EP0122519A2 - Procédé et dispositifs pour pointiller des dispositifs de moulage avec des gouttes de lubrifiant liquide ou en suspension lors de la fabrication d'objets moulés dans le domaine pharmaceutique, alimentaire ou catalytique - Google Patents

Procédé et dispositifs pour pointiller des dispositifs de moulage avec des gouttes de lubrifiant liquide ou en suspension lors de la fabrication d'objets moulés dans le domaine pharmaceutique, alimentaire ou catalytique Download PDF

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Publication number
EP0122519A2
EP0122519A2 EP84103408A EP84103408A EP0122519A2 EP 0122519 A2 EP0122519 A2 EP 0122519A2 EP 84103408 A EP84103408 A EP 84103408A EP 84103408 A EP84103408 A EP 84103408A EP 0122519 A2 EP0122519 A2 EP 0122519A2
Authority
EP
European Patent Office
Prior art keywords
lubricant
liquid
nozzles
gas
shoe
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP84103408A
Other languages
German (de)
English (en)
Other versions
EP0122519B1 (fr
EP0122519A3 (en
Inventor
Gunther M. Voss
Volker Ingo Dr. Dipl.-Chem. Gläsel
Peter Dr. Dipl.-Chem. Gruber
Walter Dr. Dipl.-Chem. Bubeck
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Priority to AT84103408T priority Critical patent/ATE34338T1/de
Publication of EP0122519A2 publication Critical patent/EP0122519A2/fr
Publication of EP0122519A3 publication Critical patent/EP0122519A3/de
Application granted granted Critical
Publication of EP0122519B1 publication Critical patent/EP0122519B1/fr
Expired legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B30—PRESSES
    • B30B—PRESSES IN GENERAL
    • B30B15/00—Details of, or accessories for, presses; Auxiliary measures in connection with pressing
    • B30B15/0005—Details of, or accessories for, presses; Auxiliary measures in connection with pressing for briquetting presses
    • B30B15/0011—Details of, or accessories for, presses; Auxiliary measures in connection with pressing for briquetting presses lubricating means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
    • B05B7/02—Spray pistols; Apparatus for discharge
    • B05B7/08—Spray pistols; Apparatus for discharge with separate outlet orifices, e.g. to form parallel jets, i.e. the axis of the jets being parallel, to form intersecting jets, i.e. the axis of the jets converging but not necessarily intersecting at a point
    • B05B7/0884—Spray pistols; Apparatus for discharge with separate outlet orifices, e.g. to form parallel jets, i.e. the axis of the jets being parallel, to form intersecting jets, i.e. the axis of the jets converging but not necessarily intersecting at a point the outlet orifices for jets constituted by a liquid or a mixture containing a liquid being aligned
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S425/00—Plastic article or earthenware shaping or treating: apparatus
    • Y10S425/115—Lubricator

Definitions

  • the invention relates to an improved method and devices for spotting molds with droplets of liquid or suspended lubricants in the production of moldings in the pharmaceutical, food or catalyst sector.
  • US Pat. No. 4,323,530 describes a method for pressing granules into tablets, dragee cores and the like, in which a certain amount of lubricant is applied in liquid or suspended form to the stressed zones of the pressing tools by means of an intermittently operating nozzle system before each pressing operation becomes.
  • This type of lubrication means that no more lubricant, for example magnesium stearate, has to be added to the granules to be pressed; this leads, for example, to drugs with a significantly improved bioavailability of the active ingredient contained therein. in the the rest you get by with significantly reduced amounts of lubricant.
  • the application is accomplished by directed spraying of certain zones of the pressing tools with the liquid or suspended lubricant with the aid of preferably single-substance or two-substance nozzles.
  • these nozzles but especially when using two-substance nozzles, in which air and lubricant liquid escape at the same time, it has been shown that droplets are formed with a particle spectrum which is dependent on the width of the air supply; these nozzles tend to form an undesirable mist which can lead to contamination of the tablet press, in particular the press plate.
  • valve systems based on the electromagnetic or piezomechanical or piezoelectric effect which are in the range of 50 microseconds. up to 5 msec. work, preferably 1 to 2 msec., alternately defined amounts of liquid, dissolved or suspended lubricants and defined volumes of gases, eg air, are released via one or more capillary systems, which in turn are provided with nozzle openings.
  • the subsequent gas surge causes the droplets to detach perfectly at the "interchangeable single-substance nozzles" and accelerate the droplets on their trajectory in the direction of the zones of the press tools to be acted on.
  • the term "interchangeable single-component nozzles" was chosen because, in contrast to known single-component and dual-component nozzles, the two substances, liquid and gas, alternately leave the same nozzle opening in succession.
  • the gas surge also causes thorough nozzle cleaning; the nozzle opening is thus pulsed and continuously cleaned.
  • nozzles can be arranged in rows or over a large area on the surface and, if appropriate, also on the lower surface of a so-called spotting shoe.
  • the attachment of the nozzles on such a spotting shoe depends on the shape and size of the compacts; the spotting shoe itself is preferably attached directly in front of the filling shoe between the die plate and the upper punch, so that the applied lubricant droplets reach and lubricate the active surfaces of the pressing tools in the shortest possible way and in a directional manner.
  • liquid lubricants is also understood to mean lubricant melts.
  • Each capillary in the spotting shoe is connected to a valve system either alone or together with certain associated capillaries; the valve system releases a small but defined amount of lubricant and gas or air alternately with each actuation.
  • the valve system is actuated and the control program is triggered by a light barrier attached to the tableting press, by a bit transmitter or by a capacitive or inductive proximity switch via electrical or magnetic or mechanical (e.g. pneumatic) impulses that act on the valves.
  • the principle according to the present invention thus consists in the metering of a small but defined amount of a liquid lubricant into the capillary system of the spotting shoe and in the subsequent detachment of the lubricant drops from the nozzle opening and application of the detached lubricant drops to the zones of the pressing tools provided for this purpose by a later inflowing, volumetrically metered gas (eg air), said metered gas accelerates the drops in a pre-determinable amount at the same time, certain predeterminable by setting the p ulsieren.
  • the amount of gas or amount of air is measured in such a way that there is no uncontrolled bursting and thus nebulization of the drops.
  • the pulse time for metering in the lubricant liquid or suspension is preferably kept small compared to the pulse time for metering in the air. However, it is advisable to keep the pressure of the lubricant liquid or suspension lower than the pressure of the following air. It has proven to be advantageous to have the pulse for air metering set in at the moment the lubricant metering is ended.
  • nozzle outlet openings between 0.05 and 0.3 mm are used with a liquid pressure between 0.1 and 2 bar and a gas pressure between 0.5 and 8 bar, the pulse times for metering the liquid are then preferably between 1.0 and 2.5 msec., for the gas between 1.0 and 2.0 msec.
  • a quantity of lubricant of approximately 10 to 500 g / hour can then be dispensed through an exchangeable single-substance nozzle.
  • the lubricant is applied to the upper and lower punches e.g. 10 interchangeable single-substance nozzles are used, each delivering 0.5 to 25 mg of lubricant liquid to the upper and lower punches.
  • the lubricant liquid generally contains 5-50% lubricant, the rest is a solvent or suspending agent. In the case of lubricating oils or fat melts, the concentration is 100% lubricant. Depending on the concentration of the lubricant liquid, 0.025 to 25 mg, based on the tablet weight, of 0.001-1% lubricant liquid are thus dispensed per compact (19 mm diameter, 2.0 g weight). The preferred range is 0.1 to 2 mg (0.005% to 0.1%) of lubricant fluid.
  • the alkali or alkaline earth salts of these acids are used as lubricants stearate, potassium stearate, aluminum stearate, also mono-, di- and triglycerides and their mixtures of medium-chain to long-chain fatty acids, such as glycerol monostearate or glycerol monolaurate, are used.
  • Water or alcohols, such as ethanol, isopropyl alcohol or mixtures thereof, are very particularly suitable as solvents or suspending agents.
  • the viscosity of the lubricant solutions is preferably between 2 and 100 mPa xs (millipascal seconds), the surface tension between 20 and 40 mN / m (millinewtons per meter). With viscous lubricants, the viscosity can be drastically reduced by heating to 100 ° C. Of course, all of the values given above can be significantly exceeded or undershot, depending on the properties of the lubricants to be used.
  • the lubrication process consisting of lubricant and air metering, is triggered one or more times, with the spotting tools being spotted across the surface with the lubricant.
  • all the nozzles or only a certain part of the nozzles can be excited to dispense drops; in principle, each nozzle can also be controlled separately, if desired.
  • Particularly stressed zones of the pressing tools e.g. Zones for the formation of engravings in the compact can preferably be spotted with drops of lubricant; this happens through a higher alternating pulse sequence in the capillaries provided for this.
  • the dotting shoe can also be divided into two separate units, which are attached offset to one another in the press and dotted the upper punch and press chamber or lower punch separately.
  • the arrangement of the nozzles on the surfaces of the spotting shoe generally depends on the geometry of the zones of the pressing tools that are particularly stressed during the pressing process, the heavily stressed zones being spotted more with the lubricant than less stressed zones.
  • the control program, the nozzles, the capillary system as well as the physical nature of the lubricant liquid and the air supply must be coordinated with the speed of the tableting press.
  • the viscosity and surface tension of the lubricant liquid contribute to the stabilization of the droplet formation and to the easing or aggravation of the droplet detachment from the nozzle opening, but, what is a particular advantage of this method according to the invention, adjustments can be made over a very broad spectrum with regard to viscosity and surface tension, for example by varying the dosage and the cycle sequences of the liquid or air or by changes in the capillary system or in the nozzle openings.
  • the temperature can be up to 100 ° C.
  • the warm air ensures that e.g. When using lubricant solutions, the solvent of the droplets has already largely evaporated when they hit the tools. This prevents solvents from penetrating into the granules or into the tablet.
  • the air therefore not only has the task of supporting the metering and acceleration of the droplets, but can also have a drying function.
  • the lifting force of the compacts which is measured by means of strain gauges, is used as a regulator for the number of lubricant droplets in the unit of time (e.g. in the second). If the strain gauges under the compacts show an increase in the lifting force, the number of droplets per unit of time increases automatically. This happens because the determined and e.g. Digitized measured values via the electronic control influence the opening times of the lubricant valves within certain limits.
  • the method according to the invention also succeeds in adding a certain number of droplets of the same diameter to a specific surface of the pressing tool Very high speeds of the tablet press to apply (stamp revolutions up to 10 m / s).
  • the invention also relates to devices for spotting molds with droplets of liquid or suspended lubricants.
  • the devices consist of a dotting shoe with abutting 'capillaries single-fluid nozzles and applied to the other ends of the capillaries separate feed lines for the lubricant liquid or suspension and the gas.
  • High-speed valves to release defined amounts of liquid or gas are installed in the liquid and gas line.
  • the pressure in the supply system is regulated absolutely and relative to one another by pressure control valves. All valves are controlled, for example, by an electronic control device.
  • Figure Ia shows a cross section through a dotting shoe (5), consisting of a capillary (1) with a fork, which is formed by a compressed air supply line (2) and a lubricant supply line (3).
  • the capillary (1) has several nozzles (4) in a row, this row also being continued on the opposite side.
  • FIG. 1b shows a top view of the dotting shoe with a row of nozzle openings (4a).
  • the figure IIa shows a plan view of a round loading tikun g sschuh (5) with a in a number of attached in geometric distribution nozzle openings (4a) and the leads (2) and (3) for the lubricant solution or suspension and Air.
  • FIG. IIb shows a cross section through the same spotting shoe, the nozzles being indicated by (4).
  • the supply of the lubricant liquid or suspension and the air via the channels (2) or (3) is made up either through a non g, a capillary e foundedes to the individual nozzles and in each case to a row of nozzles on, so that it is possible , to point out lubricant and air from individual nozzles or from geometrically assigned nozzles independently of one another in an individual pulse sequence or the feeds (2) and (3) end in the capillary-like chamber (6), from which individual nozzles (4) according to one or Lead away on both sides at right angles or at a certain angle to the plane of symmetry of the spotting shoe.
  • FIG. III describes a cross section through a spotting shoe (5) that is specially adapted to the die and upper punch.
  • the capillaries, the supply lines of air and lubricant converging in a bifurcation are not shown.
  • the nozzles are shown, (7) the upper punch, (8) the lower punch and (9) the die.
  • the nozzles are arranged at different angles to each other and to the axis of the spotting shoe and thus enable particularly intensive lubrication of the active pressing surfaces of the upper punch and the die wall.
  • FIG. IV shows a cross section through a lubricant puncturing system according to the invention on a tableting machine.
  • a capillary in the dotting shoe (5) with the fork of the compressed air supply (2) and lubricant supply (3) and a row of nozzles (4).
  • the spotting shoe (5) is attached off-center to the axis of the lower punch (8) and upper punch (7); the die is marked with (9).
  • (10a) and (10b) are valves for releasing the compressed air from the compressed air tank (11) and for controlling the lubricant from the lubricant tank (12).
  • pressure valves for regulating the pressure of the two media air and lubricant liquid are called; these pressure valves allow an individual adjustment of the pressure of both the liquid and the air, but also the adjustment of these pressures to one another;
  • (14) is a proximity switch and (15) is an electronic control device for controlling the valves (l0a) and (lOb).
  • sorbitol compresses (diameter 15 mm) were produced by the method according to the invention with direct lubrication.
  • the output was 180,000 tablets / hour, about 900 g of a lubricant consisting of 4% stearic acid and 20% caprylic-capric acid triglyceride in ethanol were consumed per hour.
  • the tablets obtained in this way showed no negative changes in their surface properties compared to conventionally produced compressed products.
  • the taste was significantly better than that of the conventional sorbitol compresses produced by adding magnesium stearate.
  • a scanning electron micrograph of a tablet fracture surface showed that the absence of a lubricant means that the sorbitol crystals are completely sintered together. There is no longer any roughness on the tongue.
  • the desired hardness could be achieved with a pressure reduced by at least 30%.
  • acetylsalicylic acid milk sugar / starch compressions (diameter 12 mm) were produced by the method according to the invention with direct lubrication.
  • the output was 180,000 tablets / hour, about 100 g of a lubricant consisting of 4% stearic acid and 6% polyoxyethylene sorbitan monooleate in ethanol being consumed.
  • a lubricant consisting of 4% stearic acid and 6% polyoxyethylene sorbitan monooleate in ethanol being consumed.
  • the tablet has a 35% higher breaking strength with the same pressing force. Since the granules have not been mixed with a hydrophobic lubricant, the disintegrant can become fully active. The tablet disintegrates from 65 to 10 seconds.
  • sorbitol compresses (diameter 15 mm) were produced by the method according to the invention with direct lubrication.
  • Example 1 The statements made under Example 1 apply to the properties of the tablets.
  • Ascorbic acid, sodium bicarbonate, citric acid, dry flavor and sugar were individually sieved and then mixed together.
  • the lubricant liquid contained 2% polyethylene glycol 6000 and 3% of a glycerin-polyethylene glycol oxystearate (Cremophor RH40 (R) ) in ethanol, the liquid pressure was 1.5 bar, the pulse width 2.5 ms. Dosed out with air at 3.5 bar and a pulse width of 3 ms. The amount of lubricant per tablet was 0.4 mg.
  • a mixture of silicon dioxide, aluminum oxide hydrate and chromium oxide (Cr 2 0 3 ) with a particle size between 0.1 and 1 mm is mixed and compressed on a tablet press to form cylinders 8 mm in diameter and 5 mm in height.
  • the machine is equipped with a scoring shoe.
  • the lubricant liquid consists of thin liquid paraffin oil.
  • the pulse width of the metering valve is coupled with the measured values for the ejection force.
  • the ejection rail was provided with strain gauges so that the force for ejecting each tablet from the die can be measured. As the ejection force increases, the amount of lubricant liquid dispensed also increases. Normally you need 0.5 mg paraffin oil per tablet.
  • This catalyst tablet has a number of advantages over conventionally manufactured catalyst tablets. As there is no hydrophobic lubricant inside, the tablets become approx. 50% harder. This is of great importance because the filling of meter-high reactors and the temperature conditions during the process require the highest compressive strength, abrasion resistance and internal cohesion of the tablets.
  • the hardness of the new tablets is as g ut that can be dispensed with the usual addition of a binder such as calcium aluminate cement. This in turn increases the purity of the catalyst, which has a positive influence on the degree of utilization and the service life of the catalyst.

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  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Nozzles (AREA)
  • Forging (AREA)
  • Lubricants (AREA)
  • Adornments (AREA)
  • Treatments Of Macromolecular Shaped Articles (AREA)
  • Medicinal Preparation (AREA)
  • Formation And Processing Of Food Products (AREA)
  • Catalysts (AREA)
EP84103408A 1983-04-08 1984-03-28 Procédé et dispositifs pour pointiller des dispositifs de moulage avec des gouttes de lubrifiant liquide ou en suspension lors de la fabrication d'objets moulés dans le domaine pharmaceutique, alimentaire ou catalytique Expired EP0122519B1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT84103408T ATE34338T1 (de) 1983-04-08 1984-03-28 Verbessertes verfahren und vorrichtungen zum bepunkten von formwerkzeugen mit troepfchen fluessiger oder suspendierter schmiermittel bei der herstellung von formlingen im pharma-, lebensmittel- oder katalysatorbereich.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3312634 1983-04-08
DE19833312634 DE3312634A1 (de) 1983-04-08 1983-04-08 Verbessertes verfahren und vorrichtungen zum bepunkten von formwerkzeugen mit troepfchen fluessiger oder suspendierter schmiermittel bei der herstellung von formlingen in pharma-, lebensmittel- oder katalysatorenbereich

Publications (3)

Publication Number Publication Date
EP0122519A2 true EP0122519A2 (fr) 1984-10-24
EP0122519A3 EP0122519A3 (en) 1986-02-05
EP0122519B1 EP0122519B1 (fr) 1988-05-18

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Application Number Title Priority Date Filing Date
EP84103408A Expired EP0122519B1 (fr) 1983-04-08 1984-03-28 Procédé et dispositifs pour pointiller des dispositifs de moulage avec des gouttes de lubrifiant liquide ou en suspension lors de la fabrication d'objets moulés dans le domaine pharmaceutique, alimentaire ou catalytique

Country Status (10)

Country Link
US (2) US4707309A (fr)
EP (1) EP0122519B1 (fr)
JP (1) JPS59205970A (fr)
AT (1) ATE34338T1 (fr)
AU (1) AU579096B2 (fr)
BR (1) BR8401606A (fr)
CA (1) CA1245419A (fr)
DD (1) DD219729A5 (fr)
DE (2) DE3312634A1 (fr)
ES (1) ES531339A0 (fr)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0379912A2 (fr) * 1989-01-26 1990-08-01 Dr. Karl Thomae GmbH Procédé pour revêtir les outils de formage dans des machines de fabrication de tablettes
EP0590963A1 (fr) * 1992-10-02 1994-04-06 Eisai Co., Ltd. Procédé et dispositif pour la préparation d'un comprimé moulé et comprimé ainsi préparé
EP0650826A1 (fr) * 1993-11-01 1995-05-03 Kyowa Hakko Kogyo Co., Ltd. Machine de fabrication de tablettes à table tournante avec dispositif pulvérisateur lubrifiant
WO1995018595A1 (fr) * 1994-01-04 1995-07-13 Voss Gunter M Procede de production de comprimes
WO1995018596A1 (fr) * 1994-01-04 1995-07-13 Voss Gunter M Procede de production de comprimes
EP0676280A1 (fr) * 1994-04-08 1995-10-11 Wilhelm Fette GmbH Procédé et dispositif pour l'application d'agent de lubrification ou de décoffrage en forme de poudre sur les outils de pressage dans des machines de fabrication de comprimés
WO2004045841A1 (fr) * 2002-11-21 2004-06-03 Mitsubishi Materials Corporation Procede de formation d'un element compact a partir de poudre, et appareil de moulage a cet effet
KR100797425B1 (ko) * 2003-08-08 2008-01-23 로디아 폴리아미드 인터미디에이츠 폴리우레탄 발포물, 이의 제조 방법 및 이의 용도
US8153053B2 (en) 2002-11-21 2012-04-10 Diamet Corporation Method for forming compact from powder and sintered product

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GB8530365D0 (en) * 1985-12-10 1986-01-22 Univ Bath Manufacture of moulded products
JPS6475218A (en) * 1987-09-18 1989-03-20 Sanri Kk Injection method of air flow to mold and its device in injection molding machine
JPH01320121A (ja) * 1988-06-22 1989-12-26 Sankyo Eng Kk 射出成形用無給油金型
US5356577A (en) * 1988-04-02 1994-10-18 Dr. Karl Thomae Gmbh Controlled release of metered quantities of finely divided solids with a venturi nozzle and regulated control
DE3811260A1 (de) * 1988-04-02 1989-10-26 Thomae Gmbh Dr K Gezielte abgabe dosierter mengen von feinverteilten feststoffen mit venturi-duese und geregelter ansteuerung
JPH0616958B2 (ja) * 1988-11-25 1994-03-09 橋本フォーミング工業株式会社 ワーク加工装置
US5056623A (en) * 1988-12-14 1991-10-15 Dr. Karl Thomae Gmbh Process for the controlled release of metered quantities of lubricant when coating pressing tools with lubricating liquids and suspensions and apparatus for carrying out the process
FR2650014B1 (fr) * 1989-07-20 1995-03-17 Wanner Isofi Isolation Rambarde de securite
DE4103413C1 (fr) * 1991-02-05 1992-11-12 Gunter M. 8918 Diessen De Voss
IT1282267B1 (it) * 1995-03-14 1998-03-16 Montecatini Tecnologie Srl Catalizzatori e supporti per catalizzatori ottenuti per pastigliatura
DK171731B1 (da) * 1995-11-30 1997-04-21 Georg Fischer Disa As Formpressemaskine med væsketågeindsprøjtning via spraydåse
IT1283207B1 (it) * 1996-03-08 1998-04-16 Montecatini Tecnologie Srl Catalizzatori per la deidrogenazione di etilbenzene a stirene
US6620358B2 (en) 1996-07-03 2003-09-16 Gunter Voss Process for manufacturing tablets
DE19647089A1 (de) * 1996-11-14 1998-05-28 Bayer Ag Vorrichtung zum kontrollierten Aufsprühen von pulverförmigen Schmiermitteln auf Stempel und Matrizen von Tablettenpressen
US6406284B1 (en) * 1996-11-19 2002-06-18 Aew Engineering Co. Limited Food portion forming
JPH11169437A (ja) 1997-12-03 1999-06-29 Kyowa Hakko Kogyo Co Ltd 錠剤の製造方法
WO2000063006A1 (fr) * 1999-04-19 2000-10-26 Kikusui Seisakusyo Ltd. Machine de moulage par compression de poudre, du type rotatif
US20030194434A1 (en) * 2000-01-17 2003-10-16 Yasushi Watanabe Bubbling tablet, bubbling bath additive tablet, bubbling washing detergent tablet, bubbling tablet for oral administration, and process for producing these
AU2001246904A1 (en) 2000-04-12 2001-10-23 Kyowa Hakko Kogyo Co. Ltd. Coating device for powder material
US6390116B1 (en) * 2001-07-16 2002-05-21 Illinois Institute Of Technology Large amplitude pneumatic oscillator
JP4582497B2 (ja) * 2004-02-27 2010-11-17 株式会社ダイヤメット 粉末成形体の成形方法
KR20070057977A (ko) * 2004-09-24 2007-06-07 바이오프로그레스 테크놀로지 리미티드 분말 압착 및 피복에 있어서의 추가 개량
EP1944002A3 (fr) * 2004-09-24 2008-07-23 BioProgress Technology Limited Améliorations supplémentaires dans le compactage et l'enrobage de poudre
EP1863460B1 (fr) 2005-03-22 2013-01-16 Losan Pharma GmbH Ibuprofen solubilisé
JP5183984B2 (ja) * 2007-06-28 2013-04-17 花王株式会社 浴用剤
DE102007031263A1 (de) * 2007-07-05 2009-01-08 Acheson Industries Deutschland Zweigniederlassung Der Findag Corp. N.V. (Curacao) Sprühwerkzeug
JP5149614B2 (ja) * 2007-12-28 2013-02-20 花王株式会社 浴用剤
EP2641593A3 (fr) * 2008-02-28 2013-11-20 AbbVie Inc. Tablettes
EP2226547B1 (fr) * 2009-03-04 2013-01-09 Delimon GmbH Dispositif de pulvérisation de lubrifiant
CN102975124B (zh) * 2012-12-17 2015-10-28 北京理工大学 异形喷头旋转式磁射流抛光装置
DE102015114202A1 (de) * 2015-07-17 2017-01-19 Sms Group Gmbh Sprühkopf zur Kühlschmierung mindestens eines Gesenks einer Umformmaschine sowie Verfahren zur Herstellung eines derartigen Sprühkopfs
DE102016123279B4 (de) * 2016-12-01 2019-02-21 Fette Compacting Gmbh Verfahren und System zum Zuführen eines Schmier- oder Trennmittels zu Presswerkzeugen einer Tablettenpresse
DE102017100438A1 (de) 2017-01-11 2018-07-12 Sms Group Gmbh Zweistoffdüse, Sprühkopf sowie Verfahren zum Zerstäuben eines Gemisches aus Sprühmittel und Sprühluft mittels einer Zweistoffdüse
FR3073227B1 (fr) * 2017-11-03 2020-01-10 Medelpharm Composition lubrifiante pour presse a comprimer

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EP0011269A1 (fr) * 1978-11-15 1980-05-28 Dr. Karl Thomae GmbH Procédé et dispositif pour pointiller des dispositifs de moulage avec des gouttes discrètes de lubrifiant liquide ou en suspension lors de la fabrication d'objets moulés dans le domaine pharmaceutique, alimentaire ou catalytique

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FR2387764A1 (fr) * 1977-04-20 1978-11-17 Thomae Gmbh Dr K Procede pour pulveriser un revetement sur les outils compresseurs de machines a fabriquer des articles moules
EP0011269A1 (fr) * 1978-11-15 1980-05-28 Dr. Karl Thomae GmbH Procédé et dispositif pour pointiller des dispositifs de moulage avec des gouttes discrètes de lubrifiant liquide ou en suspension lors de la fabrication d'objets moulés dans le domaine pharmaceutique, alimentaire ou catalytique

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EP0379912A2 (fr) * 1989-01-26 1990-08-01 Dr. Karl Thomae GmbH Procédé pour revêtir les outils de formage dans des machines de fabrication de tablettes
EP0379912A3 (fr) * 1989-01-26 1991-07-31 Dr. Karl Thomae GmbH Procédé pour revêtir les outils de formage dans des machines de fabrication de tablettes
EP0590963A1 (fr) * 1992-10-02 1994-04-06 Eisai Co., Ltd. Procédé et dispositif pour la préparation d'un comprimé moulé et comprimé ainsi préparé
EP0650826A1 (fr) * 1993-11-01 1995-05-03 Kyowa Hakko Kogyo Co., Ltd. Machine de fabrication de tablettes à table tournante avec dispositif pulvérisateur lubrifiant
WO1995018595A1 (fr) * 1994-01-04 1995-07-13 Voss Gunter M Procede de production de comprimes
WO1995018596A1 (fr) * 1994-01-04 1995-07-13 Voss Gunter M Procede de production de comprimes
EP0676280A1 (fr) * 1994-04-08 1995-10-11 Wilhelm Fette GmbH Procédé et dispositif pour l'application d'agent de lubrification ou de décoffrage en forme de poudre sur les outils de pressage dans des machines de fabrication de comprimés
WO2004045841A1 (fr) * 2002-11-21 2004-06-03 Mitsubishi Materials Corporation Procede de formation d'un element compact a partir de poudre, et appareil de moulage a cet effet
US8153053B2 (en) 2002-11-21 2012-04-10 Diamet Corporation Method for forming compact from powder and sintered product
KR100797425B1 (ko) * 2003-08-08 2008-01-23 로디아 폴리아미드 인터미디에이츠 폴리우레탄 발포물, 이의 제조 방법 및 이의 용도

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CA1245419A (fr) 1988-11-29
DD219729A5 (de) 1985-03-13
JPS59205970A (ja) 1984-11-21
BR8401606A (pt) 1984-11-13
EP0122519B1 (fr) 1988-05-18
US4707309A (en) 1987-11-17
ATE34338T1 (de) 1988-06-15
AU2648084A (en) 1984-10-11
EP0122519A3 (en) 1986-02-05
ES8501624A1 (es) 1984-12-01
ES531339A0 (es) 1984-12-01
US4758142A (en) 1988-07-19
AU579096B2 (en) 1988-11-17
JPH0380465B2 (fr) 1991-12-25
DE3471277D1 (en) 1988-06-23
DE3312634A1 (de) 1984-10-11

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