EP0702970B1 - Crayon à injection de médicaments avec échelle de dosage à pas réglable - Google Patents

Crayon à injection de médicaments avec échelle de dosage à pas réglable Download PDF

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Publication number
EP0702970B1
EP0702970B1 EP95306484A EP95306484A EP0702970B1 EP 0702970 B1 EP0702970 B1 EP 0702970B1 EP 95306484 A EP95306484 A EP 95306484A EP 95306484 A EP95306484 A EP 95306484A EP 0702970 B1 EP0702970 B1 EP 0702970B1
Authority
EP
European Patent Office
Prior art keywords
lead screw
assembly
medication
housing
pen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP95306484A
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German (de)
English (en)
Other versions
EP0702970A3 (fr
EP0702970A2 (fr
Inventor
Lawrence H. Chanoch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Becton Dickinson and Co
Original Assignee
Becton Dickinson and Co
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Filing date
Publication date
Application filed by Becton Dickinson and Co filed Critical Becton Dickinson and Co
Publication of EP0702970A2 publication Critical patent/EP0702970A2/fr
Publication of EP0702970A3 publication Critical patent/EP0702970A3/fr
Application granted granted Critical
Publication of EP0702970B1 publication Critical patent/EP0702970B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/31556—Accuracy improving means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A61M5/31551—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe including axial movement of dose setting member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
    • A61M5/31585—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod performed by axially moving actuator, e.g. an injection button
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/581—Means for facilitating use, e.g. by people with impaired vision by audible feedback
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic

Definitions

  • the subject invention relates to medication delivery pens having a cartridge holder assembly and a pen body assembly removably mounted to the cartridge holder assembly for delivering medication having an improved dose setting device.
  • Hypodermic syringes are used to deliver selected doses of medication to patients.
  • the prior art hypodermic syringe includes a syringe barrel having opposed proximal and distal ends.
  • a cylindrical chamber wall extends between the ends and defines a fluid receiving chamber.
  • the proximal end of the prior art syringe barrel is substantially open and receives a plunger in sliding fluid tight engagement.
  • the distal end of the prior art syringe barrel includes a passage communicating with the chamber.
  • a needle cannula is mounted to the distal end of the prior art syringe barrel, such that the lumen of the needle cannula communicates with the passage and the chamber of the syringe barrel.
  • Movement of the plunger in a proximal direction draws fluid through the lumen of the needle cannula and into the chamber. Movement of the plunger in a proximal-to-distal direction urges fluid from the chamber and through the lumen of the needle cannula.
  • Medication to be injected with the prior art hypodermic syringe often is stored in a vial having a pierceable elastomeric seal. Medication in the prior art vial is accessed by piercing the elastomeric seal with the needle cannula. A selected dose of the medication is drawn into the chamber of the syringe barrel by moving the plunger a selected distance in a proximal direction. The needle cannula is withdrawn from the vial, and the medication is injected into a patient by moving the plunger in a distal direction.
  • Some medication such as insulin is self-administered.
  • the typical diabetes patient will require injections of insulin several times during the course of the day.
  • the required dose of insulin will vary from patient to patient, and for each patient may vary during the course of the day and from day to day.
  • Each diabetes patient will establish a regimen that is appropriate for his or her own medical condition and for his or her lifestyle.
  • the regimen typically includes some combination of a slow or medium acting insulin and a faster acting insulin.
  • Each of these regimens may require the diabetes patient to periodically self-administer insulin in public locations, such as places of employment or restaurants.
  • the required manipulation of the standard prior art hypodermic syringe and vial can be inconvenient and embarrassing in these public environments.
  • Medication delivery pens have been developed to facilitate the self-administration of medication.
  • One prior art medication delivery pen see EP-A 554,995, includes a vial holder into which a vial of insulin or other medication may be received.
  • the vial holder is an elongate generally tubular structure with proximal and distal ends.
  • the distal end of the prior art vial holder includes mounting means for engaging a double-ended needle cannula.
  • the proximal end also includes mounting means for engaging a driver and dose setting apparatus as explained further below.
  • a disposable vial for use with the prior art vial holder includes a distal end having a pierceable elastomeric seal that can be pierced by one end of a double-ended needle cannula.
  • the proximal end of this prior art vial includes a plunger slidably disposed in fluid tight engagement with the cylindrical wall of the vial.
  • This prior art medication delivery pen is used by inserting the vial of medication into the vial holder.
  • a prior art pen body then is connected to the proximal end of the vial holder.
  • the pen body includes a dose setting apparatus for designating a dose of medication to be delivered by the pen and a driving apparatus for urging the plunger of the vial distally for a distance corresponding to the selected dose.
  • the user of the pen mounts a prior art double-ended needle cannula to the distal end of the vial holder such that the proximal point of the needle cannula pierces the elastomeric seal on the vial.
  • the patient selects a dose and operates the pen to urge the plunger distally to deliver the selected dose.
  • the dose selecting apparatus returns to zero upon injection of the selected dose with this prior art medication delivery pen.
  • the patient removes and discards the needle cannula, and keeps the prior art medication delivery pen in a convenient location for the next required medication administration.
  • the medication in the vial will become exhausted after several such administrations of medication.
  • the patient then separates the vial holder from the pen body. The empty vial may then be removed and discarded.
  • a new vial can be inserted into the vial holder, and the vial holder and pen body can be reassembled and used as explained above.
  • the above described medication delivery pen is effective and much more convenient for self-administration of medication than the typical hypodermic syringe and separate medication vial.
  • prior art medication delivery pens are limited to a particular range of dosage amounts because of the fairly complex dosage selecting and driving mechanisms within the delivery pens. To vary the dosage amounts available to a user would require more complex devices that are costly to manufacture. Hence, it is necessary to provide a medication delivery pen at a reasonable cost having a wider range of doses and more flexibility when setting doses for drug delivery.
  • the subject invention relates to a medication delivery pen having a medication cartridge assembly that is selectively engageable with and disengageable from a pen body assembly.
  • the medication cartridge assembly is an elongate generally cylindrical structure having opposed proximal and distal ends.
  • the distal end of the medication cartridge assembly includes needle mounting means for securely but releasably receiving a needle cannula assembly, the distal end being characterized by a pierceable elastomeric seal that may be repeatedly and resealable pierced by the proximal end of a double-ended needle cannula.
  • the proximal end of the medication cartridge assembly includes body mounting means for securely but releasably mounting the medication cartridge assembly to the pen body assembly.
  • the body mounting means may comprise an array of threads extending distally from the proximal end of the medication cartridge assembly.
  • the medication cartridge assembly further includes plunger means slidably disposed in fluid tight engagement therein.
  • the plunger means may initially be disposed in a proximal position within the medication cartridge assembly and may be moved in a distal direction by a driver projecting from the pen body assembly.
  • the medication cartridge assembly further comprises anti-rotation means for preventing rotation of the driver.
  • the pen body assembly of the subject invention comprises an array of mounting threads to enable threaded engagement of the pen body assembly and the medication cartridge assembly and an actuator button rotatably mounted on its proximal end.
  • an actuator button rotatably mounted on its proximal end.
  • the pen body assembly further includes a lead screw for selectively engaging the plunger of the cartridge assembly and for urging the plunger of the cartridge assembly in a distal direction. At least a portion of the lead screw includes driving threads engaged with other portions of the pen body assembly that may be operative to achieve axial movement of the lead screw in response to axial forces exerted on the rotatable actuator button.
  • the pen body assembly further comprises dose setting means for establishing and precisely controlling the amount of medication to be delivered in response to each actuation of the actuator button.
  • the dose setting means may be any of several structures as described in greater detail below.
  • a cartridge assembly that is filled with medication is mounted to the pen body assembly and the initial response to forces on the actuator button cause the lead screw to move in a proximal direction toward its starting position, while the remaining portions of the pen body assembly move distally toward the vial assembly. Further forces exerted on the actuator button cause the mounting means of the pen body to engage the mounting means of the cartridge assembly. Continued axial forces on the actuator button cause the mounting threads to engage the cartridge assembly and continue the proximal movement of the driver.
  • the pen body assembly is fully but releasably engaged with the cartridge assembly at the same time that the driver is at its proximal extreme position and is then in position to begin delivering selected doses of medication from the pen. Doses of medication can be dispensed as needed over time, and the cartridge assembly is removed and discarded when the medication therein has been exhausted. A new medication cartridge assembly may then be mounted to the pen body assembly as described above.
  • the driving means in the pen body assembly of the present invention includes a dose setting knob having a helical groove with three different regions of operation, each region having a different pitch to provide three different types of dosage increments.
  • the dose setting increments in the first region are 0.5 within a dose range of 0 to 10 units, 1.0 in the 10 to 30 unit range of the second region, and 2.0 for doses above 30 units in the third region.
  • This approach to dose setting and the associated resolution is believed to be more consistent with the way insulin doses are prescribed by physicians and the way patients are instructed to adjust their own insulin dose.
  • Fig. 1 is a perspective view of the medication delivery pen of the subject invention.
  • Fig. 2 is an exploded perspective view of the pen body assembly of the medication delivery pen shown in Fig. 1.
  • Fig. 3 is a side view of the periphery of a dose knob of the present invention operating in a first region and projected on a plane.
  • Fig. 4 is a side view of the periphery of a dose knob of the present invention operating in a second region and projected on a plane.
  • Fig. 5 is a side view of the periphery of a dose knob of the present invention operating in a third region and projected on a plane.
  • Medication delivery pen 10 includes a pen body assembly 12, a cartridge assembly 14, a needle cannula assembly 16 and a cap 17.
  • Cartridge assembly 14 includes opposed proximal and distal ends 18 and 20, respectively.
  • Proximal end 18 of cartridge assembly 14 is dimensioned and configured to threadedly engage pen body assembly 12, as explained further herein.
  • Distal end 20 of cartridge assembly 14 is configured to securely but releasably engage needle cannula assembly 16 and a shield 130 is provided to cover a distal end 126 of a needle cannula 122 in needle cannula assembly 16.
  • Pen body assembly 12 includes a generally cylindrical housing 22 having opposed proximal and distal ends 24 and 26, and a substantially hollow throughbore 28 extending axially therethrough.
  • An array of external threads 30 extends proximally from distal end 26 for threaded engagement with proximal end 18 of cartridge holder assembly 14.
  • Portions of hollow throughbore 28 of housing 22 adjacent distal end 26 are characterized by an array of clutch teeth (not shown) molded therein.
  • Proximal end 24 of housing 22 is characterized by a cut-out 33 formed therein for receiving a window insert 78.
  • Pen body assembly 12 includes a nut 34 having opposed proximal and distal ends 36 and 38, respectively. Exterior surface regions of nut 34 between proximal and distal ends 36 and 38 define a plurality of longitudinally extending splines 39. Proximal end 36 of nut 34 also includes a plurality of longitudinally extending resilient fingers 40 with enlarged ends that enable snap engagement of nut 34 into other portions of pen body assembly 12, as explained further herein. Distal end 38 of nut 34 is radially enlarged to limit axial movement of nut 34 in distal end 26 of housing 22. Thus, nut 34 is axially constrained within housing 22, however, the dimensions and configurations of nut 34 and housing 22 permit free relative rotation therebetween.
  • Pen body assembly 12 includes a clutch assembly 42 mounted therein.
  • Clutch assembly 42 includes a proximal clutch 44, a distal clutch 46 and an annular spring 48 biasingly engaged therebetween.
  • Proximal and distal clutches 44 and 46 each are configured for non-rotatable engagement over splines 39 of nut 34.
  • Distal clutch 46 includes an array of distally facing saw teeth dimensioned, disposed and configured for engagement with clutch teeth (not shown) on the interior distal end of housing 22, such that distal clutch 46 can rotate only in one direction relative to housing 22.
  • Proximal clutch 44 includes an array of proximally facing teeth which are also configured for unidirectional rotation, as explained further herein.
  • Pen body assembly 12 includes a generally cylindrical driver 50 having opposed proximal and distal ends 52 and 54.
  • Driver 50 is slidably inserted into housing 22 of pen body assembly 12 such that distal end 54 of driver 50 is snap fit over the enlarged ends of resilient fingers 40 at proximal end 36 of nut 34. This snap fit engagement prevents axial movement between nut 34 and driver 50, but permits free relative rotational movement within housing 22.
  • Distal end 54 of driver 50 is also characterized by an array of saw teeth 49 that engage with the saw teeth on proximal clutch 44.
  • Outer surface regions of driver 50 are characterized by splines 56 extending radially outwardly thereon and along a substantial portion of the length of driver 50.
  • Pen body assembly 12 includes a dose knob 58 which is a hollow generally cylindrical structure having opposed proximal and distal ends 60 and 62 and opposed inner and outer surfaces 64 and 66. Inner surface 64 is characterized by longitudinally extending grooves 68 which are disposed and dimensioned for engagement with splines 56 on driver 50. More particularly, dose knob 58 is spline mounted over driver 50 within housing 22 of pen body assembly 12. Thus, axially extending grooves 68 in dose knob 58 engage splines 56 of driver 50 to prevent relative rotation therebetween, but permitting relative axial movement.
  • Figs. 3-5 are side views of the periphery of dose setting knob 58 projected on a plane and show button 86 operating in a first, second and third region, respectively.
  • outer surface 66 of dose knob 58 is characterized by a groove 70 comprised of three regions, each region having a helical component 174, 184, 194. Each helical component has a different pitch to provide different dose increments in each region of dose setting knob 58 and thereby improve resolution and provide a greater range of potential dosage settings for the pen.
  • Outer surface 66 adjacent each helical component 174, 184, 194 of groove 70 is provided with dosage indicia to define dose setting increments corresponding to each region of groove 70.
  • the dose setting increments are 0.5 in the dose range 0 to 10 units of helical component 174, 1.0 in the 10 to 30 unit range of helical component 184, and 2.0 for doses above 30 units in helical component 194.
  • the present invention provides dosage resolution very consistent with the way insulin doses are prescribed by physicians, and the way patients are instructed to adjust their own insulin dosages.
  • Proximal end 60 of dose knob 58 is characterized by a gnarled exterior surface to facilitate manipulation for setting a selected dose.
  • An actuator button 76 is snapped into engagement with proximal end 60 of dose knob 58 to permit relative rotation therebetween.
  • An insert 78 is snapped into engagement with cut-out 33 in proximal end 24 of housing 22, insert 78 including opposed inner and outer surfaces 82 and 80 and a window 84 extending therebetween.
  • Inner surface 82 of insert 78 includes a button 86, shown in Figs. 3-5, on inner surface 82 dimensioned and disposed to engage in groove 70 of dose knob 58. Button 86 and window 84 are also disposed to enable the indicia on dose knob 58 to be visible through window 84.
  • Pen body assembly 12 further includes a lead screw 88 with opposed proximal and distal ends 90 and 92 and an array of external threads 94.
  • External threads 94 are characterized, however, by a pair of opposed axially extending grooves 96 which extend from distal end 92 substantially to the proximal end 90. Threads 94 are engaged in nut 34, such that proximal end 90 of lead screw 88 is within housing 22 and distal end 92 projects distally beyond housing 22. Threads 94 on lead screw 88 have exactly the same pitch and the same hand as threads 30 on distal end 26 of housing 22.
  • Pen body assembly 12 is assembled by placing nut 34 into housing 22 from distal end 26. Clutch assembly 42 then is mounted over splines 39 on nut 34. Driver 50 is then inserted into proximal end 24 of housing 22, and is urged sufficiently in a distal direction for snap fit engagement with nut 34. In this snapped engagement, the saw teeth of distal clutch 46 will be secured in engagement with the teeth in housing 22, and the saw teeth of proximal clutch 44 will be engaged with saw teeth 49 at distal end 54 of driver 50. Spring 48 will maintain constant selected pressure between these interengaged saw teeth. Insert 78 then is positioned over dose knob 58 such that button 86 of insert 78 is engaged in groove 70 in dose knob 58. The temporarily assembled insert 78 and dose knob 58 then are urged into housing 22. Lead screw 88 then is threaded into nut 34, and actuator button 76 is snapped into engagement with proximal end 60 of dose knob 58.
  • the assembled pen body assembly 12 and cartridge assembly 14, shown in Fig. 1, is stored until a selected dose of medication is required.
  • needle cannula assembly 16 is threadedly engaged to distal end 20 of cartridge assembly 14. This threaded engagement will cause a proximal tip 124 of needle cannula 122 to pierce a seal on the medication cartridge and provide communication with medication therein.
  • Shield 130 may then be removed.
  • a desired dose of medication is set by rotating dose knob 58 until indicia corresponding to the desired dose appears in window 84 of insert 78.
  • dose knob 58 When the desired dose is set, injection is achieved by merely pushing on actuator button 76. This causes dose knob 58 to turn about helixes 174, 184, 194 relative to pen body housing 22, so that driver 50 rotates through the same number of degrees. As dose knob 58 turns about helixes 174, 184, 194, button 86 travels through helix 174 in the first region when dispensing 1 to 10 units of medication, helix 184 in the second region when dispensing 11 to 30 units of medication, and helix 194 in the third region when dispensing 31 to 50 units of medication.
  • Dose setting knob 58 of the present invention therefore provides a wider range of dosages for the user than previously known dose setting knobs because of the different pitch of each helix, as shown in Figs. 3-5.
  • Rotation of dose setting knob 58 is opposite to the rotation generated during the dose setting procedure, when the rotational freedom of clutch assembly 42 is reversed.
  • the previously clicking proximal clutch 44 is locked to and turns with driver 50.
  • This driving movement of proximal clutch 44 causes a corresponding rotational movement of nut 34 because of the splined engagement therebetween.
  • Distal clutch 46 is therefore free to rotate against the saw teeth in housing 22, and makes an audible clicking indication during injection of medication.
  • lead screw 88 Rotation of lead screw 88 is prevented by grooves 96 and tabs unitarily molded within housing 100 of cartridge holder assembly 14. Therefore, as nut 34 rotates under the driving action of proximal clutch 44 and driver 50, lead screw 88 will be advanced axially into cartridge holder assembly 14. This axial advancement of lead screw 88 causes distal end 92 thereof to urge plunger 118 distally into cartridge 108, and hence causes a particular amount of medication to be injected through needle cannula 122 depending upon the dosage set using dose setting knob 58. Injection is terminated when proximal end 60 of dose knob 58 engages against proximal end 24 of pen body housing 22.
  • needle cannula assembly 16 may be disengaged from cartridge holder assembly 14 and safely discarded.
  • Cap 17 may be mounted over cartridge holder assembly 14, and pen 10 may be stored or carried in a convenient location until the next dose of medication is required.
  • a subsequent dose of medication will be set in exactly the manner as described above. However, for such a subsequent dose, lead screw 88 will be in a partly advanced position as a starting point. Dose setting and injections can be carried out until all of the medication has been used.
  • Cartridge holder assembly 14 may then be threadedly disengaged from pen body assembly 12, and slidably separated from lead screw 88. The separated cartridge holder assembly may then be discarded and replaced as described above.
  • the pen body assembly may have other driving and/or clutch mechanisms.
  • different means for preventing and/or enabling rotation during the dose setting and injection phases may be provided.
  • other means for mounting needle cannula to the cartridge assembly may be provided.

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  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Claims (10)

  1. Stylo d'administration d'un médicament (10), comprenant:
    un assemblage de cartouche contenant un médicament (14) comportant une extrémité distale avec un joint à percement (20) une extrémité proximale ouverte (18) comportant un ensemble de filetages, et un piston engagé par glissement et de manière étanche aux fluides dans ladite cartouche au niveau d'un emplacement distal par rapport audit ensemble de filetages; et un assemblage du corps du stylo (12), comportant:
    un boítier (22) avec des extrémités proximale et distale opposées (36, 38), ladite extrémité distale (38) comportant un ensemble de filetages (30) dimensionnés et espacés en vue d'un engagement par filetage dans lesdits filetages au niveau de ladite extrémité proximale (18) dudit assemblage de cartouche (14);
    une tige filetée (88) comportant une extrémité proximale (90), agencée dans ledit boítier (22), une extrémité distale (92) débordant au-delà de ladite extrémité distale (26) dudit boítier (22) en vue d'un engagement sélectif dans ledit piston, et des filetages (94) s'étendant entre lesdites extrémités proximale et distale (90, 92) de ladite tige filetée (88); et
    un bouton de réglage de la dose (58) comportant plusieurs repères de dosage pour un intervalle d'incréments prédéfinis de la dose, ledit bouton de réglage de la dose (58) étant raccordé par rotation et glissement à ladite tige filetée pour déplacer ladite tige filetée (88) dans une direction distale dans ledit assemblage du corps du stylo (12) sur une distance correspondant à la région sélectionnée de fonctionnement et des repères de dosage;
       caractérisé en ce que le bouton de réglage de la dose (58) comporte deux ou plusieurs régions (174, 184, 194) de fonctionnement, chaque région comportant plusieurs repères de dosage pour un intervalle prédéfini respectif de différents incréments de la dose.
  2. Stylo d'administration de médicament (10) selon la revendication 1, dans lequel ledit assemblage du corps du stylo (12) englobe en outre un bouton d'actionnement (76) monté par rotation sur ledit bouton de réglage de la dose (58), de sorte que des forces axiales exercées sur ledit bouton d'actionnement (76) entraínent le déplacement de ladite tige filetée (88) dans une direction distale dans ledit assemblage du corps du stylo (12) et dans ladite cartouche.
  3. Stylo d'administration de médicament (10) selon la revendication 1, dans lequel ledit bouton de réglage de la dose (58) définit des distances spécifiées du déplacement de ladite tige filetée (88) correspondant aux doses sélectionnées du médicament devant être administrées.
  4. Stylo d'administration de médicament (10) selon la revendication 1, dans lequel ladite extrémité scellée dudit assemblage de cartouche (14) comprend un joint élastomère à percement, ledit assemblage de cartouche (14) comprenant en outre un moyen de montage de l'aiguille adjacent à ladite extrémité distale dudit assemblage de cartouche (14), ledit stylo d'administration de médicament (10) comprenant en outre un assemblage de canule d'aiguille (16) comportant un moyeu pouvant s'engager sélectivement dans le moyen de montage dudit assemblage de cartouche (14) et une aiguille à deux extrémités comportant des pointes proximale et distale opposées, ladite pointe de ladite aiguille étant dimensionnée et agencée de sorte à percer ledit joint lors de l'engagement dans ledit assemblage de cartouche (14).
  5. Stylo d'administration de médicament (10) selon la revendication 4, comprenant en outre plusieurs assemblages de canule d'aiguille, chaque dit assemblage de canule d'aiguille pouvant être engagé sélectivement dans ledit assemblage de cartouche (14) et dégagé de celui-ci.
  6. Stylo d'administration de médicament (10) selon la revendication 1, dans lequel ladite tige filetée (88) dudit assemblage du corps du stylo (12) englobe une rainure à extension longitudinale (96), ledit assemblage de cartouche (14) englobant une patte destinée à s'engager par glissement dans la tige filetée (88), lesdites pattes empêchant ainsi une rotation relative entre ladite tige filetée (88) et ledit assemblage de cartouche (14).
  7. Stylo d'administration de médicament (10) selon la revendication 1, dans lequel ledit assemblage du corps du stylo (12) englobe un bouton (86), ledit bouton de réglage de la dose (58) englobant une rainure (70) destinée à recevoir ledit bouton (86) contrôlant ainsi le déplacement de ladite tige filetée (88) dans une direction distale dans ledit assemblage du corps du stylo (12) et dans ladite cartouche.
  8. Stylo d'administration de médicament (10) selon la revendication 7, dans lequel ladite rainure (70) sur ledit bouton de réglage de la dose (58) a un pas différent dans chaque région dudit bouton de réglage de la dose (58), chaque pas établissant des incréments différents de la dose.
  9. Stylo d'administration de médicament (10) selon la revendication 1, dans lequel ledit assemblage du corps du stylo (12) englobe un moyen d'entraínement (50) pouvant être déplacé sélectivement dans les directions proximale et distale dans ledit boítier (22) de l'assemblage du corps du stylo (12), ledit moyen d'entraínement (50) raccordant ledit bouton de réglage de la dose (58) à ladite tige filetée (88).
  10. Stylo d'administration de médicament (10) selon la revendication 9, dans lequel lesdits filetages sur ladite tige filetée (88) définissent un pas pratiquement identique audit pas desdits filetages sur ladite extrémité distale dudit boítier (22), ladite tige filetée (88) pouvant être déplacée axialement dans ledit boítier (22) en réponse au déplacement dudit moyen d'entraínement (50) par ledit bouton de réglage de la dose (58) pour faire avancer sélectivement ladite tige filetée (88) sur des distances par rapport audit boítier (22) correspondant aux doses de médicament sélectionnées;
       les pas pratiquement identiques desdits filetages sur ladite tige filetée (88) et sur ledit boítier (22) permettant le déplacement de ladite tige filetée (88) dans ledit boítier (22) de manière simultanée à l'engagement par filetage dudit boítier (22) dans ledit assemblage de support de la cartouche.
EP95306484A 1994-09-19 1995-09-14 Crayon à injection de médicaments avec échelle de dosage à pas réglable Expired - Lifetime EP0702970B1 (fr)

Applications Claiming Priority (2)

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US308767 1994-09-19
US08/308,767 US5582598A (en) 1994-09-19 1994-09-19 Medication delivery pen with variable increment dose scale

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EP0702970A2 EP0702970A2 (fr) 1996-03-27
EP0702970A3 EP0702970A3 (fr) 1996-05-15
EP0702970B1 true EP0702970B1 (fr) 2002-06-05

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US (1) US5582598A (fr)
EP (1) EP0702970B1 (fr)
JP (1) JP3745418B2 (fr)
CA (1) CA2157243C (fr)
DE (1) DE69526893T2 (fr)
ES (1) ES2177609T3 (fr)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE41956E1 (en) * 1999-09-16 2010-11-23 Novo Nordisk A/S Dose setting limiter
US8900204B2 (en) 2006-05-16 2014-12-02 Novo Nordisk A/S Gearing mechanism for an injection device
US9022991B2 (en) 2000-06-16 2015-05-05 Novo Nordisk A/S Injection device
US9028454B2 (en) 2003-03-03 2015-05-12 Sanofi-Aventis Deutschland Gmbh Drive mechanisms suitable for use in drug delivery devices
US9192727B2 (en) 2006-05-18 2015-11-24 Novo Nordisk A/S Injection device with mode locking means
US9205197B2 (en) 2003-03-03 2015-12-08 Sanofi-Aventis Deutschland Gmbh Drug delivery device dose setting mechanism
US9265893B2 (en) 2007-02-05 2016-02-23 Novo Nordisk A/S Injection button
US9533106B2 (en) 2011-12-29 2017-01-03 Novo Nordisk A/S Torsion-spring based wind-up auto injector pen with dial-up/dial-down mechanism

Families Citing this family (253)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3568959B2 (ja) * 1995-03-07 2004-09-22 イーライ・リリー・アンド・カンパニー 再利用可能な投薬装置
US6045003A (en) * 1995-06-30 2000-04-04 Concept Workshop Worldwide, Llc Liquid dosage dispensers
US5836359A (en) * 1995-06-30 1998-11-17 Concept Workshop Worldwide, Llc Liquid dosage dispensers
US5674204A (en) * 1995-09-19 1997-10-07 Becton Dickinson And Company Medication delivery pen cap actuated dose delivery clutch
US5658259A (en) * 1995-10-19 1997-08-19 Meridian Medical Technologies, Inc. Dental cartridge assembly auto-injector with protective needle cover
JP3741730B2 (ja) * 1996-04-02 2006-02-01 テクファーマ・ライセンシング・アクチェンゲゼルシャフト 注射装置
DE59609696D1 (de) 1996-04-02 2002-10-24 Disetronic Licensing Ag Injektionsgerät
EP0848623B1 (fr) 1996-07-05 2003-10-08 Disetronic Licensing AG Dispositif d'injection de liquide
WO1998001172A1 (fr) * 1996-07-05 1998-01-15 Disetronic Licensing Ag Appareil pour l'injection de liquide
US6146361A (en) 1996-09-26 2000-11-14 Becton Dickinson And Company Medication delivery pen having a 31 gauge needle
DE19717107B4 (de) 1997-04-23 2005-06-23 Disetronic Licensing Ag System aus Behältnis und Antriebsvorrichtung für einen Kolben, der in dem ein Medikamentfluid enthaltenden Behältnis gehalten ist
CN1269369C (zh) 1997-04-24 2006-08-09 株式会社Ntt都科摩 移动通信方法和移动通信系统
DE19723647C1 (de) 1997-06-05 1998-12-24 Disetronic Licensing Ag Rücksetzbare Anzeigeeinrichtung einer Vorrichtung zur dosierten Abgabe eines Medikamentfluids
AU9202398A (en) 1997-09-29 1999-04-23 Becton Dickinson & Company Injection device and drug cartridge for preventing cross-use of the device and drug cartridge
DE19740187C1 (de) * 1997-09-12 1999-04-15 Disetronic Licensing Ag Vorrichtung zur dosierten Ausschüttung eines injizierbaren Produkts
DE19755125B4 (de) 1997-12-11 2006-04-20 Tecpharma Licensing Ag Nadelschutzvorrichtung für Injektionsgeräte
PT1003581E (pt) * 1998-01-30 2001-04-30 Novo Nordisk As Seringa de injeccao
DE19822031C2 (de) 1998-05-15 2000-03-23 Disetronic Licensing Ag Autoinjektionsgerät
US6290679B1 (en) 1999-05-14 2001-09-18 Disetronic Licensing Ag Device for metered administration of an injectable product
DE19821933C1 (de) 1998-05-15 1999-11-11 Disetronic Licensing Ag Vorrichtung zur Verabreichung eines injizierbaren Produkts
BR9911930A (pt) 1998-07-08 2002-04-23 Novo Nordisk As Dispositivo de distribuição de medicamento, e, montagem de cartucho para uso no mesmo
DE19900792C1 (de) * 1999-01-12 2000-06-15 Disetronic Licensing Ag Vorrichtung zur Verabreichung eines injizierbaren Produkts
SE9901366D0 (sv) * 1999-04-16 1999-04-16 Pharmacia & Upjohn Ab Injector device and method for its operation
US6192891B1 (en) * 1999-04-26 2001-02-27 Becton Dickinson And Company Integrated system including medication delivery pen, blood monitoring device, and lancer
US6843781B2 (en) * 1999-10-14 2005-01-18 Becton, Dickinson And Company Intradermal needle
US6569143B2 (en) 1999-10-14 2003-05-27 Becton, Dickinson And Company Method of intradermally injecting substances
US20020193740A1 (en) 1999-10-14 2002-12-19 Alchas Paul G. Method of intradermally injecting substances
US6776776B2 (en) 1999-10-14 2004-08-17 Becton, Dickinson And Company Prefillable intradermal delivery device
US6382204B1 (en) * 1999-10-14 2002-05-07 Becton Dickinson And Company Drug delivery system including holder and drug container
US6569123B2 (en) 1999-10-14 2003-05-27 Becton, Dickinson And Company Prefillable intradermal injector
US6494865B1 (en) 1999-10-14 2002-12-17 Becton Dickinson And Company Intradermal delivery device including a needle assembly
EP2258424B1 (fr) * 2001-05-16 2013-01-30 Eli Lilly and Company Appareil injecteur de médication
US20060018877A1 (en) * 2001-06-29 2006-01-26 Mikszta John A Intradermal delivery of vacccines and therapeutic agents
WO2003002069A2 (fr) 2001-06-29 2003-01-09 Becton, Dickinson And Company Distribution intradermique de vaccins et d'agents therapeutiques geniques via une microcannule
US7798185B2 (en) 2005-08-01 2010-09-21 Medical Instill Technologies, Inc. Dispenser and method for storing and dispensing sterile food product
JP4405802B2 (ja) 2001-10-16 2010-01-27 メディカル・インスティル・テクノロジーズ・インコーポレイテッド 計量された量の物質を供給するための、密閉チャンバ及び一方向弁を備えたディスペンサ
EP1536853A1 (fr) * 2002-07-10 2005-06-08 Novo Nordisk A/S Dispositif d'injection
US6945961B2 (en) 2002-07-10 2005-09-20 Novo Nordisk A/S Injection device
JP4866005B2 (ja) 2002-08-13 2012-02-01 メディカル・インスティル・テクノロジーズ・インコーポレイテッド 内容物蓄蔵吐出用の容器及びこれに関連する方法
US7404796B2 (en) * 2004-03-01 2008-07-29 Becton Dickinson And Company System for determining insulin dose using carbohydrate to insulin ratio and insulin sensitivity factor
GB0304823D0 (en) 2003-03-03 2003-04-09 Dca Internat Ltd Improvements in and relating to a pen-type injector
US6997219B2 (en) 2003-05-12 2006-02-14 Medical Instill Technologies, Inc. Dispenser and apparatus and method for filling a dispenser
US20040253185A1 (en) * 2003-06-12 2004-12-16 Atrium Medical Corp. Medicated ink
US7226231B2 (en) 2003-07-17 2007-06-05 Medical Instill Technologies, Inc. Piston-type dispenser with one-way valve for storing and dispensing metered amounts of substances
US7264142B2 (en) 2004-01-27 2007-09-04 Medical Instill Technologies, Inc. Dispenser having variable-volume storage chamber and depressible one-way valve assembly for dispensing creams and other substances
GB0407627D0 (en) * 2004-04-02 2004-05-05 Vectura Ltd Corkscrew pump
US20050251152A1 (en) * 2004-05-05 2005-11-10 Atrium Medical Corp. Illuminated medicated ink marker
US20050261639A1 (en) * 2004-05-05 2005-11-24 Atrium Medical Corp. Medicated ink marker
US20050261660A1 (en) * 2004-05-24 2005-11-24 Choi Soo B Method for controlling insulin pump using Bluetooth protocol
UA87334C2 (ru) 2004-10-04 2009-07-10 Санофи-Авентис Дойчланд Гмбх Приводной механизм для применения в устройстве введения лекарств, устройство введения лекарств, применение приводного механизма (варианты) и способ сборки устройства введения лекарств
WO2006045525A1 (fr) 2004-10-21 2006-05-04 Novo Nordisk A/S Dispositif d'injection comprenant un processeur conçu pour recueillir des informations d'ejection
AU2005298944B2 (en) 2004-10-21 2010-12-23 Novo Nordisk A/S Dial-down mechanism for wind-up pen
EP1827537B1 (fr) 2004-10-21 2019-08-14 Novo Nordisk A/S Dispositif de délivrance d'un médicament avec un détecteur délivrant un signal indicatif d'une dose éjectée.
EP1877119B1 (fr) * 2005-01-25 2018-09-05 Novo Nordisk A/S Dispositif d'injection avec un signal de retour d'une dose terminée
JP4979686B2 (ja) 2005-04-24 2012-07-18 ノボ・ノルデイスク・エー／エス 注入デバイス
US20070140914A1 (en) * 2005-12-21 2007-06-21 Yoshiki Sawa Reagent-introducing medical device configured to create laminar flow and rotating flow
JP5062768B2 (ja) 2006-03-10 2012-10-31 ノボ・ノルデイスク・エー／エス 注射装置および該装置のカートリッジを交換する方法
EP1996260B1 (fr) 2006-03-10 2015-09-23 Novo Nordisk A/S Dispositif d'injection ayant un système de transmission
AU2007228715B2 (en) * 2006-03-20 2011-11-17 Novo Nordisk A/S Electronic module for mechanical medication delivery devices
US8875700B2 (en) * 2006-03-21 2014-11-04 Shl Group Ab Dose information device
EP1923085A1 (fr) 2006-11-17 2008-05-21 Sanofi-Aventis Deutschland GmbH Mechanisme de dosage et transmission pour dispositif d'administration de médicament
WO2008116766A1 (fr) 2007-03-23 2008-10-02 Novo Nordisk A/S Dispositif d'injection comprenant un écrou de blocage
US20080249477A1 (en) * 2007-04-05 2008-10-09 West Pharmaceutical Services, Inc. Pen injector having a needle shield
DE102007018696A1 (de) 2007-04-18 2008-10-23 Sanofi-Aventis Deutschland Gmbh Injektionsvorrichtung zur Abgabe eines Medikaments
WO2009080775A1 (fr) 2007-12-20 2009-07-02 Novo Nordisk A/S Dispositif d'injection pour distribuer une dose fixe de médicament liquide
NZ588808A (en) 2008-05-02 2012-04-27 Sanofi Aventis Deutschland Medication delivery device including piston with two threaded sections
NZ592172A (en) 2008-10-13 2013-04-26 Sanofi Aventis Deutschland Syringe type drug delivery device which uses a spring washer
JP5661042B2 (ja) * 2008-11-07 2015-01-28 ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ 皮内薬剤注射用の注射ペン
US8992464B2 (en) * 2008-11-11 2015-03-31 Hygieia, Inc. Apparatus and system for diabetes management
CA2746153C (fr) 2008-12-09 2019-02-26 Becton, Dickinson And Company Systeme d'administration de medicament dote d'un multiplicateur de force a levier et engrenage pour systeme d'injection haute pression
CA2746160C (fr) 2008-12-09 2017-02-14 Becton, Dickinson And Company Mecanisme de pompage d'administration a plusieurs courses pour un dispositif d'administration du medicament pour des injections haute pression
EP2364372B1 (fr) 2008-12-09 2020-11-25 Becton, Dickinson and Company Système d'administration de médicament à valve ouverte et fermée pour des injections haute pression
US9408980B2 (en) 2008-12-09 2016-08-09 Becton, Dickinson And Company Dual-chambered drug delivery device for high pressure injections
US8366680B2 (en) 2008-12-12 2013-02-05 Sanofi-Aventis Deutschland Gmbh Resettable drive mechanism for a medication delivery device and medication delivery device
EP2196232A1 (fr) * 2008-12-12 2010-06-16 Sanofi-Aventis Deutschland GmbH Mécanisme de commande pour dispositif d'administration de médicaments et dispositif d'administration de médicaments
KR101630190B1 (ko) * 2008-12-16 2016-06-14 브라코 스위스 에스.에이. 조영제의 볼러스 투여를 위한 장치
JP5717649B2 (ja) 2008-12-29 2015-05-13 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 電動モータ駆動制御を備える医療注射デバイス
NZ595343A (en) * 2009-03-30 2013-05-31 Sanofi Aventis Deutschland A piston rod and a drug delivery device incorporating the piston rod, wherein the piston rod comprises at least two axially aligned guideposts configured to engage a drive member of the drug delivery device
AU2010233831B2 (en) 2009-03-31 2014-07-24 Sanofi-Aventis Deutschland Gmbh Drug delivery device
WO2010115819A1 (fr) 2009-03-31 2010-10-14 Sanofi-Aventis Deutschland Gmbh Agencement de montage et ensemble d'accouplement pour dispositif destiné à administrer un médicament
WO2010112565A1 (fr) 2009-03-31 2010-10-07 Sanofi-Aventis Deutschland Gmbh Bouton doseur pour dispositif d'administration de médicament et procédé de fabrication d'un bouton doseur
CA2756939A1 (fr) 2009-03-31 2010-10-14 Sanofi-Aventis Deutschland Gmbh Procede pour la fabrication d'un corps de dispositif d'administration de medicaments au moyen d'un adhesif et d'un corps de dispositif d'administration de medicaments
AU2010233834B2 (en) 2009-03-31 2014-11-06 Sanofi-Aventis Deutschland Gmbh Pen cap
MX2011011298A (es) 2009-04-30 2011-11-18 Sanofi Aventis Deutschland Conexion axialmente ajustable de vastago de piston a piston para mecanismo de impulso para un dispositivo de administracion de farmacos.
WO2010133676A1 (fr) 2009-05-20 2010-11-25 Sanofi-Aventis Deutschland Gmbh Système comprenant un dispositif de distribution de médicaments et une cartouche munie d'un bouchon, et méthode d'identification de la cartouche
US9950116B2 (en) 2009-06-01 2018-04-24 Sanofi-Aventis Deutschland Gmbh Dose setting mechanism for priming a drug delivery device
US9623187B2 (en) 2009-06-01 2017-04-18 Sanofi-Aventis Deutschland Gmbh Resettable drug delivery device
US10034982B2 (en) 2009-06-01 2018-07-31 Sanofi-Aventis Deutschland Gmbh Spindle for a drug delivery device
US8672896B2 (en) 2009-06-01 2014-03-18 Sanofi-Aventis Deutschland Gmbh Inner housing for a drug delivery device
US9199040B2 (en) * 2009-06-01 2015-12-01 Sanofi-Aventis Deutschland Gmbh Drug delivery device last dose lock-out mechanism
US8257319B2 (en) 2009-06-01 2012-09-04 Sanofi-Aventis Deutschland Gmbh Drug delivery device inner housing having helical spline
US8585656B2 (en) 2009-06-01 2013-11-19 Sanofi-Aventis Deutschland Gmbh Dose setting mechanism for priming a drug delivery device
AR076722A1 (es) 2009-06-02 2011-06-29 Sanofi Aventis Deutschland Conjunto para un dispositivo para l a entrega de farmacos y dispositivo para la entrega de farmacos
EP2266647A1 (fr) 2009-06-25 2010-12-29 Sanofi-Aventis Deutschland GmbH Mécanisme d'entraînement pour dispositif d'administration de médicament
US10174751B2 (en) 2009-07-14 2019-01-08 Sanofi-Aventis Deutschland Gmbh Pump chamber for a peristaltic pump
US10232122B2 (en) 2009-09-07 2019-03-19 Sanofi-Aventis Deutschland Gmbh Drive mechanism for drug delivery device
EP2292286A1 (fr) 2009-09-07 2011-03-09 Sanofi-Aventis Deutschland GmbH Mécanisme de commande pour dispositif d'administration de médicaments et dispositif d'administration de médicaments
WO2011036134A2 (fr) 2009-09-23 2011-03-31 Sanofi-Aventis Deutschland Gmbh Ensemble et indicateur pour un dispositif de distribution de médicaments
CA2773928A1 (fr) 2009-09-30 2011-04-07 Sanofi-Aventis Deutschland Gmbh Dispositif d'injection
WO2011039206A2 (fr) 2009-09-30 2011-04-07 Sanofi-Aventis Deutschland Gmbh Dispositif de délivrance de médicament réinitialisable
CN102695531B (zh) 2009-11-03 2014-10-15 赛诺菲-安万特德国有限公司 用于输药装置的组件和输药装置
EP2335755A1 (fr) 2009-12-17 2011-06-22 Sanofi-Aventis Deutschland GmbH Dispositif et procédé pour la fourniture de deux ou plusieurs agents de médicament
WO2011067267A1 (fr) * 2009-12-02 2011-06-09 Sanofi-Aventis Deutschland Gmbh Mécanisme d'affichage de dose pour dispositif d'administration de médicaments
JP6002041B2 (ja) 2010-01-22 2016-10-05 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 薬物送達デバイスと一緒に使用するためのカートリッジホルダ
EP3421028A3 (fr) 2010-01-22 2019-04-10 Sanofi-Aventis Deutschland GmbH Réservoir de médicaments démontable codé
CA2783941A1 (fr) 2010-01-22 2011-07-28 Sanofi-Aventis Deutschland Gmbh Procede et systeme de determination d'informations relatives a un reservoir de medicament
TW201138882A (en) 2010-01-25 2011-11-16 Sanofi Aventis Deutschland Drive assembly for a drug delivery device and drug delivery device
US10207056B2 (en) 2010-03-31 2019-02-19 Sanofi-Aventis Deutschland Gmbh Set of members for a drug delivery device, drug delivery device and set of drug delivery devices
EP2577646B1 (fr) 2010-06-02 2016-09-28 Sanofi-Aventis Deutschland GmbH Cartouche d'entraînement pour un dispositif d'adminstration de médicaments
DE202011110769U1 (de) 2010-06-11 2016-04-07 Sanofi-Aventis Deutschland Gmbh Antriebsanordnung, Antriebskomponente und Arzneimittelabgabevorrichtung
JP5897007B2 (ja) 2010-08-06 2016-03-30 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング カートリッジホルダ及び薬物送達デバイス用のカートリッジユニットを組立てる方法
WO2012020087A1 (fr) 2010-08-13 2012-02-16 Sanofi-Aventis Deutschland Gmbh Système de codage pour un dispositif d'administration de médicaments et système d'administration de médicaments
CN103153368B (zh) 2010-08-13 2016-04-20 赛诺菲-安万特德国有限公司 用于防止选择剂量的机构
WO2012025590A2 (fr) 2010-08-26 2012-03-01 Sanofi-Aventis Deutschland Gmbh Procédé et système pour déterminer des informations concernant un réservoir de médicament
EP2438949A1 (fr) 2010-10-06 2012-04-11 Sanofi-Aventis Deutschland GmbH Mécanisme de commande pour dispositif d'administration de médicaments et dispositif d'administration de médicaments
EP2627376B1 (fr) 2010-10-13 2019-11-20 Sanofi-Aventis Deutschland GmbH Mécanisme de réglage de dose et procédé de réglage d'une dose
JP5946460B2 (ja) 2010-10-13 2016-07-06 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 薬物送達デバイス用の用量設定機構
US8657160B2 (en) * 2010-10-18 2014-02-25 Better Science, Llc Pump bottle adapter
US9950113B2 (en) 2010-11-03 2018-04-24 Sanofi-Aventis Deutschland Gmbh Needle assembly for the delivery of at least two medicaments
JP5955332B2 (ja) 2010-11-12 2016-07-20 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 薬剤送達デバイスおよび薬剤送達デバイスのための方法
WO2012072553A1 (fr) * 2010-11-29 2012-06-07 Sanofi-Aventis Deutschland Gmbh Dispositif d'administration de médicaments ayant un collier et un composant de liaison
WO2012072565A1 (fr) * 2010-11-29 2012-06-07 Sanofi-Aventis Deutschland Gmbh Dispositif de distribution de médicament ayant un collier un composant de liaison
US9248239B2 (en) * 2010-11-29 2016-02-02 Sanofi-Aventis Deutschland Gmbh Drug delivery device having linked dose dial components
WO2012085017A2 (fr) 2010-12-22 2012-06-28 Sanofi-Aventis Deutschland Gmbh Cartouche spécialisée
TR201902458T4 (tr) 2011-03-17 2019-03-21 Sanofi Aventis Deutschland Emniyet belirteçli kapak aracına sahip ilaç dağıtım cihazı.
US10446269B2 (en) 2011-03-24 2019-10-15 Sanofi-Aventis Deutschland Gmbh Device and method for detecting an actuation action performable with a medical device
JP6174568B2 (ja) 2011-04-28 2017-08-02 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 医療デバイス用の弁構成
EP2701777B1 (fr) 2011-04-28 2017-05-17 Sanofi-Aventis Deutschland GmbH Ensemble canal de fluide en forme de z
US10117994B2 (en) 2011-04-28 2018-11-06 Sanofi-Aventis Deutschland Gmbh Joining technology of a dispense interface
US9962500B2 (en) 2011-04-28 2018-05-08 Sanofi-Aventis Deutschland Gmbh Connection for medical device
DK2701785T3 (en) 2011-04-28 2015-05-26 Sanofi Aventis Deutschland Blocking element for rate interface
AR086257A1 (es) 2011-05-06 2013-11-27 Sanofi Aventis Deutschland Dispositivo de administracion de farmacos y soporte de cartucho para un dispositivo de administracion de farmacos
AR086255A1 (es) 2011-05-06 2013-11-27 Sanofi Aventis Deutschland Conjunto para un dispositivo de administracion de farmacos y dispositivo de administracion de farmacos
WO2012160156A2 (fr) 2011-05-25 2012-11-29 Sanofi-Aventis Deutschland Gmbh Dispositif d'administration de médicament et procédé de commande de ce dispositif
CN103717247B (zh) 2011-07-15 2016-04-27 赛诺菲-安万特德国有限公司 药物输送装置
CN106267472B (zh) 2011-07-15 2019-08-30 赛诺菲-安万特德国有限公司 带机电式驱动机构的药物递送装置
EP3400981B1 (fr) 2011-09-08 2019-12-25 Sanofi-Aventis Deutschland GmbH Procédé et dispositif de surveillance pour une opération de surveillance d'un dispositif d'administration de médicaments
CA2845249A1 (fr) 2011-09-21 2013-03-28 Sanofi-Aventis Deutschland Gmbh Pompe peristaltique
JP2014528041A (ja) 2011-09-21 2014-10-23 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 蠕動ポンプ
DK2763725T3 (en) 2011-10-06 2016-06-13 Sanofi Aventis Deutschland DISPLAY DEVICE FOR A PHARMACEUTICAL SUPPLY DEVICE
JP6351507B2 (ja) 2011-10-27 2018-07-04 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 薬物送達デバイスの構成要素および組立方法
EP2773397B1 (fr) 2011-11-02 2022-02-23 Sanofi-Aventis Deutschland GmbH Piston pour cartouche à utiliser dans un dispositif d'administration de médicaments
MX366271B (es) 2011-11-07 2019-07-04 Safety Syringes Inc Guarda de aguja para liberacion de activador de contacto.
AU2012338829A1 (en) 2011-11-18 2014-05-22 Sanofi-Aventis Deutschland Gmbh Battery disconnection circuit
EP2780059B1 (fr) 2011-11-18 2020-06-10 Sanofi-Aventis Deutschland GmbH Dispositif médical et procédé pour limiter l'utilisation du dispositif médical
CN107029319B (zh) 2011-11-22 2020-12-11 赛诺菲-安万特德国有限公司 具有控制器的笔型药物注射装置和其驱动的时间锁定机构
US10105490B2 (en) 2011-11-29 2018-10-23 Sanofi-Aventis Deutschland Gmbh Welded housing components of a drug delivery device
US10213556B2 (en) 2011-12-08 2019-02-26 Unl Holdings Llc Accurate dose control mechanisms and drug delivery syringes
US9813003B2 (en) 2011-12-22 2017-11-07 Sanofi-Aventis Deutschland Gmbh Apparatus with a main control unit, a control unit and an electromechanical device and a method for operating such an apparatus
TW201345578A (zh) 2012-01-31 2013-11-16 Sanofi Aventis Deutschland 施配組件之限制使用壽命
JP6340321B2 (ja) 2012-02-13 2018-06-06 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング ペン型注射デバイス、およびペン型注射デバイスのための電子クリップ式モジュール
EP3453416B1 (fr) 2012-02-13 2020-12-02 Sanofi-Aventis Deutschland GmbH Dispositif supplémentaire pour dispositif d'injection à fonctionnement manuel
EP2814542B1 (fr) 2012-02-13 2020-12-30 Sanofi-Aventis Deutschland GmbH Dispositif supplementaire pour fixation sur un dispositif d'injection
DK2830682T3 (en) 2012-03-28 2017-02-13 Sanofi Aventis Deutschland HOUSE FOR A PHARMACEUTICAL SUPPLY DEVICE
BR112014024651B1 (pt) 2012-04-05 2021-09-21 Sanofi-Aventis Deutschland Gmbh Injetor tipo caneta
DK2833947T3 (en) 2012-04-05 2018-06-06 Sanofi Aventis Deutschland PEN-TYPE INJECTOR WITH WINDOW ELEMENT
KR102124661B1 (ko) 2012-04-11 2020-06-18 사노피-아벤티스 도이칠란트 게엠베하 카트리지 홀더 및 펜형 주사기
GB2501109B (en) * 2012-04-12 2014-04-23 Duckworth & Kent Ltd Actuator for device for delivery of ophthalmic lenses
DK2838591T3 (da) 2012-04-19 2023-02-06 Sanofi Aventis Deutschland Indretning til en lægemiddeladministrationsanordning og lægemiddeladministrationsanordning
DK2842225T3 (da) 2012-04-25 2022-05-30 Sanofi Aventis Deutschland Apparat omfattende en elektromekanisk anordning og en bevægelsesdetektor samt metode til betjening af apparatet
AU2013255890B2 (en) 2012-05-04 2017-06-22 Sanofi-Aventis Deutschland Gmbh Drug delivery device
JP2015516250A (ja) 2012-05-16 2015-06-11 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 投薬インターフェース
WO2013171312A1 (fr) 2012-05-16 2013-11-21 Sanofi-Aventis Deutschland Gmbh Interface de distribution
CN104349808A (zh) 2012-05-30 2015-02-11 赛诺菲-安万特德国有限公司 用于药物输送装置的活塞杆主体的轴承、活塞杆组合体和活塞杆主体
JP2015525582A (ja) 2012-06-27 2015-09-07 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング リニアアクタ配置
JP2015525627A (ja) 2012-07-13 2015-09-07 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 投薬インターフェースのための毛細管チャネル構造
WO2014020008A1 (fr) 2012-08-03 2014-02-06 Sanofi-Aventis Deutschland Gmbh Dispositif d'injection de médicament de type stylo et module complémentaire de surveillance électronique pour la surveillance et l'enregistrement du réglage de la dose et l'administration
DK2879739T3 (en) 2012-08-03 2017-08-21 Sanofi Aventis Deutschland PENTYPE PHARMACEUTICAL INJECTION DEVICE AND ELECTRONIC SUPPLEMENTARY MONITORING MODULE FOR MONITORING AND REGISTRATION OF DOSAGE SETTING AND ADMINISTRATION
CN104507520B (zh) 2012-08-08 2018-04-13 赛诺菲-安万特德国有限公司 具有防盗拆封闭件的药物输送装置
CN104540535A (zh) 2012-08-20 2015-04-22 赛诺菲-安万特德国有限公司 电检测活塞杆与药筒筒塞之间的接触的方法和药物输送装置
EP2885036B1 (fr) 2012-08-20 2022-05-11 Sanofi-Aventis Deutschland GmbH Capuchon pour dispositif d'administration de medicaments et dispositif d'administration de medicaments
MX2015002635A (es) 2012-08-31 2015-06-24 Sanofi Aventis Deutschland Dispositivo de administracion de farmacos.
AR092276A1 (es) 2012-08-31 2015-04-08 Sanofi Aventis Deutschland Dispositivo de administracion de farmacos
EP2892590B1 (fr) * 2012-09-05 2018-01-10 E3D Agricultural Cooperative Association Ltd. Dispositif d'auto-injection électronique
CN104640587B (zh) * 2012-09-11 2017-11-21 赛诺菲-安万特德国有限公司 用于药物输送装置的驱动机构和药物输送装置
JP6295259B2 (ja) 2012-10-10 2018-03-14 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング ロッキング機構を備えたリザーバアセンブリを有する、注射デバイスに取り付け可能なニードルアセンブリ
JP2015536164A (ja) 2012-10-23 2015-12-21 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 薬物送達デバイスで使用されるカウンタシステム
US9675788B2 (en) 2012-10-26 2017-06-13 Golf Rite Products, LLC Handheld topical applicator
US9327545B2 (en) 2012-10-26 2016-05-03 Golf Rite Products, LLC Handheld precise liquid marker
DK2911723T3 (en) 2012-10-29 2018-02-26 Sanofi Aventis Deutschland PHARMACEUTICAL ADMINISTRATION DEVICE WITH PHARMACEUTICAL CONTAINER INCLUDING A SENSOR AND OPTICAL DATA TRANSMISSION SYSTEM
WO2014093107A1 (fr) * 2012-12-10 2014-06-19 Merck Sharp & Dohme Corp. Injecteur de médicament avec alerte de niveau bas
WO2014111335A1 (fr) 2013-01-15 2014-07-24 Sanofi-Aventis Deutschland Gmbh Dispositif d'injection de médicament de type stylo à mécanisme codeur de dose à réduction de frottement
US10888662B2 (en) 2013-01-15 2021-01-12 Sanofi-Aventis Deutschland Gmbh Apparatus for recording information concerning the use of an injection device
DK3308815T3 (da) 2013-01-15 2021-01-18 Sanofi Aventis Deutschland Pentype lægemiddelinjektionsanordning med absolut vinkeldosisindkodermekanisme
JP6316313B2 (ja) 2013-01-15 2018-04-25 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 用量エンコーダ機構（ｄｏｓｅｅｎｃｏｄｅｒｍｅｃｈａｎｉｓｍ）および用量設定／用量送達モードスイッチを有するペン型薬物注射デバイス
WO2014111338A1 (fr) 2013-01-15 2014-07-24 Sanofi-Aventis Deutschland Gmbh Dispositif d'injection de médicament de type stylo avec un mécanisme de codeur de dose à faible friction sur filetage
WO2014114574A1 (fr) 2013-01-22 2014-07-31 Sanofi-Aventis Deutschland Gmbh Ensemble d'accès avec élément d'étanchéité perforable
DK2950850T3 (en) 2013-01-29 2017-02-06 Sanofi Aventis Deutschland DEVICE FOR DETERMINING A POSITION OF A STAMP
CN110404140B (zh) 2013-01-29 2022-09-30 赛诺菲-安万特德国有限公司 电子模块和药物输送装置
JP2016504128A (ja) 2013-01-29 2016-02-12 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 薬物送達デバイス
US10173005B2 (en) 2013-01-29 2019-01-08 Sanofi-Aventis Deutschland Gmbh Drug delivery device
CN104936637B (zh) 2013-01-29 2018-04-03 赛诺菲-安万特德国有限公司 药物输送装置
WO2014122206A1 (fr) 2013-02-08 2014-08-14 Sanofi-Aventis Deutschland Gmbh Dispositif de distribution de médicament avec protection d'aiguille
TWI644693B (zh) 2013-03-11 2018-12-21 德商賽諾菲阿凡提斯德意志有限公司 藥物輸送裝置之組件
TWI653069B (zh) 2013-03-11 2019-03-11 德商賽諾菲阿凡提斯德意志有限公司 活塞桿以及包含活塞桿的藥物輸送裝置
TW201507749A (zh) 2013-03-11 2015-03-01 Sanofi Aventis Deutschland 用於藥物輸送裝置之組件
CN105142700B (zh) 2013-03-13 2019-03-08 赛诺菲-安万特德国有限公司 用于药物输送装置的组件和具有这种组件的药物输送装置
CN105228677B (zh) 2013-03-13 2020-02-11 赛诺菲-安万特德国有限公司 用于药物输送装置的包括反馈特征部的组件
US10406293B2 (en) 2013-03-13 2019-09-10 Sanofi-Aventis Deutschland Gmbh Assembly for a drug delivery device comprising a feedback feature
DK2968785T3 (da) 2013-03-13 2021-03-29 Sanofi Aventis Deutschland Lægemiddeladministrationsanordning og fremgangsmåde til eliminering af en frigang af stempelstangen til lægemiddeladministrationsanordninger
WO2014139921A1 (fr) 2013-03-13 2014-09-18 Sanofi-Aventis Deutschland Gmbh Poignée additionnelle et manchon d'actionnement pour un dispositif d'injection de médicaments du type stylo
CN105188808B (zh) 2013-03-13 2019-01-25 赛诺菲-安万特德国有限公司 具有用于清晰识别剂量值的特定光学窗口元件的药物注射装置
US10376645B2 (en) 2013-03-13 2019-08-13 Sanofi-Aventis Deutschland Gmbh Drive mechanism for a drug delivery device
CN105102028B (zh) 2013-04-10 2019-02-01 赛诺菲 用于药物输送装置的驱动组件
US10473511B2 (en) 2013-04-22 2019-11-12 Sanofi-Aventis Deutschland Gmbh Sensor device for attachment to a drug delivery device
MX2015014569A (es) 2013-04-22 2016-06-23 Sanofi Aventis Deutschland Dispositivo suplementario para la conexion a un dispositivo de inyeccion.
EP3366339B1 (fr) 2013-05-07 2020-03-04 Sanofi-Aventis Deutschland GmbH Un dispositif d'injection
DK3593843T3 (da) 2013-05-07 2023-12-18 Sanofi Aventis Deutschland Hjælpeanordning med mekanisk dosisomskifter
US10149946B2 (en) 2013-05-16 2018-12-11 Sanofi-Aventis Deutschland Gmbh Assembly for a drug delivery device and drug delivery device
JP6602290B2 (ja) 2013-05-16 2019-11-06 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 薬物送達デバイス用の機構
WO2014191190A1 (fr) 2013-05-27 2014-12-04 Sanofi-Aventis Deutschland Gmbh Ensemble d'entraînement pour dispositif d'administration de médicament et dispositif d'administration de médicament
CN105246531B (zh) 2013-05-27 2019-10-25 赛诺菲-安万特德国有限公司 用于药物输送装置的组件和药物输送装置
USRE46814E1 (en) 2013-07-16 2018-05-01 Sanofi-Aventis Deutschland Gmbh Medication delivery device
WO2015024872A1 (fr) 2013-08-22 2015-02-26 Sanofi-Aventis Deutschland Gmbh Ensemble pour un dispositif d'administration de médicament et utilisation d'un élément d'atténuation
JP6434026B2 (ja) 2013-08-29 2018-12-05 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 薬物送達デバイス用のキャップ
MX2016002588A (es) 2013-08-29 2016-06-14 Sanofi Aventis Deutschland Cuerpo y capuchon para un dispositivo de inyeccion hecho de un elemento externo de metal y un elemento interno de plastico.
HUE055023T2 (hu) 2013-08-29 2021-10-28 Sanofi Aventis Deutschland Kupakegység gyógyszerbejuttató eszközhöz, továbbá gyógyszerbejuttató eszköz
WO2015032772A1 (fr) 2013-09-03 2015-03-12 Sanofi Mécanisme pour un dispositif d'administration de médicament, et dispositif d'administration de médicament comprenant le mécanisme
DK3041538T3 (da) 2013-09-03 2020-08-24 Sanofi Sa Drivmekanisme og injektionsanornding dermed
HUE052236T2 (hu) 2013-09-23 2021-04-28 Sanofi Aventis Deutschland Szerelvény gyógyszerbejuttató eszközhöz, valamint gyógyszerbejuttató eszköz
US10478565B2 (en) 2013-11-15 2019-11-19 Sanofi-Aventis Deutschland Gmbh Assembly for a drug delivery device and drug delivery device
US10525204B2 (en) * 2013-11-22 2020-01-07 Sanofi-Aventis Deutschland Gmbh Drug delivery device
EP3071265B1 (fr) 2013-11-22 2023-04-26 Sanofi-Aventis Deutschland GmbH Dispositif d'administration de médicament assisté par ressort
DK3071268T3 (da) 2013-11-22 2019-06-24 Sanofi Aventis Deutschland Indretning til en lægemiddeladministrationsanordning
MX2016006673A (es) 2013-11-22 2016-09-06 Sanofi Aventis Deutschland Dispositivo de administracion de farmacos asistido por resorte.
DK3071264T3 (da) 2013-11-22 2023-11-06 Sanofi Aventis Deutschland Indretning til lægemiddeladministrationsanordning og lægemiddeladministrationsanordning, som omfatter en sådan indretning
EP3071270B1 (fr) 2013-11-22 2024-01-17 Sanofi-Aventis Deutschland GmbH Dispositif d'administration de médicament avec embrayage de bouton de dose
US9962494B2 (en) 2013-11-22 2018-05-08 Sanofi-Aventis Deutschland Gmbh Drug delivery device with end of dose feedback
JP6815198B2 (ja) 2013-11-22 2021-01-20 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 一方向カップリングを有する薬物送達デバイス
JP6566946B2 (ja) 2013-11-22 2019-08-28 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 偽造防止機能を有する薬物送達デバイス
US10159801B2 (en) 2013-12-20 2018-12-25 Sanofi-Aventis Deutschland Gmbh Assembly for a drug delivery device and drug delivery device
TWI709569B (zh) 2014-01-17 2020-11-11 美商健臻公司 無菌層析樹脂及其用於製造方法的用途
US10004845B2 (en) 2014-04-18 2018-06-26 Becton, Dickinson And Company Split piston metering pump
US9416775B2 (en) 2014-07-02 2016-08-16 Becton, Dickinson And Company Internal cam metering pump
AR102195A1 (es) 2014-10-09 2017-02-08 Sanofi Sa Alojamiento y dispositivo de administración de fármacos con el mismo
WO2016083347A1 (fr) * 2014-11-24 2016-06-02 Sanofi Dispositif d'affichage et dispositif d'administration de médicament associé
MA41101A (fr) 2014-12-03 2017-10-10 Lilly Co Eli Dispositif d'injection de médicament automatique comportant une indication audible de progression d'injection
EP3058970A1 (fr) 2015-02-19 2016-08-24 Sanofi-Aventis Deutschland GmbH Dispositif de collecte de données destiné à être fixé à un dispositif d'injection
TWI711472B (zh) 2015-03-23 2020-12-01 德商賽諾菲阿凡提斯德意志有限公司 注射裝置的殼體和殼體部件的互連
ES2805230T5 (es) 2015-06-09 2023-11-24 Sanofi Aventis Deutschland Aparato de recopilación de datos para su fijación a un dispositivo de inyección
WO2017102742A1 (fr) * 2015-12-14 2017-06-22 F. Hoffmann-La Roche Ag Dispositif d'administration médicale
JP6543775B2 (ja) 2016-03-25 2019-07-10 イーライ リリー アンド カンパニー 薬剤送達装置における設定及び送達された用量の判定
WO2017184401A1 (fr) 2016-04-19 2017-10-26 Eli Lilly And Company Détermination d'une dose dans un dispositif d'administration de médicament utilisant deux rangées mobiles avec des dents et un capteur
BR112018074108A2 (pt) * 2016-05-24 2019-03-06 Unl Holdings Llc seringas de administração de medicamentos e mecanismos de controle de dose exata
ES2841325T3 (es) 2016-08-12 2021-07-08 Lilly Co Eli Determinación de una dosis en un dispositivo de administración de medicamentos
ES2929301T3 (es) 2016-12-15 2022-11-28 Lilly Co Eli Dispositivo de administración de medicamentos con sistema de detección
WO2018146589A2 (fr) 2017-02-13 2018-08-16 Tata Elxsi Limited Dispositif de distribution
AR112480A1 (es) 2017-08-24 2019-10-30 Novo Nordisk As Composiciones de glp-1 y sus usos
JP7292281B2 (ja) 2017-12-21 2023-06-16 サノフイ 非接触センサを有する薬物送達デバイス
US10689243B2 (en) * 2018-02-23 2020-06-23 Mark A. Scatterday Metered dispensing device for plant extracts
EP3911383A1 (fr) 2019-01-18 2021-11-24 Sanofi Dispositif d'injection
US20210338946A1 (en) * 2020-04-30 2021-11-04 Migraine Solutions, LLC Device for Dispensing Medication for Medical Treatment
AU2021208601A1 (en) 2020-02-18 2022-07-28 Novo Nordisk A/S Glp-1 compositions and uses thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK172984D0 (da) * 1984-03-30 1984-03-30 Novo Industri As Dispenser
DE3645245C2 (de) * 1986-11-14 1994-01-27 Haselmeier Wilhelm Fa Injektionsgerät
CH675078A5 (fr) * 1988-01-22 1990-08-31 Nosta Ag
DK166948B1 (da) * 1988-02-10 1993-08-09 Dcp Af 1988 As Doseringsenhed til dosering af et antal afmaalte maengder af en vaeske, saasom insulin, fra en glastubule
GB9007113D0 (en) * 1990-03-29 1990-05-30 Sams Bernard Dispensing device
DE4013769A1 (de) * 1990-04-28 1991-10-31 Adamaszek Franz Heinz Automatisches insulin-injektionsgeraet
US5279585A (en) * 1992-02-04 1994-01-18 Becton, Dickinson And Company Medication delivery pen having improved dose delivery features

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE41956E1 (en) * 1999-09-16 2010-11-23 Novo Nordisk A/S Dose setting limiter
US9022991B2 (en) 2000-06-16 2015-05-05 Novo Nordisk A/S Injection device
US9028454B2 (en) 2003-03-03 2015-05-12 Sanofi-Aventis Deutschland Gmbh Drive mechanisms suitable for use in drug delivery devices
US9205197B2 (en) 2003-03-03 2015-12-08 Sanofi-Aventis Deutschland Gmbh Drug delivery device dose setting mechanism
US9533105B2 (en) 2003-03-03 2017-01-03 Sanofi-Aventis Deutschland Gmbh Drive mechanisms suitable for use in drug delivery devices
US9561331B2 (en) 2003-03-03 2017-02-07 Sanofi-Aventis Deutschland Gmbh Drive mechanisms suitable for use in drug delivery devices
US8900204B2 (en) 2006-05-16 2014-12-02 Novo Nordisk A/S Gearing mechanism for an injection device
US9192727B2 (en) 2006-05-18 2015-11-24 Novo Nordisk A/S Injection device with mode locking means
US9265893B2 (en) 2007-02-05 2016-02-23 Novo Nordisk A/S Injection button
US9533106B2 (en) 2011-12-29 2017-01-03 Novo Nordisk A/S Torsion-spring based wind-up auto injector pen with dial-up/dial-down mechanism

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US5582598A (en) 1996-12-10
DE69526893D1 (de) 2002-07-11
DE69526893T2 (de) 2003-01-09
JP3745418B2 (ja) 2006-02-15
EP0702970A3 (fr) 1996-05-15
ES2177609T3 (es) 2002-12-16
EP0702970A2 (fr) 1996-03-27
CA2157243C (fr) 1999-05-11
CA2157243A1 (fr) 1996-03-20
JPH08103495A (ja) 1996-04-23

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