EP0011269B1 - Procédé et dispositif pour pointiller des dispositifs de moulage avec des gouttes discrètes de lubrifiant liquide ou en suspension lors de la fabrication d'objets moulés dans le domaine pharmaceutique, alimentaire ou catalytique - Google Patents
Procédé et dispositif pour pointiller des dispositifs de moulage avec des gouttes discrètes de lubrifiant liquide ou en suspension lors de la fabrication d'objets moulés dans le domaine pharmaceutique, alimentaire ou catalytique Download PDFInfo
- Publication number
- EP0011269B1 EP0011269B1 EP79104448A EP79104448A EP0011269B1 EP 0011269 B1 EP0011269 B1 EP 0011269B1 EP 79104448 A EP79104448 A EP 79104448A EP 79104448 A EP79104448 A EP 79104448A EP 0011269 B1 EP0011269 B1 EP 0011269B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- liquid
- channels
- lubricant
- droplets
- piezoelectric
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000007788 liquid Substances 0.000 title claims description 40
- 239000000314 lubricant Substances 0.000 title claims description 37
- 238000000034 method Methods 0.000 title claims description 12
- 238000000465 moulding Methods 0.000 title claims description 5
- 238000004519 manufacturing process Methods 0.000 title claims description 3
- 235000013305 food Nutrition 0.000 title description 2
- 230000003197 catalytic effect Effects 0.000 title 1
- 238000003825 pressing Methods 0.000 claims description 12
- 239000003054 catalyst Substances 0.000 claims description 2
- 239000011248 coating agent Substances 0.000 claims description 2
- 238000000576 coating method Methods 0.000 claims description 2
- 238000000151 deposition Methods 0.000 claims 3
- 230000008021 deposition Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000000725 suspension Substances 0.000 description 9
- 239000003826 tablet Substances 0.000 description 7
- 238000009826 distribution Methods 0.000 description 6
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 6
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Chemical compound OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 4
- 239000002775 capsule Substances 0.000 description 4
- 239000007921 spray Substances 0.000 description 4
- 230000005684 electric field Effects 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 239000008187 granular material Substances 0.000 description 3
- 235000019359 magnesium stearate Nutrition 0.000 description 3
- 239000003595 mist Substances 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
- 229920002261 Corn starch Polymers 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- 239000008119 colloidal silica Substances 0.000 description 2
- 239000008120 corn starch Substances 0.000 description 2
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- 230000003068 static effect Effects 0.000 description 2
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000007938 effervescent tablet Substances 0.000 description 1
- 230000005489 elastic deformation Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 239000007903 gelatin capsule Substances 0.000 description 1
- YQEMORVAKMFKLG-UHFFFAOYSA-N glycerine monostearate Natural products CCCCCCCCCCCCCCCCCC(=O)OC(CO)CO YQEMORVAKMFKLG-UHFFFAOYSA-N 0.000 description 1
- SVUQHVRAGMNPLW-UHFFFAOYSA-N glycerol monostearate Natural products CCCCCCCCCCCCCCCCC(=O)OCC(O)CO SVUQHVRAGMNPLW-UHFFFAOYSA-N 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 229960000905 indomethacin Drugs 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229910052759 nickel Inorganic materials 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000012047 saturated solution Substances 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B30—PRESSES
- B30B—PRESSES IN GENERAL
- B30B15/00—Details of, or accessories for, presses; Auxiliary measures in connection with pressing
- B30B15/0005—Details of, or accessories for, presses; Auxiliary measures in connection with pressing for briquetting presses
- B30B15/0011—Details of, or accessories for, presses; Auxiliary measures in connection with pressing for briquetting presses lubricating means
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B17/00—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups
- B05B17/04—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods
- B05B17/06—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations
- B05B17/0607—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers
- B05B17/0638—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers spray being produced by discharging the liquid or other fluent material through a plate comprising a plurality of orifices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B5/00—Electrostatic spraying apparatus; Spraying apparatus with means for charging the spray electrically; Apparatus for spraying liquids or other fluent materials by other electric means
- B05B5/025—Discharge apparatus, e.g. electrostatic spray guns
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S425/00—Plastic article or earthenware shaping or treating: apparatus
- Y10S425/115—Lubricator
Definitions
- the invention relates to a method and device for intermittent dotting of molds z. B. of tableting machines by means of discrete droplets of liquid or suspended lubricants in the manufacture of moldings in the pharmaceutical, food or catalyst sector.
- DE-A-2 717 438 describes a method for coating press chambers in tableting machines, which is characterized in that dissolved or melted lubricants are used in a rapid time interval. the briefly (“intermittently") spraying nozzle system is applied to the inner walls of the press chamber before each pressing process.
- the pulses are generated by piezoelectric transducers.
- a system suitable for spotting the liquid or suspended lubricant consists, for example, of a whole series of channels in such a way that a tubular piezo oscillator concentrically envelops a section of each channel.
- Conductive layers e.g. B. silver layers or gold or nickel layers, on the outer surfaces of the tubular piezo oscillator.
- the outlet openings are aligned in such a way that each one dots fine lubricant droplets onto a specific area of the molds passing by.
- the individual channels are z. B. connected to a common distributor plate, which is in connection with a storage container, and are supplied from there with lubricant liquid or suspension (see FIG. 1).
- the backflow of the liquid or suspension in the nozzle channel is complicated, for example, by the fact that the nozzle channel is narrowed towards the outlet opening. Due to the property of piezo oscillators, e.g. B. of piezoceramic masses to suffer an elastic deformation when applying a certain electric field, a shock wave directed at the liquid is created in the tubular piezo oscillators. The associated increase in pressure leads to the shooting out of the smallest amounts of lubricant in the form of a club from the outlet openings, these lubricant clubs taking on a spherical shape after leaving the outlet openings.
- the diameter of a channel is advantageously approximately 1 mm in its central part, the individual channel is tapered at its outlet opening.
- the diameter of the outlet opening is, for example, 0.1 mm.
- the reservoir is lower than the outlet openings, which is why it is called a vacuum system.
- the height difference creates a static vacuum in the channels. This static negative pressure is overcompensated for a brief moment when the electric field is applied in connection with the capillary action in the channels.
- the capillary forces in the channels and in the outlet openings prevent the lubricant liquid or suspension from running back.
- 3000 droplets leave the outlet opening at a drop frequency of 3 kHz and a lubricant viscosity of approx. 20 m Pas.
- the velocity of the droplets is approx. 4 m / s with a very constant droplet weight of approx. 0.8 gg (0.0008 mg).
- the drop frequency is between a few hundred Hertz and 50 kHz, preferably 3 kHz.
- the excitation of the piezo oscillator happens z. B. with a voltage pulse of 120 volts at a pulse duration of 20 microseconds.
- the channel which is enclosed by the piezoelectric oscillator can be curved in front of or behind it; this configuration serves to better adapt to the spatial conditions such. B. the tablet press.
- the channel can also be spatially divided into two or more after the piezo oscillator Branch channels so that a piezo oscillator supplies several channels with separate outlet openings.
- the outlet openings can, for. B. holes in a glass or metal plate. If the channel consists of a glass capillary, the outlet opening can be formed by pulling out the glass tube at its end.
- Another advantageous embodiment for dotting with liquid or suspended lubricants consists in the use of platelet-shaped or planar transducers which work according to the piezoelectric principle and which are preferably arranged concentrically above the entrance of the channels; at the end of the channels there are again tapered outlet openings.
- the piezoplate is horizontally concentric with the vertically leading channel.
- the piezoplates lie in or on a chamber for receiving the lubricant liquid or suspension.
- Several channels can lead away from a common chamber, which in turn is connected to a common liquid supply. So z. B. also a planar oscillator (piezoplate) can simultaneously generate a pressure wave in several channels adjoining the same distributor chamber.
- a further advantageous, structurally simplified embodiment includes a powerful planar oscillator in the chamber and a channel extending from the chamber, which preferably runs vertically to the planar oscillator, at the end of which there are several, possibly spatially differently oriented nozzles or an entire nozzle ring.
- a surface can be dotted with a single stroke generated by the piezo oscillator (cf. FIGS. 2a, 2b and 2c).
- the upper punch or the lower punch with the die runs past the dot system in a few milliseconds. Nevertheless, a channel operating at a drop frequency of a few kHz can deliver not only one but a whole series of lubricant droplets during this period.
- the control of the dotting system consisting of a larger number of channels with outlet openings, can be carried out in such a way that all channels spray simultaneously when the molds appear or, depending on their geometric arrangement, one after the other at different times. It is also possible to choose the droplet frequency of the channels differently, depending on which area of the molding tools is to be dotted. In this way, more lubricant can be applied to special zones of the molds (e.g. to the pressing zone in the die, to the engraving of the upper or lower punch) than to less stressed areas. Finally, it is possible to feed the channels that dot the die wall with a different lubricant solution than the channels that are provided for the doting of the stamp surfaces.
- the piezoceramic bodies can also be used as valves if the lubricant liquid or suspension is supplied with pressure to the oscillator or transducer, which opens or closes depending on the control.
- a slot-shaped opening opens briefly in a channel containing the liquid under pressure, through which the filling material is released in the form of drops; the opening can be made in the vibrator itself, which closes the pressurized space as a valve, or in the edge zone between the vibrator and the material forming the walls of the channel. This process is also possible in the opposite way; when actuated, the oscillator closes the pressurized space.
- the dot system can be installed anywhere in front of the filling shoe and behind the ejection device of a tableting machine. However, it is particularly useful to arrange the opening of the dot system about 1 mm above the revolver table in which the matrices are located, so that you can point directly from above into the "cup" formed from the die hole and the active surface of the lower punches. It is even possible to point directly into the gap between the die and the lower punch.
- the control signal for triggering the intermittent and precisely directed point is z. B. with the help of photocells, or inductive or capacitive proximity switches.
- lubricant melts can be used if the distributor head is heated to the appropriate temperature by a built-in heating plate. A heated reservoir and hose ensure that the lubricant is transported to the spray head.
- All lubricant liquids are advantageously passed to the channels via a suitable small filter.
- Figures 1 to 4 are intended to illustrate schematically some possible devices for dotting molds with liquid or suspended lubricants in an exemplary manner.
- FIG. 1 shows schematically in cross section a dot system with piezoelectric transducers (1), each of which envelops a nozzle channel (8); the nozzle channel ends in a taper (7); the individual tapers (7) are in contact with corresponding openings in an outlet nozzle plate (6), the nozzles formed by the tapers (7) and the openings in the outlet plate (6) emitting liquid droplets (5) when the device is actuated.
- the nozzle channel (8) is connected to a liquid distribution chamber (2) via a tapered liquid channel (9).
- the distribution chamber (2) has a ventilation channel (10); the distribution chamber is connected to a liquid reservoir (3) via a filter plate (4).
- the piezoelectric transducers are electrically controlled via contacts (11).
- FIGS. 2a, 2b and 2c show cross sections through differently designed dotting heads with planar transducers working according to the piezoelectric principle.
- (1) is a planar piezoelectric transducer with contacts (11) for electrical control.
- the planar piezoelectric transducer is located in a liquid chamber (12) which is connected to a storage container via the liquid line (13).
- FIG. 3 schematically shows a cross section through a modified point system.
- Liquid is pressed into a nozzle (24) from a liquid storage container (21) by means of a pump (22) through a filter (23).
- the liquid jet (27) released at the nozzle (24) breaks down into droplets (28) which are charged electrically by a droplet charging ring (25) and deflected in an electrical field by means of a deflection plate (26).
- the deflected liquid drop (29) points to the pressing tools.
- the remaining drops (29) are attracted and collected by a suction electrode (100) and returned to the container (21) via the line (110).
- FIG. 4 shows a cross section through a similar point system, in which the lubricant is conveyed by a transport liquid.
- the liquid reservoir (31) contains the transport liquid, which is pressed by the pump (32) through a filter (33) into the nozzle (34).
- the tube (30) contains the lubricant liquid or suspension which is entrained on the nozzle (34a) by the jet (37) of the transport liquid released at the nozzle (30); the combined jet (37) decays into drops (38) which are charged electrically by the drop charging ring (35).
- the drops (38) are deflected electrostatically in the desired direction as they pass the deflection plates (36), the deflected drops (39) dotting the pressing tools at certain points.
- the undeflected drops are removed by a suction electrode (100).
- the converter is not shown, it could e.g. B. in the liquid channel or in the containers (21) or (31).
- the head for spotting is dimensioned so that it can also be attached to the smallest tablet press or capsule machine.
- the head can be aligned so that it releases the droplets in all desired directions.
- the head only emits droplets of the same weight in contrast to a one or two-substance nozzle with a droplet distribution between mist and coarse drops.
- the fast and precise method of working is to be emphasized; they are suitable for all high-speed tablet presses known to date.
- the lubricant or suspension can be dispensed in less than a millisecond.
- the delivery quantities are constant.
- the lubricant is applied precisely at the points of the tools where the lubricant must be used.
- the systems known until now e.g. B. spraying lubricant liquids from a nozzle, produce droplet distributions between mist and coarse drops, the coarse drops preventing an even distribution of the lubricant and the mist leading to contamination of the press plate or the tablet machine.
- the granules are pressed in a double rotary press at a rate of 220,000 tablets / h, the die wall and the active stamp surfaces being scored using a piezoceramic dot system filled with semi-saturated solution of glycerol monostearate in ethanol.
- the 24 tubes work at a frequency of 10 droplets per millisecond, and the pressing tools can be dotted in passing for about 5 milliseconds.
- the droplet weight is approximately 0.0006 mg.
- the maximum achievable breaking strength at the specified tableting speed is 35% higher compared to tablets with 1.0% magnesium stearate in the granulate.
- a powder mixture for hard gelatin capsules is made from an active ingredient A, milk sugar, corn starch and colloidal silica. Approx. A dotting device is attached 1 mm below the passing filling tube of a capsule filling machine. A planar piezo oscillator is located above the liquid channel of this device; the end of the channel is closed by a nozzle plate with 42 holes with a diameter of 0.06 mm. During a millisecond, 0.1 mg of a 5% alcoholic magnesium stearate suspension is released into the inside of the filling tube that passes by. The tested in vitro release of the active substance from this capsule was significantly faster (90% active substance release in 10 instead of 35 minutes) compared to a capsule manufactured according to conventional technology (with 2% magnesium stearate in the granulate).
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Medicinal Preparation (AREA)
- Extrusion Moulding Of Plastics Or The Like (AREA)
- Lubricants (AREA)
- Application Of Or Painting With Fluid Materials (AREA)
- General Preparation And Processing Of Foods (AREA)
Claims (8)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT79104448T ATE3012T1 (de) | 1978-11-15 | 1979-11-12 | Verfahren und vorrichtung zum bepunkten von formwerkzeugen mittels diskreter troepfchen fluessiger oder suspendierter schmiermittel bei der herstellung von formlingen im pharma-, lebensmittel- oder katalysatorenbereich. |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19782849496 DE2849496A1 (de) | 1977-04-20 | 1978-11-15 | Neues verfahren zur beschichtung der presskammer von tablettiermaschinen |
DE2849496 | 1978-11-15 | ||
DE19792932069 DE2932069A1 (de) | 1979-08-08 | 1979-08-08 | Verfahren zum beschichten von formwerkzeugen mittels diskreter troepfchen fluessiger oder suspendierter schmiermittel bei der herstelllung von formlingen im pharma-, lebensmittel- oder katalysatorenbereich |
DE2932069 | 1979-08-08 |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0011269A1 EP0011269A1 (fr) | 1980-05-28 |
EP0011269B1 true EP0011269B1 (fr) | 1983-04-13 |
Family
ID=25776482
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP79104448A Expired EP0011269B1 (fr) | 1978-11-15 | 1979-11-12 | Procédé et dispositif pour pointiller des dispositifs de moulage avec des gouttes discrètes de lubrifiant liquide ou en suspension lors de la fabrication d'objets moulés dans le domaine pharmaceutique, alimentaire ou catalytique |
Country Status (8)
Country | Link |
---|---|
US (1) | US4388343A (fr) |
EP (1) | EP0011269B1 (fr) |
AU (1) | AU536460B2 (fr) |
BR (1) | BR7907431A (fr) |
CA (1) | CA1159621A (fr) |
DD (1) | DD146890A5 (fr) |
DE (1) | DE2965223D1 (fr) |
ES (1) | ES485764A1 (fr) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE29804955U1 (de) * | 1998-03-19 | 1998-12-24 | Quénéhervé, Marianne, 88521 Ertingen | Dosiergerät für pulverförmiges Kolbenschmiermittel |
US11839487B2 (en) | 2010-07-15 | 2023-12-12 | Eyenovia, Inc. | Ophthalmic drug delivery |
US11938056B2 (en) | 2017-06-10 | 2024-03-26 | Eyenovia, Inc. | Methods and devices for handling a fluid and delivering the fluid to the eye |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4541564A (en) * | 1983-01-05 | 1985-09-17 | Sono-Tek Corporation | Ultrasonic liquid atomizer, particularly for high volume flow rates |
US4655393A (en) * | 1983-01-05 | 1987-04-07 | Sonotek Corporation | High volume ultrasonic liquid atomizer |
DE3312634A1 (de) * | 1983-04-08 | 1984-10-11 | Dr. Karl Thomae Gmbh, 7950 Biberach | Verbessertes verfahren und vorrichtungen zum bepunkten von formwerkzeugen mit troepfchen fluessiger oder suspendierter schmiermittel bei der herstellung von formlingen in pharma-, lebensmittel- oder katalysatorenbereich |
US4558598A (en) * | 1984-06-07 | 1985-12-17 | The Boeing Company | Ultrasonic linear array water nozzle and method |
DE3524701A1 (de) * | 1985-07-11 | 1987-01-15 | Bosch Gmbh Robert | Ultraschallzerstaeuberduese |
GB8530365D0 (en) * | 1985-12-10 | 1986-01-22 | Univ Bath | Manufacture of moulded products |
DE3713253A1 (de) * | 1986-07-23 | 1988-02-04 | Bosch Gmbh Robert | Ultraschallzerstaeuberanlage |
US20010023075A1 (en) * | 1992-04-03 | 2001-09-20 | Siu-Yin Wong | A immunodiagnositc device having a dessicant incorporated therein |
US5763262A (en) * | 1986-09-18 | 1998-06-09 | Quidel Corporation | Immunodiagnostic device |
DE3811260A1 (de) * | 1988-04-02 | 1989-10-26 | Thomae Gmbh Dr K | Gezielte abgabe dosierter mengen von feinverteilten feststoffen mit venturi-duese und geregelter ansteuerung |
DE3823497A1 (de) * | 1988-07-11 | 1990-01-18 | Siemens Ag | Piezoelektrische schmiereinrichtung fuer ein lager |
DE3902293A1 (de) * | 1989-01-26 | 1990-08-02 | Gunther M Voss | Neues verfahren zur presskammerbeschichtung mittels schmiermittelringbildung an der matrizenwand von tablettenpressen |
FR2665849B1 (fr) * | 1990-08-20 | 1995-03-24 | Dynamad | Dispositif ultrasonique pour la production en continu de particules. |
DE4103413C1 (fr) * | 1991-02-05 | 1992-11-12 | Gunter M. 8918 Diessen De Voss | |
EP0590165B1 (fr) * | 1992-09-22 | 1997-02-26 | Schablonentechnik Kufstein Aktiengesellschaft | Buse électrostatique, en particulier pour injecter des matériaux fluides à haute viscosité |
DE4400112A1 (de) * | 1994-01-04 | 1995-07-06 | Gunter M Voss | Verfahren zur Herstellung von Tabletten |
GB9405952D0 (en) * | 1994-03-25 | 1994-05-11 | Zeneca Ltd | Aqueous ophthalmic sprays |
US5672364A (en) * | 1994-07-07 | 1997-09-30 | Sankyo Seisakusho Co. & Eisai Co., Ltd. | Apparatus for manufacturing tablets |
US6620358B2 (en) | 1996-07-03 | 2003-09-16 | Gunter Voss | Process for manufacturing tablets |
DE19647089A1 (de) * | 1996-11-14 | 1998-05-28 | Bayer Ag | Vorrichtung zum kontrollierten Aufsprühen von pulverförmigen Schmiermitteln auf Stempel und Matrizen von Tablettenpressen |
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US6855264B1 (en) | 1997-07-15 | 2005-02-15 | Kia Silverbrook | Method of manufacture of an ink jet printer having a thermal actuator comprising an external coil spring |
US6935724B2 (en) | 1997-07-15 | 2005-08-30 | Silverbrook Research Pty Ltd | Ink jet nozzle having actuator with anchor positioned between nozzle chamber and actuator connection point |
US7556356B1 (en) | 1997-07-15 | 2009-07-07 | Silverbrook Research Pty Ltd | Inkjet printhead integrated circuit with ink spread prevention |
US7468139B2 (en) | 1997-07-15 | 2008-12-23 | Silverbrook Research Pty Ltd | Method of depositing heater material over a photoresist scaffold |
US6648453B2 (en) | 1997-07-15 | 2003-11-18 | Silverbrook Research Pty Ltd | Ink jet printhead chip with predetermined micro-electromechanical systems height |
US6886917B2 (en) * | 1998-06-09 | 2005-05-03 | Silverbrook Research Pty Ltd | Inkjet printhead nozzle with ribbed wall actuator |
WO2000060238A1 (fr) * | 1999-03-31 | 2000-10-12 | Ngk Insulators, Ltd. | Commande de pulverisateur et circuit a cet effet |
US6702196B2 (en) | 1999-03-31 | 2004-03-09 | Ngk Insulators, Ltd. | Circuit for driving liquid drop spraying apparatus |
AU3838800A (en) * | 1999-04-19 | 2000-11-02 | Kikusui Seisakusyo Ltd. | Rotary type powder compression molding machine |
WO2005110726A1 (fr) * | 2004-05-18 | 2005-11-24 | Shionogi & Co., Ltd. | Équipement rotatif de moulage de poudre par compression |
EP2559430B1 (fr) | 2005-03-22 | 2015-06-24 | Losan Pharma GmbH | Ibuprofen solubilisé |
EP2095806B1 (fr) * | 2006-12-22 | 2014-07-02 | Kikusui Seisakusho Ltd. | Mécanisme de buse |
JP5750266B2 (ja) * | 2008-02-28 | 2015-07-15 | アッヴィ・インコーポレイテッド | 錠剤およびその調製 |
JP5448501B2 (ja) * | 2008-06-10 | 2014-03-19 | 株式会社菊水製作所 | 粉末圧縮成形機 |
EP2593055A1 (fr) | 2010-07-15 | 2013-05-22 | Corinthian Ophthalmic, Inc. | Procédé et système de réalisation d'un traitement et d'une surveillance à distance |
AU2011278924B2 (en) | 2010-07-15 | 2015-06-18 | Eyenovia, Inc. | Ophthalmic drug delivery |
JP5964826B2 (ja) | 2010-07-15 | 2016-08-03 | アイノビア,インコーポレイティド | 滴生成デバイス |
AU2012229325B2 (en) | 2011-03-11 | 2015-07-09 | Intercontinental Great Brands Llc | System and method of forming multilayer confectionery |
WO2013090459A1 (fr) | 2011-12-12 | 2013-06-20 | Corinthian Ophthalmic, Inc. | Mécanisme éjecteur, dispositif éjecteur et procédés d'utilisation |
BR112016016620A2 (pt) * | 2014-03-03 | 2017-10-03 | Intercontinental Great Brands Llc | Método para fabricação de um produto comestível |
DE102016123279B4 (de) * | 2016-12-01 | 2019-02-21 | Fette Compacting Gmbh | Verfahren und System zum Zuführen eines Schmier- oder Trennmittels zu Presswerkzeugen einer Tablettenpresse |
CN112519300B (zh) * | 2020-11-12 | 2022-09-13 | 一重集团天津重工有限公司 | 一种挤压机嘴子测量与配做方法 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2512743A (en) * | 1946-04-01 | 1950-06-27 | Rca Corp | Jet sprayer actuated by supersonic waves |
US3011213A (en) * | 1958-02-19 | 1961-12-05 | Magnetics Inc | Apparatus for lubricating mold cavities |
US3158111A (en) * | 1962-06-06 | 1964-11-24 | Smith Kline French Lab | Method and apparatus for forming tablets |
US3281860A (en) * | 1964-11-09 | 1966-10-25 | Dick Co Ab | Ink jet nozzle |
CH506352A (de) * | 1969-04-18 | 1971-04-30 | Buehler Ag Geb | Verfahren und Vorrichtung zum Anbringen von Trenn- bzw. Schmiermitteln auf Metallformen |
CA976599A (en) * | 1971-04-08 | 1975-10-21 | Senichi Masuda | Electrified particles generating apparatus |
US3717875A (en) * | 1971-05-04 | 1973-02-20 | Little Inc A | Method and apparatus for directing the flow of liquid droplets in a stream and instruments incorporating the same |
IT999894B (it) * | 1973-12-05 | 1976-03-10 | Olivetti & Co Spa | Dispositivo per la lubrificazione delle matrici per la compattazione di materiali in polvere per pezzi sinterizzati |
US3960324A (en) * | 1974-01-10 | 1976-06-01 | International Business Machines Corporation | Method for generation of multiple uniform fluid filaments |
GB1500908A (en) * | 1974-06-05 | 1978-02-15 | Ici Ltd | Process for production of drop streams |
US4153467A (en) * | 1974-09-03 | 1979-05-08 | Dai Nippon Toryo Co., Ltd. | Method of ink jet printing |
US4047866A (en) * | 1976-11-22 | 1977-09-13 | The Dow Chemical Company | Automatic self-lubricating rotary tablet press |
DE2812677A1 (de) * | 1978-03-23 | 1979-10-04 | Gunter M Voss | Verfahren zum bespruehen der verdichtungswerkzeuge von maschinen zur herstellung von formlingen |
US4138687A (en) * | 1977-07-18 | 1979-02-06 | The Mead Corporation | Apparatus for producing multiple uniform fluid filaments and drops |
US4188635A (en) * | 1977-10-03 | 1980-02-12 | International Business Machines Corporation | Ink jet printing head |
-
1979
- 1979-11-07 ES ES485764A patent/ES485764A1/es not_active Expired
- 1979-11-12 EP EP79104448A patent/EP0011269B1/fr not_active Expired
- 1979-11-12 DD DD79216831A patent/DD146890A5/de not_active IP Right Cessation
- 1979-11-12 DE DE7979104448T patent/DE2965223D1/de not_active Expired
- 1979-11-14 BR BR7907431A patent/BR7907431A/pt not_active IP Right Cessation
- 1979-11-15 AU AU52856/79A patent/AU536460B2/en not_active Ceased
- 1979-11-15 CA CA000339927A patent/CA1159621A/fr not_active Expired
-
1981
- 1981-11-30 US US06/326,168 patent/US4388343A/en not_active Expired - Fee Related
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE29804955U1 (de) * | 1998-03-19 | 1998-12-24 | Quénéhervé, Marianne, 88521 Ertingen | Dosiergerät für pulverförmiges Kolbenschmiermittel |
US11839487B2 (en) | 2010-07-15 | 2023-12-12 | Eyenovia, Inc. | Ophthalmic drug delivery |
US11938056B2 (en) | 2017-06-10 | 2024-03-26 | Eyenovia, Inc. | Methods and devices for handling a fluid and delivering the fluid to the eye |
Also Published As
Publication number | Publication date |
---|---|
ES485764A1 (es) | 1980-10-01 |
AU5285679A (en) | 1980-05-22 |
US4388343A (en) | 1983-06-14 |
AU536460B2 (en) | 1984-05-10 |
DD146890A5 (de) | 1981-03-11 |
CA1159621A (fr) | 1984-01-03 |
BR7907431A (pt) | 1980-08-05 |
DE2965223D1 (en) | 1983-05-19 |
EP0011269A1 (fr) | 1980-05-28 |
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