EP0011269A1 - Procédé et dispositif pour pointiller des dispositifs de moulage avec des gouttes discrètes de lubrifiant liquide ou en suspension lors de la fabrication d'objets moulés dans le domaine pharmaceutique, alimentaire ou catalytique - Google Patents

Procédé et dispositif pour pointiller des dispositifs de moulage avec des gouttes discrètes de lubrifiant liquide ou en suspension lors de la fabrication d'objets moulés dans le domaine pharmaceutique, alimentaire ou catalytique Download PDF

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Publication number
EP0011269A1
EP0011269A1 EP79104448A EP79104448A EP0011269A1 EP 0011269 A1 EP0011269 A1 EP 0011269A1 EP 79104448 A EP79104448 A EP 79104448A EP 79104448 A EP79104448 A EP 79104448A EP 0011269 A1 EP0011269 A1 EP 0011269A1
Authority
EP
European Patent Office
Prior art keywords
liquid
droplets
lubricant
nozzle
dotting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP79104448A
Other languages
German (de)
English (en)
Other versions
EP0011269B1 (fr
Inventor
Gunther M. Voss
Peter Dr. Dipl.-Chem. Gruber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19782849496 external-priority patent/DE2849496A1/de
Priority claimed from DE19792932069 external-priority patent/DE2932069A1/de
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Priority to AT79104448T priority Critical patent/ATE3012T1/de
Publication of EP0011269A1 publication Critical patent/EP0011269A1/fr
Application granted granted Critical
Publication of EP0011269B1 publication Critical patent/EP0011269B1/fr
Expired legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B30—PRESSES
    • B30B—PRESSES IN GENERAL
    • B30B15/00—Details of, or accessories for, presses; Auxiliary measures in connection with pressing
    • B30B15/0005—Details of, or accessories for, presses; Auxiliary measures in connection with pressing for briquetting presses
    • B30B15/0011—Details of, or accessories for, presses; Auxiliary measures in connection with pressing for briquetting presses lubricating means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B17/00—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups
    • B05B17/04—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods
    • B05B17/06—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations
    • B05B17/0607—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers
    • B05B17/0638—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers spray being produced by discharging the liquid or other fluent material through a plate comprising a plurality of orifices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B5/00—Electrostatic spraying apparatus; Spraying apparatus with means for charging the spray electrically; Apparatus for spraying liquids or other fluent materials by other electric means
    • B05B5/025—Discharge apparatus, e.g. electrostatic spray guns
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S425/00—Plastic article or earthenware shaping or treating: apparatus
    • Y10S425/115—Lubricator

Definitions

  • the invention relates to a method for the intermittent dotting of molds e.g. of tableting machines using discrete droplets of liquid or suspended lubricants in the manufacture of moldings in the pharmaceutical, food or catalyst sector.
  • German patent specification ......... (patent application P 27 17 438.5) describes a method for coating press chambers in tabletting machines, which is characterized in that dissolved or melted lubricants are used briefly (“intermittently ”) spraying nozzle system before each pressing operation to be applied to the inner walls of the pressing chamber.
  • liquid or suspended lubricant is dotted onto the stressed zones of the pressing tools in defined quantities and in the form of discrete droplets of a defined volume before each pressing operation.
  • the doting happens e.g. by means of tubular or plate-shaped piezoelectric transducers intermittently before each pressing process.
  • a lubricant liquid or suspension can also be divided into discrete droplets of defined volume after application of a high pressure when passing through a narrow nozzle, the individual droplets subsequently being electrically charged and electrostatically deflected intermittently to the stressed zones of the pressing tools in order to puncture them.
  • a system suitable for spotting the liquid or suspended lubricant consists, for example, of a whole series of channels in such a way that a tubular piezo oscillator concentrically envelops a section of each channel.
  • Conductive layers such as silver layers or gold layers, serve as electrodes for applying the electrical field. or nickel layers, on the lateral surfaces of the tubular piezo oscillator.
  • the outlet openings are aligned in such a way that each one dots fine lubricant droplets onto a specific area of the molds passing by.
  • the individual channels are e.g. connected to a common distributor plate, which is connected to a storage container, and from there are supplied with lubricant liquid or suspension (cf. FIG. 1).
  • the backflow of the liquid or suspension in the nozzle channel is complicated, for example, by the fact that the nozzle channel is narrowed towards the outlet opening. Due to the nature of piezo oscillators, e.g. To suffer elastic deformation from piezoceramic masses when a certain electric field is applied, a shock wave directed at the liquid is created in the tubular piezo oscillators. The associated increase in pressure leads to the shooting out of the smallest amounts of lubricant in the form of a club from the outlet openings, these lubricant clubs taking on a spherical shape after leaving the outlet openings.
  • the diameter of a channel is advantageously approximately 1 mm in its central part, the individual channel is tapered at its outlet opening.
  • the diameter of the outlet opening is, for example, 0.1 mm.
  • the reservoir is lower than the outlet openings, which is why it is called a vacuum system.
  • the height difference creates a static vacuum in the channels. This static negative pressure is overcompensated for a brief moment when the electrical field is applied in connection with the capillary action in the channels.
  • the capillary forces in the channels and in the outlet openings prevent the lubricant liquid or suspension from running back.
  • 3000 droplets leave the outlet opening at a drop frequency of 3 KHz and a lubricant viscosity of approx. 20 m Pas.
  • the velocity of the droplets is approx. 4 m / s with a very constant droplet weight of approx. 0.8 ⁇ g (0.0008 mg).
  • the drop frequency is between a few hundred Hertz and 50 KHz, preferably 3 KHz.
  • the excitation of the piezo oscillator happens e.g. with a voltage pulse of 120 volts with a pulse duration of 20 microseconds.
  • the channel which is enclosed by the piezoelectric oscillator can be curved in front of or behind it; this configuration serves to better adapt to the spatial conditions e.g. the tablet press.
  • the channel can also branch into two or more channels spatially after the piezo oscillator, so that one piezo oscillator supplies several channels with separate outlet openings.
  • the outlet openings can e.g. Holes in a glass or metal plate. If the channel consists of a glass capillary, the outlet opening can be formed by pulling out the glass tube at its end.
  • Another advantageous embodiment for dotting with liquid or suspended lubricant consists in the use of platelet-shaped or planar transducers which work according to the piezoelectric principle and which are preferably mounted concentrically above the entrance of the channels; at the end of the channels there are again tapered exits openings.
  • the piezoplate is horizontally concentric with the vertically leading channel.
  • the piezoplates lie in or on a chamber for receiving the lubricant liquid or suspension.
  • Several channels can lead away from a common chamber, which in turn is connected to a common liquid supply.
  • a planar oscillator piezo plate
  • a planar oscillator can simultaneously generate a pressure wave in several channels that adjoin the same distribution chamber.
  • a further advantageous, structurally simplified embodiment includes a powerful planar oscillator in the chamber and a channel extending from the chamber, which preferably runs vertically to the planar oscillator, at the end of which there are several, possibly spatially differently oriented nozzles or an entire nozzle ring.
  • the upper punch or the lower punch with the die pass the dot system in a few milliseconds. Nevertheless, a channel that operates with a drop frequency of a few kHz can emit not just one but a whole series of lubricant droplets during this period.
  • the control of the dotting system consisting of a larger number of channels with outlet openings, can be carried out in such a way that all channels spray at the same time when the molds appear or, depending on their geometrical arrangement, in succession at different times. It is also possible to choose the droplet frequency of the channels differently, depending on which area of the molding tools is to be dotted. In this way, more lubricant can be applied to special zones of the molds (e.g. to the pressing zone in the die, to the engraving of the upper or lower punch) than to less stressed ones. Finally, there is the option of using a channel to puncture the die wall other lubricant solution than the channels that are intended for the puncturing of the stamp surfaces.
  • the piezoceramic bodies can also be used as valves if the lubricant liquid or suspension is supplied with pressure to the oscillator or transducer, which opens or closes depending on the control.
  • a slot-shaped opening opens briefly in a channel containing the liquid under pressure, through which the filling material is released in the form of drops; the opening can be made in the transducer itself, which closes the pressurized space as a valve, or in the edge zone between the transducer and the material forming the walls of the channel. This process is also possible in the opposite way; when actuated, the oscillator closes the pressurized space.
  • the drops required for the spotting can also be produced using the so-called high-pressure process; in the high pressure process, the lubricant liquid or suspension is forced under high pressure through one or more narrow nozzles.
  • the high pressure is generated, for example, by a pump.
  • the liquid disintegrates into fine, uniformly sized droplets, which are then charged by a charging electrode; the electrically charged Droplets are deflected electrostatically to the desired locations on the pressing tools (cf. FIG. 3 ).
  • the high pressure nozzle can also be located concentrically in the middle of a tube filled with lubricant liquid or suspension.
  • the outlet opening of the high-pressure nozzle is located just below the liquid level of the lubricant.
  • a carrier or transport liquid emerges from the high-pressure nozzle as a jet, which entrains up to 50% of the lubricant liquid or suspension surrounding it.
  • This liquid jet of carrier and lubricant liquid which is under high pressure, disintegrates immediately after leaving the nozzle-shaped opening of the tube into uniform droplets, which after electrostatic charging are electrostatically deflected in the direction of the points of the pressing tools to be punctured.
  • Suitable transport liquids are e.g. Water, alcohols, such as ethanol, or glycol, glycerin.
  • the diameter of the transport nozzle is e.g. 1o pm, the diameter of the surrounding tube 2 mm. Coarse lubricant suspensions can also be scored with this arrangement (cf. FIG. 4).
  • the droplets generated by the high-pressure system described above have a diameter of 20 ⁇ m, for example. If desired, these droplets can be further divided by applying a strong electric field of, for example, 500 to 1000 volts; These finer, charged droplets can also be used by electrostatic deflection for the targeted dotting of the pressing tools.
  • the dot system can be installed anywhere in front of the filling shoe and behind the ejection device of a tableting machine. It is particularly expedient, however, to arrange the opening of the dot system approximately 1 mm above the revolver table in which the matrices are located, so that one can point directly into the "cup" formed from the die bore and the active surface of the lower punches. It is even possible to point directly into the gap between the die and the lower punch.
  • the control signal for triggering the intermittent and precisely directed point is e.g. with the help of photocells, or inductive or capacitive proximity switches.
  • lubricant melts can be used if the distributor head is heated to the appropriate temperature by a built-in heating plate. Heated reservoir and hose ensure the lubricant is transported to the spray head.
  • All lubricant liquids are advantageously passed to the channels via a suitable small filter.
  • Figures 1 to 4 are intended to illustrate schematically some possible devices for dotting molds with liquid or suspended lubricants in an exemplary manner.
  • FIG. 1 shows schematically in cross section a point system with piezoelectric transducers (1), each of which envelops a nozzle channel (8); the nozzle channel ends in a taper (7); the individual tapers (7) are in contact with corresponding openings in an outlet nozzle plate (6), the nozzles formed by the tapers (7) and the openings in the outlet plate (6) emitting liquid droplets (5) when the device is actuated.
  • the nozzle channel (8) is connected to a liquid distribution chamber (2) via a tapered liquid channel (9).
  • the distribution chamber (2) has a ventilation channel (10); the distributor chamber is connected to a liquid reservoir (3) via a filter plate (4).
  • the piezoelectric transducers are electrically controlled via contacts (11).
  • FIGS. 2a, 2b and 2c show cross sections through differently designed dotting heads with planar transducers working according to the piezoelectric principle.
  • (1) is a planar piezoelectric transducer with contacts (11) for electrical control.
  • the planar piezoelectric transducer lies in a liquid chamber (12) which is connected to a storage container via the liquid line (13).
  • FIG. 3 schematically describes a cross section through a so-called high-pressure spotting system.
  • Liquid is pressed into a nozzle (24) from a liquid storage container (21) by means of a pump (22) through a filter (23).
  • the liquid jet (27) released at the nozzle (24) breaks down into drops (28) which are charged electrically by a drop charging ring (25) and deflected in an electrical field by means of a deflection plate (26).
  • the deflected liquid drop (29) points to the pressing tools.
  • the remaining drops (29) are attracted and collected by a suction electrode (100) and returned to the container (21) via the line (110).
  • a suction electrode 100
  • FIG. 4 shows a cross section through a high-pressure spotting system in which the lubricant is conveyed by a transport liquid.
  • the liquid storage container (31) contains the transport liquid which is pressed by the pump (32) through a filter (33) into the nozzle (34).
  • the tube (30) contains the lubricant liquid or suspension which is entrained on the nozzle (34a) by the jet (37) of the transport liquid released at the nozzle (30); the combined jet (37) decays into drops (38) which are charged electrically by the drop charging ring (35).
  • the drops (38) are deflected electrostatically in the desired direction when the baffle plates (36) are paused, the deflected drops: (39) dotting the pressing tools at certain points.
  • the undeflected drops are removed by a suction electrode (100).
  • the head for spotting is dimensioned so that it can also be attached to the smallest tablet press or capsule machine.
  • the head can be aligned so that it releases the droplets in all desired directions.
  • the head only emits droplets of the same weight in contrast to a one or two-substance nozzle with a droplet distribution between mist and coarse drops.
  • the lubricant or suspension can be dispensed in less than a millisecond.
  • the delivery quantities are constant.
  • the lubricant is applied precisely at the points of the tools where the lubricant must be used.
  • the systems known up to now e.g. Spraying lubricant liquids from a nozzle creates droplet distributions between mist and coarse drops, the coarse drops preventing an even distribution of the lubricant and the mist leading to contamination of the press plate or the tablet machine. With the help of the previously known systems, it was also not possible to apply more lubricant in a reproducible manner specifically to the particularly stressed zones of the pressing tools than in less stressed areas.
  • the granules are pressed in a double rotary press at a rate of 220,000 tablets / h, the die wall and the active stamp surfaces being scored using a piezoceramic dot system filled with semi-saturated solution of glycerol monostearate in ethanol.
  • the 24 tubes work at a frequency of 10 droplets per millisecond, and the pressing tools can be dotted in passing for about 5 milliseconds.
  • the droplet weight is approximately 0.0006 mg.
  • the maximum achievable breaking strength at the specified tableting speed is 35% higher compared to tablets with 1.0% magnesium stearate in the granulate.
  • a powder mixture for hard gelatin capsules is made from an active ingredient A, milk sugar, corn starch and colloidal silica. Approx. A dotting device is attached 1 mm below the passing filling tube of a capsule filling machine. A planar piezo oscillator is located above the liquid channel of this device; the end of the channel is closed by a nozzle plate with 42 holes with a diameter of 0.06 mm. During a millisecond, 0.1 mg of a 5% alcoholic magnesium stearate suspension is released into the inside of the filling tube that passes by. The tested in vitro release of the active ingredient from this capsule was compared to a capsule manufactured using conventional technology. (with 2% magnesium stearate in the granulate) much faster (90% active ingredient release in 10 instead of 35 minutes).

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  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Medicinal Preparation (AREA)
  • Lubricants (AREA)
  • Application Of Or Painting With Fluid Materials (AREA)
  • Extrusion Moulding Of Plastics Or The Like (AREA)
  • General Preparation And Processing Of Foods (AREA)
EP79104448A 1978-11-15 1979-11-12 Procédé et dispositif pour pointiller des dispositifs de moulage avec des gouttes discrètes de lubrifiant liquide ou en suspension lors de la fabrication d'objets moulés dans le domaine pharmaceutique, alimentaire ou catalytique Expired EP0011269B1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT79104448T ATE3012T1 (de) 1978-11-15 1979-11-12 Verfahren und vorrichtung zum bepunkten von formwerkzeugen mittels diskreter troepfchen fluessiger oder suspendierter schmiermittel bei der herstellung von formlingen im pharma-, lebensmittel- oder katalysatorenbereich.

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19782849496 DE2849496A1 (de) 1977-04-20 1978-11-15 Neues verfahren zur beschichtung der presskammer von tablettiermaschinen
DE2849496 1978-11-15
DE2932069 1979-08-08
DE19792932069 DE2932069A1 (de) 1979-08-08 1979-08-08 Verfahren zum beschichten von formwerkzeugen mittels diskreter troepfchen fluessiger oder suspendierter schmiermittel bei der herstelllung von formlingen im pharma-, lebensmittel- oder katalysatorenbereich

Publications (2)

Publication Number Publication Date
EP0011269A1 true EP0011269A1 (fr) 1980-05-28
EP0011269B1 EP0011269B1 (fr) 1983-04-13

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EP79104448A Expired EP0011269B1 (fr) 1978-11-15 1979-11-12 Procédé et dispositif pour pointiller des dispositifs de moulage avec des gouttes discrètes de lubrifiant liquide ou en suspension lors de la fabrication d'objets moulés dans le domaine pharmaceutique, alimentaire ou catalytique

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US (1) US4388343A (fr)
EP (1) EP0011269B1 (fr)
AU (1) AU536460B2 (fr)
BR (1) BR7907431A (fr)
CA (1) CA1159621A (fr)
DD (1) DD146890A5 (fr)
DE (1) DE2965223D1 (fr)
ES (1) ES485764A1 (fr)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0122519A2 (fr) * 1983-04-08 1984-10-24 Dr. Karl Thomae GmbH Procédé et dispositifs pour pointiller des dispositifs de moulage avec des gouttes de lubrifiant liquide ou en suspension lors de la fabrication d'objets moulés dans le domaine pharmaceutique, alimentaire ou catalytique
GB2177623A (en) * 1985-07-11 1987-01-28 Bosch Gmbh Robert Ultrasonic atomiser
GB2192935A (en) * 1986-07-23 1988-01-27 Bosch Gmbh Robert Ultrasonic atomiser
DE3811260A1 (de) * 1988-04-02 1989-10-26 Thomae Gmbh Dr K Gezielte abgabe dosierter mengen von feinverteilten feststoffen mit venturi-duese und geregelter ansteuerung
EP0379912A2 (fr) * 1989-01-26 1990-08-01 Dr. Karl Thomae GmbH Procédé pour revêtir les outils de formage dans des machines de fabrication de tablettes
EP0472479A1 (fr) * 1990-08-20 1992-02-26 I.P.S. Industrie des Poudres Sphériques S.A. Dispositif ultrasonique pour la production en continu de particules
EP0590165A1 (fr) * 1992-09-22 1994-04-06 Schablonentechnik Kufstein Aktiengesellschaft Buse électrostatique, en particulier pour injecter des matériaux fluides à haute viscosité
WO1995018595A1 (fr) * 1994-01-04 1995-07-13 Voss Gunter M Procede de production de comprimes
WO1995026236A1 (fr) * 1994-03-25 1995-10-05 Zeneca Limited Aerosols opthalmiques aqueux
US8684980B2 (en) 2010-07-15 2014-04-01 Corinthian Ophthalmic, Inc. Drop generating device
US8733935B2 (en) 2010-07-15 2014-05-27 Corinthian Ophthalmic, Inc. Method and system for performing remote treatment and monitoring
US9087145B2 (en) 2010-07-15 2015-07-21 Eyenovia, Inc. Ophthalmic drug delivery
US10154923B2 (en) 2010-07-15 2018-12-18 Eyenovia, Inc. Drop generating device
US10639194B2 (en) 2011-12-12 2020-05-05 Eyenovia, Inc. High modulus polymeric ejector mechanism, ejector device, and methods of use

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4655393A (en) * 1983-01-05 1987-04-07 Sonotek Corporation High volume ultrasonic liquid atomizer
US4541564A (en) * 1983-01-05 1985-09-17 Sono-Tek Corporation Ultrasonic liquid atomizer, particularly for high volume flow rates
US4558598A (en) * 1984-06-07 1985-12-17 The Boeing Company Ultrasonic linear array water nozzle and method
GB8530365D0 (en) * 1985-12-10 1986-01-22 Univ Bath Manufacture of moulded products
US5763262A (en) * 1986-09-18 1998-06-09 Quidel Corporation Immunodiagnostic device
US20010023075A1 (en) * 1992-04-03 2001-09-20 Siu-Yin Wong A immunodiagnositc device having a dessicant incorporated therein
DE3823497A1 (de) * 1988-07-11 1990-01-18 Siemens Ag Piezoelektrische schmiereinrichtung fuer ein lager
DE4103413C1 (fr) * 1991-02-05 1992-11-12 Gunter M. 8918 Diessen De Voss
US5672364A (en) * 1994-07-07 1997-09-30 Sankyo Seisakusho Co. & Eisai Co., Ltd. Apparatus for manufacturing tablets
US6620358B2 (en) 1996-07-03 2003-09-16 Gunter Voss Process for manufacturing tablets
DE19647089A1 (de) * 1996-11-14 1998-05-28 Bayer Ag Vorrichtung zum kontrollierten Aufsprühen von pulverförmigen Schmiermitteln auf Stempel und Matrizen von Tablettenpressen
US7468139B2 (en) 1997-07-15 2008-12-23 Silverbrook Research Pty Ltd Method of depositing heater material over a photoresist scaffold
US7465030B2 (en) 1997-07-15 2008-12-16 Silverbrook Research Pty Ltd Nozzle arrangement with a magnetic field generator
US7195339B2 (en) 1997-07-15 2007-03-27 Silverbrook Research Pty Ltd Ink jet nozzle assembly with a thermal bend actuator
US6855264B1 (en) 1997-07-15 2005-02-15 Kia Silverbrook Method of manufacture of an ink jet printer having a thermal actuator comprising an external coil spring
US7337532B2 (en) 1997-07-15 2008-03-04 Silverbrook Research Pty Ltd Method of manufacturing micro-electromechanical device having motion-transmitting structure
US6712453B2 (en) 1997-07-15 2004-03-30 Silverbrook Research Pty Ltd. Ink jet nozzle rim
US7556356B1 (en) 1997-07-15 2009-07-07 Silverbrook Research Pty Ltd Inkjet printhead integrated circuit with ink spread prevention
US6648453B2 (en) 1997-07-15 2003-11-18 Silverbrook Research Pty Ltd Ink jet printhead chip with predetermined micro-electromechanical systems height
US6935724B2 (en) 1997-07-15 2005-08-30 Silverbrook Research Pty Ltd Ink jet nozzle having actuator with anchor positioned between nozzle chamber and actuator connection point
US6682174B2 (en) 1998-03-25 2004-01-27 Silverbrook Research Pty Ltd Ink jet nozzle arrangement configuration
DE29804955U1 (de) * 1998-03-19 1998-12-24 Quénéhervé, Marianne, 88521 Ertingen Dosiergerät für pulverförmiges Kolbenschmiermittel
US6886917B2 (en) * 1998-06-09 2005-05-03 Silverbrook Research Pty Ltd Inkjet printhead nozzle with ribbed wall actuator
WO2000060238A1 (fr) * 1999-03-31 2000-10-12 Ngk Insulators, Ltd. Commande de pulverisateur et circuit a cet effet
US6702196B2 (en) 1999-03-31 2004-03-09 Ngk Insulators, Ltd. Circuit for driving liquid drop spraying apparatus
AU3838800A (en) * 1999-04-19 2000-11-02 Kikusui Seisakusyo Ltd. Rotary type powder compression molding machine
JP4592692B2 (ja) * 2004-05-18 2010-12-01 塩野義製薬株式会社 回転式粉末圧縮成形機
EP2559430B1 (fr) 2005-03-22 2015-06-24 Losan Pharma GmbH Ibuprofen solubilisé
EP2095806B1 (fr) * 2006-12-22 2014-07-02 Kikusui Seisakusho Ltd. Mécanisme de buse
TWI583405B (zh) * 2008-02-28 2017-05-21 艾伯維有限公司 錠劑及其製備
JP5448501B2 (ja) 2008-06-10 2014-03-19 株式会社菊水製作所 粉末圧縮成形機
BR112013022712A2 (pt) 2011-03-11 2016-08-09 Intercontinental Great Brands Llc sistema e método de formar produto de confeitaria de múltiplas camadas
RU2657021C2 (ru) * 2014-03-03 2018-06-08 Интерконтинентал Грейт Брендс Ллк Способ изготовления пищевого продукта
DE102016123279B4 (de) * 2016-12-01 2019-02-21 Fette Compacting Gmbh Verfahren und System zum Zuführen eines Schmier- oder Trennmittels zu Presswerkzeugen einer Tablettenpresse
KR102643190B1 (ko) 2017-06-10 2024-03-04 아이노비아 인코포레이티드 유체를 취급하기 위한, 그리고 눈에 유체를 전달하기 위한 디바이스들
CN112519300B (zh) * 2020-11-12 2022-09-13 一重集团天津重工有限公司 一种挤压机嘴子测量与配做方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2512743A (en) * 1946-04-01 1950-06-27 Rca Corp Jet sprayer actuated by supersonic waves
FR2132840A1 (fr) * 1971-04-08 1972-11-24 Masuda Senichi
FR2253570A1 (fr) * 1973-12-05 1975-07-04 Olivetti & Co Spa
DE2812677A1 (de) * 1978-03-23 1979-10-04 Gunter M Voss Verfahren zum bespruehen der verdichtungswerkzeuge von maschinen zur herstellung von formlingen

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3011213A (en) * 1958-02-19 1961-12-05 Magnetics Inc Apparatus for lubricating mold cavities
US3158111A (en) * 1962-06-06 1964-11-24 Smith Kline French Lab Method and apparatus for forming tablets
US3281860A (en) * 1964-11-09 1966-10-25 Dick Co Ab Ink jet nozzle
CH506352A (de) * 1969-04-18 1971-04-30 Buehler Ag Geb Verfahren und Vorrichtung zum Anbringen von Trenn- bzw. Schmiermitteln auf Metallformen
US3717875A (en) * 1971-05-04 1973-02-20 Little Inc A Method and apparatus for directing the flow of liquid droplets in a stream and instruments incorporating the same
US3960324A (en) * 1974-01-10 1976-06-01 International Business Machines Corporation Method for generation of multiple uniform fluid filaments
GB1500908A (en) * 1974-06-05 1978-02-15 Ici Ltd Process for production of drop streams
US4153467A (en) * 1974-09-03 1979-05-08 Dai Nippon Toryo Co., Ltd. Method of ink jet printing
US4047866A (en) * 1976-11-22 1977-09-13 The Dow Chemical Company Automatic self-lubricating rotary tablet press
US4138687A (en) * 1977-07-18 1979-02-06 The Mead Corporation Apparatus for producing multiple uniform fluid filaments and drops
US4188635A (en) * 1977-10-03 1980-02-12 International Business Machines Corporation Ink jet printing head

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2512743A (en) * 1946-04-01 1950-06-27 Rca Corp Jet sprayer actuated by supersonic waves
FR2132840A1 (fr) * 1971-04-08 1972-11-24 Masuda Senichi
FR2253570A1 (fr) * 1973-12-05 1975-07-04 Olivetti & Co Spa
DE2812677A1 (de) * 1978-03-23 1979-10-04 Gunter M Voss Verfahren zum bespruehen der verdichtungswerkzeuge von maschinen zur herstellung von formlingen

Cited By (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0122519A2 (fr) * 1983-04-08 1984-10-24 Dr. Karl Thomae GmbH Procédé et dispositifs pour pointiller des dispositifs de moulage avec des gouttes de lubrifiant liquide ou en suspension lors de la fabrication d'objets moulés dans le domaine pharmaceutique, alimentaire ou catalytique
EP0122519A3 (en) * 1983-04-08 1986-02-05 Dr. Karl Thomae Gmbh Method and apparatus for dotting moulding devices by means of droplets of a liquid or suspended lubricant during the manufacture of moulded objects in the pharmaceutical, food or catalytic field
GB2177623A (en) * 1985-07-11 1987-01-28 Bosch Gmbh Robert Ultrasonic atomiser
GB2192935A (en) * 1986-07-23 1988-01-27 Bosch Gmbh Robert Ultrasonic atomiser
FR2601889A1 (fr) * 1986-07-23 1988-01-29 Bosch Gmbh Robert Installation de pulverisation par ultrasons
GB2192935B (en) * 1986-07-23 1990-03-07 Bosch Gmbh Robert Ultrasonic atomiser
DE3811260A1 (de) * 1988-04-02 1989-10-26 Thomae Gmbh Dr K Gezielte abgabe dosierter mengen von feinverteilten feststoffen mit venturi-duese und geregelter ansteuerung
EP0379912A2 (fr) * 1989-01-26 1990-08-01 Dr. Karl Thomae GmbH Procédé pour revêtir les outils de formage dans des machines de fabrication de tablettes
EP0379912A3 (fr) * 1989-01-26 1991-07-31 Dr. Karl Thomae GmbH Procédé pour revêtir les outils de formage dans des machines de fabrication de tablettes
EP0472479A1 (fr) * 1990-08-20 1992-02-26 I.P.S. Industrie des Poudres Sphériques S.A. Dispositif ultrasonique pour la production en continu de particules
EP0590165A1 (fr) * 1992-09-22 1994-04-06 Schablonentechnik Kufstein Aktiengesellschaft Buse électrostatique, en particulier pour injecter des matériaux fluides à haute viscosité
WO1995018595A1 (fr) * 1994-01-04 1995-07-13 Voss Gunter M Procede de production de comprimes
WO1995026236A1 (fr) * 1994-03-25 1995-10-05 Zeneca Limited Aerosols opthalmiques aqueux
EP0678337A1 (fr) * 1994-03-25 1995-10-25 Zeneca Limited Aérosol ophthalmologique aqueux
US5630793A (en) * 1994-03-25 1997-05-20 Zeneca Limited Aqueous ophthalmic sprays
AU693871B2 (en) * 1994-03-25 1998-07-09 Astrazeneca Ab Aqueous ophthalmic sprays
US10073949B2 (en) 2010-07-15 2018-09-11 Eyenovia, Inc. Ophthalmic drug delivery
US8733935B2 (en) 2010-07-15 2014-05-27 Corinthian Ophthalmic, Inc. Method and system for performing remote treatment and monitoring
US9087145B2 (en) 2010-07-15 2015-07-21 Eyenovia, Inc. Ophthalmic drug delivery
US8684980B2 (en) 2010-07-15 2014-04-01 Corinthian Ophthalmic, Inc. Drop generating device
US10154923B2 (en) 2010-07-15 2018-12-18 Eyenovia, Inc. Drop generating device
US10839960B2 (en) 2010-07-15 2020-11-17 Eyenovia, Inc. Ophthalmic drug delivery
US11011270B2 (en) 2010-07-15 2021-05-18 Eyenovia, Inc. Drop generating device
US11398306B2 (en) 2010-07-15 2022-07-26 Eyenovia, Inc. Ophthalmic drug delivery
US10639194B2 (en) 2011-12-12 2020-05-05 Eyenovia, Inc. High modulus polymeric ejector mechanism, ejector device, and methods of use
US10646373B2 (en) 2011-12-12 2020-05-12 Eyenovia, Inc. Ejector mechanism, ejector device, and methods of use

Also Published As

Publication number Publication date
BR7907431A (pt) 1980-08-05
DE2965223D1 (en) 1983-05-19
DD146890A5 (de) 1981-03-11
AU5285679A (en) 1980-05-22
CA1159621A (fr) 1984-01-03
US4388343A (en) 1983-06-14
ES485764A1 (es) 1980-10-01
EP0011269B1 (fr) 1983-04-13
AU536460B2 (en) 1984-05-10

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