EP1536853A1 - Dispositif d'injection - Google Patents

Dispositif d'injection

Info

Publication number
EP1536853A1
EP1536853A1 EP03732261A EP03732261A EP1536853A1 EP 1536853 A1 EP1536853 A1 EP 1536853A1 EP 03732261 A EP03732261 A EP 03732261A EP 03732261 A EP03732261 A EP 03732261A EP 1536853 A1 EP1536853 A1 EP 1536853A1
Authority
EP
European Patent Office
Prior art keywords
dose setting
injection device
dose
injection
rotatable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP03732261A
Other languages
German (de)
English (en)
Inventor
Thomas Dedenroth Miller
Claus Schmidt M Ller
Steffen Hansen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Novo Nordisk AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS
Publication of EP1536853A1 publication Critical patent/EP1536853A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31525—Dosing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
    • A61M5/31585—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod performed by axially moving actuator, e.g. an injection button
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A61M2005/31518—Piston or piston-rod constructions, e.g. connection of piston with piston-rod designed to reduce the overall size of an injection device, e.g. using flexible or pivotally connected chain-like rod members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/581—Means for facilitating use, e.g. by people with impaired vision by audible feedback
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3146—Priming, e.g. purging, reducing backlash or clearance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
    • A61M5/31541—Means preventing setting of a dose beyond the amount remaining in the cartridge
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/31556—Accuracy improving means
    • A61M5/31558—Accuracy improving means using scaling up or down transmissions, e.g. gearbox
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3156—Mechanically operated dose setting member using volume steps only adjustable in discrete intervals, i.e. individually distinct intervals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31566—Means improving security or handling thereof
    • A61M5/31568—Means keeping track of the total dose administered, e.g. since the cartridge was inserted
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/3159—Dose expelling manners
    • A61M5/31593—Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir
    • A61M5/31595—Pre-defined multi-dose administration by repeated overcoming of means blocking the free advancing movement of piston rod, e.g. by tearing or de-blocking

Definitions

  • the invention relates to injection devices of the kind comprising a housing accommodating a cartridge, a dose setting and injection mechanism, a rotatable dose setting member coupled to the dose setting and injection mechanism, and an injection button coupled to the dose set- ing and injection mechanism and by which a piston rod drive can be activated for advancing the piston forward to press out a set dose through a conduit connected to the cartridge.
  • a prior art injection device of this kind is disclosed in WO 01/83008.
  • This injection device comprises of three basic parts; a dose setting and injection mechanism, a dose setting member and an injection button.
  • the dose setting and injection mechanism of this prior art injection device is best shown in figure 4 of WO 01/83008.
  • the coupling ring (29) is rotated by the arm (32).
  • the barb (40) rides over the barbs (41) of the driver (27) which produces a clicking and audible sound.
  • the bulging ends (43, 44) of the coupling ring (29) also makes an audible sound by riding over the barbs (45) on the inside surface of the rod guiding part (20).
  • the driver (27) and the guiding part (20) are both provided with the same number of barbs, such that the produced audible sounds amplify each other.
  • the barbs also work as incremental clicks indicating the number of set doses.
  • the number of barbs or clicks are set to equal the dose scale of the injection device, such that one barb or click is dedicated each single dose setting.
  • the number of barbs or clicks is 60 such that the scale, which scale indications correlate with the barbs or clicks, resembles the scale of an ordinary clock bearing 60 scale indications on one full circle. All though in same cases the full circle is not used and henceforth there are fewer scale indications.
  • This prior art injection device is to be used by diabetics needing regular injections of insulin.
  • the distance between each barb is therefore set to correlate with one international unit of insulin (1 IU). In this way the user will feel and hear one incremental click for each interna- tional unit being set.
  • Insulin is typically made with 100 international units (IU) pr. millilitre of insulin.
  • This prior art injection device has proven itself very attractive to people suffering from diabetes. Due to the number of barbs, the prior art injection device is only suitable for one particular type of fluid medicament, since the tactile guidance is incorporated in the distance between the barbs and in the number of barbs. The prior art injection device is particular suit- able for a fluid medication which are injected in a dose regimen requiring fine adjustment of the dose setting.
  • the present invention aims to solve the problem of handling different types of medicaments being injected in different dose volumes or in different concentrations by providing the injection device with additional clicking means provided between the rotatable dose setting member and a non-rotatable clicker element, which clicking mechanism provides clicks that corre- sponds to a new dose volume, as defined in claim 1.
  • the general concept of the present invention is to provide an additional clicking mechanism which overrides the general clicking mechanism of the injection device. This has the advantages that the tactile and audible feedback of the injection device can be easily changed with out changing the underlying injection mechanism.
  • An injection device for insulin is usually provided with a tactile and audible feedback that correlates to international units of insulin, such that the user is provided with one click for each international unit being set.
  • the injection device can now be utilized for a number of different fluid medicaments or concentrations of medicaments only by changing the dose setting member as long as the additional dose setting clicks provided from the interaction between the dose setting member and the non-rotatable clicker element is a multiplication of the underlying clicks provided by the dose setting and injection mechanism.
  • the same injection device with the same dose setting and injection mechanism can be utilized for a number of different fluid medicaments or concentrations of medicaments only by changing the dose setting member.
  • the clicking means comprises a curved track provided as a part of the rotatable dose setting member, which curved track engages a non-rotatable clicker element provided on or as a part of the injection device, it is ensured that the distance between the indentations making up the curve can be designed quit freely.
  • the clicker element is a protrusion provided either on the housing as specified in claim 4 or on the dose setting and injection member as specified in claim 5, a very clear and distinct tactile guidance is obtained.
  • the protrusion is carried on a flexible arm, it is ensured that the rotatable dose setting member can be easy rotated.
  • the spaced indentations specified in claim 7 define the size of the dosage. These indenta- tions should be a multiplication of the underlying smaller incremental clicks provided by the interaction between the barbs on the coupling ring and the outer toothing on the driver.
  • the underlying incremental clicks represent international units of insulin it will be beneficial if a full circle represents 60 units. If the doses of medication to be injected by the new injec- tion device is e.g. five time higher, the number of indentations then needs to be 12 indentations on a full circle.
  • indentations It is however not necessary to provide the full number of indentations. With some medicaments there are a limit to the number of doses that can be injected at one time thus it is not necessary to provide more indentations than the maximum allowed number of doses. As specified in claim 8, the preferred range of indentations is from 5 to 60. 60 indentations are preferred when the injection device is to be used for U 100 insulin. In this case the additional clicking will follow and amplify the underlying injection mechanism.
  • one new dosage equals 10 international units of insulin a total of 6 indentations will be needed on a full circle.
  • Prior to injecting the fluid medicament it is customary to make a so called air shot in order to empty the ampoule for air trapped inside the ampoule.
  • An air shot is usually done by holding the device in a vertical upright position and deliver one unit. How- ever, if one indentation representing one new dose of medicament contains 10 international units a large amount of medicament will be wasted. It is therefore preferred as specified in claim 9 to provide an air shot indentation located between the first and the second ordinary indentation.
  • the size of the air shot defined by the location of the air shot indentation can be freely designed.
  • the rotatable dose setting member is provided with a scale where the indications correlate to the indentations, it is ensured that the user beside the tactile and the audible incremental feedback also is provided with a visual indication.
  • Figure 1 Shows an exploded view of the prior art injection device
  • Figure 2 Shows an exploded view of the dose setting and injection mechanism of the prior art injection device.
  • Figure 3 Shows a schematically top view of the dose setting and injection mechanism of the prior art injection device.
  • Figure 4 Shows a schematically bottom view of the dose setting and injection mechanism of the prior art injection device.
  • Figure 5 Shows an exploded view of the dose setting and injection mechanism according to the invention.
  • Figure 6 Shows a cross sectional view through the dose setting and injection mechanism according to the invention.
  • Figure 7 Shows the dose setting and injecting mechanism according to the invention with the dose setting button.
  • Figure 8 Shows the dose setting button according to an embodiment of the invention
  • Figure 1-4 shows the dose setting and injection mechanism 1 known from WO 01.83008.
  • the injection device 1 disclosed in figure 1 comprises a dose and injection mechanism 2 in- sertable into a housing 3. Also insertable into the housing 3 is the cartridge 4 containing the fluid medicament. A dose setting button 5 and an injection button 6 is connected to the dose and injection mechanism 2 inside the housing 3. The injection button 6 is provided with a toothed rack 7, which operates the dose and injection mechanism 2 to deliver a dose.
  • This prior art dose setting and injection mechanism 2 comprises a rod guiding part 8 in which a flexible piston rod 9 is guided.
  • the rod guiding part 8 has a slot 10 into which the toothed rack 7 of the injection button 6 is guided.
  • the flexible piston rod 9 is driven by a first gear wheel 11 , which again is driven by the hub-wheel 12 of the second gear wheel 13.
  • the sec- ond gear wheel 13 is made up from an outer toothed wheel 14 which is integral with the hub- wheel 12.
  • the outer toothed wheel 14 is driven by the toothed axis 15 on the driver 16.
  • This driver 16 has an outer tooting 17, which is located inside a coupling ring 18.
  • the coupling ring 18 is provided with a coupling ring wheel 19, which is driven by the toothed rack 7 of the injection button 6 when a dose is being injected.
  • the coupling ring wheel 19 is connected to coupling ring 18 through a rigid part 20 and a more flexible part 21.
  • the coupling ring 18 has on its inside surface one or more barbs 22, which interconnects with the outer tooting 17 of the driver 16, such that the driver 16 is driven by the coupling ring 18 in one direction, but not necessarily in the opposite direction.
  • a protrusion 23 provided on an inside surface of the rod guiding part 8 prevents the driver 16 from rotation in one direction.
  • the direction in which the driver 16 can move freely is the direction in which the piston rod 9 is moved forward in the cartridge 4.
  • An arm 24 is at the centre 25 connected to the central portion of the rod guiding part 8. On the other end, the arm 24 is equipped with a cam 26 interacting with a notch 27 provided at the rim of the coupling ring 18.
  • the arm 24 also has a depression 28, which is operational connected to the dose setting button 5, such that the arm 24 is rotated around the central portion of the rod guiding part 8 when the dose setting button 5 is rotated to set a dose.
  • a second arm 29 is situated parallel to the first arm 24 and is permanently connected thereto through a flexible beam.
  • the second arm 29 bears on its backside a not shown cam, which cam is movable locked in the spiral shaped track of the driver 16.
  • the number of rotations the driver 16 can perform relatively to the second arm 29 is limited to the length of the spiral shaped track.
  • the total length of this track is adapted to the total amount of medicine in the cartridge 4 thereby ensuring that a dose larger than the amount of medicine remaining in the cartridge 4 can not be set.
  • the dose is set by turning the dose setting button 5 in the clockwise direction.
  • the arm 24, which is operational connected to the dose setting button 5 rotates simultaneously.
  • the notch 26 on the arm 24 rotates the coupling ring 18 too. Since the coupling ring wheel 19 interacts with the toothed rack 7 of the injection button 6, this injection button 6 is lifted away from the housing 3. Due to the protrusion 23, the driver 16 is prevented from rotating.
  • the bulging ends 30, 31 rides over the toothed surface 32 of the rod guiding part 8.
  • the injection device shown in figure 1-4 is to be used by diabetics needing regular injections of insulin. Therefore the distance between each of the indentations making up the toothed surface 32 corresponds to one international unit of insulin (1 IU). In this way the user can feel every increment being set when rotating the dose setting button 5. In addition an audible sound is produced when the bulging ends 30, 31 ride over the toothed surface 32. The incremental feeling and the incremental sound follows the number of indentations on the toothed surface 32.
  • the barb 22 on the coupling ring 18 rides over the outer toothing 17 of the driver 16 when a dose is set, which adds to the incremental feeling and to the incremental sound.
  • the injection button 6 When delivering the set dose, the injection button 6 is pressed home. The toothed rack 7 of the injection button 6 then rotates the coupling ring wheel 19. The barb 22 interacts with the outer toothing 17 of the driver 16 hence rotating the driver 16 in the anti-clockwise direction. The rotation of the driver 16 is transmitted through the second gear wheel 13 to the first gear wheel 11 , which first gear wheel 11 engages the piston rod 9. Rotation of the first gear wheel 11 causes the piston rod 9 to move forward inside the cartridge 4 thereby expelling the set dose of medicine through a not shown conduit connected to the distal end of the cartridge 4.
  • the dose setting member 5 is rotated in the anti clockwise direction. Due to the flexible part 21 of the coupling ring 18, the coupling ring 18 expands outwardly when rotated anti clockwise, allowing the barb 22 to slide over the outer toothing 17 of the driver 16. Hence the driver 16 is not affected by this backward rotation of the coupling ring 18.
  • Figure 5-6 discloses a dose setting and injecting mechanism 102 according to the invention.
  • the toothed rack 107 of the injection button 106 engages the coupling ring wheel 119 through a slot in the rod guiding part 108.
  • the coupling ring wheel 119 is integral with the coupling ring 118, which coupling ring 118 engages the driver 116. This engagement is made by one or more barb 122 located on the inside surface of the coupling ring 118 engaging the outer toothing 117 of the driver 116.
  • a protrusion 123 provided on an inside surface of the rod guiding part 108 prevents the driver 116 from rotation in one direction.
  • the direction in which the driver 116 can move freely is the direction in which the piston rod 109 is moved forward inside the cartridge 104.
  • the toothed axis 115 of the driver 116 engages the second gear wheel 113.
  • the second gear wheel 113 engages the first gear wheel 111 which transmits the rotational movement to the piston rod 109.
  • the inside surface 132 of the rod guiding part 108 is left as a smooth surface without any indentations.
  • the bulging ends 131 , 132 of the coupling ring 118 slides along this smooth inside surface 132 when a dose is set.
  • the incremental feedback delivered to the user from the dose setting and injection mechanism 102 of the injection device 1 is very gentle. Only a very silent clicking sound coming from the barbs 122 sliding over the outer toothing 117 of the driver 116 is heard when a dose is set.
  • the dose setting button 105 is on the surface pointing towards the rod guiding part 108 provided with a number of indentations 135.
  • the rod guiding part 108 is provided with a protru- sion 136, which interacts with the dose setting button 105 when the injection device 1 is assembled.
  • the protrusion 136 is located on a resilient arm 137 which is integral with the rod guiding part 108, but could as well be located on the housing.
  • the interaction between the indentations 135 of the dose setting button 105 and the protrusion 136 will provide the user with a tactile feedback containing both an incremental click feeling and an incremental click sound.
  • the incremental indentations 135 of the dose setting button 105 is preferably located on a circular curved track 138 provided adjacent the upper part 139 of the dose setting button 105.
  • the upper part 139 is also provided with a finger grip 140, by which the user can grip when setting up the dose to be injected.
  • the carrier 143 provided on the backside of the dose setting button 105 connects the dose setting button with the coupling ring 118 such that the coupling ring 118 rotates with the dose setting button 105.
  • the distance between the indentations 135 determines the size of the dose volume to be set. With the distance between the indentations 135 shown in figure 7 some rather large dose volumes are set.
  • the number of the indentations 135 should be a multiplication of the number of teeth provided on the outer toothing 117 of the driver 116. If the injection device e.g. is made with 60 teeth on the outer toothing 117, there should be 2, 3, 5, 6, 10, 12, 15, 20, 25, 30, or 60 indentations 135 such that the overriding dose setting clicks works with the underlying dose setting mechanism on the full circle.
  • the distance between the indentations 142 of the dose setting button 105, is in figure 8 shown as a short distance corresponding to a small dose volume.
  • the specific dose setting button 105 shown in figure 8 has 60 indentations 142 on one full circle, such that the scale can be made to resemble that of an ordinary egg timer such as shown in US 5.947.934.

Abstract

L'invention concerne un dispositif d'injection comprenant un mécanisme de cliquage incrémental fournissant à l'utilisateur une indication sur le nombre de doses administrées. Pour gérer différents types de médicaments ayant des doses de différents volumes dans le même type de dispositif d'injection, il est avantageux de prévoir un moyen de cliquage supplémentaire, aisé à remplacer. Des doses de différents volumes peuvent ainsi être administrées par des dispositifs d'injection du même type, simplement par utilisation de différents moyens de cliquage. Le moyen de cliquage est de préférence une courbe prévue entre l'élément de dosage et un élément de cliquage non rotatif.
EP03732261A 2002-07-10 2003-06-25 Dispositif d'injection Withdrawn EP1536853A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200201084 2002-07-10
DK200201084 2002-07-10
PCT/DK2003/000435 WO2004007002A1 (fr) 2002-07-10 2003-06-25 Dispositif d'injection

Publications (1)

Publication Number Publication Date
EP1536853A1 true EP1536853A1 (fr) 2005-06-08

Family

ID=30011011

Family Applications (1)

Application Number Title Priority Date Filing Date
EP03732261A Withdrawn EP1536853A1 (fr) 2002-07-10 2003-06-25 Dispositif d'injection

Country Status (4)

Country Link
EP (1) EP1536853A1 (fr)
JP (1) JP2005532128A (fr)
AU (1) AU2003239784A1 (fr)
WO (1) WO2004007002A1 (fr)

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Publication number Priority date Publication date Assignee Title
US6663602B2 (en) 2000-06-16 2003-12-16 Novo Nordisk A/S Injection device
DE602005016952D1 (de) 2004-10-21 2009-11-12 Novo Nordisk As Wählmechanismus für einen drehstift
BRPI0607012A2 (pt) 2005-01-25 2009-12-01 Novo Nordisk As dispositivo de injeção
US20090043264A1 (en) 2005-04-24 2009-02-12 Novo Nordisk A/S Injection Device
US8298194B2 (en) 2006-03-10 2012-10-30 Novo Nordisk A/S Injection device and a method of changing a cartridge in the device
EP1996260B1 (fr) 2006-03-10 2015-09-23 Novo Nordisk A/S Dispositif d'injection ayant un système de transmission
ATE458517T1 (de) 2006-05-16 2010-03-15 Novo Nordisk As Getriebemechanismus für ein injektionsgerät
BRPI0712028A2 (pt) 2006-05-18 2011-12-20 Novo Nordisk As dispositivo de injenção com um meio de travamento de modo
AR076716A1 (es) 2009-06-02 2011-06-29 Sanofi Aventis Deutschland Modulo medicado con medicamento de premezcla
CN102946931B (zh) * 2010-04-26 2015-09-16 Shl集团有限责任公司 药物供给装置
EP2797650A2 (fr) 2011-12-29 2014-11-05 Novo Nordisk A/S Auto-injecteur avec mécanisme de dosage tournant en avant et an arrière avec ressort de torsion
KR101524678B1 (ko) * 2014-04-29 2015-06-03 최규동 길이단축형 주사기 구동장치
JP6734862B2 (ja) 2014-12-08 2020-08-05 サノフイＳａｎｏｆｉ 駆動機構およびそれを有する薬物送達デバイス
US11058823B2 (en) 2014-12-08 2021-07-13 Sanofi Clicker arrangement and drug delivery device herewith

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5582598A (en) * 1994-09-19 1996-12-10 Becton Dickinson And Company Medication delivery pen with variable increment dose scale
US5947934A (en) * 1996-09-13 1999-09-07 Novo Nordisk A/S Dose display for an injection syringe
AU2001226650A1 (en) * 2000-01-28 2001-08-07 Novo-Nordisk A/S A dose setting limiter
AU2001252111A1 (en) * 2000-05-04 2001-11-12 Novo-Nordisk A/S An injection device, a preassembled dose setting and injection mechanism for an injection device, and a method of assembling an injection device

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO2004007002A1 *

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AU2003239784A1 (en) 2004-02-02
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