EP3439612B1 - Dispositif et procédé de dosage de substances actives pour la préparation de médicaments - Google Patents

Dispositif et procédé de dosage de substances actives pour la préparation de médicaments Download PDF

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Publication number
EP3439612B1
EP3439612B1 EP17724616.2A EP17724616A EP3439612B1 EP 3439612 B1 EP3439612 B1 EP 3439612B1 EP 17724616 A EP17724616 A EP 17724616A EP 3439612 B1 EP3439612 B1 EP 3439612B1
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EP
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Prior art keywords
droplets
dosing
active agent
substrate
nozzle
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Active
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EP17724616.2A
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German (de)
English (en)
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EP3439612A1 (fr
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Jan Franck
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Individual
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Individual
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/005—Coating of tablets or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B41—PRINTING; LINING MACHINES; TYPEWRITERS; STAMPS
    • B41F—PRINTING MACHINES OR PRESSES
    • B41F17/00—Printing apparatus or machines of special types or for particular purposes, not otherwise provided for
    • B41F17/36—Printing apparatus or machines of special types or for particular purposes, not otherwise provided for for printing on tablets, pills, or like small articles

Definitions

  • the invention relates to a method and a device for dosing active substances for the preparation of medicaments.
  • a method and such an apparatus are out WO201012470 known.
  • the term “medicament” is not only intended to encompass medicinal products for the treatment of diseases, but also preventive medicinal products such as vaccines, or cosmetic articles such as beauty pills, or healthy preparations such as dietary supplements or tablets with certain vitamins or minerals such as magnesium, Zinc, iron, etc.
  • the problem initiating the invention results, to create a metering device and a metering device for the preparation of medicaments, which can be controlled individually, so that a medicament can be prepared individually with high accuracy.
  • This problem is solved in the context of a generic dosing process by storing one or more active ingredients dissolved in a liquid in a storage container, and for dosing a number of drops corresponding to the desired amount of active ingredient is actively passed through a nozzle onto a substrate or into a Pressed receptacle.
  • the device used to carry out the method comprises at least one storage container for storing a liquid together with one or more active ingredients dissolved therein, and a nozzle for actively squeezing out a number of drops corresponding to the desired amount of active ingredient onto a substrate or into a collecting vessel.
  • pharmacies or patient-related pharmaceutical companies would, for example, enable pharmacies or patient-related pharmaceutical companies to be able to create the right medication for a patient based on a medically prescribed total medication, e.g. in the form of a liquid, but possibly also enclosed in gel beads, etc.
  • the patient would therefore be relieved of the responsibility to always select and take the types of medication required per meal from a large number of medication packs.
  • a device having a number of at least corresponding to the required number of active substances Containers, in which just now an active ingredient or a typical active ingredient composition is contained in dissolved, liquid form, and by entering the desired types and amounts of active ingredient in a control device, the desired active ingredients in appropriate doses are then injected through nozzles into a collecting vessel or onto another, For example, sprayed absorbent substrate and thereby put together.
  • each active ingredient or typical active ingredient composition for spraying exactly the liquid contained in the connected storage container.
  • the active substance liquids stored in the storage containers do not mix, and any active substance liquid that is not required and is therefore collected is returned exactly to its original storage container.
  • the different active ingredients do not mix, and it is therefore possible to differentiate precisely between the different active ingredients even after a longer production period.
  • spray devices are used which can be used for nozzle heads working according to the continuous ink jet method or according to the ink jet printing method, droplets being generated continuously, but droplets which are not required may be deflected, caught and returned.
  • the method according to the invention according to claim 1 can preferably be characterized by one or more of the following features:
  • the method can be designed in such a way that drops are continuously generated, of which, however, depending on the desired amount of active ingredient, only the drops required for this are pressed onto a substrate or into a collecting vessel, while the drops not required are collected and returned to the storage container.
  • the differentiation between required drops and unnecessary drops can be made by differently deflecting the drop jet.
  • the drops After passing through an inner dosing nozzle, the drops can be charged electrically on a charging electrode.
  • the electrically charged drops can be deflected differently between two deflecting electrodes, so that required drops get onto a substrate or into a collecting vessel, while unnecessary drops get to a collecting device, from where they are returned to the storage container.
  • a print head of a continuous ink jet printer can be used as the metering device.
  • the at least one dosing device and / or the at least one dosing nozzle and / or the at least one deflection device should be disinfected before the start of the medicament preparation and / or at regular intervals.
  • the device according to the invention as claimed in claim 6 can preferably be characterized by one or more of the following elements or features:
  • an activator for the at least one dosing nozzle which constantly produces drops, of which, depending on the desired amount of active substance, only the drops required for this are pressed onto a substrate or into a collecting vessel, while the drops not required are collected and returned to the storage container .
  • At least one deflection device which exerts a different degree of deflection on required drops and on unnecessary drops.
  • At least one charging electrode arranged outside the at least one metering nozzle in order to charge the drops electrically after passing through the at least one metering nozzle.
  • deflection electrodes arranged after the at least one charging electrode, in order to deflect the electrically charged drops to different extents, depending on their determination, so that the required drops drop get a substrate or into a collecting vessel, while unnecessary drops reach at least one collecting device, from where they are returned to the storage container.
  • the at least one metering nozzle, the at least one charging electrode and / or the deflecting electrodes can be components of at least one print head of a continuous ink jet printer.
  • metering devices in particular with one metering nozzle and / or each with one metering nozzle unit, can be arranged in a row.
  • Exactly one active substance storage container can be assigned to each dosing device and / or each dosing nozzle and / or each dosing nozzle unit.
  • the active ingredient metering device and / or the at least one metering device, and / or the at least one metering nozzle, and / or the at least one deflecting device, and / or the at least one metering nozzle device can be arranged in a stationary manner, that is to say not on a movable carriage.
  • the invention undergoes a preferred development through one or more of the following elements and / or features: Through one or more receptacles to collect the required drops of a dosed active ingredient, especially for the preparation of liquid medication.
  • a device for generating a relative movement between one or more active substance collecting vessels relative to the at least one active substance metering nozzle in particular in the form of a transport device for one or more active substance collecting vessels.
  • a device for generating a relative movement between one or more tablet-shaped substrates relative to the at least one active substance metering device and / or metering nozzle device in particular in the form of a transport device for one or more tablet-shaped substrates.
  • the conveying direction of the transport device can be parallel to the row of the several metering devices and / or metering nozzle devices or (inner) metering nozzles.
  • the invention is preferably further characterized by a control device for the deflection electrodes of the at least one metering device and / or metering nozzle device.
  • This control device can be designed in such a way that drops are only released onto the substrate or collecting vessel if this is located at a location provided along the conveying direction.
  • this control device can also be designed such that different drops hit the substrate or collecting vessel at different locations or grid fields.
  • this control device can also be designed in such a way that a predefined number of drops are dispensed onto the substrate or collecting vessel for each type of active substance.
  • the at least one dosing device and / or dosing nozzle device and / or the at least one deflection device should be disinfected.
  • medicaments can be produced in various forms, for example in the form of tablets, particles for use in capsules, juices, ointments, aerosols or infusion and other solutions.
  • a low-viscosity active ingredient or a low-viscosity active ingredient solution is dispensed in metered form onto a solid substrate or into a liquid solvent.
  • Solid substrates in tablet form and liquids such as, for example, juices, infusion or other solutions can then be immediately packaged and shipped and / or administered.
  • the drug particles are still enclosed in the capsules; in the case of creams or other viscous medications such as syrups, the substances should be stirred before packaging or administration.
  • Fig. 1 Active substance dosing device 1 shown Fig. 1 is specially designed for the production of medication in the form of tablets, but could also be used in almost unchanged form for the production of medication in other forms of administration.
  • Fig. 1 on the right are several tablet-shaped substrate bodies 2 for receiving active substances.
  • the tablet-shaped substrate bodies 2 are, for example, "tablet blanks", that is to say tablet bodies from a health point of view harmless, degradable substance in the digestive tract, which should, however, be absorbent, i.e. porous, in order to be able to absorb and retain an active substance.
  • Such a tablet-shaped substrate body 2 could therefore be pressed from a powder into a typical tablet shape.
  • the tablet body 2 could possibly already contain preservatives so that an active ingredient which has been absorbed remains longer-lasting; however, it should still be free of active substances itself, so that those can be dosed individually into the tablet-shaped substrate body 2 with the dosing device 1 according to the invention.
  • the tablet-shaped substrate bodies 2 are, for example, in troughs 3. These can be troughs of a so-called blister tray 4, i.e. troughs 3 in a flat plate or in a flat band, which ensures that the tablet-shaped substrate bodies 2 are always in precisely specified positions, namely within the troughs 3.
  • the troughs 3 could also be incorporated in a correspondingly preformed film, which can later be completed to form a blister card.
  • a film provided with corresponding troughs 3 for a later blister card could also be placed on a blister tray 4 in such a way that a trough 3 of the film engages precisely in a trough 3 of the blister tray 4 so that through the blister tray 4 has a centering alignment of the film provided with depressions 3 and, in turn, a corresponding alignment of the tablet-shaped substrate bodies 2 accommodated therein.
  • medicaments according to the invention can also be packaged in the form of tubular blisters or cup blisters.
  • a conveyor device is preferably provided, for example, to hold a blister tray 4 and / or a film provided with depressions 3 in one To convey conveying direction 5, wherein the conveying direction 5 is preferably horizontal.
  • metering devices 6A, 6B, 6C there are one or more (three in the example shown) metering devices 6A, 6B, 6C.
  • a plurality of metering devices 6A, 6B, 6C are preferably arranged in a row one behind the other, this row then running parallel to the conveying direction 5.
  • the (three in the example shown) metering devices 6A, 6B, 6C are arranged one behind the other in the conveying direction 5.
  • the metering devices 6A, 6B, 6C are preferably not arranged to be movable, that is to say in particular not on slides or the like, but are preferably permanently installed, that is to say fixed in place.
  • a possibility can be provided, for example, in order to be able to lift or dismantle it for the purpose of disinfection, maintenance, repair and / or replacement.
  • the conveying direction 5 and their conveying speed alone determine the relative movement between the metering devices 6A, 6B, 6C on the one hand and the tablet-shaped substrate bodies 2 transported past them on the other hand.
  • Each metering device 6A, 6B, 6C has a metering nozzle unit 7A, 7B, 7C, which is preferably arranged on the underside thereof, the direction of discharge of which is directed precisely at a tablet-shaped substrate body 2 located below or transported past.
  • the offset of adjacent metering nozzle units 7A, 7B, 7C in the conveying direction 5 is preferably equal to the offset of two adjacent troughs 3 of the blister tray 4. This has the consequence that at certain times one metering nozzle unit 7A, 7B, 7C is located precisely above one tablet-shaped substrate body 2 each.
  • Each metering device 6A, 6B, 6C is fed with a liquid A, B, C from a storage container 9A, 9B, 9C via a respective first hose 8A, 8B, 8C, the liquids A, B, C optionally being can act different liquid active substances and / or different active substances dissolved in a liquid.
  • a separate feed pump 10 can be provided in each hose 8A, 8B, 8C Fig. 1 is not shown, but only in Fig. 2 which shows a metering device 6 as an example for the plurality of metering devices 6A, 6B, 6C, which are preferably structurally identical to one another.
  • each metering device 6A, 6B, 6C is coupled to the respectively assigned storage container 9A, 9B, 9C via a second hose 11A, 11B, 11C.
  • hoses 11A, 11B, 11C liquid A, B, C which is not required can flow back into the storage containers 9A, 9B, 9C.
  • FIG. 2 The schematic representation of an individual metering device 6 in Fig. 2 serves to explain their mode of action. However, following the process sequence, the metering device 6 is shown in a horizontal position, the outer nozzle or nozzle unit 7 being on the right, although it is in accordance with FIG Fig. 1 is usually used in a vertical position, the outer nozzle or nozzle unit 7 being at the bottom.
  • the pump 10 conveys the active substance liquid 12 from the respective storage container through the assigned first hose 8 into a chamber 13 within the relevant metering device 6.
  • the chamber 13 has an inner nozzle 14 and an at least partially movable edge section 15, which is deflected via an actuator arranged behind it, for example a piezo actuator 16 can.
  • This (piezo) actuator 16 is connected to a control device, not shown in the drawing, which specifies its respective deflection and thus the position of the movable edge section 15.
  • the edge section 15 of the chamber 13 is moved outwards, that is to say away from the chamber 13, the active substance liquid 12 is drawn into the chamber 13 from the first hose line 8. If the edge section 15 then swings into the chamber 13, controlled by the (piezo) actuator 16, then a drop 17 of the active substance liquid 12 is moved out of the chamber 13 at high speed through the inner nozzle 14.
  • This drop 17 initially flies through a pair of charging electrodes 18, where it charges itself electrically.
  • These pairs of deflection electrodes 19, 20 have two functions:
  • the piezo actuator 16 is usually controlled with an uninterrupted alternating voltage with a frequency set to the resonance frequency of the chamber 13, so that drops 17 are constantly produced in short time intervals, that is to say even when there is there is currently no tablet-shaped substrate body 2 at the desired position in the area or below the metering nozzle unit 7. So that these drops 17 are not wasted, at least one pair of deflection electrodes 19, 20 is actuated for such actually superfluous drops 17 in such a way that the drop 17 in question is strongly deflected, in the direction of a collecting unit 21 in the relevant one Dosing device 6, from where the collected liquid 12 is then returned via the second hose 11 to the reservoir 9 and is therefore not lost.
  • the trajectory of a drop 17 with the deflecting electrode pairs 19, 20 is controlled such that it hits the tablet-shaped substrate body 2; provided that sufficient drops 17 of the active substance 12 in question have not already been dispensed onto that substrate body 2.
  • the surface 22 of the tablet-shaped substrate body 2 facing the metering nozzle unit 7 is virtually divided into a grid 23 with a plurality of fields 24, which are preferably subdivided into rows 25 and columns 26, similar to a matrix or a chess board.
  • virtual means that the grid 23 is not actually present on the substrate body 2 or in any case does not have to be present there, but is only stored in a control unit which is then able to control the deflection electrodes 19, 20 in such a way that a drop 17 hits exactly a predetermined field 24 of the grid 23, that is to say hits the surface 22 of the substrate body 2 in exactly the desired row 25 and column 26.
  • All metering devices 6A, 6B, 6C are preferably connected to a common control.
  • a higher-level control program can then be stored there, which assigns an active substance liquid A, B, C to each field 24 of the grid 23.
  • This control can then cause the different metering devices 6A, 6B, 6C to set different drops 17 one after the other in such a way that each field 24 is composed of only one drop 17 with the associated active substance liquid A, B, C is hit and therefore the substrate body is not locally flooded with a liquid 12.
  • metering devices 6A, 6B, 6C do not print simultaneously on the same substra body 2, but on different substrate bodies 2 which follow one another in series, either on substrate bodies 2 immediately following one another or possibly even on substrate bodies 2 which do not even succeed one another.
  • the time interval which elapses in order to transport a substrate body from the dosing unit 6A (or 6B) to the next dosing unit 6B (or 6C) at the speed of the conveyor along the conveying direction 5 gives the substrate body 2 sufficient time to absorb the active ingredient liquid A , B soak up before the next active substance liquid B, C is applied.
  • FIG. 4a At the first metering station or metering device 6A, only a first active substance liquid A was initially applied to the tablet-shaped substrate body 2, specifically to the fields 24 marked by hatching to the top right. Each of these hatched fields 24 can contain one or more drops 17 have received the active ingredient liquid A.
  • a second active substance liquid B has already been applied to the tablet-shaped substrate body 2 at the second dosing station or dosing device 6B, specifically to the dotted fields 24 next to or between the hatched fields 24.
  • Each of these dotted fields 24 can have one or received several drops 17 of the active ingredient liquid B.
  • FIG. 4c the finished state, in addition to which a third active substance liquid C was additionally applied to the tablet-shaped substrate body 2 at the third metering station or metering device 6C, specifically to the dashed fields 24 next to or between the hatched and dotted fields 24.
  • Each of these dashed lines Fields 24 may have received one or more drops 17 of the active substance liquid C.
  • a film with a plurality of tablet-shaped substrate bodies 2, each of which is accommodated in troughs 3 and soaked with active substance liquids A, B, C, is transported to such an extent that it has arrived beyond all metering devices 6A, 6B, 6c, it can be carried out immediately
  • the following packaging station is covered with a card and welded to the jender to produce a finished blister card.
  • a closed blister card can then fall, for example, into a container, for example into a shipping carton, in which it finally reaches the patient or other consumer.
  • a certain active substance liquid A is first applied to certain fields 24 one above the other and later another active substance liquid B or C.

Claims (15)

  1. Procédé de dosage de substances actives pour la préparation de médicaments, en ce que
    - une ou plusieurs substances actives (A, B, C) sont dissoutes chacune dans un liquide (12) et stockées dans un récipient de stockage (9), et
    - pour le dosage d'un nombre de gouttes (17) correspondant à la quantité souhaitée de substances actives (A, B, C), c'est-à-dire pas seulement sous l'influence de la force de gravité, sont projetées activement par le biais d'une buse de dosage (7, 14) sur un substrat (2) ou dans un récipient collecteur,
    - caractérisé en ce que les gouttes (17) sont absorbées par un substrat (2) absorbant, sous forme de compriméou par un solvant liquide.
  2. Procédé selon la revendication 1, caractérisé en ce que des gouttes (17) sont produites en continu dont, toutefois en fonction de la quantité souhaitée de substances actives (A, B, C), seules les gouttes (17) qui y sont nécessaires sont projetées sur un substrat (2) ou dans un récipient collecteur tandis que les gouttes (17) non nécessaires sont recueillies et redirigées dans le récipient de stockage (9), en ce que de préférence la distinction entre gouttes (17) nécessaires et gouttes (17) non nécessaires se fait par déviation différente du jet de gouttes.
  3. Procédé selon l'une des revendications 1 à 2, caractérisé en ce que les gouttes (17) après le passage d'une buse de dosage interne (14) sont chargées électriquement à une électrode de charge (18), en ce que de préférence les gouttes (17) chargées électriquement en fonction de leur destination sont déviées différemment entre deux électrodes de déviation (19, 20), de sorte que des gouttes (17) nécessaires pénètrent sur un substrat (2) ou dans un récipient collecteur tandis que des gouttes (17) non nécessaires pénètrent dans un dispositif récepteur (21) d'où elles sont redirigées vers le récipient de stockage (9).
  4. Procédé selon l'une des revendications précédentes, caractérisé en ce que plusieurs gouttes de substances actives (17) sont déviées différemment, de sorte qu'elles ont un impact à différents points sur un substrat (2), en ce que de préférence plusieurs gouttes de substances actives (17) sont déviées différemment dans deux orientations dans l'espace, de sorte qu'elles ont un impact au niveau de différents champs (24) d'une grille (23) sur un substrat (2).
  5. Procédé selon l'une des revendications précédentes, caractérisé en ce que plusieurs gouttes (17) de substances actives identiques ou différentes (A, B, C) sont déviées aux mêmes points ou champs (24) d'une grille (23) sur un substrat (2).
  6. Dispositif de dosage de substances actives (1) pour la préparation de médicaments comprenant
    - au moins un récipient de stockage (9) destiné au stockage d'un liquide (12) ainsi que d'une ou de plusieurs substances actives (A, B, C) qui y sont dissoutes; et
    - au moins une buse de dosage (7, 14) destinée à projeter activement un nombre de gouttes (17) correspondant à la quantité souhaitée de substances actives, c'est-à-dire pas seulement sous influence de la force de gravité, sur un substrat (2) ou dans un récipient collecteur,
    - caractérisé par un substrat (2) absorbant, sous forme de comprimé pour absorberles gouttes (17) ou un solvant dans le récipient collecteur pour dissoudre les gouttes.
  7. Dispositif (1) selon la revendication 6, caractérisé par un activateur (16) pour au moins une buse de dosage (14) laquelle produit des gouttes (17) en continu dont, toutefois en fonction de la quantité souhaitée de substances actives (A, B, C), seules les gouttes (17) qui y sont nécessaires sont projetées sur un substrat (2) ou dans un récipient collecteur tandis que les gouttes (17) non nécessaires sont recueillies et redirigées dans le récipient de stockage (9).
  8. Dispositif (1) selon la revendication 6 ou 7, caractérisé par au moins un dispositif de déviation lequel exerce une déviation de différente importance sur des gouttes (17) nécessaires et des gouttes (17) non nécessaires.
  9. Dispositif (1) selon l'une des revendications 6 à 8, caractérisé par au moins une électrode de déviation (18) disposée en dehors d'au moins une buse, de dosage (14) afin de charger électriquement les gouttes (17) après passage d'au moins une buse de dosage (14), comportant de préférence des électrodes de déviation (19, 20) disposées en aval d'au moins une électrode de charge (18) pour dévier de manière différente les gouttes (17) chargées électriquement en fonction de leur destination, de sorte que des gouttes (17) nécessaires pénètrent sur un substrat (2) ou dans un récipient collecteur tandis que des gouttes (17) non nécessaires parviennent au moins à un dispositif collecteur (21) d'où elles sont redirigées vers un récipient de stockage (9), et/ou comportant de préférence deux paires d'électrodes de déviation (19, 20) qui sont tournées de 90° l'une par rapport à l'autre dans le sens de vol des gouttes (17) pour dévier les gouttes (17) chargées électriquement à différents points ou champs (24) d'une grille (23) du substrat (2).
  10. Dispositif (1)selon l'une des revendications 6 à 9, caractérisé en ce que plusieurs dispositifs de dosage (6A, 6B, 6C), en particulier avec chacun une buse de dosage (14) et/ou avec chacun une unité de buse de dosage (7A, 7B, 7C) sont disposés en série, en ce que exactement un récipient de stockage de substances actives (9A, 9B, 9C) est associé de préférence à chaque dispositif de dosage (6A, 6B, 6C), et/ou à chaque buse de dosage (14), et/ou à chaque unité de buse de dosage (7A, 7B, 7C).
  11. Dispositif (1) selon l'une des revendications 6 à 10, caractérisé en ce que le dispositif de dosage de substances actives (1) et/ou au moins un dispositif de dosage (6A, 6B, 6C), et/ou au moins une buse de dosage (14), et/ou au moins un dispositif de déviation (18, 19, 20), et/ou au moins un dispositif de buse de dosage (7A, 7B, 7C) est disposé de manière stationnaire, donc pas sur un chariot mobile.
  12. Dispositif (1) selon l'une des revendications 6 à 11, comportant un ou plusieurs récipients collecteurs servant à recueillir les gouttes (17) nécessaires d'une substance active (A, B, C) dosée, en particulier pour la préparation de médicaments liquides, et comportant en outre un dispositif générant un mouvement relatif (5) entre un ou plusieurs récipients collecteurs de substances actives par rapport à au moins une buse de dosage de substances actives (7A, 7B, 7C, 14), en particulier sous forme de dispositif de transport pour un ou plusieurs récipients collecteurs de substances actives.
  13. Dispositif (1) selon l'une des revendications 6 à 11, comportant un ou plusieurs substrats (2) de préférence sous forme de comprimé pour recueillir la substance active dosée (A, B, C), en particulier pour l'imprégnation avec la substance active dosée (A, B, C), ainsi que comportant en outre un dispositif générant un mouvement relatif (5) entre un ou plusieurs substrats (2) sous forme de comprimé par rapport à au moins l'un des dispositifs de dosage de substances actives (6A, 6B, 6C) et/ou dispositif de buse de dosage (7A, 7B, 7C), en particulier sous forme d'un dispositif de transport pour un ou plusieurs substrats (2) sous forme de comprimé.
  14. Dispositif (1) selon la revendication 10 en association avec la revendication 12 ou 13, caractérisé en ce que lesens de transport du dispositif de transport est parallèle à la série de plusieurs dispositifs de dosage (6A, 6B, 6C) et/ou dispositifs de buse de dosage (7A, 7B, 7C) ou buses de dosage (internes) (14).
  15. Dispositif (1) selon l'une des revendications 6 à 14, caractérisé par un dispositif de commande pour les électrodes de déviation (19, 20) d'au moins un dispositif de dosage (6A, 6B, 6C) et/ou dispositif de buse de dosage (7A, 7B, 7C),
    en ce que le dispositif de commande est de préférence tel
    - que des gouttes (17) ne sont déposées sur le substrat (2) ou le récipient collecteur que si celui-ci se trouve à un point prévu à cet effet dans le sens de transport (5),
    - et/ou de préférence tel que différentes gouttes (17) atteignent le substrat (2) ou le récipient collecteur à des points différents ou des champs de grille (24),
    - et/ou de préférence tel qu'un nombre prédéfini de gouttes par type de substance active (A, B, C) est déposé sur le substrat (2) ou le récipient collecteur.
EP17724616.2A 2016-04-05 2017-04-05 Dispositif et procédé de dosage de substances actives pour la préparation de médicaments Active EP3439612B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102016003872 2016-04-05
PCT/IB2017/000390 WO2017175057A1 (fr) 2016-04-05 2017-04-05 Dispositif et procédé de dosage de substances actives pour la préparation de médicaments

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WO2017175057A1 (fr) 2017-10-12
US11285082B2 (en) 2022-03-29
US20190159970A1 (en) 2019-05-30

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