if there is one, essentially one tubular insert is arranged, which abuts the edge of the opening and has a bottom which is closed in a first state of the arrangement and before the first dispensing of the liquid container content by the action of a Force is opened.
  • the front end portion of the preferably used as an airless pump engages, the peripheral wall of this front end portion or Suction section abuts the wall of the insert, and being the peripheral wall upon application of a corresponding force in the axial direction of the container can be moved relative to the insert.
  • the in the closed state of the floor of one in the rest of the interior of the Container second substance is separated. If the bottom of the But opened by pushing the pump device forward or is torn open, the one in use Substance out of use and can with the substance be mixed in the container.
  • This is in use preferably a freeze-dried active ingredient of a medicament first of all a solvent in the container, e.g. sterile water, isolated and after opening the bottom with mixed this liquid.
  • a solvent in the container e.g. sterile water
  • the essentially tubular insert has expediently a cylindrical shape, even if the bottle neck of the container and the front housing section of the pump device has a corresponding one Cylindrical shape - but with a larger or smaller one Diameter- has.
  • the pump device extends over the front end region projecting tubular projection with the ball valve has, which is aligned with the circumferential groove of the bottom and on its free end is cut away obliquely, so that the projection when feeding the pump device into the container only with the tip of the projection into the groove occurs and the seam tears open with a high pressing force, whereby an increasing circumferential area the weakened seam with persistent Feed further tears open, so that finally the bottom in the position of use folds down and the content of the insert is fully released.
  • the protrusion is preferred formed by the peripheral wall of the front suction area the pump device beyond the valve area is extended.
  • the insert expediently lies on a ring shoulder the top of the container or the top edge of the container neck if there is one.
  • an additional peripheral wall is arranged on the container, partially overlapped by a housing part of the pump device that is axially displaceable.
  • the additional peripheral wall is expediently part of an outer cap that comprises at least the lower region of the container. It can the outer cap also extends to the top of the container.
  • the outer cap on its upper Edge of a thickening with an outwardly projecting ring shoulder has, while the housing part of the pump device a thickening at the bottom with an inward protrusion Has ring shoulder.
  • the thickening of the outer cap is accordingly facing the inner wall of the housing part while thickening of the housing part faces the outer wall of the outer cap. in the the two ring shoulders are in abutting condition the pump device is in the retracted starting position, in which the bottom of the insert is closed and the one inside Substance separated from the rest of the interior of the container is.
  • both ring shoulders have bevels on the outside, which when feeding the housing part in the direction of Outer cap hit each other, creating the area of thickening of the housing part of the pump is expanded radially, while the housing part with its thickening over the thickening the outer cap slides. That way, these two can Part can be assembled easily.
  • either the thickening of the Outer cap or the thickening of the housing part a small has radial excess, such that this thickening with a bias on the associated wall of the other Partial.
  • this other wall is at an axial distance from the thickening formed a circumferential groove into which the The thickening engages with the radial oversize.
  • This groove defines the position of the pump device in which the bottom of the Is torn open and unfolded and in which the Arrangement is in the state in which the container contents can be applied by the pump device.
  • the pump device two axial positions of the pump device limited relative to the container, namely the withdrawn Initial situation due to the application of the ring shoulders to each other and the ready-to-use inserted into the container Location in which a thickening in the associated groove locks.
  • the container sits in an outer cap that extends to the top of the container neck can be enough.
  • the outer cap is at its upper edge area provided with a thread that is preferably on the Outside of the outer cap. With this thread is a Internal thread of a housing part of the pump device engages.
  • the pump device By turning the housing part, the pump device is also pushed their suction section into the container until one Ring shoulder of another housing part of the pump device runs onto the container, causing the use position of the Pump device is defined.
  • the front end portion of the pump means the bottom of the insert torn open and opened so that the active ingredient in the Container can enter.
  • This screwing process makes the pump device continuous and smoothly pushed into the container with its suction section, tilting the suction section in the insert is reliably prevented.
  • the one required to tear open the floor Force can also be achieved by screwing less skillful people can be easily applied.
  • thread Sawtooth thread is used.
  • the thread sections are preferably so short that in the advanced end position Thread of the housing part beyond the thread of the outer cap is screwed so that the housing part of the pump device can no longer be screwed back. Through this self-locking the thread, which also causes other measures can be reliably prevented that the pump device is moved out of its position of use.
  • the figures show a bottle-shaped container 1 with a Neck 2, in which an insert 3 is arranged, with one after externally facing ring shoulder 4 on the upper edge of the bottle neck 2 rests.
  • the insert 3 has a circular cylindrical shape and lies close to the inner wall of the container neck 2.
  • the insert 3 has a bottom 5, which is shown in FIG Initial state of the arrangement is closed.
  • the inner wall of the base 5 is a circumferential V-shaped groove 30 trained, which represents a predetermined breaking seam.
  • the front end or suction section 31 engages in the insert 3 a pump device designated overall by reference number 6 on.
  • the pump device has conventional means in the area of the suction opening 7, a ball valve 8, which acts upon of an overpressure closes the suction opening 7 and at Exposure to a vacuum from the valve seat so that the front suction chamber 9 by lifting the upper pump part due to the force of the coil spring 10 with from the container chamber 11 can suck in liquid.
  • the liquid from fine channels 12 of the upper Part of the pump device and an atomizing nozzle 13 are applied.
  • Cap 14 has been removed.
  • the known components of the pump device can be found here to be dispensed with.
  • a second receiving chamber 15 Between the lower suction end of the pump device 6 and the Bottom 5 of the insert 3 is a second receiving chamber 15, in which, for example, a solution that is not long-term stable in solution Active ingredient of a drug that is liquid in the delivery state freeze-dried form can be kept as long as that Medicines should not be administered.
  • the bottle 1 is in its lower area in a cup-shaped Outer cap 16 taken close to the outer wall of the vial.
  • the outer cap 16 has at its top End of an outwardly facing circumferential thickening 17 with a lower ring shoulder 18 and at the top of a slope 19.
  • An outwardly facing annular shoulder 20 of a pump part 21 is by an inwardly facing annular flange 22nd of a housing part 23 of the pump device 6, which with a cylindrical outer wall 24 partially over the cylindrical outer wall of the outer cap 16 extends.
  • the housing part 24 also has a circumferential thickening 25 on its lower end with an overhead ring shoulder 25a and below lying slope 26.
  • the annular thickening of the housing part 23 has a radial after inside a little oversize so that the thickening with a certain bias is applied to the outer wall of the outer cap 16.
  • a predetermined distance from the thickening 17 of the outer cap is located in the outer wall of the outer cap 16 circumferential annular groove 27a, in the insertion of the pump device into the vial 1 in the liquid dispensing position shown in Figure 2 the thickening of the housing 23 engages. As a result, the delivery position of the pump device is fixed.
  • the pump device 6 sits with the one surrounding the suction chamber 9
  • the peripheral wall 27 is tight in the insert 3.
  • the peripheral wall 27 sits down (in the figures down) in a tubular Projection 28 continues, which is cut away obliquely at its end and the suction opening 7 of the pump device 6 protrudes.
  • the invention extends the outer cap 31 in which the container 1 is arranged up to the upper edge of the container neck.
  • the container 1 sits with radial play in the outer cap 13 and is non-rotatably connected to it by one of the Bottom of the outer cap 31 projecting web 32 in a corresponding shaped bottom groove of the container 1 engages.
  • the outer cap 31 has an axial in its upper end region short threaded section 33, in which a likewise axially short Threaded portion 34 on the inside of the housing part 35 of the Pump device 6 engages.
  • a sawtooth thread is preferred for this.
  • the bottom 5 of the insert 3 is torn open in that the Housing part 35 is screwed clockwise, opening it an annular extension (39) of another housing part (40) the pump device slides until an end edge 36 of a Housing part 37 on the shoulder portion 38 of the container 1st incident.
  • the bottom 5 of the insert 3 is in this end position torn open, as Figure 4 indicates.
  • the threaded portion 34 of the housing part 35 is in this Position no longer with the threaded section 33 of the outer cap 31 engaged so that it is not possible for a user to screw the housing part 35 back into the initial state.

Landscapes

  • Closures For Containers (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Package Specialized In Special Use (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Centrifugal Separators (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Reciprocating Pumps (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Spinning Or Twisting Of Yarns (AREA)
EP98104631A 1997-09-26 1998-03-14 Behälter mit versiegeltem Einsatz und Pumpe zum Öffnen der Versiegelung Expired - Lifetime EP0904847B1 (de)

Priority Applications (21)

Application Number Priority Date Filing Date Title
DE19742559A DE19742559C2 (de) 1997-09-26 1997-09-26 Behälter mit Pumpe
DK98104631T DK0904847T3 (da) 1997-09-26 1998-03-14 Beholder med forseglet indsats og pumpe til at bryde forseglingen
EP98104631A EP0904847B1 (de) 1997-09-26 1998-03-14 Behälter mit versiegeltem Einsatz und Pumpe zum Öffnen der Versiegelung
DE59809472T DE59809472D1 (de) 1997-09-26 1998-03-14 Behälter mit versiegeltem Einsatz und Pumpe zum Öffnen der Versiegelung
AT98104631T ATE248660T1 (de) 1997-09-26 1998-03-14 Behälter mit versiegeltem einsatz und pumpe zum öffnen der versiegelung
PT98104631T PT904847E (pt) 1997-09-26 1998-03-14 Recipente com parte de insercao selada e bomba para romper a selagem
ES98104631T ES2206776T3 (es) 1997-09-26 1998-03-14 Recipiente con un inserto cerrado y bomba para abrir el cierre.
JP2000513677A JP4231623B2 (ja) 1997-09-26 1998-08-21 ポンプを備える容器
CZ20000956A CZ297286B6 (cs) 1997-09-26 1998-08-21 Nádobka s cerpacími prostredky
UA2000042377A UA53752C2 (uk) 1997-09-26 1998-08-21 Контейнер, що містить насос
CN98809483A CN1112262C (zh) 1997-09-26 1998-08-21 开口中设置有一个注出所盛放的液体的泵装置的容器
TR2000/00857T TR200000857T2 (tr) 1997-09-26 1998-08-21 Bir pompa içeren konteyner.
BR9812367-0A BR9812367A (pt) 1997-09-26 1998-08-21 Recipiente com uma guarnição vedada e bomba para a bertura da referida vedação
PCT/DE1998/002444 WO1999016552A1 (de) 1997-09-26 1998-08-21 Behälter mit versiegeltem einsatz und pumpe zum öffnen der versiegelung
AU96204/98A AU731460B2 (en) 1997-09-26 1998-08-21 Container comprising a pump
SK411-2000A SK286670B6 (sk) 1997-09-26 1998-08-21 Nádobka s čerpacími prostriedkami
RU2000110627/12A RU2201296C2 (ru) 1997-09-26 1998-08-21 Контейнер, содержащий насос
CA2303880A CA2303880C (en) 1997-09-26 1998-08-21 Container comprising a pump
US09/508,893 US6412659B1 (en) 1997-09-26 1998-08-21 Container and pump assembly
HU0003839A HU223435B1 (hu) 1997-09-26 1998-08-21 Edény szorosan illeszkedő betéttel és a betétet nyitó szivattyúval
NO20001467A NO319538B1 (no) 1997-09-26 2000-03-21 Beholder som i en apning inneholder en pumpeanordning for a drive ut et flytende beholderinnhold

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19742559A DE19742559C2 (de) 1997-09-26 1997-09-26 Behälter mit Pumpe
DE19742559 1997-09-26
EP98104631A EP0904847B1 (de) 1997-09-26 1998-03-14 Behälter mit versiegeltem Einsatz und Pumpe zum Öffnen der Versiegelung

Publications (2)

Publication Number Publication Date
EP0904847A1 EP0904847A1 (de) 1999-03-31
EP0904847B1 true EP0904847B1 (de) 2003-09-03

Family

ID=26040344

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98104631A Expired - Lifetime EP0904847B1 (de) 1997-09-26 1998-03-14 Behälter mit versiegeltem Einsatz und Pumpe zum Öffnen der Versiegelung

Country Status (20)

Country Link
US (1) US6412659B1 (cs)
EP (1) EP0904847B1 (cs)
JP (1) JP4231623B2 (cs)
CN (1) CN1112262C (cs)
AT (1) ATE248660T1 (cs)
AU (1) AU731460B2 (cs)
BR (1) BR9812367A (cs)
CA (1) CA2303880C (cs)
CZ (1) CZ297286B6 (cs)
DE (2) DE19742559C2 (cs)
DK (1) DK0904847T3 (cs)
ES (1) ES2206776T3 (cs)
HU (1) HU223435B1 (cs)
NO (1) NO319538B1 (cs)
PT (1) PT904847E (cs)
RU (1) RU2201296C2 (cs)
SK (1) SK286670B6 (cs)
TR (1) TR200000857T2 (cs)
UA (1) UA53752C2 (cs)
WO (1) WO1999016552A1 (cs)

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DE10131174A1 (de) * 2001-06-29 2003-01-16 Boehringer Ingelheim Pharma Vernebler zur Applikation von Flüssigkeiten auf die Augenoberfläche oder das Augenbindegewebe
US7201296B2 (en) * 2001-09-21 2007-04-10 Ing. Erich Pfeiffer Gmbh Dosing device with a pumping device
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JP5763053B2 (ja) 2009-05-18 2015-08-12 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング アダプタ、吸入器具及びアトマイザ
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WO2013152894A1 (de) 2012-04-13 2013-10-17 Boehringer Ingelheim International Gmbh Zerstäuber mit kodiermitteln
WO2015018904A1 (en) 2013-08-09 2015-02-12 Boehringer Ingelheim International Gmbh Nebulizer
EP2835146B1 (en) 2013-08-09 2020-09-30 Boehringer Ingelheim International GmbH Nebulizer
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TR200000857T2 (tr) 2000-11-21
AU731460B2 (en) 2001-03-29
RU2201296C2 (ru) 2003-03-27
NO319538B1 (no) 2005-08-29
ES2206776T3 (es) 2004-05-16
CN1271301A (zh) 2000-10-25
EP0904847A1 (de) 1999-03-31
BR9812367A (pt) 2000-09-19
HUP0003839A2 (hu) 2001-02-28
WO1999016552A1 (de) 1999-04-08
AU9620498A (en) 1999-04-23
DE19742559A1 (de) 1999-05-06
HUP0003839A3 (en) 2001-04-28
DE19742559C2 (de) 1999-08-05
JP4231623B2 (ja) 2009-03-04
CA2303880A1 (en) 1999-04-08
HU223435B1 (hu) 2004-07-28
NO20001467D0 (no) 2000-03-21
DK0904847T3 (da) 2004-01-12
SK286670B6 (sk) 2009-03-05
PT904847E (pt) 2004-01-30
ATE248660T1 (de) 2003-09-15
DE59809472D1 (de) 2003-10-09
SK4112000A3 (en) 2000-09-12
NO20001467L (no) 2000-03-21
UA53752C2 (uk) 2003-02-17
US6412659B1 (en) 2002-07-02
CZ2000956A3 (en) 2001-06-13
CZ297286B6 (cs) 2006-10-11
JP2001518428A (ja) 2001-10-16
CN1112262C (zh) 2003-06-25
CA2303880C (en) 2010-04-27

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